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师资队伍
杰出人才
博士后

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周渊

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周渊,男,2011年博士毕业于北京大学药学院生药学专业,随后进入扬子江药业集团药物研究院任职项目主管,负责多个中药新药研发工作,先后被评为集团公司“技术标兵”和“先进个人”。2013年进入中国农业科学院蔬菜花卉研究所博士后流动站,对葫芦科植物中葫芦素开展生物合成研究。2014年被评为中国农业科学院“优秀博士后”。2015年11月作为中国优秀博士后的唯一在站代表参加国务院“中国博士后青年创新人才座谈会”,受到李克强总理等中央领导的接见,并作为报告人在会上向中央领导做了工作报告。2016年获《中国博士后》杂志专访,并荣登杂志首期封面人物。2016年12月起任华中科技大学同济药学院副教授。

主要研究方向为药用植物、微生物的活性天然产物的发现及生物合成。在ScienceNature PlantsMolecular Plant,Science Bulletin,Organic Chemistry Frontiers,Journal of Natural Products等学术期刊上发表论文20余篇。

联系方式

电子信箱: zhouyuan@hust.edu.cn

地址:武汉市航空路13号华中科技大学同济医学院药学院430030


教育及工作经历

2016.12至今 副教授,华中科技大学同济药学院,博士生导师

2013.09-2016.12 博士后助理研究员,中国农业科学院蔬菜花卉研究所导师黄三文研究员

2011.08-2013.09 项目主管,扬子江药业集团中药研究院

2008.09-2011.07 博士,北京大学药学院 导师屠鹏飞教授

2005.09-2008.07 硕士,大连大学环境与化学工程学院王永奇,冯宝民教授

2001.09-2005.07 学士,衡阳师范学院化学与材料科学系


主持及参与项目

1.基于基因组扫描的黄柄曲霉“隐形”异戊烯基吲哚生物碱的发现.国家自然科学基金面上项目. 2020.01-2023.12.主持

2.黄柄曲霉产细胞松弛二聚体黄柄曲霉素A的生物合成研究.国家自然科学基金面上项目. 2018.01-2021.12.主持

3.曲霉真菌Z23中抑癌活性物质asperspiropene A的生物合成研究.中德PPP合作项目. 2018.01-2019.12.主持

4.黄瓜苦味物质葫芦素C生物合成途径及关键酶基因CMOG1的功能研究.国家自然科学基金青年项目. 2015.01-2017.12.主持

5.黄瓜苦味物质葫芦素C合成中间体的分析.博士后面上基金. 2014.03-2015.09.主持

6.华中科技大学人才引进基金. 2016.12-2019.12.主持

7.逆境下黄瓜果实苦味形成的分子机理.国家自然科学基金面上项目. 2017.01-2020.12.参与

8.基于LC-MS-DS技术的新型二聚倍半萜类化合物的快速发现及其功能研究.国家自然科学基金面上项目. 2010.01-2012.12.参与

主要学术论文及专利#第一作者,*通讯作者)

2020

1.Shuangshuang Xie#, Changxing Qi#, Yulin Duan#, Xincai Hao, Yi Guo,
Mengyi Deng, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Lianghu Gu*,Yuan Zhou*, Yonghui Zhang*. Wilsonglucinols A–C, homoadamantane-type polycyclic polyprenylated acylphloroglucinols with unusual fused epoxy ring skeletons fromHypericum wilsonii.Organic Chemistry Frontiers. 2020,7, 464–471. (IF: 5.1)

2.Shuangshuang Xie#, Changxing Qi#, Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Xu Yin, Weiguang Sun*,Yuan Zhou*, Yonghui Zhang*. Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors.Organic Chemistry Frontiers. 2020,7, 349–1357. (IF: 5.1)

3.Shuangshuang Xie#, Xiaosheng Tan#, Yaping Liu, Yunlin Duan, Gang Chen, Hao Feng, Lingjuan Sun, Yingying Huang, Yi Guo, Zhengyi Shi,Yuan Zhou*,Changxing Qi*, Yonghui Zhang*.Hypersonins A−D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture fromHypericum wilsonii.Journal Natural Products. 2020,83, 1804−1809. (IF: 3.8)


2019

1. Xudong Zhou, Xiangwei Xu, Yiyuan Xi,Yuan Zhou*. Terpenoid and phenolic constituents from the roots ofIlex pubescens.Fitoterapia. 2019,138, 104298.(IF: 2.5)

2. Dawei Li#, Yongshuo Ma#,Yuan Zhou#, Junbo Gou, Yang Zhong, Lingling Zhao, Lida Han, Sergey Pvchinnikov, Ling Ma, Sanwen Huang, Per Greisen*, Yi Shang*. A structural and data-driven approach to engineering a plant cytochrome P450 enzyme.Science China–Life Science. 2019,62, 873–882. (IF: 4.6)


2018

1.Changxing Qi#, Yuben Qiao#, Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu, Zhengxi Hu*,Yuan Zhou*, Yonghui Zhang*. New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities fromAspergillus terreus.Organic & Biomolecular Chemistry. 2018,16, 9046.(IF: 3.4)


2017

1. Yang Zhong#, Xiaofeng Xue#, Zhiqiang Liu#, Yongshuo Ma, Kewu Zeng, Lida Han, Dae-Kyun Ro, Sanwen Huang,Yuan Zhou*, Yi Shang*.Developmentally regulated glucosylation of bitter triterpenoid in cucumber by the UDP-glucosyltransferase UGT73AM3.Molecular Plant.2017,10, 1000–1003.(IF: 12.1)

2. Xiubin Liu#, Yisong Liu#, Peng Huang#, Yongshuo Ma#, Zhixing Qing#, Qi Tang#, Huifen Cao#, Pi Cheng, Yajie Zheng, Zejun Yuan,Yuan Zhou, et al.The Genome of Medicinal PlantMacleaya cordataProvides New Insights into BenzylisoquinolineAlkaloids Metabolism.Molecular Plant.2017,10, 957–989.(IF: 12.1)


2016

1.Yuan Zhou#, Yongshuo Ma#, Jiangguo Zeng#, Lixin Duan#, Xiaofeng Xue, Huaisong Wang, …, Pengfei Tu, Zhonghua Zhang, Anne Osbourn, Dae-Kyun Ro, Yi Shang*, Sanwen Huang*.Convergence and divergence of bitterness biosynthesis and regulation in cucumber, melon and watermelon.Nature Plants, 2016,2, 16183. (IF: 13.3)

2. Yongsuo Ma#,Yuan Zhou#, Sergey Ovchinnikov, Per Jr Greisen, Sanwen Huang, Yi Shang*.New insights into substrate folding preference of plant OSCs.Science Bulletin, 2016,61, 1407–1414. (IF: 9.5)


2015年及以前

1. Yi Shang#, Yongshuo Ma#,Yuan Zhou#, Huimin Zhang#, Lixin Duan, Huiming Chen, Jianguo Zeng, …, William J. Lucas, Sanwen Huang*. Biosynthesis, regulation, and domestication of bitterness in cucumber.Science, 2014,346, 1084–1088. (IF: 41.8)

2.Yuan Zhou, Kewu Zeng, Jiayu Zhang, Ning Li, Xingyun Chai, Yong Jiang, Pengfei Tu*. Triterpene saponins from the roots ofIlex pubescens
.Fitoterapia, 2014,97,98–104.(IF: 2.5)

3.Yuan Zhou, Ning Li, Jiayu Zhang, Yong Jiang, Pengfei Tu*. Simultaneous determination of four triterpenoid saponins and two liganoids in the roots ofIlex pubescensby RP­HPLC­DAD.Journal of Chinese Pharmaceutical Sciences, 2014,23, 866–872.

4. Zhixing Qing#,Yuan Zhou#, Xiubin Liu, Pi Cheng, Jianguo Zeng*. 23, 24-Dihydrocucurbitacin C: a new compound regarded as the next metabolite of cucurbitacin C.Natural Product Research, 2014,28, 1165–1170.

5. Lu Zheng#,Yuan Zhou#, Jiayu Zhang, Min Song, Ye Yuan, Yanjiao Xiao, Ting Xiang*. Two new steroidal saponins from the rhizomes ofDioscorea zingiberensis.Chinese Journal of Natural Medicine, 2014,12, 142–147.

6.Yuan Zhou, Xingyun Chai, Kewu Zeng, Jiayu Zhang, Ning Li, Yong Jiang, Pengfei Tu*. Ilexpublesnins C–M, Eleven New Triterpene Saponins from the Roots ofIlex pubescens.Planta Medica, 2013,79, 70–77.

7.Yuan Zhou, Baomin Feng*, Liying Shi, Huiguo Wang, Ling Tang and Yongqi Wang. Two new 3-oxo-α-ionol glucosides fromUrtica laetevirensMaxim.Natural Product Research, 2011,25, 1219–1223.

8.Yuan Zhou, Wei Wang, Ling Tang, Xingguo Yan, Liying Shi, Yongqi Wang, Baomin Feng*. Lignan and flavonoid glycosides fromUrtica laetevirensMaxim.Journal of Natural Medicines, 2009,63, 100–101.


1.葫芦素C及其类似物的制备方法及其应用.黄三文,周渊,曾建国,尚轶,马永硕.授权,专利号:ZL 201510181868.0

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