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师资队伍
杰出人才
博士后

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朱虎成

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朱虎成

博士,副教授,博士生导师,湖北省杰出青年基金获得者。主要从事药用植物和真菌来源活性天然药物的提取分离、结构鉴定及药理活性研究。主持国家自然科学基金面上项目和青年基金,湖北省杰出青年基金,中国博士后科学基金特别资助和面上项目,华中科技大学2016年人才引进基金等。在Angew. Chem. Int. Ed.(三篇)和Org. Lett.(六篇)等学术期刊上发表SCI论文40余篇。

联系方式

邮箱:zhuhucheng@hust.edu.cn;zhuhucheng0@163.com

地址:武汉市航空路13号同济药学院1号楼

研究方向

药用植物和真菌来源活性天然药物的提取分离、结构鉴定及药理活性。

教育及工作经历

2016.9-至今, 华中科技大学同济药学院,副教授

2014.7-2016.8,华中科技大学 同济药学院,博士后

2011.9-2014.6,华中科技大学 同济药学院,博士

2008.9-2011.6,西南大学,药学院,硕士

2004.9-2008.6,西南交通大学,生命科学学院,大学本科

主持项目

湖北省杰出青年基金项目,编号2018CFA076,2018.3-2021.3(10万)

国家自然科学基金面上项目,编号21772048,2018.1-2021.12(66万)

华中科技大学人才引进基金,编号2006514113,执行时间2016.9-2019.8(50万)

国家自然科学基金青年项目,编号21502057,2016.1-2018.12(21万)

中国博士后科学基金特别资助,编号2016T90695,2016.1-2016.12(15万)

中国博士后科学基金面上项目,编号2015M572154,2015.7-2016.6(5万)

华中科技大学自主创新基金-面上项目,项目号5003514012,2017.1-2019.12(7.5万)

主要学术论文

1.Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong(#), Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang(*),Asperflavipine A: A Cytochalasan Heterotetramer Uniquely Definedby a Highly Complex Tetradecacyclic Ring System from Aspergillusflavipes QCS12,Angewandte Chemie-International Edition,2017,56, 5242 –5246.

2.Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, and Yonghui Zhang(*), Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units fromAspergillus flavipes.Angewandte Chemie-International Edition, 2016, 55: 3486–3490.

3.Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, and Yonghui Zhang(*), Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, fromAspergillus flavipes.Angewandte Chemie-International Edition, 2015, 54: 13374–13378.

4.Guangzheng Wei(#), Chunmei Chen(#), Qingyi Tong(#), Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang,Hucheng Zhu(*), and Yonghui Zhang(*),Aspergilasines A–D: four merocytochalasans with new carbon skeletons fromAspergillus flavipesQCS12,Organic Letters, 2017, 19, 4399−4402.

5.Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue(*), and Yonghui Zhang(*), Bioactive Acylphloroglucinols with Adamantyl Skeleton fromHypericum sampsonii,Organic Letters, 2014, 16: 6322–6325.

6.Chunmei Chen(#),Hucheng Zhu(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*), Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived FungusChaetomium globosum,Organic Letters, 2015, 17: 644–647.

7.Zhengxi Hu(#), Weiguang Sun(#), Fengli Li(#), Jiankun Guan(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang(*),Hucheng Zhu(*), and Yonghui Zhang(*), Fusicoccane-Derived Diterpenoids fromAlternaria brassicicola: Investigation of the Structure-Stability Relationship and Discovery of a IKKβ Inhibitor,Organic Letters, 2018, 20, 5198–5202.

8.Keliang Chen(#), Xuwen Zhang(#), Weiguang Sun(#), Junjun Liu, Jing Yang, Chunmei Chen, Xiulan Liu, Limin Gao, Jianping Wang, Hua Li, Zengwei Luo, Yongbo Xue,Hucheng Zhu(*), and Yonghui Zhang(*), Manginoids A–G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System fromGuignardia mangiferae,Organic Letters, 2017, 19 (21), 5956–5959.

9.Yi Zang, Gregory Genta-Jouve, Yingyu Zheng, Qing Zhang, Chunmei Chen, Qun Zhou, Jianping Wang(*),Hucheng Zhu(*), Yonghui Zhang(*). Griseofamines A and B: Two indole-tetramic acid alkaloids with 6/5/6/5 and 6/5/7/5 ring systems from Penicillium griseofulvum.Organic Letters, 2018, 20, 2046-2050.

10.Huaqiang Li(#), Weiguang Sun(#), Mengyi Deng(#), Qun Zhou, Jianping Wang, Junjun Liu, Chunmei Chen, Changxing Qi, Zengwei Luo, Yongbo Xue(*),Hucheng Zhu(*), and Yonghui Zhang(*), Asperversiamides, Linearly Fused Prenylated Indole Alkaloids from the Marine-Derived Fungus Aspergillus versicolor,Journal of Organic Chemistry, 2018, 83, 8483−8492.

11.Changxing Qi(#), Mengting Liu(#),Qun Zhou(#), Weixi Gao, Chunmei Chen, Yongji Lai, Zhengxi Hu, Yongbo Xue, Jinwen Zhang, Dongyan Li, Xiao-Nian Li, Qing Zhang, Jianping Wang(*),Hucheng Zhu(*), and Yonghui Zhang(*). BACE1 Inhibitory Meroterpenoids fromAspergillus terreus.Journal of Natural Products,accepted, DOI: 10.1021/acs.jnatprod.7b01050.

12.Changxing Qi, Weixi Gao, Jianping Wang, Mengting Liu, Jinwen Zhang, Chunmei Chen, Zhengxi Hu, Yongbo Xue, Dongyan Li, Qing Zhang, Yongji Lai, Qun Zhou(*),Hucheng Zhu(*), and Yonghui Zhang(*). Terrusnolides A-D, new butenolides with anti-inflammatory activities from an endophyticAspergillusfromTripterygium wilfordii.Fitoterapia, 2018, 130, 134–139.

13.Keliang Chen(#), Weiguang Sun(#), Qiong Bie, Xiulan Liu, Chunmei Chen, Junjun Liu, Yongbo Xue, Jianping Wang, Zengwei Luo,Hucheng Zhu(*), Yonghui Zhang(*), Fusopoltide A and fusosterede A, A polyketide with a pentaleno[1,2-c]pyran ring system and A degraded steride, from the fungusFusarium solani,Tetrahedron Letters, 2018, 59, 2679-2682.

14.Dongyan Li,Guang Du, Xuepeng Gong, Jieru Guo, Jinwen Zhang, Chunmei Chen, Yongbo Xue,Hucheng Zhu(*), and Yonghui Zhang(*), Hyperattenins L and M, two new polyprenylated acylphloroglucinols with adamantyl and homoadamantyl core structures fromHypericum attenuatum,Fitoterapia, 2018,125, 130–134.

15.Peng Zhou(#), Zhaodi Wu(#), Dongdong Tan, Jing Yang, Qun Zhou, Fanrong Zeng, Mi Zhang, Qiong Bie, Chunmei Chen, Yongbo Xue, Zengwei Luo, Jianping Wang(*),Hucheng Zhu(*), Yonghui Zhang(*), Atrichodermones A–C, three new secondary metabolites from the solid culture of an endophytic fungal strain,Trichoderma atroviride,Fitoterapia, 2017, 123, 18–22.

16.Guangzheng Wei(#), Dongdong Tan(#), Chunmei Chen(#), Qingyi Tong, Xiao-Nian Li, Jinfeng Huang, Junjun Liu, Yongbo Xue, Jianping Wang, Zengwei Luo,Hucheng Zhu(*), and Yonghui Zhang(*), Flavichalasines A–M, cytochalasan alkaloids fromAspergillus flavipes,Scientific Reports, 2017, 7: 42434.

17.Hucheng Zhu(#), Chunmei Chen(#), Jinwen Zhang, Yi Guo, Dongdong Tan, Guangzheng Wei, Jing Yang, Jianping Wang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*), Hyperisampsins N and O, Two New Benzoylated Phloroglucinol Derivatives fromHypericum sampsonii,Chinese Chemical Letters, 2017, 28, 986-990.

18.Hucheng Zhu(#), Chunmei Chen(#), Dongdong Tan, Dongyan Li, Yi Guo, Guangzheng Wei, Jinwen Zhang, Jianping Wang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*), Sampbenzophenones A–G, prenylated benzoylphloroglucinol derivatives fromHypericum sampsonii,RSC Advances, 2016, 6, 86710-86716.

19.Chunmei Chen(#),Hucheng Zhu(#), Jianping Wang, Jing Yang, Xiao-Nian Li, Jing Wang, Keliang Chen, Yanyan Wang, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), and Yonghui Zhang(*), Armochaetoglobins K–R, Anti-HIV Pyrrole-based Cytochalasans fromChaetomium GlobosumTW1-1,European Journal of Organic Chemistry, 2015: 3086–3094.

20.Hucheng Zhu(#), Chunmei Chen(#), Junjun Liu, Bin Sun, Guangzheng Wei, Yan Li, Jinwen Zhang, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*), Hyperascyrones A–H, Polyprenylated Spirocyclic Acylphloroglucinol Derivatives fromHypericum ascyronLinn.,Phytochemistry, 2015, 115: 222–230.

21.Hucheng Zhu(#), Chunmei Chen(#), Jing Yang(#), Dongyan Li, Jinwen Zhang, Yi Guo, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*), Hyperhexanone A, a crucial intermediate from bicyclo[3.3.1]- to cyclohexanone monocyclic-polycyclic polyprenylated acylphloroglucinols,Tetrahedron, 2016, 72, 4655–4659.

22.Hucheng Zhu(#), Lijun Huan(#), Chunmei Chen, Jing Yang, Jiangbo He, Yong Chen, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*),A Pair of Unprecedented Cyclohexylethanoid Enantiomers Containing Unusual Trioxabicyclo[4.2.1]nonane Ring fromClerodendrum bungei,Tetrahedron Letters,2014, 55: 2277–2279.

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030