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师资队伍
杰出人才
博士后

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尚先梅

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尚先梅:女,博士,副教授。2000年7月至今任教于华中科技大学同济医学院药学院。其间,曾于2009年4月至2010年8月在葡萄牙里斯本技术大学从事博士后研究。

讲授科目:基础有机化学;高等有机化学。

主要研究方向:有机金属药物的设计与合成。

通讯地址:华中科技大学同济医学院药学院,武汉市航空路13号,430030

办公地点:药学院一号楼613室

Email: shangxianmei@hust.edu.cn

近年来发表的部分论文:

(1)Xianmei Shang, Telma F.S. Silva, Lu.iacute;sa M.D.R.S. Martins, Qingshan Li, M. F´tima C. Guedes da Silva, Maxim L. Kuznetsov, Armando J.L. Pombeiro.Synthesis, characterization, electrochemical behavior and in vitro protein tyrosine kinase inhibitory activity of the cymenehalogenobenzohydroxamato [Ru(η6-cymene)(bha)Cl] complexes.Journal of Organometallic Chemistry,2013, 730, 137-143.

(2)Xianmei Shang*, Shaozhong Wei, Jia Yan, Jianping Wang.Synthesis, characterization and cytotoxicity of novel mixed-ligand butyl-hexyltin(IV) complexes with N-hydroxybenzamides.Polyhedron,2013, 52, 429-434.

(3)Xianmei Shang*, Nan Ding, Guangya Xiang*.Novel di-n-butyltin(IV) derivatives: synthesis, high levels of cytotoxicity in tumor cells and the induction of apoptosis in KB cancer cells.European Journal of Medicinal Chemistry,2012, 48, 305-312.

(4)Xianmei Shang, Elisabete C.B.A. Alegria, M. F.tima C. Guedes da Silva, Maxim L. Kuznetsov, Qingshan Li, Armando J.L. Pombeiro, Redox-active cytotoxic diorganotin(IV) cycloalkylhydroxamate complexes with different ring sizes: Reduction behaviour and theoretical interpretation.Journal of Inorganic Biochemistry,2012, 117, 147–156.

(5)Xianmei Shang,Xianggao Meng,Elisabete C.B.A. Alegria,Qingshan Li,M.Fatima C. Guedes da Silva, Maxim L. Kuznetsov,and Armando J.L. Pombeiro.Syntheses, Molecular Structures, Electrochemical Behavior, Theoretical Study, and Antitumor Activities of Organotin(IV) Complexes Containing 1-(4-Chlorophenyl)-1-cyclopentanecarboxylato Ligands.Inorganic Chemistry,2011, 50(18), 8158-8167.

(6) Wang, Jian-ping; Zhou, Ya-ming; Ye, Yu-jie;Shang, Xian-mei; Cai, Ya-ling; Xiong, Chao-mei; Wu, Yun-xia; Xu, Hai-xing. Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis.Journal of Ethnopharmacology,2011, 137(3), 1089-1094.

(7)Xianmei Shang; Xianggao Meng; Qingshan Li,Synthesis, structure andin vitroantitumor activity of a multinuclear diorganotin(IV) complex (n-Bu)4Sn2{2,5-F2C6H3C(=O)NHO}2{2,5-F2C6H3C(=NO)O}]2.Chinese Journal of Chemistry,2010, 28(2), 289-293.

(8)Xianmei Shang; Jingrong. Cui; Jizhou Wu; Armando J.L. Pombeiro; Qingshan. Li,Polynuclear diorganotin(IV) complexes with arylhydroxamates: syntheses, structures andin vitrocytotoxic activities.Journal of Inorganic Biochemistry,2008, 102(4), 901-909.

(9) Yunlan Li; Li Yang; Xiaoqiang Niu;Xianmei Shang; Jianping Guo; Qingshan Li, Syntheses and antitumor activity of a new mixed-ligand complexdi-n-butyl-(4-chlorobenzohydroxamato)tin(IV) chloride.Journal of Inorganic Biochemistry,2008, 102(9), 1731-1735.

(10)Xianmei Shang; Jizhou Wu; Qingshan Li, Interaction of dialkyltin(IV)bishydroxamateswith 5’-AMP or DNA: the impact of carbon chainlength to coordination properties.Chinese Journal of Chemistry,2008, 26(4), 627-630.

(11)XianmeiShang; Xianggao Meng, Crystal structure, spectroscopic and coordination properties of bis(4-fluorobenzohydroxamato)dimethyltin(IV).Chinese Journal of Structural Chemistry,2008, 27(6), 683-686.

(12)尚先梅,吴军,李青山.芳香异羟肟酸有机锡抗癌化合物的初步构效关系,中国科学B.2008, 38(5), 429-440.

(13)Xianmei Shang;Jizhou Wu; Armando J.L. Pombeiro; Qingshan Li,Mononuclear diorganotin(IV) complexes with arylhydroxamates: syntheses, structures and assessment ofin vitrocytotoxicity.Applied Organometallic Chemistry,2007, 21(11), 919-925.

(14)Xianmei Shang; Jizhou Wu; Qingshan Li, New coordination modes of substituted benzohydroxamic acid with dialkyltin(IV): structural diversity through ligand isomerization.European Journal of Inorganic Chemistry,2006, 4143-4150.

(15)Xianmei Shang; Jizhou Wu; Qingshan Li, Synthesis and crystal structure of a novel diorganotin(IV) complex containing 3,4-difluorobenzohydroxamato ligand.Chinese Chemical Letters,2006, 17(6), 821-824.

(16)Xianmei Shang; Qingshan Li; Jizhou Wu, Synthesis and crystal structure of a mixed-ligand compound di-n-butyl(4-chlorobenzoxy)(4-chlorobenzohydroxam ato)tin(IV).Journal of Organometallic Chemistry,2005,690(17),3997-4000.

主持的在研项目:

2012.1-2014.12,国家自然科学基金青年基金《新型有机金属化合物的抗癌构效关系及其诱导肿瘤细胞凋亡机制研究》(81102311)。

获奖:

1、2005年获华中科技大学研究生(博士)优秀论文奖和科技创新奖。

2、2007年4月被评为华中科技大学“优秀青年教工”;。

3、2009年2月,《芳香异羟肟酸有机锡抗癌化合物的构效关系、作用机制及药代动力学》获山西省自然科学二等奖(排名第三)。

4、2012年11月,获华中科技大学教学质量优秀奖二等奖。

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030