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卢瑶

来源: 发布时间 2018-11-28 10:26:08 点击数:

卢瑶

   博士,华中科技大学药剂系,主要从事新型药物递释系统的研究,近几年着重在新型递释系统用于肿瘤免疫治疗联合化疗、基因治疗等方面的研究。已在国际重要学术期刊Angewandte Chemie IF=12.12), Journal of The American Chemical Society (JACS)IF=14.357), Advanced Functional Materials IF=13.325), Biomaterials (IF= 8.806)Nano researchIF=7.994), Molecular Therapy IF=7.008), Cancer Letters IF6.491), 等上发表SCI论文总共16篇。

 

工作经历:

2018/07-今,华中科技大学,药学院

2016/09-2018/02,昆士兰大学,AIBN

2016/04-2018/06,华中科技大学,基础医学院,博士后

教育经历

2013/09-2015/10,北卡罗来纳大学教堂山,联合培养博士

2009/09-2016/01,华中科技大学,博士

2005/09-2009/06,华中科技大学,药学院,本科

 

在研基金

1. 国家自然科学基金青年科学基金项目,81603046铂类/免疫佐剂共载纳米粒诱导原位抗原产生用于治疗晚期黑色素瘤,在研,主持

2. 国家自然科学基金青年科学基金项目,81703446, 氧化还原敏感性可降解多功能介孔硅纳米粒的构建及其抑制肿瘤干细胞逆转肿瘤耐药的作用研究, 在研,参加。

3. 国家自然科学基金面上项目,81673368,新型脂包被顺铂/磷酸钙共载纳米粒抑制肝癌干细胞并协同治疗肝癌的实验研究, 在研, 参加。

 

近几年部分研究成果:

 

(1) Yannan Yang#, Yao Lu #, et al. Stepwise degradable nanocarriers enabled cascade delivery for synergistic cancer therapy. Advanced Functional Materials, (2018), 28: 1800706. (共同第一作者) IF=13.325)

(2) Yao Lu#, Yannan Yang#, et al. Glutathione-Depletion Mesoporous Organosilica Nanoparticles as a Self-Adjuvant and Co-delivery Platform for Enhanced Cancer Immunotherapy. Biomaterials. 2018,82-92. (IF= 8.806)

(3) Hao Song, Meihua Yu, Yao Lu, Zhengying Gu, et al. Plasmid DNA Delivery: Nanotopography Matters, Journal of the American Chemical Society, 2017, 139(50): 18247-18254. IF=14.357)

(4) Yannan Yang#, Yao Lu#, Prasanna Lakshmi Abbaraju, et al. Multishelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy, Angewandte Chemie, 2017, 129(29): 8566-8570 (共同第一作者) IF=12.12)

(5) Yao Lu, Yuhua Wang, Lei Miao, Matthew Haynes, et al. Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: a combination nanomedicine approach, Cancer letters, 2016, 379(1): 32-38. IF6.491)

(6) Yao Lu, Lei Miao, Yuhua Wang, Zhenghong Xu, et al. Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model. Molecular Therapy. 2016. 24(2): 364-374 (IF=7.008)

(7) Yao Lu#, Nan Ding#, Chang Yang, Lei Huang L, Jian Liu, Guangya Xiang. Preparation and in vitro Evaluation of a Folate-Linked Liposomal Curcumin Formulation. Journal of Liposome Research. 2012, 22, 110-119.

(8) Nan DingYao Lu# Robert J Lee# Chang YangLei HuangJian LiuGuangya XiangFolate receptor targeted fluorescent paramagnetic bimodal liposomes for tumor imaging, International Journal of Nanomedicine2011,6:2513-2520 (共同第一作者)

(9) Peng Ye, Wendian Zhang, Tan Yang, Yao Lu, Mao Lu, Yongkang Gai, Xiang Ma, Guangya Xiang. Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting. International Journal of Nanomedicine. 2014, 9, 2167-2178.

 

 

 

 

 

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