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张志平

来源:未知 发布时间 2015-09-14 09:57:00 点击数:

张志平,1975年出生,安徽省太湖县人,华中科技大学同济药学院、国家纳米药物工程技术研究中心教授,博士生导师,湖北省楚天学者,药剂学系主任。1996年毕业于武汉化工学院本科,1999年天津大学化工学院硕士,1999-2003年天津石化公司和中国海洋石油公司工程师,2003-2007年新加坡国立大学博士、博士后,2007-2010年美国哈佛大学医学院博士后。2010年至今在华中科技大学任教授、博士生导师。主要研究方向为智能靶向纳米药物递送系统和纳米免疫治疗:1)基于维生素E TPGS的新型纳米药物逆转肿瘤多药耐药性研究;2)基于脂包被或仿生结构的新型抗肿瘤纳米疫苗。目前任中国颗粒学会第二届青年理事会理事和生物颗粒专业委员会委员,中国抗癌协会纳米肿瘤专业委员会委员,中国生物物理学会纳米生物物理专业委员会委员,湖北省药学会制药工程委员会副主任委员,武汉市药学会药学教育委员会常务委员等。在国际重要学术期刊ACS Nano、Advanced Drug Delivery Reviews、Biomaterials、Theranostics、Nanoscale、Biomacromolecules、Nanomedicine、Expert Opinion on Drug Delivery、Pharmaceutical Research、Molecular Pharmaceutics、International Journal of Nanomedicine、International Journal of Pharmaceutics、European Journal of Pharmaceutical Sciences等杂志发表SCI收录文章41篇,引用1000余次,2014年ESI高被引文章3篇。其中以第一/通讯作者文章29篇,大于10.0的文章1篇,大于5.0的文章13篇,文章已被引700余次,单篇引用次数100次文章4篇,有4篇文章被Sciencedirect.com评为当年度季度最高下载25篇文章。担任《中国药剂学杂志(网络版)》第二届编委会编委,国际学术期刊Biomaterials、Small、Theranostics、ACS Applied Materials & Interfaces、Biomacromolecules、Nanomedcine-NBM、Nanomedicine-UK、Molecular Pharmaceutics、Polymer Chemistry、Journal of Biomedical Nanotechnology、RSC Advances、Journal of Materials Chemistry B等的审稿人。曾在ChinaNanomedicine2015(杭州)、第7届世界颗粒协会(北京2014)、2014国际创新药物制放研讨会(台北)、中国抗癌协会第1届纳米肿瘤年会(武汉2013)、ChinaNano2013(北京)、湖北省药学会(2013)、第9届世界生物材料大会(2012)、2012年、2013年和2014年中国药物制剂大会、第33届国际控制释放大会(2006)等做报告。目前承担国家自然科学基金委面上项目、科学部主任基金项目、教育部博士点新进教师基金项目,参与承担国家重大科学研究计划(主要学术骨干)等项目。曾获得2012年世界生物材料大会颁发的“Young Scientist”奖、2013年中国药物制剂大会优秀论文报告二等奖、华中科技大学2013年度“学术新人奖”、2015年华科“十佳青年教工”和2006年国际控制释放协会颁发的“口服吸收创新”奖等。

1.发表论文及获奖情况(*为通讯作者)

[1] Guo YY, WangD, SongQL, WuTT, Zhuang XT, Bao YL, KongM, QiY, Tan SW,Zhang ZP*. Erythrocyte membrane-enveloped polymeric nanoparticles as nano-vaccine for induction of antitumor immunity against melanoma. ACS Nano 2015, 9(7): 6918-6933(影响因子12.881)

[2] Wu YP, Chu Q, Tan SW, Zhuang XT, Bao YL, Wu TT,Zhang ZP*.D-α-tocopherol polyethylene glycol succinate-basedderivativenanoparticles as a novel carrier for paclitaxel delivery. International Journal of Nanomedicine 2015, 10: 5219-5235(影响因子4.383)

[3] Songwei Tan, Tingting Wu, Dan Zhang, Zhiping Zhang*. Cell or cell membrane-based drug delivery systems. Theranostics 2015, 5(8): 863-881(影响因子8.022)

[4] Xu Li, Cuixia Gao, Yupei Wu, C-Yan Cheng, Weiliang Xia and Zhiping Zhang*. Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug resistant cancer cells. Journal of Materials Chemistry B 2015, 3: 1556-1564(影响因子4.726,引用次数1)

[5] Shuna Jin, Chengwu Song, Sen Li, Yang Zhang, Chang Chen, Xin Zhou, Yong Xu, Yulin Feng, Zhiping Zhang*, Hongliang Jiang*. Preventive effects of turmeric on the high-fat diet-induced hyperlipidaemia in mice associated with a targeted metabolomic approach for the analysis of serum lysophosphatidylcholine using LC-MS/MS. Journal of Functional Foods 2014, 11: 130-141.(影响因子3.5744)

[6] Qingle Song, Songwei Tan, Xiangting Zhuang, Yuanyuan Guo, Yongdan Zhao, Tingting Wu, Qi Ye, Luqin Si*, and Zhiping Zhang*.Nitric oxide releasing d-α-tocopheryl polyethylene glycol succinate for enhancing antitumor activity of doxorubicin. Molecular Pharmaceutics 2014, 11(11): 4118-4129.(影响因子4. 384,引用次数2)

[7] Yuling Bao, Yuanyuan Guo, Xiangting Zhuang, Dan Li, Bolin Cheng, Songwei Tan*, Zhiping Zhang*. D-α-tocopherol polyethylene glycol succinate based redox-sensitive paclitaxel prodrug for overcoming multidrug resistance in cancer cells. Molecular Pharmaceutics 2014, 11(9): 3196-3209.(影响因子4. 384,引用次数5)

[8] Guo YY, Chu M, Tan SW, Zhao S, Liu HX, Otieno BO, Yang XL, Xu CR*,ZhangZP*. Chitosan-g-TPGS nanoparticles for anticancer drug delivery and overcoming multidrug resistance. Molecular Pharmaceutics 2014, 11(1): 59-70.(影响因子4. 384,引用次数9)

[9] Cao N, Liu SQ, Wu M, Deng RH, Wang JY,Zhang ZP*, Zhu JT*.Synthesis of polymer-inorganic patchy microcapsules with tunable patches.European Polymer Journal2013, 49(11): 3691-3701.(影响因子3.005)

[10] Zhao S, Tan SW, Guo YY, Huang J, Chu M, Liu HD,Zhang ZP*. pH-sensitive docetaxel-loaded TPGS-poly(β-amino ester) copolymer nanoparticles for overcoming multidrug resistance. Biomacromolecules 2013, 14(8): 2636-46.(影响因子5.750,引用次数17)

[11] Yu YN, Tan SW, Zhuang XT, Song QL, Wang YL, Zhou Q,Zhang ZP*.Antitumor activity of docetaxel-loaded polymeric nanoparticles fabricated by Shirasu porous glass membrane emulsification technique. International Journal of Nanomedicine 2013, 8: 2641-52.(影响因子4.383,引用次数7)

[12] Tan SW, Sasada T, Bershteyn A, Yang KY, Ioji T,Zhang ZP*. Combinational delivery of lipid-enveloped polymeric nanoparticles carrying different peptides for anti-tumor immunotherapy. Nanomedicine 2014, 9(5): 635-647.(影响因子5.413,引用次数3)

[13] Guo YY, Luo J, Tan SW, Otieno BO andZhang ZP*.The applications of Vitamin E TPGS in drug delivery. European Journal of Pharmaceutical Sciences 2013, 49(2): 175-186.(影响因子3.350,引用次数32)

[14]Zhang ZP, Mei L, Feng SS*.Paclitaxel drug delivery system. Expert Opinion on Drug Delivery 2013, 10(3): 325-40.(影响因子4.840,引用次数33)

[15] Tan SW, Li X, Guo YJ,Zhang ZP*.Lipid-enveloped hybrid nanoparticles for drug delivery.Nanoscale2013, 5(3): 860-72.(影响因子7.394,引用次数24)

[16]Zhang ZP, Mei L, Feng SS*. Vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate-based nanomedicine. Nanomedicine 2012, 7(11): 1645-7.(影响因子5.413,引用次数20)

[17]Zhang ZP, Tan SW, Feng SS*. Vitamin E TPGS as a molecular biomaterial for drug delivery, Biomaterials 2012, 33(19): 4889-906.(影响因子8.557,引用次数98)

[18]Zhang ZP, Guo YJ, Feng SS*. Nanoimmunotherapy: application of nanotechnology for sustained and targeted delivery of antigens to dendritic cells, Nanomedicine 2012, 7(1): 1-4.(影响因子5.413,引用次数7)

[19]Zhang ZP, Yang XL, Feng SS*.Copolymer technology for advanced nanomedicine. Nanomedicine 2011, 6(4): 583-7.(影响因子5.413,引用次数2)

[20]Zhang ZP,Tongchusak S, Mizukami Y, Kang YJ, Ioji T, Touma M, Reinhold B, Keskin DB, Reinherz EL, Sasada T*. Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery.Biomaterials2011, 32(14): 3666-3678.(影响因子8.557,引用次数55)

[21] Radiosensitization of TPGS emulsified docetaxel-loaded poly (DL-lactide-co-glycolide) nanoparticles in CNE-1 and A549 cells. Journal of Biomaterials Applications 2015(影响因子2.197).

[22] Jia Ma, Zhanjie Zhang, Jing Huang, You Qin, Xu Li, Hongli Liu,Zhiping Zhang*, Kunyu Yang*, Gang Wu. Magnetic nanoparticle clusters radiosensitizes human nasopharyngeal and lung cancer cells after alternating magnetic field treatment. International Journal of Hyperthermia 2015(影响因子2.645).

[23]Zhang ZP, Lee SH, Gan CW, Feng SS*. In vitro and in vivo investigation on PLA-TPGS nanoparticles for controlled and sustained small molecule chemotherapy. Pharmaceutical Research 2008, 25(10): 1925-35.(影响因子3.420,引用次数52)

[24]Zhang ZP, Lee SH, Feng SS*. Folate decorated poly(lactide-co-glycolide)-Vitamin E TPGS nanoparticles for targeted drug delivery. Biomaterials 2007, 28(10): 1889-1899.It has been ranked by ScienceDirect. com as a TOP 25 Hottest Paper in Q1 2007, 13th position in the subject area ofEngineering;23th position in the subject area ofChemical Engineering; 14th Positionin the subject area ofMaterials Science and 11th Positionin the subject area of Biomaterials.(影响因子8.557,引用次数116)

[25]Zhang ZP, Feng SS*. The drug encapsulation efficiency, in vitro drug release, cellular uptake and cytotoxicity of paclitaxel-loaded poly(lactide)-tocopheryl polyethylene glycol succinate nanoparticles.Biomaterials2006, 27(21): 4025-33.It has been ranked by ScienceDirect. com as a TOP 25 Hottest Paper in Q2 2006, 7th position in the subject area ofEngineering; 20th Positionin the subject area ofMaterials Science;and 6th position in the journal of Biomaterials.(影响因子8.557,引用次数137)

[26]Zhang ZP, Feng SS*. In vitro investigation on poly(lactide)-tween 80 copolymer nanoparticles fabricated by dialysis method for chemotherapy. Biomacromolecules 2006, 7(4): 1139-46.(影响因子5.750,引用次数48)

[27]Zhang Z, Feng SS*.Self-assembled poly(lactide)/Vitamin E TPGS copolymers nanoparticles for oral chemotherapy. International Journal of Pharmaceutics 2006, 324(2): 191-8.(影响因子3.650,引用次数41)

[28]Zhang ZP, Feng SS*. Nanoparticles of poly(lactide)/Vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release.Biomaterials2006, 27(2): 262-70.It has been ranked by ScienceDirect. com as a TOP 25 Hottest Paper in Q4 2006,6th position in the subject area ofEngineering;6th position in the subject area ofChemical Engineering; and 4th Positionin the subject area ofMaterials Science.(影响因子8.557,引用次数115)

[29]Zhang ZP, Lin HH*. Genomic profiling by machine learning. 2011 IEEE International Conference in Bioinformatics and Biomedicine Worksjops (BIBMW 2011) 2011: 662-8.

[30] Xindong Teng, Maopeng Tian, Jianrong Li, Songwei Tan, Xuefeng Yuan, Qi Yu, Yukai Jing, Zhiping Zhang, Tingting Yue, Lei Zhou, Xionglin Fan. Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine. Human Vaccines & Immunotherapeutics 2015, 11(6): 1456-1464(影响因子3.643,引用次数0).

[31] Haiqiang Cao, Zhiwen Zhang*, Shuang Zhao, Xinyu He, Haijun Yu, Qi Yin, Zhiping Zhang, Wangwen Gu, Lingli Chen, Yaping Li*. Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression. Journal of Controlled Release 2015, 205: 162-171.

[32] Gan Tian, Xiaopeng Zheng, Xiao Zhang, Wenyan Yin, Jie Yu, Dongliang Wang, Zhiping Zhang, Xiangliang Yang, Zhanjun Gu*, Yuliang Zhao*. TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance. Biomaterials 2015, 40: 107-116.

[33] Tan Yang, Bin Li, ShiBo Qi, Yong Liu, Yongkang Gai, Peng Ye, Guang Yang, Wendian Zhang, Peng Zhang, Xingxing He, Weijie Li, Zhiping Zhang, Guangya Xiang*, Chuanrui Xu*. Co-delivery of doxorubicin and Bmi1 siRNA by folate receptor targeted liposomes exhibits enhanced anti-tumor effects in vitro and in vivo. Theranostics 2014; 4(11): 1096-1111.(影响因子7.827)

[34] Mei L,Zhang ZP, Zhao LY, Huang LQ, Yang XL, Tang JT, Feng SS*. Pharmaceutical nanotechnology for oral delivery of anticancer drugs. Advanced Drug Delivery Reviews 2013, 65(6): 880-90.(影响因子15.038,引用次数13)

[35] Li JL*, Wang L, Liu XY*,Zhang ZP, Guo HC, Liu WM, Tang SH. In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles. Cancer Letters 2009, 274(2): 319-26.(影响因子5.621,引用次数84)

[36] Dong Y,Zhang Z, Feng SS*.D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) modified poly(L-lactide) (PLLA) films for localized delivery of paclitaxel.International Journal of Pharmaceutics 2008, 350(1-2): 166-71.(影响因子3.650,引用次数13)

[37] Feng SS*, Zhao LY,Zhang ZP, Bhakta G, Win KY, Dong YC, Chien S. Chemotherapeutic engineering: Vitamin E TPGS-emulsified nanoparticles of biodegradable polymers realized sustainable paclitaxel chemotherapy for 168 h in vivo. Chemical Engineering Science 2007, 62(23): 6641-8.(影响因子2.337,引用次数43)

[38] Lee SH,Zhang ZP, Feng SS*. Nanoparticles of poly(lactide)-vitamin E TPGS copolymers for protein drug delivery. Biomaterials 2007, 28(11): 2041-50.It has been ranked by ScienceDirect. com as a TOP 25 Hottest Paper in Q1 2007, 9th position in the subject area ofEngineering;10th position in the subject area ofChemical Engineering; 11th Positionin the subject area ofMaterials Science and 7th Positionin the subject area of Biomaterials.(影响因子8.557,引用次数50)

2.已申请或已授权的发明专利:

张志平,谭松巍,一种多西他赛纳米制剂及其制备方法(发明专利,公开号:CN102357075A)

谭松巍,张志平,一种具有P-糖蛋白抑制功能的抗肿瘤前药(发明专利,公开号:CN 102935236 A, PCT/CN2012/087617)

张志平,谭松巍,宋庆乐,一种具有抗癌活性的化合物及抗癌组合物(发明专利,申请号:201410417939.8)

张志平,李旭,高翠霞,吴玉佩,郑全仁,夏伟梁,一种具有抗肿瘤作用的化合物、其制备方法及应用(发明专利,申请号:201410621102.5)

3.所获奖励:

2015年获华中科技大学“十佳青年教工”

2013年获“中国药物制剂大会”优秀论文报告二等奖

2013年获华中科技大学“学术新人奖”

2013年推送的大学生创新性实验成果“具有P-糖蛋白抑制功能的紫杉醇前药研究”获得第六届大学生“药苑论坛”成果创新二等奖

2013年推送的大学生创新性实验成果“可逆转肿瘤多药耐药的pH敏感性TPGS-b-PBAE脂包被纳米粒”获得第六届大学生“药苑论坛”成果创新三等奖

2012年获得世界生物材料大会“Young Scientist”奖(每四年一届会议)

2006年获得国际控制释放协会和美国辉瑞医药公司委员会授予“Innovative Aspects of Oral Drug Delivery and Absorption Graduate/Post-Doc Award”奖。

指导的2013级硕士研究生鲍宇玲同学负责的项目“逆转肿瘤耐药的新型TPGS纳米药物体系的构建”荣获湖北省第十届“挑战杯”大学生课外学术科技作品竞赛二等奖。

4.国际国内学术交流

2013年中国药物制剂大会组会会副秘书长。曾邀请波士顿大学林鸿煌博士(2014年)、新加坡国立大学冯思慎教授(2010、2011、2012年)、美国UIUC程建军教授(2012年)、美国马歇尔研究所谢敬伟研究员(2012年)、澳大利亚科廷大学陈妍讲师(2012年)、美国明尼苏达大学孙常全教授(2011年)、英国阿斯顿大学药学院欧阳德方博士(2011、2013年)、美国约翰霍普金斯大学徐庆国博士(2013年)和2012年纳米药学国际化课程邀请北京大学药学院张强教授、四川大学华西药学院张志荣教授、孙逊教授、复旦大学陆伟跃教授、中国科学院上海药物所李亚平研究员、中国科技大学王均教授。2013年邀请国家纳米科学技术中心梁兴杰研究员、苏州大学陈华兵教授、天津工业大学潘杰副教授;2014年邀请浙江大学高建青教授、美国北卡大学药学院顾臻教授和黄力夫教授、肯塔基大学药学院郭培宣教授、沈阳药科大学何仲贵教授、复旦大学蒋晨教授、日本日本滋贺医科大学小松直树副教授、深圳先进技术研究院蔡林涛研究员和马轶凡研究员、美国U Mass的韩纲教授、美国西北大学郝靓靓博士、美国北卡大学药学院郭术涛博士、美国匹兹堡大学医学中心覃斌博士、复旦大学蒋晨教授、国家纳米科学中心聂广军研究员、中国科学院过程工程研究所马光辉研究员、四川大学华西药学院黄园教授、美国哈佛医学院许小丁博士、占昌友博士和刘倩博士、新加坡国立大学彭娟娟博士、南洋理工大学赵灵之博士和罗忠博士、沈阳药科大学孙进教授等来院/课题组讲座/交流。

5.联系方式

课题组招收免疫学、高分子材料科学、药学、化学等专业背景的博士后、博士和硕士研究生。Email:zhulinyulaoliu@msn.com

通信地址:武汉市航空路13号同济医学院药学院邮政编码:430030

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030