旧版入口 | English

师资队伍
杰出人才
博士后

您当前所在位置: 首页 - 师资队伍 - 药物化学系 - 正文

王锐

来源: 发布时间 2017-09-15 08:25:53 点击数:

王锐,教授 博士生导师

药学院,华中科技大学同济医学院

电话:(86)-13647228297

邮箱:ez_rwang at hust.edu.cn

地址:武汉市硚口区航空路13号药学院1号楼5504,430030


工作经历:

2017-今 教授,博士生导师,华中科技大学同济医学院药学院

2014-2016 博士后,美国纽约州立大学奥巴尼分校艺术与科学学院

2011-2014 博士后,美国德克萨斯大学西南医学中心生物化学系


教育经历:

2005-2011 理学博士,中国科学院上海有机化学研究所天然产物实验室

2001-2005 理学学士,吉林大学化学学院


主要荣誉及主持项目:

华中科技大学人才引进基金 (2017-2020,¥100)

美国纽约西蒙斯基金会奖学金 (2015-2016,$25)


受邀审稿:

Chem. Eur. J., Tetrahedron, Tetrahedron Lett., Studies in Natural Products Chemistry, ChemSusChem, ChemBioChem, ChemCatChem, RCS Adv., J. Organomet. Chem., Chinese J. Org. Chem., iMedPub, Chemistry Select Journals.


研究领域:

核酸化学、结构生物学,体内修饰核酸的检测与标记;能量释放的生物正交反应及药物化学;有机合成,以及生命起源等


学术专著:

23. Sweta Vangaveti, Phensinee Haruehanroengra, Rui Wang, Srivathsan V Ranganathan, Jia Sheng, * Biophysical Journal, 2017, 12(3), 488a.

22. P Haruehanroengra, S Vangaveti, S. R Ranganathan, Rui Wang, Alan Chen, Jia Sheng, Nature's selection of geranyl group as a tRNA modification, ACS Chemical Biology, 2017, 12(6), 1504-1513.

21. Vibhav Valsangkar, Arun R. Chandrasekaran, Rui Wang, Phensinee Haruehanroengra, Oksana Levchenko, Ken Halvorsen, and Jia Sheng*, "Functionalization of Branched DNA Nanostructures". J. Mater. Chem. B, 2017, in press. 10.1039/C6TB03277J.

20. Fusheng Shen, Zhipu Luo, Hehua Liu, Rui Wang, Shenglong Zhang, Jianhua Gan, Jia Sheng*, Structural Insights into RNA Duplexes with Multiple 2′-5′-Linkages, Nucleic Acids Res., 2017, 45(6), 3537-3546.

19. Maria Basanta-Sanchez, Rui Wang, Zhenzhen Liu, Xiaohan Ye, Paul F. Agris, Minyong Li, Xiaodong Shi, Yubin Zhou, Yun Huang*, and Jia Sheng* TET1-mediated Oxidation of 5-formylcytosine (5fC) to 5-carboxycytosine (5caC) in RNA, ChemBioChem., 2017, 18(1), 72-76.

18. Rui Wang, Phensinee Haruehanroengra, Jia Sheng*, Synthesis of a Geranylated 2Thiouridine Phosphoramidite and Its Incorporation into Oligoribonucleotides, Current Protocols in Nucleic Acid Chemistry, 2016, accept.

17. Rui Wang, Sweta Vangaveti, Srivathsan V. Ranganathan, Maria Basanta-Sanchez, Phensinee Haruehanroengra, Alan Chen, and Jia Sheng* Synthesis, base pairing and structure studies of geranylated RNA, Nucleic Acids Res., 2016, 44(13), 6036-6045.

16. Rui Wang, Zhipu Luo, Kaizhang He, Michael O. Delaney, Doris Chen, Jia Sheng* Synthesis and Base-Paring Studies of Epigenetic 5-Formyl Cytidine, Nucleic Acids Res., 2016, 44(10), 4968-4977.

15. Rui Wang, Srivathsan V. Ranganathan, Angelo C. Setaro, Vibhav A. Valsankar, Stephanie M. Magliocco, Fusheng Shen, Alan Chen and Jia Sheng* Water-bridged hydrogen bond formation between 5-hydroxylmethylcytosine (5-hmC) and its 3′-neighbouring bases in A- and B-form DNA Duplexes Chem. Commun., 2015, 51, 16389-16392.

14. Edgar Agustin, Okai Papa-Ni, Irfan Khan, Michael Miller, Rui Wang, Jia Sheng and Maxim Royzen* Fast Click-Slow Release Strategy towards HPLC-Free Synthesis of RNA Chem. Commun., 2016, 52, 1405-1408.

13. Neil Robertson, Mustafa Hizir, Mustafa Balcioglu, Rui Wang, Mustafa Yavuz, Hasan Yumak, Birol Ozturk, Jia Sheng, Mehmet Yigit* Discriminating a Single Nucleotide Difference for Enhanced miRNA Detection Using Tunable Graphene and Oligonucleotide Nanodevices Langmuir, 2015, 31, 9943-9952.

12. Rui Wang, Srivathsan V. Ranganathan, Alan Chen and Jia Sheng* Synthesis and Base Pairing Studies of Geranylated 2-thiothymidine, a natural Variant of Thymidine Chem. Commun., 2015, 51, 16369-16372.

11. Rui Wang, Fusheng Shen, Stephanie M. Magliocco, Vibhav A. Valsangkar and Jia Sheng* Synthesis and Base Pairing Studies of Geranylated DNA. J. Biomol. Struct. Dyn., 33, Supplement, 138, 2015.

10. Rui Wang*, J. R. Falck Studies Towards Asymmetric Synthesis of 4(S)-11-Dihydroxy- docosahexaenoic acid (diHDHA) Featuring Cross-Coupling of Chiral Stannane under Mild

l Conditions Org. Biomol. Chem., 2015, 13, 1624-1628 and 2196-2196.

9. Rui Wang*, and J. R. Falck Room Temperture, Open-flask C-H Arylation of Electrondeficient Heteroarenes with Triazenes: Rapid Synthesis of Heterobiryls Org. Chem. Front., 2014, 1(9), 1029-1034. (Selected as Front Cover)

8. Rui Wang*, J. R. Falck Transition Metals Catalyzed Element-cyano Bonds Activations Cat. Rev., 2014, 56, 288-331.

7. Rui Wang*, J. R. Falck Ruthenium Catalyzed Oxidative Annulation with Alkynes via Cascade C-H/ N-H Bond Functionalizations J. Organomet.Chem., 2014, 759, 33-36.

6. Rui Wang*, J. R. Falck Transformations of X (C, O, N)-CN bonds: cases of selective X (C, O, N)-C activation RSC Adv., 2014, 4, 1062-1066.

5. Rui Wang*, J. R. Falck, Rh(I)-Catalyzed N-CN Bond Cleavage: Intramolecular β-Cyanation of Styrenes Chem. Commun., 2013, 49, 6516-6518.

4. Rui Wang, Ping Tian and Guo-Qiang Lin* Stereoselective Total Synthesis of Tubulysin V Chin. J. Chem., 2013, 31, 40-48 (Special issue in memory of Professor Weishan Zhou).

3. Chen Zhu*, Rui Wang and J. R. Falck Amide-Directed Tandem C-C/C-N Bond Formation through C-H Activation Chem. Asian J., 2012, 7, 1502-1514.

2. Chen Zhu*, Rui Wang and J. R. Falck* Mild and Rapid Hydroxylation of Aryl/Heteroaryl Boronates with N-Oxides Org. Lett., 2012, 14, 3494-3497.

1. Rui Wang, Kai Fang, Ming-Hua Xu*, and Guo-Qiang Lin* Concise Asymmetric Total Synthesis of Antimalarial Alkaloid (+)-Febrifugine Synlett., 2009, 14, 2301-2304.


邀请及报告:

6. SCOL Quarterly Investigator and Fellows Meeting-October 25, 2016. Simons Foundation, New York City.

5. SCOL Quarterly Investigator and Fellows Meeting in Harvard Faculty Club of Cambridge, Boston, MA- July 21, 2016.

4. SCOL Quarterly Meeting-May 19-20, 2016. Simons Foundation, Boston, MA.

Poster: RNA Aptamers in the Origin of Biological Catalysis

Talk: RNA Aptamers in the Origin of Biological Catalysis

3. SCOL Quarterly Meeting-May 19-20, 2016. Simons Foundation, New York City.

2. SCOL Quarterly Meeting-October 16, 2015. Simons Foundation, New York City.

Talk: Evolutionary Roles of RNA Aptamers in the Origin of Biological Catalysis

1. Gordon Research Conferences: Nucleosides, Nucleotides & Oligonucleotides, June 28-July 3, 2015, Salve Regina University, Newport, Rhode Island.

Poster: Synthesis and Base Pairing Studies of Geranylayed DNA and RNA



华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030