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师资队伍
杰出人才
博士后

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万谦

来源: 发布时间 2017-02-07 10:16:17 点击数:

万谦, 教授


电子信箱:wanqian@hust.edu.cn

地址: 武汉市航空路13号华中科技大学同济医学院药学院 430030

工作经历:

2014 今 副院长,华中科技大学同济药学院

2012 今 教授,博士生导师,华中科技大学同济药学院

2007 2011 研究科学家, 美国安进制药, 药物化学部

2004 2007 博士后,美国哥伦比亚大学,斯隆-凯特林癌症研究中心

2000 2004 研究助理, 法国巴黎第十一大学分子与材料化学学院

教育经历:

2007 “药品生产质量管理规范” 课程, 美国斯隆-凯特林癌症研究中心

2000 2004 理学博士, 法国巴黎第十一大学分子与材料化学学院

1999 2000 理学硕士, 法国巴黎第十一大学分子与材料化学学院

1997 1999 硕士研究生, 华中师范大学化学系

1993 1997 理学学士, 华中师范大学化学系

研究领域:

•具有自主知识产权的新药开发

•新的糖化学的合成方法和策略发展

•具有生物活性有机小分子的设计与合成

•自由基化学及水相有机反应

•以糖化合物为基础的抗癌疫苗的研制(设计, 合成及评价)

•生物活性寡糖(包括肿瘤相关寡糖抗原)的合成及活性评价

主要荣誉及主持项目:

2017 Asian Core Program/Advanced Research Network Lectureship Award (from Taiwan)

2017 Asian Core Program/Advanced Research Network Lectureship Award (from Singapore)

2017 2020 国家自然科学基金面上项目No. 21672077 (直接经费:66 万)

2015 2016 华中科技大学自主创新研究基金:创新交叉重点项目(15万)

2016 2019 武汉市创新人才开发资金 (20 万)

2015 华中科技大学 “三育人奖”

2015 2017 湖北省杰出青年基金 No. 2015CFA035 (20 万)

2015 2018 国家自然科学基金面上项目No. 21472054 (85 万)

2014 华中科技大学科技创新活动优秀指导教师

2014 2015 华中科技大学自主创新研究基金: 国际科技合作专项No.2014ZZGH015 (10万)

2014 2015 上海有机化学研究所生命有机化学国家重点实验室开放基金 (5 万)

2013 湖北省特聘专家

2013 2016 国家自然科学基金面上项目No. 21272082 (80 万)

2012 2015 高等学校博士学科点专项科研基金(新教师类)No. 20120142120092 (4 万)

2012 2015 中共中央组织部“千人计划-青年项目”入选者 (200 万)

2012 2015 华中科技大学人才引进基金 (200 万)

2011 美国安进制药“第一届绿色药物化学奖”

2006 美国威廉和爱丽丝·古德温公益癌症研究基金会基金 (13 万美元)

2000 2004 法国外交与欧洲事务部“艾菲尔-优秀人才”国际学生奖学金

专业学会: 美国化学学会、美中生物医药协会、美中医药开发协会、中国化学会

学术兼职: 《Frontiers in Chemical Biology》Review Editor;荆楚理工学院客座教授

《The Pharmaceutical Index-Worldwide 2014 NCEs》编委会委员

专利申请:

3.万谦,苏朋华,曾 静,赵岳琦“一种糖基硫醇及金诺芬的合成方法”CN201410459125.0

2. Danishefsky, S. J.; Zhu, J.;Wan, Q.;Jeon, I.; Kim, W.; Nagorny, P.; Lee, D.; Livingston, P.; Ragupathi, G. “Glycopeptide constructs and uses thereof”. US2011/0229510 A1.

1. Danishefsky, S. J.; Warren, J. D.; Chen, J.; Wu, B.; Chen, G.;Wan, Q.;Tan, Z.; Kan, C.; Yuan. Y.; Hua, Z.; Ranganathan, K.; Trzupek, J. D. “Preparation of homogeneous erythropoietin and other peptides and proteins”. US2010/0081786 A1.

学术专著与教材:

3. Carbohydrate Chemistry: Proven Synthetic Methods 2017, invited contribution

2.《药物化学》(第八版,编委) 人民卫生出版社,2015.

1.Luo, J.;Wan, Q.* “Recent Advances in Gold-Catalyzed Glycosylation”Carbohydrate Chemistry: Chemical and Biological Approaches2014,40, 140-159.

发表论文:

48. Xu, Y.; Zhang, Q.; Xiao, Y.; Wu, P.; Chen, W.; Song, Z.; Xiao, X.; Meng, L.; Zeng, J.; Wan, Q.*Practical Synthesis of Latent Disarmed S-2-(2-Propylthio)benzyl Glycosides for Interrupted Pummerer Reaction Mediated GlycosylationTetrahedron Lett. 2017, 58, 2381.

47. Zeng, J.*; Sun, G.; Yao, W.; Zhu, Y.; Wang, R.; Cai, L.; Liu, K.; Zhang, Q.; Liu, X.; Wan, Q.* “3-Aminodeoxypyranoses in Glycosylation: Diversity-Oriented Synthesis and Assembly in Oligosaccharides” Angew. Chem. Int. Ed. 2017, 56, 5227. (IF: 11.709)

Front Cover Article: Angew. Chem. Int. Ed. 2017, 56, 5133.

《有机化学》“亮点介绍”

Highlighted by Wiley Advanced Science News (ASNChina)2017 April 05

Highlighted by Chemistryviews: A Practical Glycodiversification Method, 2017 April 14

Highlighted by Wiley Advanced Science News (Chemviews)2017 April 18

46. Zeng, J.; Xu, Y.; Wang, H.; Meng, L.;Wan, Q.*“Recent Progress on the Synthesis of 2-Deoxy Glycosides”Sci. China Chem.2017, 60, DOI:10.1007/s11426-016-9010-9. (IF. 2.429). Invited contribution

45. Xiao, X.; Zhao, Y.; Shu, P.; Zhao, X.; Liu, Y.; Sun, J.; Zhang, Q.; Zeng, J.; Wan, Q.* “Remote Activation of Disarmed Thioglycosides in Latent-Active Glycosylation via Interrupted Pummerer Reaction” J. Am. Chem. Soc. 2016, 138, 13402. (IF: 13.038)

Highlighted by X-MOL: http://www.x-mol.com/news/5072

Highlighted by Synpacts, 2017 February.

44.方静,朱阳斌,陈薇,刘艳,孙久常,曾静,万谦*“四乙酰基-d-吡喃岩藻糖的合成”中国科技论文在线, 2016,http://www.paper.edu.cn/releasepaper/content/201605-876.;中国科技论文在线精品论文, 2016, 9 (19): 2030.;Highlights of Sciencepaper Online, 2016, 9 (19): 2030.

43.舒朋华,孙久常,方静,曾静,万谦*“11(S)-药喇叭酸甲酯的制备”中国科技论文在线, 2016,http://www.paper.edu.cn/releasepaper/content/201605-599.;中国科技论文在线精品论文, 2016, 9 (13): 1288.;Highlights of Sciencepaper Online, 2016, 9 (13):1288.

• Highlighted as月热门优秀论文

• Highlighted as周热门新增论文

42.O’Cearbhaill, R. E.; Ragupathi, G.; Zhu, J.;Wan, Q.; Yang, G.; Spassova, M. K.; Iasonos, A.; Kravetz, S.; Mironov, S.; Livingston, P. O.; Ouerfelli, O.; Spriggs, D. R.; Danishefsky, S. J.; Sabbatini, P. J. “A phase I study of unimolecular pentavalent (GLOBO-H-GM2-STN-TF-TN) immunization of patients with epithelial ovarian, fallopian tube, or peritoneal cancer in first remission”Cancers2016,8, 46: doi:10.3390/cancers8040046.

41. Shu, P.; Yao, W.; Xiao, X.; Shun, J.; Zhao, X.; Zhao, Y.; Xu, Y.;Yao, G.; Zeng, J.;Wan, Q.*“Glycosylation via Remote Activation of Anomeric Leaving Groups: Development of 2-(2-Propylsulfinyl)benzyl Glycosides as Novel Glycosyl Donors”Org. Chem. Front.2016,3,177. (IF: 4.693)

• the1stEmerging Investigators Themed Collection

• Hot article in December 2015 (Org. Chem. Front.)

• Abstracted byCheminform47(24), 2016 May.

40. Li, S.; Jin, S.; Song, C.; Chen, C.; Zhang, Y.; Xiang, Y.; Xu, Y.; Feng, Y.;Wan, Q.*; Jiang, H*. “The Metabolic Change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis rhizoma on high-fat diet induced hyperlipidemia mice”J. Ethnopharmacology2016,177, 10.(IF: 3.055).

39. Shu, P.; Xiao, X.; Zhao, Y.; Tao, J.; Wang, H.; Lu, Z.; Yao, G.; Zeng, J.; Wan, Q.* “Interrupted Pummerer Reaction in Latent-Active Glycosylation: A Novel Type of Glycosyl Donors with Recyclable and Regenerative Leaving Group” Angew. Chem. Int. Ed. 2015, 54, 14432. (IF: 11.709).

Highlighted by X-MOL: http://www.x-mol.com/news/1422

7th ACGG 2015 Best Poster Award, Miyagi, Japan,

Abstracted by Cheminform 47(15), 2016 March.

Highlighted by Synpacts, 2017 February.

第三届阿达玛斯学术论文奖“探索优秀奖”

38. Zhang, M.; Xie, Y.; Zhan, G.; Lei, L.; Shu, P.; Chen, Y.; Xue, Y.; Luo, Z.;Wan, Q.; Yao, G.;*Zhang, Y.*“Grayanane and Leucothane Diterpenoids from Rhododendron Micranthum and Their Immunomodulatory Activities”Phytochemistry2015,117, 107.(IF: 2.779)

37. Ma, J.; Zeng, J.;Wan, Q.*“Postligation-Desulfurization: A General Approach for Chemical Protein Synthesis”Topics in Current Chemistry2015,363, 57. (IF: 4.014)

36. Shu, P.; Zeng, J.; Tao, J.; Zhao, Y.; Yao, G.;Wan, Q.*“Selective S-deacetylation Inspired by Native Chemical Ligation:Practical Syntheses of Glycosyl Thiols and Drug Mercapto-analogues”Green Chem.2015,17, 2545. (IF: 8.506)

•第二届阿达玛斯学术论文奖“探索优秀奖”

35. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Zhao, Y.; Xu, Y.; Yao, W.; Zeng, J.;Wan, Q.*“Stereoselective Synthesis of α-linked 2-Deoxy Glycosides Enabled by Visible Light Mediated Reductive Deiodination”Chem. Eur. J.2014,20, 17319.(IF: 5.771)

• Highlighted by Photocatalysis:Wiley-VCH Hot Topics

•第二届阿达玛斯学术论文奖 “探索鼓励奖”

34. Copeland, K. W.; Boezio, A. A.; Cheung, E.; Lee, J.; Olivieri, P.; Schenkel, L. B.;Wan, Q.; Wang, W.; Wells, M. C.; Youngblood, B.; Gavva, N. R.; Lehto, S. G.; Geuns-Meyer, S.Bioorg. Med. Chem. Lett.2014, 3464.(IF: 2.486)

33.张孟科, 朱焰, 詹冠群, 薛永波, 罗增伟,万谦, 姚广民*, 张勇慧, “照山白花水溶性成分研究”,中国科技论文在线, 2014,http://www.paper.edu.cn/releasepaper/content/201401-1247.

32.张孟科, 詹冠群, 雷亮, 薛永波, 罗增伟,万谦, 姚广民*, 张勇慧,“照山白枝叶化学成分研究”,中国科技论文在线, 2014,http://www.paper.edu.cn/releasepaper/content/201401-1244.;中国科技论文在线精品论文, 2015, 8 (17): 1861-1865.;Highlights of Sciencepaper Online, 2015, 8(17):1861-1865.

31. Yang, K.; Li, S.; Wang, Y.; Zhang, W.; Xu, Z.; Zhou, X.;Zhu, R.*; Luo, J.*;Wan, Q.*“Enantio-selective recognition of inherently chiral calyx[4]arene crown-6 carboxylic acid cone conformer towards chiral aminoalcohols”RSCAdvances,2014,4, 6517. (IF: 3.289)

30.Li, S.; Yang, K.; Liu, H., Xia, Y.; Zhu, R.*; Luo, J.*;Wan, Q.*“Inherently chiral biscalixarene conecone conformers consisting of calix[4]arene and calix[5]arene subunits”Tetrahedron Lett.2013,54, 5901. (IF: 2.347)

29.Zhang, M.; Zhu, Y.; Zhan, G.; Shu, P.; Sa, R.; Lei, L.; Xiang, M.; Xue, Y.; Luo, Z.;Wan, Q.; Yao, G.;*Zhang, Y.*“Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum”Org. Lett.2013, 3094. (IF: 6.732)

28.Shi, J.; Li, S.; Xia, X.; Wang, X.;*Luo, J.;*Wan, Q.“An inherently chiral calix[4]crown carboxylic acid in the 1,2-alternate conformation”J. Incl . Phenom. Macrocycl. Chem.2013, 327.(IF: 1.426)

27.Schenkel, L.; Huang, X.; Cheng, A.; Deak, H.; Doherty, E.; Emkey, R.; Gu, Y.; Gunaydin, H.; Kim, J.; Lee, J.; Loberg, R.; Olivieri, P. Pistillo, J.; Tang, J.;Wan, Q.; Wang, H.; Wang, S.; Wells, M.; Wu, B.; Yu, V.; Liu, L.; Geuns-Meyer, S.*“Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors”J. Med. Chem.2011,54, 8440. (IF: 5.447)

26. Yuan, Y.; Chen, J.;Wan, Q.;Wilson, R. M.; Danishefsky, S. J.*“Toward Fully Synthetic, Homogeneous Glycoproteins: Advances in Chemical Ligation ”Biopolymers2010,94, 373. (IF: 2.248)

25. Chen, J.; Wang, P.; Zhu, J.;Wan, Q.;Danishefsky, S. J.*“A Program for Ligation at Threonine Sites: Application to the Controlled Total Synthesis of Glycopeptides”Tetrahedron2010,66, 2277. (IF: 2.645)

• Highlighted as Cover

24. Nagorny, P.; Kim, W. H.;Wan, Q.; Lee, D.; Danishefsky, S. J.*“On the Emerging Role of Chemistry in the Fashioning of Biologics: Synthesis of a Bidomainal Fucosyl GM1-Based Vaccine, for the Treatment of Small Cell Lung Cancer”J. Org. Chem.2009,74, 5157. (IF: 4.785)

• Highlighted as Featured Article

23. Zhu, J.;Wan, Q.;Lee, D.; Yang, G.;Spassova, M. K.;Ouerfelli, O.; Ragupathi, G.; Damani, P.; Livingston, P. O.; Danishefsky, S. J.*“From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine”J. Am. Chem. Soc.2009,131, 9298. (IF: 13.038)

22. Kan, C.; Trupek, J.; Wu, B.;Wan, Q.;Chen, G.; Tan, Z.; Yuan, Y.; Danishefsky, S. J.*“Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala1-Gly28 Glycopeptide Domain by “Alanine” Ligation”J. Am. Chem. Soc.2009,131, 5438. (IF: 13.038)

21. Yuan, Y.; Chen, J.;Wan, Q.;Tang, Z.; Chen, G.; Kan, C.; Danishefsky, S. J.*“Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys29–Gly77 Glycopeptide Domain”J. Am. Chem. Soc.2009,131, 5432. (IF: 13.038)

20. Zhu, J.;Wan, Q.;Ragupathi, G.; George, C. M.; Livingston, P. O.; Danishefsky, S. J.*“ Biologic Through Chemical: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer Orchestration of Oligosaccharide and Polypeptide Domains”J. Am. Chem. Soc.2009,131, 4151. (IF: 13.038)

• Highlighted inACS Chemical Biology2009, 4, 238 (spotlight).

19. Zhu, J.;Wan, Q.;Yang, G.; Ouerfelli, O.; Danishefsky, S. J.*“Synthesis of Human Cancer Associated Globo-H (MBR1) Glycosylamino Acid: Some Mechanistic and Conformational Reinvestigations”Heterocycles, 2009,79, 441. (IF: 1.107)

18. Zhu, J.;Wan, Q.;Danishefsky, S. J.*“Synthesis of Biotinylated Tumor-Associated Carbohydrate Antigens for Immunological Studies”Tetrahedron Lett.2009,50, 712. (IF: 2.347)

17. Chen, J.;Wan, Q.;Yuan, Y.; Zhu, J.; Danishefsky, S. J.*“Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis”Angew. Chem.2008,120, 8649;Angew. Chem. Int. Ed.2008,47, 8521. (IF: 11.709)

16.Wan, Q.;Chen, J.; Yuan, Y.; Danishefsky, S. J.*“Oxo-ester Mediated Native Chemical Ligation: Concept and Applications”J. Am. Chem. Soc.2008,130,15814. (IF: 13.038)

• Highlighted inFaculty of 1000 Biology2009 (article ID 1147955)

15.Wan, Q.;Lubineau, A.; Guillot, R.;Scherrmann, M. -C.*“Synthesis of C-disaccharidesviaa Hetero-Diels-Alder Reaction and Further Stereocontrolled Transformations”Carbohydrate Res.2008,343, 1754-1765. (IF: 1.817).

14.Wan, Q.;Danishefsky, S. J.*“Free Radical Based, Specific Desulfurization of Cysteine: A Powerful Advance in the Synthesis of Polypeptides and Glycopolypeptides”Angew. Chem.2007,119, 9408;Angew. Chem. Int. Ed.2007,46, 9248. (IF: 11.709)

• Highlighted as a Very Important Paper (VIP)

• Highlighted inAngew. Chem. Int. Ed.2008, 47, 1553.

• Abstracted byCheminform2008, 13-185.

13. Chen, G.;Wan, Q.;Tan, Z.; Kan, C.; Hua, Z.;Ranganathan, K.;Danishefsky, S. J.*“ Development of Efficient Methods for Accomplishing Cysteine-Free Peptide and Glycopeptide Coupling”Angew. Chem.2007,119, 7527;Angew. Chem. Int. Ed.2007,46, 7383. (IF: 11.709)

• Highlighted as a Hot Paper

• Abstracted byCheminform2007, 51-199

12. Wu, B.; Tan, T.; Chen, G.; Chen, J.; Hua, Z.;Wan, Q.;Ranganathan, K.;Danishefsky, S. J.*“Mature Homogeneous Erythropoietin Building Blocks by Chemical Synthesis: The EPO 22-37 Glycopeptide Domain Presenting the FullyN-Linked Dodecasaccharide”Tetrahedron Lett.2006,47,8009. (IF: 2.347)

• Abstracted byCheminform2007, 02-181

11. Chen, J.; Chen, G.; Wu, B.;Wan, Q.;Tan, Z.; Hua, Z.; Danishefsky, S. J.*“Mature Homogeneous Erythropoietin Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain Presenting ItsO-Linked Glycophorin”Tetrahedron Lett.2006,47, 8013. (IF: 2.347)

• Abstracted byCheminform2007, 02-182

10.Wan, Q.;Chen, J.; Chen, G.; Danishefsky, S. J.*“A Valuable Advance in the Synthesis of Carbohydrate Based Anticancer Vaccines Through Extended Cycloaddition Chemistry:”J. Org. Chem.2006,71, 8244. (IF: 4.785)

• Abstracted byCheminform2007, 01-187

9. Wu, B.; Hua, Z.; Warren, D. J.;Ranganathan, K.;Wan, Q.;Chen, G.; Tang, Z.; Chen, J.; Endo, A.;Danishefsky, S. J.*“Synthesis of the BiantennaryN-Glycan of Erythropoietin”Tetrahedron Lett.2006,47, 5577. (IF: 2.347)

8. Chen, J.; Warren, D. J.; Wu, B.; Chen, G.;Wan, Q.;Danishefsky, S. J.*“ Synthesis of Cyclic Peptides and Glycopeptides by Native Chemical Ligation Usingin situDerived Thioester”Tetrahedron Lett.2006,47, 1969. (IF: 2.347)

7. Chen, G.; Warren, D. J.; Chen, J.; Wu, B.;Wan, Q.;Danishefsky, S. J.*“New Chemical Ligation Method for Peptide Synthesis: Concept, Model Study, and Mechanistic Investigation”J. Am. Chem. Soc.2006, 7460. (IF: 13.038)

• Highlighted inChem. Eng. News, 2006, 84 (June, 5).

6. Ragupathi, G.; Koide, F.; Livingston, P. O.; Cho, Y. S.; Atsushi, E.;Wan, Q.;Spassova, M. K.; Keding, S. J.; Allen, J.; Ouerfelli, O.; Wilson, R. M.; Danishefsky, S. J.*“Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer: A Synthetic Route to Anticancer Vaccines Candidates”J. Am. Chem. Soc.2006, 2715. (IF: 13.038)

•科学通报 2008, 53, 17, 2126. 动态报道

5.Wan, Q.;Cho, Y. S.; Lambert, T. H.; Danishefsky, S. J.*“Olefin Cross-Metathesis: A Powerful Tool for Constructing Vaccines Composed of Multimeric Antigens.”J. Carbohydr.Chem.2005,24, 425. (IF: 0.738)

4. Cho, Y. S.;Wan, Q.;Danishefsky, S. J.*“Organic Synthesis in Pursuit of Immunology: Large Scale Synthesis of Peracetylated GM2Glycosylamino Acid for Preparation of a Multiantigenic Prostate Cancer Vaccine”Bioorg. Med. Chem.2005,13, 5259. (IF: 2.932)

3.Wan, Q.*“Di-n-butyltin oxide (DBTO)”Synlett.2004, 1847. (IF: 2.323)

2.Wan, Q.;Lubineau, A.*; Scherrmann, M. -C.*“Synthesis ofC-3 branched allyl and pentadienyl glucosaminesviaradical coupling of sugar-thionocarbonates.”J. Carbohydr.Chem.2004,23, 83. (IF: 0.738)

• Abstracted byCheminform2004, 41-190

1. Yu, X.Y.; Lu, B. X.;Wan, Q.;Wang, Y. G.*“Synthesis and biological activity of Schiff base on carboxylate of triazole.”J. Central China Normal. University. (Natural Sciences).1999,225.

邀请及口头报告:

23. 第十三届SINO-US华人化学教授会议,南通-如东,20176

22. 254th ACS National Meeting, Washington D. C. U.S.A., Auguest 20-24, 2017.

21. 第二届糖合成化学青年学术研讨会,山东大学,济南,2017513

20. 山东大学化学与化工学院,济南,2017512

19.第二届糖合成化学青年学术研讨会,山东大学,济南,2017年5月

18.日本化学会年会,The 7th CCS-CSJ Joint Forum, Keio University, 东京,18 March, 2017.

17.瑶湖讲坛,国家单糖化学合成工程技术研究中心,江西师范大学, 南昌, 2016 年12月27日

16.国家糖工程技术研究中心,山东大学,济南,2016年11月22日

15.中国化学会第十一届全国天然有机化学学术会议, 上海, 25-28 September, 2016.

14.中国化学会第30届学术年会, 大连理工大学,4 July, 2016.

13.华中师范大学,武汉,2015年12月11日

12.化学生物学发展调研暨青年学术研讨会,西安,2015年12月7日

11.山东大学,济南, 2015年6月1日

10.中国海洋大学,青岛,2015年5月29日

9.扬州大学, 2015年4月24日

8.糖合成化学青年高峰论坛,南昌,江西师范大学, 2015年4月11日

7.中国化学会第29届学术年会, 北京大学, 6 August, 2014.

6. 2014全国糖生物学学术会议,西安,18 July, 2014.

5. Frontier Research in Advanced Organic Synthesis and Catalysis, Wuhan University, May 28, 2014 .

4.武汉工程大学,2014年4月25日.

3.华中科技大学基础医学院第二期青年学术论坛,2014年4月10日.

2.“千人计划”常州化工新材料产业发展高峰论坛, 2013年7月21日.

1. 2013International Symposium of Frontier Sciences on New Drug Discovery and Symposium of Medicinal Chemistry and Antibiotics of Pharmaceutical Association of Hubei Province, Wuhan University, Wuhan, Hubei, China, December 24, 2013.

会议论文:

31. Zhao, Y. ; Liu, Y. ; Sun, G. ; Xiao, X. ; Zhao, X. ; Shu, P. ; Meng, L. ; Zeng, J. ; Wan, Q.* “苯乙醇苷类天然产物的发散性合成”第二届糖合成化学青年学术研讨会,山东大学,济南,2017年5月13日

30.赵岳琦,肖雄,刘艳,赵翔,舒朋华,张茜,孟令奎,曾静,万谦* “生物活性苯乙醇苷类天然产物的全合成”2016 年华中地区药物化学学术会议暨国际药学前沿科学研讨会 (2016 International Symposium of Frontier Sciences on New Drug Discovery and Central China Symposium on Medicinal Chemistry),武汉大学, October, 27-28, 2016.

• Best Poster Award

29.肖雄,赵岳琦,舒朋华,赵翔,刘艳,孙久常,张茜,孟令奎,曾静,万谦* “基于Interrupted Pummerer反应的糖苷化方法”2016 年华中地区药物化学学术会议暨国际药学前沿科学研讨会 (2016 International Symposium of Frontier Sciences on New Drug Discovery and Central China Symposium on Medicinal Chemistry),武汉大学, October, 27-28, 2016.

28. Xiao, X.; Zhao, Y.; Shu, P.; Zhao, X.; Liu, Y.; Sun, J.; Zhang, Q.; Zeng, J.;Wan, Q.* “Interrupted Pummerer Reaction in Glycosylation”第十一届尖端有机化学亚洲国际会议(the 11th International Conference on Cutting‐Edge Organic Chemistryin Asia:ICCEOCA-11) Daejeon,Korea, October 26-29, 2016.

27. Xiao, X.; Zhao, Y.; Shu, P.; Zhao, X.; Liu, Y.; Sun, J.; Zhang, Q.; Zeng, J.;Wan, Q.*“Remote Activation of Disarmed Thioglycosides”8thAsian Community of Glycoscience and Glycotechnology Conference, Wuxi, China, October 13-16, 2016.

26. Wang, H.; Xu, Y.; Chen, W.; Shu, P.; Zhao, X.; Tao, J.; Yao, W.; Zhao, Y.; Xiao, X.; Imberg, L.; Zhang, Q.; Zeng, J.;Wan, Q.*“A Non-precious Metal Catalyzed High Efficient Reductive Deiodination”The 12thInternational Symposium on Organic Free Radicals, Shanghai, China, October 9-14, 2016.

25.孙久常,肖雄,舒朋华,方静,宋泽金,肖莹,张茜,曾静,万谦*“具有逆转多药耐药功能的树脂糖苷的合成研究进展”中国化学会第十一届全国天然有机化学学术会议, 上海, 25-28 September, 2016.

24.肖雄,赵岳琦,舒鹏华,赵翔,刘艳,孙久常,张茜,曾静,万谦* “Interrupted Pummerer反应在糖链合成中的应用及机理研究”2016年全国糖生物学会议,南通,5-7 August,2016.

23. Xiao, X.; Zhao, X.; Shu, P.; Zhao, Y.; Liu, Y.; Sun, J.; Zeng, J.;Wan, Q.*“The Interrupted Pummerer Reaction in Glycosylation”28thInternational Carbohydrate Symposium, New Orleans, USA, July 12-21, 2016, ICS-321.

22. Yao, W.; Sun, G.; Zhu, Y.; Cai, L.; Liu, K.; Zhang, Q.; Liu, X.;Wan, Q.*;Zeng, J.*“Diversified Stereoselective Synthesis of 3-Amino and 3-Nitro-2,3,6-trideoxypyranose”中国化学会第30届学术年会, 大连理工大学, 3 July, 2016.

• Best Poster Award

21. Xiao, X.; Zhao, Y.; Shu, P.; Zhao, X.; Liu, Y.; Sun, J.; Zhang, Q.; Zeng, J.;Wan, Q.*“The Interrupted Pummerer Reaction in Glycosylation” 青年学者大会化学化工月度论坛暨Grubbs论坛, 深圳南方科技大学,19-21 June, 2016.

20. Shu, P.; Zeng, J.; Tao, J.; Zhao, Y.; Yao, G.;Wan, Q.*“Selective S-deacetylation: Practical Syntheses of Glycosyl Thiols and Drug Mercapto-analogues”2015 International Chemical Congress of Pacific Basin Societies, Honolulu, USA, December 15-20, 2015.

19. Wang, H.; Shu, P.; Tao, J.; Chen, W.; Yao, W.; Xu, Y.; Zhao, X.; Zhao, Y.; Xiao, X.; Zhu, Y.; Imberg, L.; Zeng, J.;Wan, Q.*“Synthesis of α-linked 2-deoxy glycosides enabled by visible light mediated tin free deiodination”2015 International Chemical Congress of Pacific Basin Societies, Honolulu, USA, December 15-20, 2015.

18.Shu, P.; Xiao, X.; Zhao, Y.; Xu, Y.; Yao, W.; Tao, J.; Wang, H.; Xu, Z.; Yao, G.; Zeng, J.;Wan, Q.*“Interrupted Pummerer Reaction in Latent-Active Glycosylation”7thAsian Community of Glycoscience and Glycotechnology Conference, Miyagi, Japan, November 12-15, 2015.

• Best Poster Award

17.Shu, P.; Xiao, X.; Zhao, Y.; Xu, Y.; Yao, W.; Tao, J.; Wang, H.; Xu, Z.; Yao, G.; Zeng, J.;Wan, Q.*“Interrupted Pummerer Reaction in Latent-Active Glycosylation”第十届尖端有机化学亚洲国际会议(the 10th International Conference on Cutting‐Edge Organic Chemistryin Asia:ICCEOCA-10)高雄,November 2-5, 2015.

16.Shu, P.; Xiao, X.; Zhao, Y.; Xu, Y.; Yao, W.; Tao, J.; Wang, H.; Xu, Z.; Yao, G.; Zeng, J.;Wan, Q.*“Interrupted Pummerer Reaction in Latent-Active Glycosylation: A Novel Type of Glycosyl Donors with Recyclable and Regenerative Leaving Group”国家自然科学基金委-英国皇家化学会国际学术研讨会:有机合成的新兴前沿(NSFC-RSC International Symposium on Emerging Frontiers in Organic Synthesis) Shanghai, October 8-10, 2015.

15. Wang, H.; Shu, P.; Tao, J.; Chen, W.; Yao, W.; Xu, Y.; Zhao, X.; Zhao, Y.; Xiao, X.; Zhu, Y.; Imberg, L.; Zeng, J.;Wan, Q.*“Stereoselective Synthesis of alpha-Linked 2-Deoxy Glycosides Enabled

by Visible-Light-Mediated Reductive Deiodination”7thPacific Symposium on Radical Chemistry, Singapore, 15-18 July, 2015.

14.Shu, P.; Zeng, J.; Tao, J.; Zhao, Y.; Yao, G.;Wan, Q.*“Selective S-deacetylation Inspired by Native Chemical Ligation: Practical Syntheses of Glycosyl Thiols and Drug Mercapto-analogues”Gordon Research Conferences Frontiers of Science, Vermont, USA, June 14-19, 2015.

13.舒朋华,曾静,陶锦毅,赵岳琦,姚广明,万谦*“基于自然化学连接法的选择性脱硫乙酰基合成糖基硫醇”糖合成化学青年高峰论坛,南昌, April 11-12, 2015.

12.王浩,舒朋华,陶锦毅,陈薇,姚旺,徐阳,赵祥,赵岳琦,肖雄,Imberg Lukas,蔡鑫培,曾静,万谦*“可见光催化的碘脱除反应在脱氧糖合成中的应用” 糖合成化学青年高峰论坛,南昌, April 11-12, 2015.

11. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Xu, Y.; Zhao, Y.; Zeng, J.;Wan, Q.* “Synthesis of 2-Deoxy Oligosaccharides via Visible Light Mediated Tin Free Deiodination”第十三届国际华人有机化学研讨会暨第十届国际华人无机化学研讨会,厦门, 19-22, December, 2014.

10. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Xu, Y.; Zhao, Y.; Luo, J.; Zeng, J.;Wan, Q.* 2014French-Chinese Conference on Green Chemistry, Wuhan, 3-7 November, 2014.

9.王浩,陶锦毅,蔡鑫培,陈薇,赵岳琦,徐阳,罗钧,曾静,万谦*“可见光催化的碘脱除反应在2-脱氧糖苷的合成中的应用”2014全国糖生物学学术会议, 西安,16-19 July, 2014.

8. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Xu, Y.; Zhao, Y.; Luo, J.; Zeng, J.;Wan, Q.* “Visible Light Mediated Tin Free Deiodination: An Application in the Stereoselective Synthesis of 2-Deoxy Oligosaccharides ” The 10thSino-US Chemistry Professors Conference,济南, 15-17 June, 2014.

7. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Xu, Y.; Zhao, Y.; Luo, J.;Wan, Q.* “Visible Light Mediated Deiodination: An Application in the Stereoselective Synthesis of 2-Deoxy Oligosaccharides”15thTetrahedron Symposium, London, UK, 24-27thJune 2014.

6.王浩; 陶锦毅; 蔡鑫培; 陈薇; 赵岳琦; 徐阳; 罗钧; 万谦*“可见光催化反应在脱氧糖苷的合成中的应用” 2013年国际药学前沿科学研讨会暨药物化学与抗生素专业委员会学术年会, 武汉大学, 24 Dec 2013.

5. Schenkel, R.; Deak, H.; Doherty, E.; Olivieri, P.;Wan, Q.; Wang, H.; Wu, B.; Chen, A.; Emkey,R.; Gunaydin, H.; Huang, X.; Kim, J,; Loberg, R.; Pistillo, J.; Sinclair, A.; Wang, S.; Yu, V.; Liu, L.; Geuns-Meyer, S.“Discovery of Potent Jak2 Inhibitors That Demonstrate High Jak Family Selectivity in Enzyme, Engineered Cell, and Cytokine-Stimulated Primary Whole Blood Assays”Gordon Research Conference Medicinal Chemistry, Colby-Sawyer College, New London, NH, USA 08-13 Aug 2010.

4.Kan, C.; Trupek, J.; Wu, B.;Wan, Q.;Chen, G.; Tan, Z.; Yuan, Y.; Danishefsky, S. J.“Towards the chemical synthesis of homogeneous erythropoietin: The EPO(Ala1-Gly28) glycopeptide domain via native chemical ligation and desulfurization”239thACS National Meeting, San Francisco, CA, United States, March 21-25, 2010.

3. Scherrmann, M. -C.;Wan, Q.;Lubineau, A.“Synthèse deC-disaccharides par reaction d’Hétéro Diels-Alder et fonctionalisations stérérocontrollées des adduits”XXthJournées de Chimie et Biochimie des Glucides,Douran, France, 2004.

2.Wan, Q.;Lubineau, A.; Scherrmann, M. -C. “Synthesis ofC-disaccharidesviahetero-Diels-Alder reaction and further stereo-controlled transformations”12thEuropean Carbohydrate Symposium, Grenoble, France, July 6-11, 2003, Abstract PB061, P. 273.

1.Wan, Q.;Lubineau, A.; Scherrmann, M. -C. “Synthesis ofC-3 diene branched glucosamine”XIXthJournées de Chimie et Biochimie des Glucides, Albé,France, 2002.

Wan, Q.;Lubineau, A.; Scherrmann, M. -C. 揝ynthesis ofC-3 diene branched glucosamine?XIXthJourn閑s de Chimie et Biochimie des Glucides, Alb?/span>,France, 2002.

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