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师资队伍
杰出人才
博士后

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黄建耿

来源: 发布时间 2017-09-07 10:05:06 点击数:

黄建耿,男,博士,副教授,硕士研究生导师。美国药学会会员、中国抗癌协会纳米肿瘤学专业委员会委员武汉市药学会药学教育专业委员会委员、国家自然科学基金评审专家、教育部学位论文评审专家、《医药导报》编委

 

联系方式jiangenghuang@hust.edu.cn

 

研究方向

1. 基于药物转运体与代谢酶功能改变引发药物性肝损伤机理研究

2. 肝损伤、帕金森等疾病状态下药物转运体与代谢酶调控机制研究

教育背景:

博士 2008.07 华中科技大学同济医学院药学院

本科 2003.07 华中科技大学同济医学院(原同济医科大学)药学院

 

工作经历:

副教授  2012.04-至今  华中科技大学同济医学院药学院

博士后  2010.08-2012.03 美国University of Iowa药学院

兼职讲师 2011.08-2011.11 美国Drake University药学院

博士后  2008.10-2010.07 美国University of Nebraska Medical Center药学院

 

主持科研课题:

1. 国家自然科学基金项目:α-突触核蛋白调控uptake 2转运体:多巴胺受体激动剂抗帕金森降效机制研究2018.01-2021.12 课题编号:81773811

2. 国家自然科学基金项目:基于NTCP/NtcpBSEP/Bsep介导的胆汁酸转运受阻导致托伐普坦药物性肝损伤机理研究 2014.01-2016.12 课题编号:81302837

3. 湖北省自然科学基金项目:基于胆汁酸代谢的药物性肝损伤诊断研究2014.01-2015.12 课题编号:2014CFB956

4. 湖北省卫生厅青年科技人才项目:普拉克索鼻黏膜给药脑靶向治疗帕金森及其跨鼻黏膜转运机制研究 2013.01-2014.12 课题编号:QJX2012-02

代表作:

1. Sijie He#, Sanlan Wu#, Wenwen Zhu, Yeli Guan, Gao Li, Luqin Si*, Jiangeng Huang*. Enantioselective determination of 1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol hydrochloride, a novel antihypertensive agent, in rat plasma and tissues by LC–MS/MS. J Sep Sci. 2017, DOI: 10.1002/jssc.201700710(#Both authors contributed equally)

2. Li Kang#, Luqin Si#, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang*. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes. Toxicol In Vitro. 2017, 40:313-323. (#Both authors contributed equally)

3. Mengzhu Zheng#, Weiguang Sun#, Suyu Gao#, Shanshan Luan, Dan Li, Renqi Chen, Qian Zhang, Lixia Chen*, Jiangeng Huang* and Hua Li*. Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. Oncotarget. 2017, 8:44255-44265.

4. Jiaqiang Xu, Gao Li, Zhuoyi Wang, Luqin Si, Sijie He, Jialing Cai, Jiangeng Huang*, Maureen D. Donovan*. The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues. Chemosphere. 2016, 145:487-494.

5. Peng Cao, Gao Li, Ling Huang, Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si*, Jiangeng Huang*. Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood. Bioanalysis. 2015, 8(17):1823-1835.

6. Kewen Xue, Gao Li, Xiao Sun, Yang Hu, Lei Hu, Jiangeng Huang*, Luqin Si*. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug. J Chromatogr B Analyt Technol Biomed Life Sci. 2015, 990:141-149.

7. Lei Hu, Zhenhua Lv, Gao Li, Xiaolong Xu, Chenghao Zhang, Peng Cao, Jiangeng Huang*, Luqin Si*. Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry. J Sep Sci. 2015, 38(11):1837-1849.

8. Weilin Guo, Gao Li, Yanxia Yang, Conglian Yang, Luqin Si*, Jiangeng Huang*. LC-MS/MS analysis of pramipexole in mouse plasma and tissues: Elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2015, 988:157-165.

9. Jiangeng Huang, Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li, Luqin Si*. In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2012, 891-892:98-101.

10. Jiangeng Huang, Juanjuan Liu, Cong Zhang, Jiaojiao Wei, Li Mei, Shan Yu, Gao Li*, Li Xu*. Determination of sulfonamides in food samples by membrane-protected micro-solid phase extraction coupled with high performance liquid chromatography. J Chromatogr A. 2012, 1219:66-74.

11. Jiangeng Huang, Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*. In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2011, 879(30):3386-3392.

12. Jiangeng Huang, Nagsen Gautam, Sai Praneeth R. Bathena, Upal Roy, JoEllyn McMillan, Howard E. Gendelman, Yazen Alnouti*. UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 2011, 879(23):2332-2338.

13. Jiangeng Huang, Sai Praneeth R. Bathena, Ivan L. Csanaky, Yazen Alnouti*. Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS. J Pharm Biomed Anal. 2011, 55(5):1111-1119.

14. Jiangeng Huang, Sai Praneeth R. Bathena, Yazen Alnouti*. Metabolite profiling of Praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple-quadrupole linear ion trap mass spectrometer. Drug Metab Pharmacokinet. 2010, 25(5):487-499.

15. Jiangeng Huang, Sai P. Bathena, Jing Tong, Megan Roth, Bruno Hagenbuch, Yazen Alnouti*. Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010, 40(3):184-194.

16. Jiangeng Huang, Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism. Int J Pharm. 2008, 356(1-2):351-353.

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