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师资队伍
杰出人才
博士后

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尚先梅

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尚先梅

女,博士,湖北宜昌人,2007年获华中科技大学博士学位。2008年起任华中科技大学药学院副教授。2009年4月至2010年8月在葡萄牙里斯本技术大学从事博士后研究。

讲授科目:基础有机化学;生物有机化学。

主要研究方向:有机金属药物的设计与合成。

通讯地址:华中科技大学同济医学院药学院,武汉市航空路13号,430030

办公地点:药学院一号楼613室。

Email: shangxianmei@hust.edu.cn

近年来发表的部分论文:

(1)Li Wang, Yihui He, Guangya Xiang, Xianmei Shang*Synthesis, cytotoxic and anti-metastaticproperties of newpyridyl-thiazole arene ruthenium(II) complexes,Applied Organometallic Chemistry,DOI:10.1002/aoc.4311. 2018., 32(5), e4311(1-11).

(2)Yihui He, Huiying Xue, Wendian Zhang, Li Wang, Guangya Xiang, Lei Li*, Xianmei Shang*,Discovery of a series of ruthenium(II) derivatives with adicarbonylmonoxime as novel inhibitors of cancer cells invasion and metastasis,Journal of Organometallic Chemistry,2017,842,82-92.

(3)Xianmei Shang*, Bin Zhao, Guangya Xiang,Fátima C. Guedes da Silva*, Armando J.L. Pombeiro.Dimeric diorganotin(IV) complexes with arylhydrazones of ß-diketones: synthesis, structures, cytotoxicity and apoptosis properties.RSC Advances, 2015,5, 45053-45060.

(4)Jia Yan, Li Wang, Xianggao Meng*, Xianmei Shang*.Ladder-like diorganotin(IV) complexescontaining cyclohexanecarboxylates: Synthesis, characterization andbiologicalactivities.Polyhedron, 2015, 93, 23-27.

(5) Bin Zhao, Xianmei Shang*, Ling Xu, Wendian Zhang, Guangya Xiang*,Novel mixed ligand di-n-butyltin(IV) complexes derived from acylpyrazolones andfluorinated benzoic acids: Synthesis, characterization, cytotoxicity and the induction of apoptosis in Hela cancer cells,European Journal of Medicinal Chemistry2014, 76. 87-97.

(6) Xianmei Shang, Telma F.S. Silva, Luísa M.D.R.S. Martins, Qingshan Li, M. Fátima C. Guedes da Silva, Maxim L. Kuznetsov, Armando J.L. Pombeiro.Synthesis, characterization, electrochemical behavior and in vitro protein tyrosine kinase inhibitory activity of the cymenehalogenobenzohydroxamato [Ru(η6-cymene)(bha)Cl] complexes.Journal of Organometallic Chemistry, 2013, 730, 137-143.

(7) Xianmei Shang*, Shaozhong Wei, Jia Yan, Jianping Wang.Synthesis, characterization and cytotoxicity of novel mixed-ligand butyl-hexyltin(IV) complexes with N-hydroxybenzamides.Polyhedron, 2013, 52, 429-434.

(8) Xianmei Shang*, Nan Ding, Guangya Xiang*.Novel di-n-butyltin(IV) derivatives: synthesis, high levels of cytotoxicity in tumor cells and the induction of apoptosis in KB cancer cells.European Journal of Medicinal Chemistry, 2012, 48, 305-312.

(9)Xianmei Shang, Elisabete C.B.A. Alegria, M. Fátima C. Guedes da Silva, Maxim L. Kuznetsov, Qingshan Li, Armando J.L. Pombeiro, Redox-active cytotoxic diorganotin(IV) cycloalkylhydroxamate complexes with different ring sizes: Reduction behaviour and theoretical interpretation.Journal of Inorganic Biochemistry, 2012, 117, 147–156.

(10) Xianmei Shang, Xianggao Meng, Elisabete C.B.A. Alegria, Qingshan Li, M.Fatima C. Guedes da Silva, Maxim L. Kuznetsov, and Armando J.L. Pombeiro.Syntheses, Molecular Structures, Electrochemical Behavior, Theoretical Study, and Antitumor Activities of Organotin(IV) Complexes Containing 1-(4-Chlorophenyl)-1-cyclopentanecarboxylato Ligands.Inorganic Chemistry, 2011, 50(18), 8158-8167.

(11) Wang, Jian-ping; Zhou, Ya-ming; Ye, Yu-jie; Shang, Xian-mei; Cai, Ya-ling; Xiong, Chao-mei; Wu, Yun-xia; Xu, Hai-xing. Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis.Journal of Ethnopharmacology, 2011, 137(3), 1089-1094.

(12) Xianmei Shang; Xianggao Meng; Qingshan Li, Synthesis, structure andin vitroantitumor activity of a multinuclear diorganotin(IV) complex (n-Bu)4Sn2{2,5-F2C6H3C(=O)NHO}2{2,5-F2C6H3C(=NO)O}]2.Chinese Journal of Chemistry, 2010, 28(2), 289-293.

(13) Xianmei Shang; Jingrong Cui; Jizhou Wu; Armando J.L. Pombeiro; Qingshan Li, Polynuclear diorganotin(IV) complexes with arylhydroxamates: syntheses, structures andin vitrocytotoxic activities.Journal of Inorganic Biochemistry, 2008, 102(4), 901-909.

(14) Yunlan Li; Li Yang; Xiaoqiang Niu; Xianmei Shang; Jianping Guo; Qingshan Li, Syntheses and antitumor activity of a new mixed-ligand complexdi-n-butyl-(4-chlorobenzohydroxamato)tin(IV) chloride.Journal of Inorganic Biochemistry, 2008, 102(9), 1731-1735.

(15) Xianmei Shang; Jizhou Wu; Qingshan Li, Interaction of dialkyltin(IV)bishydroxamateswith 5’-AMP or DNA: the impact of carbon chainlength to coordination properties.Chinese Journal of Chemistry, 2008, 26(4), 627-630.

(16) Xianmei Shang; Xianggao Meng, Crystal structure, spectroscopic and coordination properties of bis(4-fluorobenzohydroxamato)dimethyltin(IV).Chinese Journal of Structural Chemistry, 2008, 27(6), 683-686.

(17)尚先梅,吴军,李青山.芳香异羟肟酸有机锡抗癌化合物的初步构效关系,中国科学B.2008, 38(5), 429-440.

(18) Xianmei Shang;Jizhou Wu; Armando J.L. Pombeiro; Qingshan Li, Mononuclear diorganotin(IV) complexes with arylhydroxamates: syntheses, structures and assessment ofin vitrocytotoxicity.Applied Organometallic Chemistry, 2007, 21(11), 919-925.

(19) Xianmei Shang; Jizhou Wu; Qingshan Li, New coordination modes of substituted benzohydroxamic acid with dialkyltin(IV): structural diversity through ligand isomerization.European Journal of Inorganic Chemistry, 2006, 4143-4150.

(20) Xianmei Shang; Jizhou Wu; Qingshan Li, Synthesis and crystal structure of a novel diorganotin(IV) complex containing 3,4-difluorobenzohydroxamato ligand.Chinese Chemical Letters, 2006, 17(6), 821-824.

(21) Xianmei Shang; Qingshan Li; Jizhou Wu, Synthesis and crystal structure of a mixed-ligand compound di-n-butyl(4-chlorobenzoxy)(4-chlorobenzohydroxam ato)tin(IV).Journal of Organometallic Chemistry,2005,690(17),3997-4000.

主持的研究项目:

2012.1-2014.12,国家自然科学基金青年基金《新型有机金属化合物的抗癌构效关系及其诱导肿瘤细胞凋亡机制研究》(81102311)。

2016.1-2017.12,湖北省自然科学基金一般面上项目《基于协同效应的含Sn/Ru异活性中心吡唑酮肟类抗癌化合物的设计合成及其抗转移作用研究》(2016CFB433)。

教材编写:

2013年参与编写《有机化学》和《有机化学学习指导》第二版,中国医药科技出版社。

获奖:

1、2005年获华中科技大学研究生(博士)优秀论文奖和科技创新奖。

2、2007年4月被评为华中科技大学“优秀青年教工”;。

3、2009年2月,《芳香异羟肟酸有机锡抗癌化合物的构效关系、作用机制及药代动力学》获山西省自然科学二等奖(排名第三)。

4、2012年11月,获华中科技大学教学质量优秀奖二等奖。

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030