旧版入口 | English

师资队伍
杰出人才
博士后

您当前所在位置: 首页 - 师资队伍 - 药剂学系 - 正文

黄建耿

来源: 发布时间 2018-09-19 11:00:22 点击数:

黄建耿,男,博士,副教授,硕士研究生导师。


联系方式:jiangenghuang@hust.edu.cn


研究方向:药代动力学研究(药物体内转运与代谢)


教育背景:

博士    2008.07  华中科技大学同济医学院药学院

本科    2003.07  华中科技大学同济医学院(原同济医科大学)药学院


工作经历:

副教授    2012.04-至今  华中科技大学同济医学院药学院

博士后    2010.08-2012.03  美国University of Iowa药学院

兼职讲师  2011.08-2011.11  美国Drake University药学院

博士后  2008.10-2010.07  美国University of Nebraska Medical Center药学院


主持科研课题:

1. 国家自然科学基金项目:α-突触核蛋白调控uptake 2转运体:多巴胺受体激动剂抗帕金森降效机制研究2018.01-2021.12  课题编号:81773811

2. 企业委托项目:苦荞麦提取物体内代谢谱研究  2018.03-2018.12

3. 国家自然科学基金项目:基于NTCP/NtcpBSEP/Bsep介导的胆汁酸转运受阻导致托伐普坦药物性肝损伤机理研究 2014.01-2016.12  课题编号:81302837

4. 湖北省自然科学基金项目:基于胆汁酸代谢的药物性肝损伤诊断研究2014.01-2015.12  课题编号:2014CFB956

5. 湖北省卫生厅青年科技人才项目:普拉克索鼻黏膜给药脑靶向治疗帕金森及其跨鼻黏膜转运机制研究 2013.01-2014.12  课题编号:QJX2012-02


代表作:

1. Yang Hu#, Wenwen Zhu#, Yeli Guan, Sanlan Wu, Xiaoyin Zhang, Gao Li, Luqin Si*, Jiangeng Huang*. Accurate determination of a novel vasodilatory βblocker TJ0711 using LCMS/MS: Resolution of an isobaric metabolite interference in dog plasma. Biomed Chromatogr. 2018 Jun;32(6):e4196. doi: 10.1002/bmc.4196. (#Both authors contributed equally)

2. Sijie He#, Sanlan Wu#, Wenwen Zhu, Yeli Guan, Gao Li, Luqin Si*, Jiangeng Huang*. Enantioselective determination of 1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol hydrochloride, a novel antihypertensive agent, in rat plasma and tissues by LC–MS/MS. J Sep Sci. 2017, DOI: 10.1002/jssc.201700710(#Both authors contributed equally)

3. Li Kang#, Luqin Si#, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang*. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes. Toxicol In Vitro. 2017, 40:313-323. (#Both authors contributed equally)

4. Mengzhu Zheng#, Weiguang Sun#, Suyu Gao#, Shanshan Luan, Dan Li, Renqi Chen, Qian Zhang, Lixia Chen*, Jiangeng Huang* and Hua Li*. Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. Oncotarget. 2017, 8:44255-44265.

5. Jiaqiang Xu, Gao Li, Zhuoyi Wang, Luqin Si, Sijie He, Jialing Cai, Jiangeng Huang*, Maureen D. Donovan*. The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues. Chemosphere. 2016, 145:487-494.

6. Peng Cao, Gao Li, Ling Huang, Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si*, Jiangeng Huang*. Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood. Bioanalysis. 2015, 8(17):1823-1835.

7. Kewen Xue, Gao Li, Xiao Sun, Yang Hu, Lei Hu, Jiangeng Huang*, Luqin Si*. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug. J Chromatogr B Analyt Technol Biomed Life Sci. 2015, 990:141-149.

8. Lei Hu, Zhenhua Lv, Gao Li, Xiaolong Xu, Chenghao Zhang, Peng Cao, Jiangeng Huang*, Luqin Si*. Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry. J Sep Sci. 2015, 38(11):1837-1849.

9. Weilin Guo, Gao Li, Yanxia Yang, Conglian Yang, Luqin Si*, Jiangeng Huang*. LC-MS/MS analysis of pramipexole in mouse plasma and tissues: Elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2015, 988:157-165.

10. Jiangeng Huang, Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li, Luqin Si*.  In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2012, 891-892:98-101.

11. Jiangeng Huang, Juanjuan Liu, Cong Zhang, Jiaojiao Wei, Li Mei, Shan Yu, Gao Li*, Li Xu*.  Determination of sulfonamides in food samples by membrane-protected micro-solid phase extraction coupled with high performance liquid chromatography. J Chromatogr A. 2012, 1219:66-74.

12. Jiangeng Huang, Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*.  In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2011, 879(30):3386-3392.

13. Jiangeng Huang, Nagsen Gautam, Sai Praneeth R. Bathena, Upal Roy, JoEllyn McMillan, Howard E. Gendelman, Yazen Alnouti*.  UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 2011, 879(23):2332-2338.

14. Jiangeng Huang, Sai Praneeth R. Bathena, Ivan L. Csanaky, Yazen Alnouti*.  Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS. J Pharm Biomed Anal. 2011, 55(5):1111-1119.

15. Jiangeng Huang, Sai Praneeth R. Bathena, Yazen Alnouti*. Metabolite profiling of Praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple-quadrupole linear ion trap mass spectrometer. Drug Metab Pharmacokinet. 2010, 25(5):487-499.

16. Jiangeng Huang, Sai P. Bathena, Jing Tong, Megan Roth, Bruno Hagenbuch, Yazen Alnouti*. Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010, 40(3):184-194.

17. Jiangeng Huang, Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism. Int J Pharm. 2008, 356(1-2):351-353.


学术任职

2018.04--至今     国家食品药品监督管理局药物临床试验数据核查检查员

2017.11--至今     中国药理学会药物代谢专业委员会青年委员会委员

2017.11--至今      国际药物及化学异物代谢学会(ISSX会员

2015.05--至今      国家自然科学基金委评审专家

2015.01--至今      教育部学位论文评审专家

2014.05--至今  《医药导报》编委

2013.04--至今      武汉市药学会药学教育专业委员会委员

2012.12--2017.11    中国抗癌协会纳米肿瘤学专业委员会委员

2010.10--至今      美国药学科学家协会(AAPS会员


华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030