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师资队伍
杰出人才
博士后

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曾静

来源: 发布时间 2017-09-11 17:49:58 点击数:

曾静,男,博士,湖北恩施人,20139月获新加坡南洋理工大学博士学位,201312月起任华中科技大学同济药学院副教授,2014年入选湖北省“楚天学子”。主要研究方向为糖化学及糖类药物,在Angew. Chem. Int. Ed., Org. Lett., Chem. Commun. 等学术期刊上发表论文20余篇。

联系方式

电子信箱:zengjing0052@hust.edu.cn

地址:武汉市航空路13号华中科技大学同济医学院药学院430030

办公室:药学院3号楼406

研究兴趣

糖化学及糖药物,天然产物及药物合成.

工作经历

2013.12 至今  副教授,华中科技大学同济药学院

2013.02-2013.12  博士后,新加坡南洋理工大学化学与生物化学系

2008.08-2009.08  研究助理,新加坡南洋理工大学化学与生物化学系

2007.10-2008.06  上海开拓者化学

教育背景

2009.08-2013.02 博士,新加坡南洋理工大学化学与生物化学系

2004.09-2007.09  硕士,厦门大学化学化工学院

2000.09-2004.07 学士,东南大学化学化工学院

主持项目及荣誉

2018.01-2021.12 国家自然科学基金面上项目, No. 21772050

2016.01-2018.12 华中科技大学自主创新基金

2015.06-2017.06 教育部第50批“留学回国科研启动基金”

2015.01  湖北省楚天学者计划“楚天学子”

2015.01-2017.12 国家自然科学基金青年基金, No. 21402055

2014.01-2015.12 华中科技大学自主创新基金

2013.12-2016.12 华中科技大学人才引进基金

文章及专利.

28. Zeng J.;* Sun G.; Wang R.; Zhang S.; Teng S.; Liao Z.; Meng L.; Wan Q.* Gold-catalyzed Diversified Synthesis of 3-Aminosugar Analogues of Digitoxin and Digoxin. Org. Chem. Front. 2017. in press. doi:10.1039/C7QO00648A (invited).

27. Zeng J.;* Sun G.; Yao W.; Zhu Y.; Wang, R.; Cai, L.; Liu, K.; Zhang Q.; Liu, X.-W.; Wan, Q.* 3-Amino-deoxypyranoses in Glycosylation: Diversified Synthesis and Assembly in Oligosaccharides. Angew. Chem. Int. Ed. 2017, 56, 5227.

l Selected as front cover paper: Angew. Chem. Int. Ed. 2017, 56, 5133

l Highlighted by Wiley Advanced Science News China (ASNChina):2017.04.05.

l Highlighted by ChemistryViews:2017.04.14.

l Highlighted by Wiley Advanced Science News (Chemviews)2017.04.18.

l 《有机化学》“亮点介绍”Chin. J. Org. Chem. 2017,37,1585

l Highlighted by X-Mol:

l 阿达玛斯学术论文优秀奖

26. Zeng J.; Xu Y.; Wang, H.; Meng L.; Wan Q.* Recent Progress on the Synthesis of 2-Deoxy Glycosides. Sci. China Chem., 2017, 60, 1162. (invited)

25. Xiao, X.; Zhao, Y.; Shu, P.; Zhao, X.; Liu, Y.; Sun, J.; Zhang, Q.; Zeng, J.; Wan, Q.* Remote Activation of Disarmed Thioglycosides using the Interrupted Pummerer Reaction. J. Am. Chem. Soc. 2016, 138, 13402. (IF: 13.038)

 24. 方静,朱阳斌,陈薇,刘艳,孙久常,曾静,万谦*“四乙酰基-d-吡喃岩藻糖的合成”中国科技论文在线, 2016, http://www.paper.edu.cn/releasepaper/content/201605-876.;中国科技论文在线精品论文, 2016, 9 (19):2030.; Highlights of Sciencepaper Online, 2016, 9 (19): 2030.

 24. 舒朋华,孙久常,方静,曾静,万谦*11(S)-药喇叭酸甲酯的制备”中国科技论文在线, 2016, http://www.paper.edu.cn/releasepaper/content/201605-599.;中国科技论文在线精品论文, 2016, 9 (13): 1288.; Highlights of Sciencepaper Online, 2016, 9 (13):1288.

23. Shu, P.; Yao, W.; Xiao, X.; Shun, J.; Zhao, X.; Zhao, Y.; Xu, Y.; Yao, G.; Zeng, J.; Wan, Q.* Glycosylation via Remote Activation of Anomeric Leaving Groups: Development of 2-(2-Propylsulfinyl)benzyl Glycosides as Novel Glycosyl Donors. Org. Chem. Front. 2016, 3, 177. (IF: 4.963)

22. Shu, P.; Xiao, X.; Zhao, Y.; Xu, Y.; Yao, W.; Tao, J.; Wang, H.; Xu, Z.; Lu, Z.; Yao, G.; Zeng, J.; Wan, Q.* Interrupted Pummerer Reaction in Latent-Active Glycosylation: A Novel Type of Glycosyl Donors with Recyclable and Regenerative Leaving Group. Angew. Chem. Int. Ed. 2015, 54, 14432-14436 (IF: 11.709)

21. Shu, P.; Zeng, J.; Tao, J.; Zhao, Y. Yao, G.; Wan, Q.* Selective S-deacetylation Inspired by Native Chemical LigationPractical Syntheses of Glycosyl Thiols and Drug Mercapto-analogues. Green Chem., 2015, 17, 2545. (IF: 8.506)

20. Ma, J.; Zeng, J.; Wan, Q.* “Postligation-Desulfurization: A General Approach for Chemical Protein Synthesis” Topics in Current Chemistry 2015, 363, 57 (invited, IF: 4.464).

19. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Zhao, Y.; Xu, Y.; Yao, W.; Zeng, J.; Wan, Q.* Stereoselective Synthesis of Alfa-linked 2-Deoxy Glycosides Enabled by Visible Light Mediated Reductive Deiodination. Chem. Euro. J., 2014, 20, 17319. (IF: 5.771)

18 Wu, J.; Xiang, S.; Zeng, J.; Leow, M.; Liu, X.-W.* Practical Route to 2-Quinolinones via Pd-catalyzed C-H Bond Activation/C-C Bond Formation/Cyclization Cascade Reaction. Org. Lett., 2015, 17, 222. (IF: 6.732)

17. Cai, S.; Zeng, J.; Li, Y. X.; Liu, X.-W.* Polysubstituted Pyrole Derivatives via 1,2-Alkenyl Migration of Novel γ-Amino-α,β-unsaturated Aldehydes and α-Diazocarbonyls. RSC Advances. 2014, 4, 7275. (IF: 3.289)

16. Zeng, J.#; Ma, J.#; Xiang, S.; Cai, S.; Liu, X. -W.* Stereoselective β-C-Glycosylation via Palladium-Catalyzed Decarboxylative Allylation: Formal Synthesis of Aspergillide A. Angew. Chem. Int. Ed., 2013, 52, 5134. (IF: 11.709) (Highlight in Synfacts 2013, 8, 870)

15. Zeng, J.; Tan, Y. J.; Leow M. L.; Tirtorahardjo, D.; Liu, X. -W.* Facile Access to Cis-2,6-Disubstituted Ddihydrapyranes via Palladium Catalyzed Intramolecular Decarboxylative Allylation: Total Syntheses of (±)-Centrolobine, (+)-Decytospolide A and B. Chem. Eur. J. 2014, 20, 405. (IF: 5.771)

14. Zeng, J.; Zhang, Q.; Zhang, H. K.*; Chen, A.* Synthesis of trans-Dihydroxybutyrolactols as Efficient 4C Building Blocks: Application to the Synthesis of Polyhydroxylated Alkaloids. RSC, Advances, 2013, 3, 20298. (IF: 3.840)

13. Zeng, J.; Tan, Y. J.; Leow, M. L.; Liu, X. -W.* Copper(II)/Iron(III) Co-catalyzed Intermolecular Diamination of Alkynes: Facile Synthesis of Imidazopyridines. Org. Lett. 2012, 14, 4386. (IF: 6.364) (Highlight in Synfacts 2012, 8, 1300.)

12. Zeng, J.; Bai, Y. G.; Ma, J. M.; Cai, S. T.; Liu, X. -W.*, Direct Synthesis of Pyrroles via A Silver Promoted Three-component Reaction Involving an Unsual Imidazole Ring Opening. Chem. Commun. 2011, 47, 12855. (IF: 6.834)

11. Zeng, J.; Vedachalam, S.; Xiang, S. H., Liu, X. -W.*, Direct C-Glycosylation by Coupling of Organotrifluoroborates with Glycosyl Flouorides and Iits Application to The Total Synthesis of (+)-Varitriol. Org. Lett. 2011, 13, 42. (IF: 6. 6.732) (Highlighted in Organic Chemistry Portal, 2012, http://www.organic-chemistry.org /Highlights/2012/16January.shtm).

10. Xiang, S.; Lu, Z.; He, J.; Hoang, K. L. M.; Zeng, J.; Liu, X. -W.* β-Type Glycosidic Bong Formation by Palladium-Catalyzed Decarboxylative Allylation. Chem. Eur. J. 2013, 19, 14047. (IF: 5.731)

9. Cai, S. T.; Zeng, J.; Bai, Y. G.; Liu, X. -W.* Access to Quinolines through Gold-Catalyzed Intermolecular Cycloaddition of 2-Aminoaryl Carbonyls and Internal Alkynes. J. Org. Chem. 2012, 77, 801. (IF:4.721)

8. Xiang, S. H.; Cai, S. T.; Zeng, J.; Liu, X. -W.* Regio- and Stereoselective Synthesis of 2-Deoxy-C-aryl Glycosides via Palladium Catalyzed Decarboxylative Reactions. Org. Lett. 2011, 13, 4608. (IF: 6. 6.732)

7 Bai, Y. G.; Leow, M.; Zeng, J.; Liu, X. -W.* Palladium Catalyzed Stereoselective C-Glycosylation of Glycals with Enol Triflates. Org. Lett. 2011, 13, 5648. (IF: 6. 6.732)

6. Bai, Y. G.; Zeng, J.; Cai, S. T.; Liu, X. -W.* Palladium catalyzed direct cross-coupling reactions of glycols with activated alkenes. Org. Lett. 2011, 13, 4394. (IF: 6.364)

5. Cai, S. T.; Xiang, S. H.; Zeng, J.; Gorityala, B. K.; Liu, X. -W.* Facile synthesis of carbohydrate-integrated isoxazolines through tandem [4 +1] cycloaddition and rearrangement of 2-nitroglycals. Chem. Commun. 2011 47, 8676. (IF: 6.834)

4. Vedachalam, S.; Wang, Q. S.; Maji, B.; Zeng, J.; Ma, J.; Liu, X. -W.* N-Heterocyclic Carbene Catalyzed Intramolecular Hydroacylation of Activated Alkynes: Synthesis of Chromones. Adv. Synth. Catal. 2011, 353, 219. (IF:5.663)

3. Bai, Y. G.; Zeng, J.; Ma, J.; Gorityala, B. K.; Liu, X. -W.* Quick Access to Druglike Heterocycles: Facile Silver-Catalyzed One-Pot Multicomponent Synthesis of Aminoindolizines. J. Comb. Chem. 2010, 12, 696. (IF: 3.032)

2. Vedachalam, S.; Zeng, J.; Gorityala, B. K.; Antonio, M.; Liu, X. -W.* N-Heterocyclic Carbene-Catalyzed Intramolecular Aldehyde-Nitrile Cross Coupling: An Easy Access to 3-Aminochromones. Org. Lett. 2010, 12, 352. (IF: 6. 6.732)

1. Ma, J. M.; Zhao, Y. Y.; Ng, S.; Zhang, J.; Zeng, J.; Than, A.; Chen, P.; Liu, X. -W.* Sugar-Based Synthesis of Tamiflu and Its Inhibitory Effects on Cell Secretion. Chem. Eur. J. 2010, 16, 4533. (IF: 5.771)

专利

万谦,舒朋华,曾静,赵岳琦,一种糖基硫醇及金诺芬的合成方法 中国发明专利,申请号:201410459125.0

张洪奎,曾静光学活性2,3-二羟基丁内半缩醛衍生物的制备方法;中国发明专利,申请号:200710009462.X,公开号:CN 101130529A.

口头报告

2. Tongji-Marburg Summit Forum on Pharmaceuticals. 武汉. 2017.05.21.

1. 第二届糖合成化学青年学术研讨会,山东大学,济南. 2017.05.14.

会议论文

5. Guangfei Sun, Wang Yao, Yangbin Zhu, Ruobin Wang, Lei Cai, Ke Liu, Qian Zhang, Xue-Wei Liu, Qian Wan,* Jing Zeng*, Stereoselective Synthesis of 3-Amino-2,3,6- trideoxypyranose and Their Assembly in Oligosaccharides. International Conference on New Challenges in organic Synthesis, Guangzhou, China , Nov. 26-29, 2016

4. 姚旺, 孙广飞, 朱阳斌, 蔡磊, 刘珂, 张茜, 刘学伟, 万谦*, 曾静* 2016 年华中地区药物化学学术会议暨国际药学前沿科学研讨会 (2016 International Symposium of Frontier Sciences on New Drug Discovery and Central China Symposium on Medicinal Chemistry), 武汉大学, October, 27-28, 2016

3. Wang Yao, Guangfei Sun, Yangbin Zhu, Lei Cai, Ke Liu, Xue-Wei Liu, Qian Wan,* Jing Zeng*, Diversified Stereoselective Synthesis of 3-Amino trideoxypyranose and Application in Oligosaccharide Assembly. 8th Asian Community of Glycoscience and Glycotechnology Conference, Wuxi, China , October 13-16, 2016.

2. 姚旺,孙广飞,朱阳斌,蔡磊,刘珂,刘学伟,万谦*曾静* 2016年全国糖生物学会议,南通,5-7 August2016.

1. Yao, W.; Sun, G.; Zhu, Y.; Cai, L.; Liu, K.; Zhang, Q.; Liu, X.; Wan, Q.*; Zeng, J.* “Diversified Stereoselective Synthesis of 3-Amino and 3-Nitro-2,3,6-trideoxypyranose” 中国化学会第30届学术年会, 大连理工大学, 3 July, 2016.

l 优秀墙报奖

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030