旧版入口 | English

师资队伍
杰出人才
博士后

您当前所在位置: 首页 - 师资队伍 - 药物化学系 - 正文

曾静

来源: 发布时间 2018-09-19 11:09:43 点击数:

曾静

男,博士,湖北恩施人,2013年9月获新加坡南洋理工大学博士学位,2013年12月起任华中科技大学同济药学院副教授。主要研究方向为糖化学及糖类药物。

联系方式

电子信箱:zengjing0052@hust.edu.cn

课题组主页:http://sugar.pharm.hust.edu.cn/

地址:武汉市航空路13号华中科技大学同济医学院药学院430030

办公室:药学院3号楼406

研究兴趣

糖化学及糖药物,天然产物及药物合成.

工作经历

2013.12至今 副教授,华中科技大学同济药学院

2013.02-2013.12 研究助理,新加坡南洋理工大学化学与生物化学系

2008.08-2009.08 项目助理,新加坡南洋理工大学化学与生物化学系

2007.10-2008.06 上海开拓者化学

教育背景

2009.08-2013.09 博士,新加坡南洋理工大学化学与生物化学系

2004.09-2007.09 硕士,厦门大学化学化工学院

2000.09-2004.07 学士,东南大学化学化工学院

主持项目及荣誉

2018.01-2021.12国家自然科学基金面上项目, No. 21772050

2016.01-2018.12华中科技大学自主创新基金

2015.06-2017.06教育部第50批“留学回国科研启动基金”

2015.01-2017.12国家自然科学基金青年基金, No. 21402055

2014.01-2015.12华中科技大学自主创新基金

2013.12-2016.12华中科技大学人才引进基金

文章及专利.

1.Zeng J.; Liu Y.; Chen W.; Zhao X.; Meng L.; Wan Q.* Glycosyl Sulfoxides in Glycosylation Reactions.Top. Curr. Chem.2018,376, 27-58

2.Liu Y.; Zeng J.; Sun J.; Cai L.; Zhao Y.; Fang J.; Hu B.; Shu P.; Meng L.; Wan Q.* 1,4-Dithiothreitol Mediated Cleavage of the Acetal and Ketal Type of Diol Protecting Groups.Org. Chem. Front.2018, 5, 2427-2431.

3.Meng L.; Zeng J.; Wan Q.* Interrupted Pummerer Reaction in Latent/Active Glycosylation.Synlett. 2018,29, 148-156. (invited account)

4.Chen W.; Zeng J.; Wang H.; Xiao X.; Meng L.; Wan Q.* Tracking the Leaving Group in the Remote Activation of O-2-[(propan-2-yl)sulfinyl]benzyl (OPSB) Glycoside.Carbohydr. Res.2017,452, 1-5.

5.Xu Y.; Zhang Q.; Xiao Y., Wu P.; Chen W.; Song Z.; Xiao X.; Meng L.; Zeng J., Wan Q.* Practical Synthesis of Latent Disarmed S-2-(2-propylthio) Benzyl Glycosides for Interrupted Pummerer Reaction Mediated Glycosylation.Tetrahedron Lett.2017,58,2381-2384.

6.Zeng J.;* Sun G.; Wang R.; Zhang S.; Teng S.; Liao Z.; Meng L.; Wan Q.* Gold-catalyzed Diversified Synthesis of 3-Aminosugar Analogues of Digitoxin and Digoxin.Org. Chem. Front.2017,4, 2450(invited in a themed colletion: Synthetic Approaches to Natural Products via Catalytic Processes)

lOrganic Chemistry Frontiers HOT article for 2017

7. Zeng J.;* Sun G.; Yao W.; Zhu Y.; Wang, R.; Cai, L.; Liu, K.; Zhang Q.; Liu, X.-W.; Wan, Q.* 3-Amino-deoxypyranoses in Glycosylation: Diversified Synthesis and Assembly in Oligosaccharides.Angew. Chem. Int. Ed.2017,56, 5227.

lSelected as front cover paper: Angew. Chem. Int. Ed. 2017,56, 5133

lHighlighted by Wiley Advanced Science News China (ASNChina):2017.04.05.

lHighlighted by ChemistryViews:2017.04.14.

lHighlighted by Wiley Advanced Science News (Chemviews):2017.04.18.

l《有机化学》“亮点介绍”Chin. J. Org. Chem.2017,37,1585

lHighlighted by X-Mol:

l阿达玛斯学术论文优秀奖

8. Zeng J.; Xu Y.; Wang, H.; Meng L.; Wan Q.* Recent Progress on the Synthesis of 2-Deoxy Glycosides.Sci. China Chem., 2017,60, 1162. (invited review)

9. Xiao, X.; Zhao, Y.; Shu, P.; Zhao, X.; Liu, Y.; Sun, J.; Zhang, Q.; Zeng, J.; Wan, Q.* Remote Activation of Disarmed Thioglycosides using the Interrupted Pummerer Reaction.J. Am. Chem. Soc. 2016,138, 13402. (IF: 13.038)

10.方静,朱阳斌,陈薇,刘艳,孙久常,曾静,万谦*“四乙酰基-d-吡喃岩藻糖的合成”中国科技论文在线, 2016, http://www.paper.edu.cn/releasepaper/content/201605-876.;中国科技论文在线精品论文, 2016, 9 (19):2030.; Highlights of Sciencepaper Online, 2016,9(19): 2030.

11.舒朋华,孙久常,方静,曾静,万谦*“11(S)-药喇叭酸甲酯的制备”中国科技论文在线, 2016, http://www.paper.edu.cn/releasepaper/content/201605-599.;中国科技论文在线精品论文, 2016, 9 (13): 1288.; Highlights of Sciencepaper Online, 2016,9(13):1288.

12.Shu, P.; Yao, W.; Xiao, X.; Shun, J.; Zhao, X.; Zhao, Y.; Xu, Y.; Yao, G.; Zeng, J.; Wan, Q.* GlycosylationviaRemote Activation of Anomeric Leaving Groups: Development of 2-(2-Propylsulfinyl)benzyl Glycosides as Novel Glycosyl Donors.Org. Chem. Front.2016,3, 177.(IF: 4.963)

13.Shu, P.; Xiao, X.; Zhao, Y.; Xu, Y.; Yao, W.; Tao, J.; Wang, H.; Xu, Z.; Lu, Z.; Yao, G.; Zeng, J.; Wan, Q.* Interrupted Pummerer Reaction in Latent-Active Glycosylation: A Novel Type of Glycosyl Donors with Recyclable and Regenerative Leaving Group.Angew. Chem. Int. Ed.2015,54, 14432-14436 (IF: 11.709)

14.Shu, P.; Zeng, J.; Tao, J.; Zhao, Y. Yao, G.; Wan, Q.* Selective S-deacetylation Inspired by Native Chemical Ligation:Practical Syntheses of Glycosyl Thiols and Drug Mercapto-analogues.Green Chem., 2015,17, 2545.(IF:8.506)

15.Ma, J.; Zeng, J.; Wan, Q.* “Postligation-Desulfurization: A General Approach for Chemical Protein Synthesis”Topics in Current Chemistry2015,363, 57(invited, IF: 4.464).

16.Wang, H.; Tao, J.; Cai, X.; Chen, W.; Zhao, Y.; Xu, Y.; Yao, W.; Zeng, J.; Wan, Q.* StereoselectiveSynthesis ofAlfa-linked 2-DeoxyGlycosidesEnabled byVisibleLightMediatedReductiveDeiodination.Chem. Euro. J.,2014, 20,17319.(IF:5.771)

17Wu, J.; Xiang, S.; Zeng, J.; Leow, M.; Liu, X.-W.* PracticalRoute to 2-Quinolinones via Pd-catalyzed C-HBondActivation/C-CBondFormation/CyclizationCascadeReaction.Org. Lett., 2015,17, 222.(IF: 6.732)

18.Cai, S.; Zeng, J.; Li, Y. X.; Liu, X.-W.* PolysubstitutedPyroleDerivatives via 1,2-AlkenylMigration ofNovel γ-Amino-α,β-unsaturatedAldehydes and α-Diazocarbonyls. RSC Advances.2014,4, 7275.(IF: 3.289)

19.Zeng,J.#; Ma, J.#; Xiang, S.; Cai, S.; Liu,X.-W.*Stereoselectiveβ-C-Glycosylation via Palladium-Catalyzed Decarboxylative Allylation: Formal Synthesis of Aspergillide A.Angew. Chem. Int. Ed., 2013,52, 5134. (IF:11.709) (Highlight in Synfacts 2013,8, 870)

20.Zeng, J.; Tan, Y. J.;Leow M. L.;Tirtorahardjo, D.; Liu, X. -W.* Facile Access toCis-2,6-Disubstituted DdihydrapyranesviaPalladium Catalyzed Intramolecular Decarboxylative Allylation: Total Syntheses of (±)-Centrolobine, (+)-Decytospolide A and B.Chem. Eur. J. 2014,20, 405.(IF:5.771)

21.Zeng, J.; Zhang, Q.; Zhang, H. K.*; Chen, A.*Synthesis of trans-Dihydroxybutyrolactols as Efficient 4C Building Blocks: Application to the Synthesis of Polyhydroxylated Alkaloids.RSC, Advances, 2013,3, 20298.(IF: 3.840)

22.Zeng, J.;Tan, Y.J.; Leow, M. L.; Liu, X. -W.* Copper(II)/Iron(III) Co-catalyzed Intermolecular Diamination of Alkynes: Facile Synthesis of Imidazopyridines.Org. Lett.2012,14, 4386. (IF: 6.364) (Highlight in Synfacts 2012,8,1300.)

23.Zeng, J.; Bai, Y. G.; Ma, J. M.; Cai, S. T.; Liu, X.-W.*, Direct Synthesis of Pyrroles via A Silver Promoted Three-component Reaction Involving an Unsual Imidazole Ring Opening.Chem. Commun. 2011,47, 12855.(IF:6.834)

24.Zeng, J.; Vedachalam, S.; Xiang, S. H., Liu, X. -W.*,DirectC-Glycosylation by Coupling of Organotrifluoroborates with Glycosyl Flouorides and Iits Application to The Total Synthesis of (+)-Varitriol.Org. Lett. 2011,13, 42. (IF: 6. 6.732) (Highlighted in Organic Chemistry Portal, 2012, http://www.organic-chemistry.org/Highlights/2012/16January.shtm).

25.Xiang, S.; Lu, Z.; He, J.; Hoang, K. L. M.; Zeng, J.; Liu, X.-W.* β-Type Glycosidic Bong Formation by Palladium-Catalyzed Decarboxylative Allylation.Chem. Eur. J. 2013,19, 14047.(IF:5.731)

26.Cai, S. T.; Zeng, J.; Bai, Y. G.; Liu, X. -W.* Access to Quinolines through Gold-Catalyzed Intermolecular Cycloaddition of 2-Aminoaryl Carbonyls and Internal Alkynes.J. Org. Chem.2012,77, 801. (IF:4.721)

27.Xiang, S. H.; Cai, S. T.; Zeng, J.; Liu, X. -W.* Regio- and Stereoselective Synthesis of 2-Deoxy-C-aryl Glycosides via Palladium Catalyzed Decarboxylative Reactions.Org. Lett.2011,13, 4608. (IF: 6. 6.732)

28.Bai, Y. G.; Leow, M.; Zeng, J.; Liu, X. -W.* Palladium Catalyzed Stereoselective C-Glycosylation of Glycals with Enol Triflates.Org. Lett.2011,13, 5648. (IF: 6. 6.732)

29.Bai, Y. G.; Zeng, J.; Cai, S. T.; Liu, X.-W.*Palladium catalyzed direct cross-coupling reactions of glycols with activated alkenes.Org. Lett. 2011,13, 4394.(IF: 6.364)

30.Cai, S. T.; Xiang, S. H.; Zeng, J.; Gorityala, B. K.; Liu, X.-W.*Facile synthesis of carbohydrate-integrated isoxazolines through tandem [4 +1] cycloaddition and rearrangement of 2-nitroglycals.Chem. Commun. 201147, 8676.(IF:6.834)

31.Vedachalam, S.; Wang, Q. S.; Maji, B.; Zeng, J.; Ma, J.; Liu, X.-W.*N-Heterocyclic Carbene Catalyzed Intramolecular Hydroacylation of Activated Alkynes: Synthesis of Chromones.Adv. Synth. Catal.2011,353, 219.(IF:5.663)

32.Bai, Y. G.; Zeng, J.; Ma, J.; Gorityala, B. K.; Liu, X. -W.*Quick Access to Druglike Heterocycles: Facile Silver-Catalyzed One-Pot Multicomponent Synthesis of Aminoindolizines.J. Comb. Chem.2010,12, 696. (IF: 3.032)

33.Vedachalam, S.; Zeng, J.; Gorityala, B. K.; Antonio, M.; Liu, X. -W.*N-Heterocyclic Carbene-Catalyzed Intramolecular Aldehyde-Nitrile Cross Coupling: An Easy Access to 3-Aminochromones.Org. Lett.2010,12, 352.(IF: 6. 6.732)

34.Ma, J. M.; Zhao, Y. Y.; Ng, S.; Zhang, J.; Zeng, J.; Than, A.; Chen, P.; Liu, X.-W.*Sugar-Based Synthesis of Tamiflu and Its Inhibitory Effects on Cell Secretion.Chem. Eur. J.2010,16, 4533.(IF:5.771)

专利

1.万谦,曾静,王浩,孟令奎,赵祥,陈薇,陶景毅,舒朋华,“一种有机卤代化合物的还原脱卤方法”;中国发明专利,申请号:201710580852.6。

2.万谦,曾静,孟令奎,陈薇,赵祥,王浩,赵祥,“一种氘代化合物的合成方法”,申请号:201710580851.1。

3.万谦,舒朋华,曾静,赵岳琦,“一种糖基硫醇及金诺芬的合成方法”; 中国发明专利,申请号:201410459125.0.

4.张洪奎,曾静,“光学活性2,3-二羟基丁内半缩醛衍生物的制备方法”;中国发明专利,申请号:200710009462.X,公开号:CN 101130529A.

口头报告

1.第一届糖科学青年论坛。苏州,2018.05.27.

2.Tongji-Marburg Summit Forum on Pharmaceuticals.武汉. 2017.05.21.

3.第二届糖合成化学青年学术研讨会,山东大学,济南. 2017.05.14.

会议论文

1.Yao, W.; Sun, G.; Zhu, Y.; Cai, L.; Liu, K.; Zhang, Q.; Liu, X.; Wan, Q.*;Zeng, J.*“Diversified Stereoselective Synthesis of 3-Amino and 3-Nitro-2,3,6-trideoxypyranose”中国化学会第30届学术年会,大连理工大学, 3 July, 2016.

2.姚旺,孙广飞,朱阳斌,蔡磊,刘珂,刘学伟,万谦*,曾静*2016年全国糖生物学会议,南通,5-7 August,2016.

3.Wang Yao, Guangfei Sun, Yangbin Zhu, Lei Cai, Ke Liu, Xue-Wei Liu, Qian Wan,* Jing Zeng*, Diversified Stereoselective Synthesis of 3-Amino trideoxypyranose and Application in Oligosaccharide Assembly.8thAsian Community of Glycoscience and Glycotechnology Conference, Wuxi, China, October 13-16, 2016.

4.姚旺,孙广飞,朱阳斌,蔡磊,刘珂,张茜,刘学伟,万谦*,曾静*2016年华中地区药物化学学术会议暨国际药学前沿科学研讨会(2016 International Symposium of Frontier Sciences on New Drug Discovery and Central China Symposium on Medicinal Chemistry),武汉大学, October, 27-28, 2016

5.王若镔,孙广飞,张书新,姚旺,万谦*,曾静*.天然产物和药物的3-氨基糖修饰。中国化学会第31届学术年会,杭州,5May, 2018.l优秀墙报奖

6.孙广飞,王若镔,张书新,姚旺,曾静*,万谦*. 3-氨基脱氧糖的多样性合成及其糖苷键的构建。中国化学会第十届全国有机化学学术会议。深圳,2017年12,19-21.

7.Guangfei Sun, Wang Yao, Yangbin Zhu, Ruobin Wang, Lei Cai, Ke Liu, Qian Zhang, Xue-Wei Liu, Qian Wan,* Jing Zeng*, Stereoselective Synthesis of 3-Amino-2,3,6- trideoxypyranose and Their Assembly in Oligosaccharides.International Conference on New Challenges in organic Synthesis,Guangzhou, China, Nov. 26-29, 2016

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030