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师资队伍
杰出人才
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阮汉利

来源: 发布时间 2018-09-17 10:05:19 点击数:

阮汉利

阮汉利,医学博士,教授,博士生导师。现任华中科技大学同济药学院中药与天然药物学系主任。兼任世界中医药学联合会中药化学专业委员会常务理事、湖北省药学会中药和天然药物专委会委员。湖北省新世纪高层次人才工程第三层次入选人才。2005年9月-2006年9月、2007年7-10月、2008年7-10月、2014年1-6月国家留学基金委公派访问留学德国,主修生物药学。

主要从事天然药物活性成分的提取分离、结构鉴定和活性测试工作。对野核桃、麻核桃、泡核桃、忽地笑、换锦花、长筒石蒜、石蒜、金山五味子、兴山五味子、矢镞叶蟹甲草、湖北贝母、鄂北贝母、杂交贝母等多种植物进行过系统研究,并对湖北省民间药材蛇菰和千屈菜的部颁标准进行了制定;对曲霉属真菌中吲哚类生物碱的异戊烯基转移酶相关生物合成基因进行过研究。擅长天然产物的结构解析工作。主持和参加多项国家级和省部级课题。在国内外各种权威期刊发表论文100余篇,其中70多篇为SCI收载。国家精品课程《天然药物化学》主讲教师之一。主讲本科生天然药物化学、波谱解析,及研究生天然药物研究方法、结构解析和中药提取分离新技术等课程。主编、副主编和参编多部人民卫生出版社、高等教育出版社、医药科技出版社和中国中医药出版社的本科生国家统编教材。

学习经历:2001.9-2004.7:华中科技大学同济医学院药学院,获得药理学博士学位;

1996.9-1999.7:同济医科大学药学院,获药物化学专业硕士学位;

1985.9-1989.7:中国药科大学中药系,获理学学士学位;

2014.1-2014.6:德国马尔堡大学,访问学者

2007.7-10;2008.7-10:德国杜塞尔多夫大学,访问学者

2005.9-2006.9:德国图宾根大学及杜塞尔多夫大学,访问学者

工作经历:2014.11-今:华中科技大学同济药学院教授,硕士、博士生导师,中药与天然药物学系主任;

2011.3-2014.11:华中科技大学同济药学院教授,硕士、博士生导师,天然药物化学与中药学系副主任;天然药物化学课程群负责人;

2009.11-2011.2:华中科技大学同济药学院教授,硕士、博士生导师;

2002.7-2009.10:华中科技大学同济药学院副教授,硕士生导师;

1997.1-2002.6:华中科技大学同济医学院药学院讲师;

1992.12-1996.12:同济医科大学药学院助教

近几年主持科研项目:

2018.01-2021.12:国家自然科学基金《基于多靶点机制的三种五味子属植物及其内生真菌抗AD活性成分研究》/负责/项目编号31770380;

2016.01-2019.12:国家自然科学基金《三种核桃属植物PIN1靶向抗肿瘤萘醌类成分及作用机制》/负责/项目编号21572073;

2013.01-2016.12:国家自然科学基金《金山五味子治疗阿尔茨海默症活性成分及机制》/负责/课题编号31270394;

2011.1-2013.12:国家自然科学基金《换锦花抗AD活性成分及作用机制研究》/负责/课题编号81072547;

2009.1-2011.12:国家自然科学基金《野核桃青果皮抗肿瘤活性成分及作用机制研究》/负责/课题编号30873361;

2010.7-2013.6:科技部国际合作重点项目《石蒜属植物中化学成分治疗阿尔茨海默症的临床前研究》/负责;

2013.01-2015.12:武汉市科技攻关项目《野核桃中新型凋亡诱导剂YHT-2和YHT-3抗肿瘤成药性评价》/负责;

2010.1-2012.12:教育部留学回国人员启动基金《Aspergillus fischerianus次生代谢物生物合成研究》/教外司留(2008)890号/负责;

2009.9-2011.8:重大新药创制专项创新药物研究项目《来源于野核桃青果皮的抗肿瘤药物的研究与开发》/ 20万/负责;

2009.1-2009.12:中韩合作课题《从传统中药中开发出天然药物或功能性食品的新原料》/ 3万/负责。

近几年专利申请:

2013106738541一种用于预防和治疗阿尔茨海默症的药物及其制备方法

2013100756654具有神经保护作用的石蒜科生物碱类化合物

2013100764684具有神经保护作用的石蒜伦碱类化合物

2013100764665一个具有神经保护作用的石蒜碱类化合物

WO 2012/026641 A1 Composition for preventing or treating dementia

2012104169575一种木脂素类化合物及其制备方法和应用

2012104179007一种木脂素类化合物及其在防治阿尔茨海默症中的应用

KR 2010104064 Lycoris aurea extracts for preventing and treating dementia, Repub. Korean

2010105959577两个萘醌类化合物在制备抗肿瘤类药物中的应用

2009100611697用于预防或治疗痴呆症的组合物

发表的主要论文(标*的为通讯作者):

* Xiaogang Peng, Fangfang Duan, Yangzhou He, Ying Gao, Juan Chen, Jinling Chang andHanli Ruan* Ergocytochalasin A, a polycyclic merocytochalasan from an endophytic fungusPhoma multirostrataXJ-2-1Organic & Biomolecular Chemistry, 2020, 18, 4056-4062

* Jia Zhou, Ying Gao, Jin-Ling Chang, Heng-Yi Yu, Juan Chen, Ming Zhou, Xiang-Gao Meng, andHan-Li Ruan*Resorcylic Acid Lactones from anIlyonectriasp.Journal of Natural Products2020, 83 (5): 1505-1514

* Ying Gao, Jia Zhou,Hanli Ruan* Trichothecenes from an Endophytic FungusAlternariasp. sb23,Planta Medica2020,DOI: 10.1055/a-1091-8831, https://www.thieme-connect.com/products/ejournals/html/10.1055/a-1091-8831

* Juan Chen, Xiao-Gang Peng, Junjun Liu, Ying Gao, Ming Zhou, Jia Zhou, Jian Song, andHan-Li Ruan*Incarnolides A and B, Two Schinortriterpenoids with a Tricyclo[9.2.1.02,8]tetradecane-Bridged System fromSchisandra incarnata,Organic Letters2020 22 (3), 1071-1075

*Xiaogang Peng, Yi Lin, Jingjing Liang, Ming Zhou, Jia Zhou,Hanli Ruan*Triterpenoids from the barks ofJuglans hopeiensis.Phytochemistry, 170 (2019): 112201.https://doi.org/10.1016/j.phytochem.2019.112201

* Ming Zhou, Xiaogang Peng, Jia Zhou, Ye Liu, Xianggao Meng,Hanli Ruan*Triterpenoids from the stems and leaves of Schisandra incarnata,Phytochemistry, 177 (2020): 112448, https://doi.org/10.1016/j.phytochem.2020.112448.

* Yi Lin, Xiaogang Peng,Hanli Ruan*Diarylheptanoids from the fresh pericarps of Juglans hopeiensisFitoterapia136 (2019) 104165. https://doi.org/10.1016/j.fitote.2019.05.004

* Yi Lin, Jingjing Liang, Xiaogang Peng &Hanli Ruan*Phenolic constituents from the fresh pericarps of Juglans sigillataNatural Product Research, Published online: 22 Jul 2019.DOI: 10.1080/14786419.2019.1644631

* Yi Lin, Xiaogang Peng, Juan Chen, Jia Zhou &Hanli Ruan*Triterpenoids from the fresh pericarps of Juglans hopeiensisNatural Product Research, Published online: 29 May 2019. DOI: 10.1080/14786419.2019.1622111

* Jing-Jing Liang, Jia Zhou, Jian Song, andHan-Li Ruan* Anthraquinone and Naphthoquinone Derivatives from the Pericarps ofJuglans sigillataChemistry of Natural Compounds, 2019, 55(3): 435-439

* Aiqian Li#, Zhifeng Du#, Mei Liao, Yulin Feng,Hanli Ruan*and Hongliang Jiang*Discovery and Characterisation of Lycorine-Type Alkaloids inLycorisSpp. (Amaryllidaceae) Using UHPLC-QTOF-MS.Phytochemical Analysis, 2019, 30: 268–277

* Wenming Wu &Hanli Ruan*Triterpenoids and lignans from the stems ofSchisandra glaucescensNatural Product Research, 2019, 33(3), 328–334

* Ming Zhou, Jia Zhou, Junjun Liu, Jing-Jing Liang, Xiao-Gang Peng, Fang-Fang Duan, andHan-Li Ruan*. Parasubindoles A-G, Seven Eremophilanyl Indoles from the Whole Plant ofParasenecio albus.The Journal of Organic Chemistry, 2018, 83 (19), 12122–12128

* Jian Song, Ming Zhou, Jia Zhou, Jing-Jing Liang, Xiao-Gang Peng, Junjun Liu, andHan-Li Ruan*. Schincalactones A and B, Two 5/5/6/11/3 Fused Schinortriterpenoids with a 13-Membered Carbon Ring System fromSchisandra incarnate.Organic Letters, 2018, 20 (8), 2499-2502

*Ye Liu, Heng-Yi Yu, Hong-Zhe Xu, Jun-Jun Liu, Xiang-Gao Meng, Ming Zhou, andHan-Li Ruan*. Alkaloids with Immunosuppressive Activity from the Bark ofPausinystalia yohimbe.Journal of Natural Products, 2018, 81 (8), 1841–1849

* Jingjing Liang, Xiaogang Peng, Jia Zhou, Ming Zhou &Hanli Ruan*Diarylheptanoids from the fresh pericarps ofJuglans sigillata,Natural Product Research, 2018, 32(20), 2457-2463

*Jian Song, Ye Liu, Ming Zhou, Hui Cao, Xiao-Gang Peng, Jing-Jing Liang, Xiao-Ya Zhao, Ming Xiang,Han-Li Ruan*. Spiroschincarins A–E: Five Spirocyclic Nortriterpenoids from the Fruit ofSchisandra incarnata.Organic Letters, 2017, 19 (5), 1196–1199

*Ye Liu, Heng-Yi Yu, Yan-Mei Wang, Tian Tian, Wen-Ming Wu, Ming Zhou, Xiang-Gao Meng,Han-Li Ruan*. Neuroprotective Lignans from the Fruits ofSchisandra bicolorvar.tuberculata.Journal of Natural Products, 2017, 80 (4), 1117–1124

*Ye Liu, Tian Tian, Heng-Yi Yu, Ming Zhou,Han-Li Ruan*. Nortriterpenoids from the stems and leaves ofSchisandra viridis,Fitoterapia, 2017, 118: 38-41

* An Jin, Wen-Ming Wu,Han-Li Ruan*.Sesquiterpenoids and monoterpenoid coumarins fromParasenecio rubescens,Rsc Advances, 2017, 7(9), 5167–5176

*Ye Liu,Yan-Mei Wang, Wen-Ming Wu, Jian Song,Han-Li Ruan*. Triterpenoids and lignans from the fruit of Schisandra sphenanthera.Fitoterapia, 2017, 116:10–16

*Ming Zhou, Ye Liu, Jian Song, Xiao-Gang Peng, Qi Cheng, Hui Cao, Ming Xiang, andHan-Li Ruan*,Schincalide A, a Schinortriterpenoid with a Tricyclo[5.2.1.01,6]decane-Bridged System from the Stems and Leaves of Schisandra incarnate.Organic Letters, 2016, 18 (18), 4558–4561

*Wen-Ming Wu, Xu Chen, Ye Liu, Yan-Mei Wang, Tian Tian, Xiao-Ya Zhao, Juan Li,Han-Li Ruan*. Triterpenoids from the branch and leaf of Abies fargesii.Phytochemistry, 2016,130, 301–312

*Heng-Yi Yu, Juan Li, Ye Liu, Wen-Ming Wu,Han-Li Ruan*. Triterpenoids from the fruit of Schisandra glaucescens.Fitoterapia, 2016, 113, 64–68.

*Wen-Ming Wu, Ye Liu, Xu Chen, An Jin, Ming Zhou, Tian Tian,Han-Li Ruan*, Diterpenoids from the branch and leaf of Abies fargesii,Fitoterapia, 2016, 110: 123-128.

*毛瑞华,钟志宏,吴文明,刘叶,阮汉利*.鄂西大蓟茎叶化学成分研究[J].中草药, 2016,47(13): 2236-2240.

*Tian Tian, Ye Liu, Heng-Yi Yu, Yun-Yun Zhu, Xiao-Ya Zhao,Han-Li Ruan* Dibenzocyclooctadiene Lignans from the Fruits of Schisandra viridis,Chemistry of Natural Compounds, 2015,51 (6):1046-1048

*An Jin, Wen-Ming Wu, Heng-Yi Yu, Ming Zhou, Ye Liu, Tian Tian, andHan-Li Ruan* Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens,Journal of Natural Products, 2015,78 (8): 2057–2066

*Yun-Yun Zhu, Xue Li, Heng-Yi Yu, Yu-Fang Xiong, Peng Zhang, Hui-Fang Pi,Han-Li Ruan*Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activitiesArchives of Pharmacal Research, 2015, 38 (5): 604-613

*Yuan Gan, Yang Zhang, Aiqian Li, Chengwu Song, Chang Chen, Yong Xu,Hanli Ruan*, Hongliang*. Jiang, A Novel Four-step Approach for Systematic Identification of Naphthoquinones in Juglans cathayensis Dode using Various Scan Functions of Liquid Chromatography-Tandem Mass Spectrometry along with Data Mining Strategies.Phytochemical Analysis,2015, 26(6): 413–422

*Heng-Yi Yu, Zu-Yu Chen, Bin Sun, Junjun Liu, Fan-Yu Meng, Ye Liu, Tian Tian, An Jin, andHan-Li Ruan*, Lignans from the Fruit of Schisandra glaucescens with Antioxidant and Neuroprotective Properties,Journal of Natural Products, 2014, 77 (6): 1311–1320

*An Jin, Xue Li, Yun-Yun Zhu, Heng-Yi Yu, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Four New Compounds from the Bulbs of Lycoris aurea with Neuroprotective Effects against CoCl2 and H2O2-induced SH-SY5Y Cell Injuries,Archives of Pharmacal Research2014, 37: 315-323

*Wen-Ming Wu, Yun-Yun Zhu, Hao-ran Li, Heng-Yi Yu, Peng Zhang, Hui-Fang Pi,Han-Li Ruan*Two new alkaloids from the bulb of Lycoris sprengeriJournal of Asian Natural Products Research,2014, 16(2): 192-199.

*Heng-Yi Yu, Xiao-Qiong Zhang, Xue-Li, Fan-Bo Zeng,Han-Li Ruan*2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma Model,Journal of Natural Products2013, 76(5): 889−895

*Juan Li, Jia-Xiang Sun, Heng-Yi Yu, Zu-Yu Chen, Xiao-Ya Zhao,Han-Li Ruan*Diarylheptanoids from the root bark ofJuglans cathayensis,Chinese Chemical Letters2013, 24: 521-523

*Xue Li, Heng-Yi Yu, Zhuo-Yi Wang, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Neuroprotective Compounds from the Bulbs ofLycoris radiate,Fitoterapia2013, 88: 82-90.

* Heng-Yi Yu, Cui Hao, Fan-Yu Meng, Xue Li, Zu-Yu Chen, Xi Liang,Han-Li Ruan*Neuroprotective Lignans from the Stems ofSchisandra glaucescensPlanta Medica2012,78: 1962-1966

* Jia-Xiang Sun, Xiao-Ya Zhao, Xiao-Fang Fu, Heng-Yi Yu, Xue Li, Shu-Ming Li,Han-Li Ruan*Three new naphthalenyl glycosides from the root bark ofJuglans cathayensis,Chemical and Pharmaceutical Bulletin 2012, 60: 785-789.

* Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Heng-Yi Yu, Shu-Ming Li, andHan-Li Ruan*. Schiglautone A, a New Tricyclic Triterpenoid with a Unique 6/7/9-Fused Skeleton from the Stems ofSchisandra glaucescens.Organic Letters,2011, 13 (6): 1502–1505

*Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*. Triterpenoids from the Stems ofSchisandra glaucescens.Helvetica Chimica Acta,2011,94(10):1778-1785

* Heng-Yi Yu, Xue Li, Fan-Yu Meng, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Naphthoquinones from the root barks ofJuglans cathayensisDode.Journal of Asian Natural Products Research,2011,13 (7): 581-587.

*陈超,胡钰,孙家祥,皮慧芳,张鹏,阮汉利*.野核桃叶化学成分研究.中草药, 2011,42(11), 2177-2180

*张悦,阮汉利*,张勇慧,皮慧芳,吴继洲鄂西大蓟根的化学成分的研究天然产物研究与开发,2010, 22(1): 58-59

Han-Li Ruan, Edyta Stec and Shu-Ming Li. Production of diprenylated indole derivatives by tandem incubation of two recombinant dimethylallyltryptophan synthasesArch Microb 2009, 191: 791-795

*PI Hui-fang, ZHANG Peng,RUAN Han-li*, ZHANG Yong-hui, SUN Han-dong, WU Ji-zhou A new triterpenoid from the leaves and stems ofFritillaria hupehensisJournal of Asian Natural Products Research2009,11 (9): 779-782

Nicola Steffan, Alexander Grundmann, Shamil Afiyatullov,Hanli Ruanand Shu-Ming Li FtmOx1, a non-heme Fe(II) and a-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatusOrg Biomol Chem. 2009, 7(19): 4082-7

Han-Li Ruan,Wen-Bing Yin,Ji-Zhou Wu, Shu-Ming Li.Reinvestigation of a Cyclic Dipeptide N-Prenyltransferase Reveals Rearrangement of N-1 Prenylated Indole Derivatives.ChemBioChem2008, 9: 1044-1047.

*Hui Fang Pi Zhi Hong ZhongHan Li Ruan*Peng Zhang Yong Hui Zhang Ji Zhou Wu A new hopane triterpenoid from Saxiglossum angustissimumChinese Chemical Letters 2008, 19: 835–836

*LI Yi-xiu;RUAN Han-li*; ZHOU Xue-feng; ZHANG Yong-hui; PI Hui-fang and WU Ji-zhou Cytotoxic Diarylheptanoids from Pericarps ofJuglans CathayensisDodeChem.Res. Chinese Universities2008, 24(4), 427 -429

*Pi, Hui Fang; Zhang, Peng; Zhu, Tian;Ruan, Han Li*; Zhang, Yong Hui; Sun, Han Dong; Wu, Ji Zhou. A new cycloartane triterpenoid from the leaves and stems of Fritillaria hupehensis.Chinese Chemical Letters2007, 18(4), 418-420.

Yin, Wen-Bing;Ruan, Han-Li; Westrich, Lucia; Grundmann, Alexander; Li, Shu-Ming. CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterization.ChemBioChem2007, 8(10), 1154-1161.

Ruan Han-li, Zhang Yong-hui,Wu Ji-zhou. Two new diterpenoid dimers, fritillebinide D and E, from bulbs offritillaria ebeiensisJournal of Asian Natural Products Research2002;4(4): 309-314

Ruan Han-li, Zhang Yong-hui,Wu Ji-zhou.Structure of a novel diterpenoid ester, fritillahupehin, from bulbs offritillaria hupehensisHsiaoetK. C. HsiaFitoterapia2002: 73(4): 288-291

Wu Ji-zhou,Ruan Han-li, Yao Nian-huan.Structures of Two Diterpenoid Dimers from Bulbs ofFritillaria ebeiensis.Journal of Asian Natural Products Research2000, 2 (3): 161-167

Wu Ji-zhou, Wen Yu-ping,Ruan Han-li. Structural Elucidation of TwoEnt-kauran Dimers from Bulbs ofFritillariaebeiensisvar.purpurea. Journal of Asian Natural Products Research2000, 2(3): 213-218

Wu Ji-zhou,Ruan Han-li, Zeng Chun-lan. Structures of Two New Diterpenoid Dimers from Bulbs of Fritillaria ebeiensis. J Asia Nat Prod Reseach 1999; 1: 251-257

副主编和参编教材:

主编《天然药物化学》(医药科技出版社,2016年出版);

参编《波谱解析》第二版(人民卫生出版社,2016年出版);

副主编《天然药物化学》(医药科技出版社,2015年8月出版);

参编《波谱解析》(中医药出版社,2014年出版);

副主编《天然药物化学》(高等教育出版社,2010年5月出版);

参编《波谱解析》(人民卫生出版社,2011年7月出版);

参编《天然药物化学》(医药科技出版社,2008年8月出版);

参编《天然药物化学图表解》(人民卫生出版社,2008年10月出版);

参编《天然药物化学学习指导》(人卫出版社,2005年2月出版);

参编《天然药物化学习题集》第二版(人卫出版社,2007年8月出版);

参编《药物计量学》(医药科技出版社,2006年4月出版)。

参加会议:

2016. 9. 25-28,中国化学会第十一届全国天然有机化学学术会议,上海,中国

2014. 11. 21-23,中国化学会第十届全国天然有机化学学术会议,广州,中国

2014. 10. 20-24, 28th International Symposium on the Chemistry of Natural Products and the 8th International Conference on Biodiversity (ISCNP28 & ICOB8), Shanghai, China

2012. 8. 23-26,韩国首尔the 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy (第7届中日韩三国生药学联合学术研讨会)交流论文Diarylheptanoids from the root bark of Juglans cathayensis Dode

2011. 8. 10-12,昆明野核桃根皮化学成分研究,第十届全国药用植物及植物药学术研讨会PP159

Zongfang Wang, Hengyi Yu, Hanli Ruan*, Huifang Pi, Peng Zhang, Jizhou Wu.Five new compounds fromJuglans cathayensisthe 5th JSP-CCTCNM-KSP Joint Symposium. September 24th 2010.Tokushima-Japan.


获奖情况:

2003年被评为华中科技大学“三育人积极分子”。2001-2002学年获华中科技大学教学质量优秀二等奖。1999、2000、2001、2015、2017-2019年考核优秀。2005年湖北省自然科学三等奖(排名第二)。2005年华中科技大学优秀博士学位论文。2009和2010年指导本科生论文获湖北省大学本科生毕业论文一等奖。

Email:ruanhl@hust.edu.cn;ruanhl@mails.tjmu.edu.cn

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