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阮汉利

来源: 发布时间 2018-09-17 10:05:19 点击数:

阮汉利

女,河南永城县人。医学博士,教授,硕士/博士生导师,华中科技大学同济药学院中药天然药物学系主任,世界中医药学联合会中药化学专业委员会常务理事,湖北省药学会中药和天然药物专委会委员,湖北省天然药物化学与资源评价重点实验室副主任。

主要从事天然药物活性成分的提取分离、结构鉴定、活性测试和生物合成工作。致力于核桃属、五味子属、蟹甲草属、石蒜属、贝母属等多种植物及其内生真菌的化学成分和生物活性研究;并曾对曲霉属真菌中吲哚类生物碱的异戊烯基转移酶相关生物合成基因进行过研究。主持和参加多项国家级和省部级课题。在Organic LettersThe Journal of Organic ChemistryJournal of Natural ProductsChemBioChemPhytochemistry等期刊上发表论文100余篇。主讲本科生的天然药物化学和波谱解析、留学生的天然药物化学、研究生的天然药物研究方法和结构解析等课程。国家精品课程《天然药物化学》主讲教师之一,华中科技大学《波谱解析》本科课程责任教授。主编、副主编和参编多部人民卫生出版社、高等教育出版社、医药科技出版社和中国中医药出版社的本科生国家统编教材。


联系方式:

湖北省武汉市航空路13号,华中科技大学同济医学院药学院1号楼409,邮编430030Email: ruanhl@hust.edu.cn; ruanhl@mails.tjmu.edu.cn


教育经历:

2001.9-2004.7: 华中科技大学同济医学院药学院,获得药理学博士学位。

1996.9-1999.7: 同济医科大学药学院,获药物化学专业硕士学位。

1985.9-1989.7: 中国药科大学中药系,获理学学士学位。


工作经历:

2014.11-: 华中科技大学同济药学院教授,硕士、博士生导师,中药与天然药物学系主任。

2011.3-2014.11: 华中科技大学同济药学院教授,硕士、博士生导师,天然药物化学与中药学系副主任;天然药物化学课程群负责人。

2009.11-2011.2: 华中科技大学同济药学院教授,硕士、博士生导师。

2002.7-2009.10: 华中科技大学同济药学院副教授,硕士生导师。

1997.1-2002.6: 华中科技大学同济医学院药学院讲师。

1992.12-1997.12: 同济医科大学药学院助教。


海外经历:

2014.1-2014.6: 德国马尔堡大学,访问学者。

2007.7-10; 2008.7-10: 德国杜塞尔多夫大学,访问学者。

2005.9-2006.9: 德国图宾根大学及杜塞尔多夫大学,访问学者。


近几年主持课题:

2018.01-2021.12国家自然科学基金《基于多靶点机制的三种五味子属植物及其内生真菌抗AD活性成分研究/负责/项目编号31770380

2016.01-2019.12国家自然科学基金《三种核桃属植物PIN1靶向抗肿瘤萘醌类成分及作用机制/负责/项目编号21572073

2013.01-2016.12国家自然科学基金《金山五味子治疗阿尔茨海默症活性成分及机制/负责/课题编号31270394

2011.1-2013.12:国家自然科学基金《换锦花抗AD活性成分及作用机制研究/ 负责/课题编号81072547

2009.1-2011.12国家自然科学基金野核桃青果皮抗肿瘤活性成分及作用机制研究/负责/课题编号30873361

2010.7-2013.6:  科技部国际合作项目石蒜属植物中化学成分治疗阿尔茨海默症的临床前研究/ 89/ 负责。

2013.01-2015.12:武汉市科技攻关项目《野核桃中新型凋亡诱导剂YHT-2YHT-3抗肿瘤成药性评价》/负责。

2010.1-2012.12:教育部留学回国人员启动基金《Aspergillus fischerianus次生代谢物生物合成研究》/教外司留(2008)890/ 负责。

2009.9-2011.8:重大新药创制专项创新药物研究项目来源于野核桃青果皮的抗肿瘤药物的研究与开发/ 20/负责。

2009.1-2009.12:中韩合作课题《从传统中药中开发出天然药物或功能性食品的新原料/ 3/负责。


近几年申请专利:

2013106738541 一种用于预防和治疗阿尔茨海默症的药物及其制备方法

2013100756654 具有神经保护作用的石蒜科生物碱类化合物

2013100764684 具有神经保护作用的石蒜伦碱类化合物

2013100764665 一个具有神经保护作用的石蒜碱类化合物

WO 2012/026641 A1 Composition for preventing or treating dementia

2012104169575 一种木脂素类化合物及其制备方法和应用

2012104179007 一种木脂素类化合物及其在防治阿尔茨海默症中的应用

KR 2010104064 Lycoris aurea extracts for preventing and treating dementia, Repub. Korean

2010105959577 两个萘醌类化合物在制备抗肿瘤类药物中的应用

2009100611697 用于预防或治疗痴呆症的组合物

近几年发表的主要论文(标*的为通讯作者):

*  Ming Zhou, Jia Zhou, Junjun Liu, Jing-Jing Liang, Xiao-Gang Peng, Fang-Fang Duan, and Han-Li Ruan*. Parasubindoles A-G, Seven Eremophilanyl Indoles from the Whole Plant of Parasenecio albus. The Journal of Organic Chemistry, 2018, Just Accepted Manuscript, DOI: 10.1021/acs.joc.8b02089, Publication Date (Web): September 10, 2018

*  Jian Song, Ming Zhou, Jia Zhou, Jing-Jing Liang, Xiao-Gang Peng, Junjun Liu, and Han-Li Ruan*. Schincalactones A and B, Two 5/5/6/11/3 Fused Schinortriterpenoids with a 13-Membered Carbon Ring System from Schisandra incarnate. Organic Letters, 2018, 20 (8), 2499-2502

* Ye Liu, Heng-Yi Yu, Hong-Zhe Xu, Jun-Jun Liu, Xiang-Gao Meng, Ming Zhou, and Han-Li Ruan*. Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe. Journal of Natural Products, 2018, 81 (8), 1841–1849

* Jingjing Liang, Xiaogang Peng, Jia Zhou, Ming Zhou, Hanli Ruan* Diarylheptanoids from the Fresh Pericarps of Juglans sigillata, Chemistry of Natural Compounds, 2018, accepted

*  Wenming Wu & Hanli Ruan* Triterpenoids and lignans from the stems of Schisandra glaucescens Natural Product Research, 2018 Mar 12:1-7

*  Jingjing Liang, Xiaogang Peng, Jia Zhou, Ming Zhou & Hanli Ruan* Diarylheptanoids from the fresh pericarps of Juglans sigillata, Natural Product Research, 2017 Dec 28:1-7

* Jian Song, Ye Liu, Ming Zhou, Hui Cao, Xiao-Gang Peng, Jing-Jing Liang, Xiao-Ya Zhao, Ming Xiang, Han-Li Ruan*. Spiroschincarins A–E: Five Spirocyclic Nortriterpenoids from the Fruit of Schisandra incarnata. Organic Letters, 2017, 19 (5), 1196–1199

* Ye Liu, Heng-Yi Yu, Yan-Mei Wang, Tian Tian, Wen-Ming Wu, Ming Zhou, Xiang-Gao Meng, Han-Li Ruan*. Neuroprotective Lignans from the Fruits of Schisandra bicolor var. tuberculata. Journal of Natural Products, 2017, 80 (4), 1117–1124

* Ye Liu, Tian Tian, Heng-Yi Yu, Ming Zhou, Han-Li Ruan*. Nortriterpenoids from the stems and leaves of Schisandra viridis, Fitoterapia, 2017, 118: 38-41

*  An Jin, Wen-Ming Wu, Han-Li Ruan*. Sesquiterpenoids and monoterpenoid coumarins from Parasenecio rubescens, Rsc Advances, 2017, 7(9), 5167–5176

* Ye Liu, Yan-Mei Wang, Wen-Ming Wu, Jian Song, Han-Li Ruan*. Triterpenoids and lignans from the fruit of Schisandra sphenanthera. Fitoterapia, 2017, 116:10–16

* Ming Zhou, Ye Liu, Jian Song, Xiao-Gang Peng, Qi Cheng, Hui Cao, Ming Xiang, and Han-Li Ruan*, Schincalide A, a Schinortriterpenoid with a Tricyclo[5.2.1.01,6]decane-Bridged System from the Stems and Leaves of Schisandra incarnate. Organic Letters, 2016, 18 (18), 4558–4561

* Wen-Ming Wu, Xu Chen, Ye Liu, Yan-Mei Wang, Tian Tian, Xiao-Ya Zhao, Juan Li, Han-Li Ruan*. Triterpenoids from the branch and leaf of Abies fargesii. Phytochemistry, 2016, 130, 301–312

* Heng-Yi Yu, Juan Li, Ye Liu, Wen-Ming Wu, Han-Li Ruan*. Triterpenoids from the fruit of Schisandra glaucescens. Fitoterapia, 2016, 113, 64–68.

* Wen-Ming Wu, Ye Liu, Xu Chen, An Jin, Ming Zhou, Tian Tian, Han-Li Ruan*, Diterpenoids from the branch and leaf of Abies fargesii, Fitoterapia, 2016, 110: 123-128.

* 毛瑞华,钟志宏,吴文明,刘叶,阮汉利*.鄂西大蓟茎叶化学成分研究[J].中草药, 2016,47(13): 2236-2240.

* Tian Tian, Ye Liu, Heng-Yi Yu, Yun-Yun Zhu, Xiao-Ya Zhao, Han-Li Ruan* Dibenzocyclooctadiene Lignans from the Fruits of Schisandra viridis, Chemistry of Natural Compounds, 2015, 51 (6):1046-1048

* An Jin, Wen-Ming Wu, Heng-Yi Yu, Ming Zhou, Ye Liu, Tian Tian, and Han-Li Ruan* Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens, Journal of Natural Products, 2015, 78 (8): 20572066

* Yun-Yun Zhu, Xue Li, Heng-Yi Yu, Yu-Fang Xiong, Peng Zhang, Hui-Fang Pi, Han-Li Ruan* Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activities Archives of Pharmacal Research, 2015, 38 (5): 604-613

* Yuan Gan, Yang Zhang, Aiqian Li, Chengwu Song, Chang Chen, Yong Xu, Hanli Ruan*, Hongliang*. Jiang, A Novel Four-step Approach for Systematic Identification of Naphthoquinones in Juglans cathayensis Dode using Various Scan Functions of Liquid Chromatography-Tandem Mass Spectrometry along with Data Mining Strategies. Phytochemical Analysis, 2015, 26(6): 413–422

Zhenzhong Chen, Ling Tong, Yuanli Feng, Jizhou Wu, Xiaoya Zhao, Hanli Ruan, Huifang Pi, Peng Zhang, Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus. Phytochemistry 2015, 116, 329-336.

* Heng-Yi Yu, Zu-Yu Chen, Bin Sun, Junjun Liu, Fan-Yu Meng, Ye Liu, Tian Tian, An Jin, and Han-Li Ruan*, Lignans from the Fruit of Schisandra glaucescens with Antioxidant and Neuroprotective Properties, Journal of Natural Products , 2014, 77 (6): 1311–1320

* An Jin, Xue Li, Yun-Yun Zhu, Heng-Yi Yu, Hui-Fang Pi, Peng Zhang, Han-Li Ruan* Four New Compounds from the Bulbs of Lycoris aurea with Neuroprotective Effects against CoCl2 and H2O2-induced SH-SY5Y Cell Injuries, Archives of Pharmacal Research 2014, 37: 315-323

* Wen-Ming Wu, Yun-Yun Zhu, Hao-ran Li, Heng-Yi Yu, Peng Zhang, Hui-Fang Pi, Han-Li Ruan* Two new alkaloids from the bulb of Lycoris sprengeri  Journal of Asian Natural Products Research, 2014, 16(2): 192-199.

Ke Jiao, Huo-Yun Li, Peng Zhang, Hui-Fang Pi, Han-Li Ruan, Ji-Zhou Wu Two new ent-kaurane diterpenoids from the aerial parts of Isodon excisoides Chinese Chemical Letters 2014, 25(1): 131-133.

Ling Tong, Tu Chen, Zhenzhong Chen, Peng Zhang, Huifang Pi, Hanli Ruan, Jizhou. Wu, Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae. Journal of Ethnopharmacology 2014, 155 (3), 1553-1560.

Juan Li, Hang Chang, Wenyu Zhao, Huifang Pi, Hanli Ruan, Peng. Zhang, New Alkaloids from Aconitum vaginatum. Helvetica Chimica Acta 2014, 97 (5), 689-693.

* Heng-Yi Yu, Xiao-Qiong Zhang, Xue-Li, Fan-Bo Zeng, Han-Li Ruan* 2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma Model, Journal of Natural Products 2013, 76(5): 889−895

* Juan Li, Jia-Xiang Sun, Heng-Yi Yu, Zu-Yu Chen, Xiao-Ya Zhao, Han-Li Ruan* Diarylheptanoids from the root bark of Juglans cathayensis, Chinese Chemical Letters 2013, 24: 521-523

* Xue Li, Heng-Yi Yu, Zhuo-Yi Wang, Hui-Fang Pi, Peng Zhang, Han-Li Ruan* Neuroprotective Compounds from the Bulbs of Lycoris radiate, Fitoterapia 2013, 88: 82-90.

Ke Jiao, Huo-Yun Li, Peng Zhang, Hui-Fang Pi, Han-Li Ruan, Ji-Zhou Wu Three new ursane-type triterpenoids from the aerial parts of Isodon excisoides Journal of Asian Natural Products Research 2013, 15(9): 962-968.

Kun Yang, Ling Tong, Chunxia Chen, Peng Zhang, Huifang Pi, Hanli Ruan, Jizhou. Wu, Therapeutic effects of extracts from Radix Toddaliae Asiaticae on collagen-induced arthritis in Balb/c mice. Journal of Ethnopharmacology 2013, 146 (1), 355-362.

*  Heng-Yi Yu, Cui Hao, Fan-Yu Meng, Xue Li, Zu-Yu Chen, Xi Liang, Han-Li Ruan* Neuroprotective Lignans from the Stems of Schisandra glaucescens Planta Medica 2012, 78: 1962-1966

* Jia-Xiang Sun, Xiao-Ya Zhao, Xiao-Fang Fu, Heng-Yi Yu, Xue Li, Shu-Ming Li, Han-Li Ruan*  Three new naphthalenyl glycosides from the root bark of Juglans cathayensis, Chemical and Pharmaceutical Bulletin 2012, 60: 785-789.

Kathrin Mundt, Beate Wollinsky, Han-Li Ruan, Tianjiao Zhu and Shu-Ming Li, Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches. Chembiochem 2012, Nov 26; 13(17): 2583-2592 (This paper was selected as issue cover)

* Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Heng-Yi Yu, Shu-Ming Li, and Han-Li Ruan*. Schiglautone A, a New Tricyclic Triterpenoid with a Unique 6/7/9-Fused Skeleton from the Stems of Schisandra glaucescens. Organic Letters, 2011, 13 (6): 1502–1505

* Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Hui-Fang Pi, Peng Zhang, Han-Li Ruan*. Triterpenoids from the Stems of Schisandra glaucescens. Helvetica Chimica Acta, 2011, 94(10):1778-1785

* Heng-Yi Yu, Xue Li, Fan-Yu Meng, Hui-Fang Pi, Peng Zhang, Han-Li Ruan* Naphthoquinones from the root barks of Juglans cathayensis Dode. Journal of Asian Natural Products Research, 2011, 13 (7): 581-587.

Li, Lujun; Zhang, Yue; Zhang, Peng; Pi, Huifang; Ruan, Hanli; Wu, Jizhou.   Appraisal of anti-inflammatory and free radical scavenging activities of ethanol extract of Ilex ficoidea Hemsl and Ilex centrochinensis S.Y. Hu.  Environmental Toxicology and Pharmacology 2011, 32(2), 122-127.  

Zhang, Yue; Li, Lu-Jun; Zhang, Peng; Pi, Hui-Fang; Ruan, Han-Li; Wu, Ji-Zhou.   Three New E-Secoursane Triterpenoid Saponins from the Leaves of Ilex dunniana.    Helvetica Chimica Acta 2011, 94(12): 2207-2214.  

Chen Chunxia, Zhang Peng, Pi Huifang, Ruan Hanli, Hu Zehua,Wu Jizhou. Extracts of Arisaema rhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice. Journal of Ethnopharmacology. 2011, 133: 573-582

Li, Lu-Jun; Zhang, Yue; Zhang, Peng; Pi, Hui-Fang; Ruan, Han-Li; Wu, Ji-Zhou.   Flavans from the leaf of Ilex centrochinensis. Journal of Asian Natural Products Research  2011, 13(4): 367-372.

Li, Lu-Jun; Zhang, Yue; Zhang, Peng; Pi, Hui-Fang; Ruan, Han-Li; Wu, Ji-Zhou.   Two new 5,8-quinoflavans from the leaf of Ilex centrochinensis.  Journal of Asian Natural Products Research  2011, 13(4): 341-345.  

*  陈超,胡钰,孙家祥,皮慧芳,张鹏,阮汉利*. 野核桃叶化学成分研究. 中草药, 201142(11), 2177-2180

张悦, 李陆军, 张鹏, 皮慧芳, 阮汉利, 吴继洲.冬青属两种植物的抗炎作用及自由基清除能力研究. 华中科技大学学报(医学版), 2011, 40(1), 71-74.

* 张悦,阮汉利*,张勇慧,皮慧芳,吴继洲 鄂西大蓟根的化学成分的研究 天然产物研究与开发,2010, 22(1): 58-59


副主编和参编教材:

主编《天然药物化学》(医药科技出版社,2016年出版)

参编《波谱解析》第二版(人民卫生出版社,2016年出版)

副主编《天然药物化学》(医药科技出版社,20158月出版)

参编《波谱解析》 (中医药出版社,2014年出版)

副主编《天然药物化学》(高等教育出版社,20105月出版)

参编《波谱解析》(人民卫生出版社,20117月出版)

参编《天然药物化学》(医药科技出版社,20088月出版)

参编《天然药物化学图表解》(人民卫生出版社,200810月出版)

参编《天然药物化学学习指导》(人卫出版社,20052月出版)

参编《天然药物化学习题集》第二版 (人卫出版社,20078月出版)

参编药物计量学(医药科技出版社,20064月出版)


参加会议:

2016. 9. 25-28,中国化学会第十一届全国天然有机化学学术会议,上海,中国

2014. 11. 21-23, 中国化学会第十届全国天然有机化学学术会议,广州,中国

2014. 10. 20-24, 28th International Symposium on the Chemistry of Natural Products and the 8th International Conference on Biodiversity (ISCNP28 & ICOB8), Shanghai, China

2012. 8. 23-26, 韩国首尔 the 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy (7届中日韩三国生药学联合学术研讨会) 交流论文Diarylheptanoids from the root bark of Juglans cathayensis Dode  

2011. 8. 10-12, 昆明 野核桃根皮化学成分研究,第十届全国药用植物及植物药学术研讨会 PP159

Zongfang Wang, Hengyi Yu, Hanli Ruan*, Huifang Pi, Peng Zhang, Jizhou Wu.  Five new compounds from Juglans cathayensis the 5th JSP-CCTCNM-KSP Joint Symposium. September 24th 2010. Tokushima-Japan.

获奖情况:

2003年被评为华中科技大学“三育人积极分子”。2001-2002学年获华中科技大学教学质量优秀二等奖。19992000200120152017年考核优秀。2005年湖北省自然科学三等奖(排名第2005年华中科技大学优秀博士学位论文20092010年指导本科生论文获湖北省大学本科生毕业论文一等奖。


华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030