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师资队伍
杰出人才
博士后

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薛永波

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  薛永波 博士,1982年生,四川德阳人,副教授。2005年毕业于大理大学(原大理医学院),获理学学士学位。2011年于中国科学院昆明植物研究所获药物化学博士学位,师从著名植物化学家孙汉董院士。毕业之后被引进到华中科技大学同济药学院,任讲师。2016年晋升为副教授。2017年至2018年赴澳大利亚昆士兰大学任访问学者。主持国家自然科学基金三项、湖北省自然科学基金一项、华中科技大学自主创新项目三项,指导国家级和校级大学生创新训练项目三项;主要负责参与国家自然科学基金、国家高技术研究发展计划(“863”计划)、“重大新药创制”科技重大专项、国家国际科技合作专项等二十余项。

  薛永波副教授研究领域为中药化学和天然产物化学。致力于从中药和天然产物活性成分中快速高效地发现结构新颖、生物功能显著多环天然产物,通过提取分离、结构测定、结构修饰、化学或生物转化与合成、生物活性评价、构效关系研究,并基于天然产物开展新药开发研究工作。研究团队已从 40 多种药用植物及内生菌中分离鉴定天然产物(Natural ProductsNP)逾 1200 余个,包括 400 多个新化合物、具新颖碳架类型 30 余种,其中 11 个分子被天然产物领域权威综述期刊Nat Prod Rep评为热点化合物(Hot off the press);部分化合物显示重要生物活性,已开发为先导化合物。现已在《Angew Chem Int Edit》,《Chem Sci》,《Org Lett》,《J Org Chem》,《Org Chem Front》,《J Nat Prod》,《Phytochemistry》等SCIE收录的国际学术期刊上发表论文近 100 篇,以一作(含共同一作)和共同通讯作者在Angew Chem Int EditOrg Lett等发表论文 36 。申请发明专利 6 项。

热忱欢迎同学咨询报考研究生或申请博士后,一起在中药与天然药物研究事业中挥洒青春

一、教育与工作经历

2001–2005 大理大学,药学专业本科

2005–2008 大理大学,药物化学专业硕士研究生,导师:钱金栿 教授(副校长)

2006–2008 中国科学院昆明植物所,药物化学专业联培研究生,导师:赵勤实 研究员

2008–2011 中国科学院昆明植物所,药物化学专业博士研究生,导师:孙汉董 院士

2011–2016 华中科技大学同济药学院,讲师

2016–  华中科技大学同济药学院,副教授

2017–2018 澳大利亚昆士兰大学,访问学者,导师:Prof. Craig M Williams

二、科研课题

  1. 国家自然科学基金(3177037920182021年,60万元,在研)

  2. 国家自然科学基金(8164112920172017年,10万元,在研)

  3. 国家自然科学基金(3120025820132015年,22万元,已结题)

  4. 国家级大学生创新训练计划项目(20171048710020172017年,1万元,在研)

  5. 国家留学基金管理委员会国家公派访问学者项目(20160616502120172018年,2.16万澳元,在研)

  6. 湖北省自然科学基金(2012FFB0233320122013年,3万元,已结题)

  7. 华中科技大学自主创新基金(2016YXMS14920162018年,8万元,在研)

  8. 华中科技大学自主创新基金(2014QN12820142015年,4万元,已结题)

  9. 华中科技大学自主创新基金(2012QN01220122013年,4万元,已结题)

  10. 华中科技大学人才引进基金(天然药物化学,20122014年,5万元)

三、开展课程

本科生《天然药物化学》,《中药学概论》,《波谱解析》;研究生《波谱解析》,《天然药物研究方法》,《中药代谢化学》;留学生《天然药物化学》;指导本科毕业论文设计。

四、学术兼职与获奖

受邀担任中文核心期刊《天然产物研究与开发》青年编委;中国植物学会高级会员、美国化学会会员、中国化学会会员;湖北省药学会中药与天然药专业委员会秘书;担任Phytochemistry》,J Nat Prod》,Org Chem FrontRSC AdvFood FunctHelv Chim ActaChinese Chem Lett等十余种学术期刊特邀审稿人。获中科院研究生院“三好学生标兵”,中科院研究生院“地奥一等奖”,华中科技大学“教师教学竞赛二等奖”,华中科技大学同济药学院“先进个人”,第十九届世界植物学大会the Excellent Scholar Award奖。

五、主要科研成果与学术论文

  1. Structural revisions of a class of natural products: scaffolds of aglycon analogs of fusicoccins and cotylenins isolated from fungi. Ying Tang(#), Yongbo Xue(#), Guang Du(#), Jianping Wang, Junjun Liu, Bin Sun, Xiao-Nian Li, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*): Angew. Chem. Int. Ed. 2016; 55: 4069–73. DOI: 10.1002/anie.201600313. (引用:7IF = 11.994,一区)

  2. Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes. Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*): Angew. Chem. Int. Ed. 2015; 54: 13374–8. DOI: 10.1002/anie.201506264. (引用:15IF = 11.994,一区)

  3. Asperterpenes A and B, Two Unprecedented Meroterpenoids from Aspergillus terreus with BACE1 Inhibitory Activities. Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-guo Chen, Yonghui Zhang(*): Chem. Sci. 10/2016; 7(10): 6563–72. DOI: 10.1039/C6SC02464E. (引用:6IF = 8.668,一区)

  4. Phomopsterones A and B, Two Highly Functionalized Ergostane-type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A. Zhengxi Hu(#), Ye Wu(#), Shuangshuang Xie, Weiguang Sun, Yi Guo, Xiaonian Li, Junjun Liu, Hua Li, Jianping Wang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): Org. Lett. 2017; 19(1): 258–61. DOI: 10.1021/acs.orglett.6b03557. (引用:1IF = 6.579,一区)

  5. Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. Chunmei Chen(#), Hucheng Zhu(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Org. Lett. 2015; 17(3): 644–7. DOI: 10.1021/ol503666b. (引用:14IF = 6.579,一区)

  6. Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii. Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue(*), Yonghui Zhang(*): Org. Lett. 2014; 16(23): 6322–5. DOI: 10.1021/ol5030579. (引用:31IF = 6.579,一区)

  7. Henrischinins A–C: three new triterpenoids from Schisandra henryi. Yongbo Xue, Jian-Hong Yang, Xiao-Nian Li, Xue Du, Jian-Xin Pu(*), Wei-Lie Xiao, Jia Su, Wei Zhao, Yan Li, Han-Dong Sun(*): Org. Lett. 2011; 13(6): 1564–7. DOI: 10.1021/ol200283y. (引用:19IF = 6.579,一区)

  8. Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp. TJ23. Yan He(#), Zhengxi Hu(#), Weiguang Sun, Qin Li, Xiao-Nian Li, Hucheng Zhu, Jinfeng Huang, Junjun Liu, Jianping Wang, Yongbo Xue(*), and Yonghui Zhang(*): J. Org. Chem. 2017; 82, 3125–3131. DOI:10.1021/acs.joc.7b00056 (引用:1IF = 4.849,二区)

  9. Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1. Yan He(#), Mengzhu Zheng(#), Qin Li(#), Zhengxi Hu, Hucheng Zhu, Junjun Liu, Jianping Wang, Yongbo Xue(*), Hua Li(*), and Yonghui Zhang(*): Org. Chem. Front. 2017, 4, 1137–1144. DOI: 10.1039/C6QO00847J. (引用:0IF =4.955,二区)

  10. Bioassay-Guided Isolation of Antibacterial Metabolites from Emericella sp. TJ29. Yan He, Zhengxi Hu, Qin Li, Jinfeng Huang, Xiao-Nian Li, Hucheng Zhu, Junjun Liu, Jianping Wang, Yongbo Xue(*), and Yonghui Zhang(*): J. Nat. Prod. 09/2017, (AcceptedIF = 3.205,二区)

  11. Tricyclic Polyprenylated Acylphloroglucinols from St John’s Wort, Hypericum perforatum. Yi Guo, Na Zhang, Chunmei Chen, Jinfeng Huang, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Qingyi Tong, Jinwen Zhang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): J. Nat. Prod. 2017; 26, 80, 1493–504. DOI:10.1021/acs.jnatprod.6b01178. (引用:1IF = 3.205,二区)

  12. Diterpenoids of the Cassane Type from Caesalpinia decapetala. Yuben Qiao(#), Qianqian Xu(#), Zhengxi Hu, Xiao-Nian Li, Ming Xiang, Junjun Liu, Jinfeng Huang, Hucheng Zhu, Jianping Wang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): J. Nat. Prod. 12/2016; 79 (12): 3134–42. DOI: 10.1021/acs.jnatprod.6b00910. (引用:3IF = 3.205,二区)

  13. (±)-Acortatarinowins A–F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii. Yuanyuan Lu(#), Yongbo Xue(#)(*), Junjun Liu, Guangmin Yao, Dongyan Li, Bin, Sun, Jinwen Zhang, Yanfei Liu, Changxing Qi, Ming Xiang, Zengwei Luo, Guang Du,(*) Yonghui Zhang(*): J. Nat. Prod. 2015; 78(9): 2205–14. DOI:10.1021/acs.jnatprod.5b00328. (引用:15IF = 3.205,二区)

  14. Armochaetoglobins A–J: cytochalasan alkaloids from Chaetomium globosum TW1-1, a fungus derived from the terrestrial arthropod Armadillidium vulgare. Chunmei Chen, Jianping Wang, Junjun Liu, Hucheng Zhu, Bin Sun, Jing Wang, Jinwen Zhang, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): J. Nat. Prod. 2015, 78(6): 1193–201. DOI: 10.1021/np500626x. (引用:8IF = 3.205,二区)

  15. (±)-Japonicols A–D, Acylphloroglucinol-based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum. Linzhen Hu, Yongbo Xue, Jinwen Zhang, Hucheng Zhu, Chunmei Chen, Xiao−Nian Li, Junjun Liu, Zhenzhen Wang, Yu Zhang(*), Yonghui Zhang(*): J. Nat. Prod. 2016; 79: 13228. DOI: 10.1021/acs.jnatprod.5b01119. (引用:4IF = 3.205,二区)

  16. Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis. Yongbo Xue, Xifeng Li, Xue Du, Xiaonian Li, Weiguang Wang, Jianhong Yang, Jijun Chen, Jianxin Pu(*), Handong Sun(*): Phytochemistry 2015; 116: 253–61. DOI: 10.1016/j.phytochem.2015.03.009. (引用:15IF = 3.205,二区)

  17. Hyperascyrones A–H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn. Hucheng Zhu(#), Chunmei Chen(#), Junjun Liu, Bin Sun, Guangzheng Wei, Yan Li, Jinwen Zhang, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Phytochemistry 2015, 115: 222–30. DOI: 10.1016/j.phytochem.2015.02.009. (引用:10IF = 3.205,二区)

  18. Scapiformolactones A–I: Germacrane sesquiterpenoids with an unusual Δ(3)-15,6-lactone moiety from Salvia scapiformis. Yongji Lai(#), Yongbo Xue(#), Mengke Zhang, Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*): Phytochemistry 2013; 96: 378–88. DOI: 10.1016/j.phytochem.2013.10.003. (引用:9IF = 3.205,二区)

  19. Enantiomeric Lignans and Neolignans from Phyllanthus glaucus: Enantioseparation and Their Absolute Configurations. Zhaodi Wu(#), Yongji Lai(#), Lei Zhou, Ye Wu, Hucheng Zhu, Zhengxi Hu, Jing Yang, Jinwen Zhang, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Sci. Rep.-UK 04/2016; 6: 24809. DOI: 10.1038/srep24809. (引用:2IF = 4.259,二区)

  20. (±)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum. Linzhen Hu(#), Hucheng Zhu(#), Lei Li(#), Jinfeng Huang, Weiguang Sun, Junjun Liu, Hua Li, Zengwei Luo, Jianping Wang, Yongbo Xue(*), Yu Zhang(*), Yonghui Zhang(*): Sci. Rep.-UK 06/2016; 6: 27588. DOI: 10.1038/srep27588. (引用:2IF = 4.259,二区)

  21. Hyperisampsins H−M, cytotoxic polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii. Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xintao Chen, Jing Yang, Junjun Liu, Bin Sun, Jianping Wang, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Sci. Rep.-UK 2015; 5: 14772. (引用:6IF = 4.259,二区)

  22. Coumarin derivatives from Ainsliaea fragrans and their anticoagulant activity. Liang Lei(#), Yongbo Xue(#), Zhong Liu, Sisi Peng, Yan He, Yang Zhang, Rong Fang, Jianping Wang, Zengwei Luo, Guangmin Yao, Jinwen Zhang, Geng Zhang, Hongping Song,(*) Yonghui Zhang(*): Sci. Rep.-UK 2015; 5: 13544. DOI:10.1038/srep13544. (引用:8IF = 4.259,二区)

  23. Sampbenzophenones A–G, prenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. Hucheng Zhu(#), Chunmei Chen(#), Dongdong Tan, Dongyan Li, Yi Guo, Guangzheng Wei, Jinwen Zhang, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Rsc Adv. 01/2016; 6(89): 86710–6. DOI: 10.1039/C6RA17885E. (引用:2IF = 3.108,二区)

  24. Hyperattenins A–I, Bioactive Polyprenylated Acylphloroglucinols from Hypericum attenuatum Choisy. Dongyan Li(#), Yongbo Xue(#), Hucheng Zhu, Yan Li, Bin Sun, Junjun Liu, Guangmin Yao, Jinwen Zhang, Guang Du(*), Yonghui Zhang(*): RSC Adv. 2015; 5: 5277–87. DOI: 10.1039/C4RA11675E. (引用:17IF = 3.108,二区)

  25. Armochaetoglobins K–R, Anti-HIV Pyrrole-based Cytochalasans from Chaetomium Globosum TW1-1. Chunmei Chen, Hucheng Zhu, Jianping Wang, Jing Yang, Xiao-Nian Li, Jing Wang, Keliang Chen, Yanyan Wang, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): Eur. J. Org. Chem. 2015; 14: 3086–94. DOI: 10.1002/ejoc.201403678. (引用:8IF = 2.834,三区)

  26. Hyperhexanone A, a crucial intermediate from bicyclo[3.3.1]- to cyclohexanone monocyclic-polycyclic polyprenylated acylphloroglucinols. Hucheng Zhu(#), Chunmei(#), Jing Yang(#), Dongyan Li, Jinwen Zhang, Yi Guo, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Tetrahedron, 2016, 72: 4655–9. DOI: 10.1016/j.tet.2016.06.035. (引用:4IF = 2.645,三区)

  27. Two New Adamantyl-Like Polyprenylated Acylphloroglucinols from Hypericum attenuatum choisy. Dongyan Li, Hucheng Zhu, Changxing Qi, Yongbo Xue(*), Guangmin Yao, Zengwei Luo, Jianping Wang, Jinwen Zhang, Guang Du(*), Yonghui Zhang(*): Tetrahedron Lett. 2015; 56(15): 1953–5. DOI: 10.1016/j.tetlet.2015.02.056. (引用:6IF = 2.193,三区)

  28. A pair of unprecedented cyclohexylethanoid enantiomers containing unusual trioxabicyclo[4.2.1]nonane ring from Clerodendrum bungei. Hucheng Zhu, Lijun Huan, Chunmei Chen, Jing Yang, Jiangbo He, Yong Chen, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Tetrahedron Lett. 2014; 55(14): 2277–9. DOI: 10.1002/chin.201437219. (引用:9IF = 2.193,三区)

  29. Colletotrichumine A, a novel indole–pyrazine alkaloid with an unprecedented C16N3-type skeleton from cultures of Colletotrichum capsici. Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue(*), Yingda Yang, Zengwei Luo, Guangmin Yao, Yonghui Zhang(*): Tetrahedron Lett. 2014; 55(44): 6093–5. DOI: 10.1016/j.tetlet.2014.09.041. (引用:7IF = 2.193,三区)

  30. Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii. Zheng-Xi Hu(#), Yongbo Xue(#), Xiao-Bin Bi, Jin-Wen Zhang, Zeng-Wei Luo, Xiao-Nian Li, Guang-Min Yao, Jian-Ping Wang(*), Yong-Hui Zhang(*): Mar. Drugs 2014; 12(11): 5563–75. DOI: 10.3390/md12115563. (引用:9IF = 3.503,三区)

  31. Salviprzols A and B, C21- and C22-terpenoids from the roots of Salvia przewalskii Maxim. Yongbo Xue(*), Ye Wu, Hucheng Zhu, Xiao-Nian Li, Jin-Fu Qian, Yongji Lai, Chunmei Chen, Guangmin Yao, Zengwei Luo, Yan Li, Yonghui Zhang(*): Fitoterapia 2014; 99: 204–10. DOI: 10.1016/j.fitote.2014.09.022. (引用:4IF = 2.698,三区)

  32. Hyperisampsins N and O, Two New Benzoylated Phloroglucinol Derivatives from Hypericum sampsonii. Hu-Cheng Zhu(#), Chun-Mei Chen(#), Jin-Wen Zhang, Yi Guo, Dong-Dong Tan, Guang-Zheng Wei, Jing Yang, Jian-Ping Wang, Zeng-Wei Luo, Yong-Bo Xue(*), and Yong-Hui Zhang(*): Chinese Chem. Lett. 2017, 28, 968−90. Doi: 10.1016/j.cclet.2016.11.014 (引用:1IF = 1.932,四区)

  33. Penicamedine A, a highly oxygenated hexacyclic indole alkaloid from Penicillium camemberti. Hucheng Zhu(#), Chunmei Chen(#), Jianping Wang, Xiao-Nian Li, Guangzheng Wei, Yi Guo, Guangmin Yao, Zengwei Luo, Jinwen Zhang, Yongbo Xue(*), Yonghui Zhang(*): Chem. Biodivers. 2015; 12: 1547−53. Doi: 10.1002/cbdv.201400412 (引用:4IF = 1.440,四区)

  34. Phytochemical and chemotaxonomic studies on Phyllanthus urinaria. Zhengxi Hu, Yongji Lai, Jinwen Zhang, Ye Wu, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): Biochem. System. Ecol. 2014; 56: 60–4. Doi: 10.1016/j.bse.2014.04.0160305-1978 (引用:5IF = 0.929,四区)

  35. Nortriterpenoids and lignans from the fruit of Schisandra chinensis. Yongbo Xue, Yan-Long Zhang, Jian-Hong Yang, Xue Du, Jian-Xin Pu(*), Wei Zhao, Xiao-Nian Li, Wei-Lie Xiao, Han-Dong Sun(*): 2010; 58(12): 1606–11. Doi: 10.1248/cpb.58.1606 (引用:27IF = 1.333,四区)

    (注:(#) 共同第一作者;(*) 通讯作者)

    六、联系方式

    通信地址:湖北省武汉市航空路13 华中科技大学同济药学院 一号楼507

    邮编430030

    邮箱地址yongboxue@mail.hust.edu.cn; y.xue_93@hotmail.com

 

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030