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师资队伍
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项光亚

来源: 发布时间 2017-09-14 15:38:11 点击数:

项光亚,男,1968年生,湖北黄梅人,博士,教授,博士生导师,教育部新世纪优秀人才支持计划入选者。现任全国药学教学指导委员会委员,中国高等教育学会医学教育专业委员会药学教育研究分会理事,中国药学会湖北省药物化学专业委员会副主任委员。1990年毕业于华东师范大学化学系,1995年毕业于武汉大学获硕士学位;2000年毕业于同济医科大学获博士学位。先后在德国蒂宾根大学和美国俄亥俄州立大学分别进行为期一年进修访问。现主要从事靶向药物传递系统和药物合成研究。

主要讲授的课程包括《有机化学》、《生物偶联技术》、《药学文献检索与利用》等,曾多次荣获华中科技大学教学质量奖,荣获过2004年华中科技大学“三育人奖”、2011年华中科技大学第二届研究生导师“师表奖”。近年来,参编的教材包括人民卫生出版社出版的有机化学(第七版,第八版,副主编),有机化学学习指导(第三版,第四版)等以及中国医药科技出版社出版的《有机化学》(主编,2016年)《药学文献检索与利用》(第二版,副主编)等近十本教材。教学研究方面,曾主持过校级省级教学研究项目多项,获得过华中科技大学优秀教学成果奖二等奖一次(第二),一等奖一次(第一),此外还多次指导国家大学生创新科研训练计划项目,主持教育部“质量工程”药学国家特色专业建设以及参与建设生物药学创新人才培养试验区建设。科学研究方面,近年来先后主持了国家级、省部级科研项目十多项,发表论文六十余篇,其中在包括《Theranostics》、《Molecular Therapy》、《Bioconjugate Chemistry》、《Journal of Pharmaceutical Sciences》、《International Journal of Pharmaceuticals》、《Journal of Drug Targeting》、《International Journal of Nanomedicine》、《European Journal of Medicinal Chemistry》等国际著名刊物发表的SCI收录论文三十余篇。


发表的部分论文列表:

Yannan Yang#, Yao Lu#, Prasanna Lakshmi Abbaraju, Jun Zhang, Min Zhang,Guangya Xiang,* and Chengzhong Yu*Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer ImmunotherapyAngew. Chem. Int. Ed.,2017,56:8446-8450

Pengxuan Zhao,Shuangping Wu,Yao Cheng,Jia You,Yan Chen,Minsi Li, Chuanchuan He,Xiaojuan Zhang,TanYang,Yao Lu,Robert J. Lee,Xingxing He, Guangya Xiang, MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinomaNanomedicine: Nanotechnology, Biology, and Medicine2017In press.

Muhammad Sarfraz#, Attia Afzal1#, Shahid Masood Raza, Sajid Bashir, Asadullah Madni, Muhammad Waseem Khan, Xiang Ma*, Guangya Xiang*Liposomal co-delivered oleanolic acid attenuates doxorubicin induced multi-organ toxicity in hepatocellular carcinomaOncotarget20178(29):47136-47153

Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min1, Weiguang Sun,Lixia Chen*, Guangya Xiang* and Hua Li*Benserazide, a dopadecarboxylase inhibitor,suppresses tumor growth by targeting hexokinase, Journal of Experimental & Clinic Cancer Research, 20173658

Zhongping Hu, Shasha Zhang, Weicheng Zhou, Xiang Ma*, Guangya Xiang*Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ InhibitorsBioorganic & Medicinal Chemistry Letters,2017271854-1858

Tan Yang#Ling Xu#Bin LiWeijie LiXiang MaLingling FanRobert J LeeChuanrui Xu* Guangya Xiang*Antitumor activity of a folate receptor-targeted immunoglobulin G-doxorubicin conjugate Internatioal Journal of Nanomedicine2017122505-2515

Yongkang Gai#, Lingyi Sun#, Wenqi Hui, Qin Ouyang, Carolyn J. Anderson, Guangya Xiang*, Xiang Ma*, and Dexing Zeng*New Bifunctional Chelator pSCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET ImagingInorganic Chemistry20165514):6892-6901IF=4.82

Yao Lu, Yuhua Wang, Lei Miao, Matthew Haynes, Guangya Xiang*, Leaf Huang*, Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: A combination nanomedicine approachCancer Letters20163791):32–38(IF=5.992)

Yongkang Gai, Guangya Xiang, Xiang Ma, Wenqi Hui, Qin Ouyang, Lingyi Sun, Jiule Ding, Jing Sheng, and Dexing Zeng*, Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging ProbesBioconjugate Chemistry201627:515-520IF=4.513

Lu, Yao; Miao, Lei; Wang, Yuhua; Xu, Zhenghong; Zhao, Yi; Shen, Youqing; Xiang, Guangya*; Huang, Leaf*Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma ModelMolecular Therapy2016,242):364-374IF=6.938

Yang, Tan; Zhao, Pengxuan; Rong, Zhao; Li, Bin; Xue, Huiying; You, Jia; He, Chuanchuan; Li, Weijie; He, Xingxing; Lee, Robert J; Ma, Xiang*; Guangya Xiang*Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375Theranostics20166(1)142-154IF=8.854

Gai, YKHu, ZP ; Rong, ZMa, X*Xiang, GY*A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant ArmMolecules201520(10):19393-19405IF=2.416

Zhang, Wendian; Peng, Fangqi; Zhou, Taotao; Huang, Yifei; Zhang, Li; Ye, Peng; Lu, Miao; Yang, Guang; Gai, Yongkang; Yang, Tan; Ma, Xiang*; Xiang, Guangya*Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomesInternational Journal of Nanomedicine, 2015104825-4836. IF=4.195  

◆  Yifei Huang,* Tan Yang,*Wendian ZhangYao LuPeng YeGuang YangBin LiShibo QiYong LiuXingxing HeRobert J LeeChuanrui Xu*Guangya Xiang*A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivoInternational Journal of Nanomedicine 2014:9 4581–4595IF=4.195

Guang Yang, Tan Yang, Wendian Zhang, Miao Lu Xiang Ma,*, and Guangya Xiang*In Vitro and in Vivo Antitumor Effects of Folate-Targeted Ursolic Acid Stealth LiposomeJ. Agric. Food Chem. 201462:2207-2215IF=3.107

Peng YeWendian ZhangTan YangYao LuMiao LuYongkang GaiXiang Ma*Guangya Xiang*Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting International Journal of Nanomedicine2014,9:2167-2178IF=4.195

Bin Zhao, Xianmei Shang*, Ling Xu, Wendian Zhang, Guangya Xiang*Novel mixed ligand di-n-butyltin(IV) complexes derived from acylpyrazolones and fluorinated benzoic acids: Synthesis, characterization, cytotoxicity and the induction of apoptosis in Hela cancer cellsEuropean Journal of Medicinal Chemistry2014,76:87-97IF=3.432

Zhi-Gang ChengXu-Yong Dai, Li-Wei Li, Qiong Wan, Xiang Ma,* and Guang-Ya Xiang*Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug SubstanceMolecules2014,19:1344-1352IF=2.095

Miao Lu, Wendian Zhang, Yongkang Gai, Tan Yang, Peng Ye, Guang Yang, Xiang Ma* and Guangya XiangFolate–PEG functionalized silica CdTe quantum dots as fluorescent probes for cancer cell imaging New Journal of Chemistry, 2014,38:4519-4526IF=3.159

Tan Yang, Bin Li, Shibo Qi, Yong Liu, Yongkang Gai, Peng Ye, Guang Yang, Wendian Zhang, Peng Zhang, Xingxing He, Weijie Li, Zhiping Zhang, Guangya Xiang*, Chuanrui Xu*, Co-delivery of Doxorubicin and Bmi1 siRNA by Folate Receptor Targeted Liposomes Exhibits Enhanced Anti-Tumor Effects in vitro and in vivo, Theranostics, 2014,4(11):1096-1111(IF=7.827)

Chang Yang, Lun Ma, Jason Maley, Ramaswami Sammynaiken,Renfei Feng, Guangya Xiang, and Wei ChenPhotoluminescence and X-Ray Excited Luminescence from Glutathione-Stabilized Gold NanoparticlesJournal of Biomedical Nanotechnology201391827–1836(IF=7.578)

Changqin Xiao, Minqiong Tang, Jian Li, Chen-ru Yin, Guangya Xiang, Li XuDetermination of sildenafil, vardenafil and aildenafil in human plasma by dispersive liquid–liquid microextraction-back extraction based on ionic liquid and high performance liquid chromatography-ultraviolet detectionJournal of Chromatography B2013931111-116(IF=2.694)

Chang YangLun MaXiaoju ZouGuangya XiangWei ChenSurface plasmon-enhanced Ag/CuS nanocomposites for cancer treatmentCancer Nano 2013481-89

Xianmei Shang*, Nan Ding, Guangya Xiang*Novel di-n-butyltin(IV) derivatives: Synthesis, high levels of cytotoxicity in tumor cells and the induction of apoptosis in KB cancer cellsEuropean Journal of Medicinal Chemistry201248305-312IF=3.432

Yao Lu, Nan Ding, Chang Yang, Lei Huang, Jian Liu, and Guangya XiangPreparation and in vitro evaluation of a folate-linked liposomal curcumin formulationJournal of Liposome Research, 2012222):110-119(IF=1.533)

Ye, L; Huang, YF; Li; Xiang, GY; Xu, LNonaqueous capillary electrophoresis of imatinib mesylate and related substancesJOURNAL OF SEPARATION SCIENCE 20123516):2108-2113(IF=2.594)

Jian Li, Yifei Huang, Lei Huang, Lei Ye, Zhou Zhou, Guangya Xiang, Li Xu, Determination of imatinib mesylate and compounds by field amplified sample stacking with large volume sample injection capillary electrophoresis, Journal of Pharmaceutical and Biomedical Analysis, 2012,70:26-31(IF=2.829)

Chang Yang, Wei Chen, Brian Quang Bui, and Guangya Xiang,Recent Progress on the Liposomes Loaded with Quantum Dots, Rev. Nanosci. Nanotechnol, 2012, 1(4):1-14

Nan DingYao Lu Robert J Lee Chang Yang Lei Huang Jian Liu Guangya XiangFolate receptor targeted fluorescentparamagnetic bimodal liposomes for tumor imagingInternational Journal of Nanomedicine2011,6:2513-2520IF=4.195

Xiaolan QuChang YangJing ZhangNan DingYao LuLei HuangGuangya XiangIn-vitro evaluation of a folate-bovine serum albumin doxorubicin conjugateJournal of Drug Targeting, 2010 ,18(5): 351-61. (IF=2.723)

Chang Yang, Nan Ding, Yibing Xu, Xiaolan Qu, Jing Zhang1, Chaoyang Zhao, Liang Hong, Yao Lu, Guangya Xiang*, Folate receptor–targeted quantum dot liposomes as fluorescence probes, Journal of Drug Targeting, 2009, 17(7): 502-511(IF=2.723)

Guangya Xiang*Jun WuYanhui Lu Zhilan LiuRobert J LeeSynthesis and evaluation of a novel ligand for folate-mediated targeting liposomesInternational Journal of Pharmaceuticals200835629-36 (IF=3.785)

Qi Zhang, Guang Ya Xiang*, Youjiu Zhang, et al. Increase of Doxorubicin Sensitivity for Folate Receptor Positive Cells when given as the Prodrug N-(phenylacetyl) doxorubicin in Combination with Folate-conjugated PGAJournal of Pharmaceutical Sciences2006, 2006, 95(10):2266-75. (IF=3.007)

联系方式

通信方式:武汉市华中科技大学同济医学院药学院,430030

eMail: gyxiang1968@hotmail.comyoujti@mails.tjmu.edu.cn

主要合作实验室

美国俄亥俄州立大学药学院Robert Lee教授实验室

美国北卡罗莱纳州立大学教堂山分校药学院Leaf Huang实验室

美国匹兹堡大学放射医学中心曾德兴教授实验室

美国华盛顿大学(西雅图)Rodeny Ho教授实验室

美国NIH陈小元教授实验室

  澳大利亚昆士兰大学余承忠教授实验室

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华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030