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师资队伍
杰出人才
博士后

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胡正喜

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胡正喜

胡正喜,博士,男,湖北武汉人。中药与天然药物学系,主要从事药用植物与微生物中活性复杂天然产物的结构鉴定与生物功能研究。主持国家自然科学基金青年基金,中国博士后科学基金面上项目(一等)和特别资助项目各一项,华中科技大学人才引进基金(2019年)等。担任期刊Organic Letters、Journal of Natural Products、Frontiers in Chemistry、Natural Product Research等杂志的审稿人。以第一作者或共同通讯作者在Angewandte Chemie、Organic Letters、Organic Chemistry Frontiers、Journal of Organic Chemistry、Journal of Natural Products、Frontiers in Microbiology、Phytochemistry、Organic & Biomolecular Chemistry、Bioorganic Chemistry、Chinese Chemical Letters、Bioorganic & Medicinal Chemistry、European Journal of Organic Chemistry等本专业权威期刊上发表SCI论文约50篇。

1.联系方式

邮箱:huzhengxi@hust.edu.cn

    hzx616@126.com

地址:武汉市硚口区航空路13号同济医学院药学院1号楼509室邮编430030

2.研究方向

药用植物与微生物中活性复杂天然产物的结构鉴定与生物功能研究。

3.教育经历

2014/2–2016/6 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室 药物化学 联合培养博士 导师:孙汉董院士&张勇慧教授

2011/9–2016/6 华中科技大学同济药学院 药物化学 博士 导师:张勇慧教授

2007/9–2011/6 华中科技大学同济药学院 中药学 本科

4.工作经历

2019/3–至今 华中科技大学同济药学院 讲师

2016/7–2019/2 华中科技大学同济药学院 博士后 合作导师:张勇慧教授&王小川教授

5.主持科研项目

1)华中科技大学人才引进基金,2019/03–2022/03,15万元

2)国家自然科学基金青年项目,编号21702067,基于反向虚拟筛选的新颖天然11β-HSD1抑制剂的发现与抗糖尿病活性研究,2018/01–2020/12,25万元,在研

3)中国博士后科学基金特别资助项目,编号2018T110777,芸薹生链格孢中具有IKKβ抑制活性的新颖二萜的研究,2018/07–2019/06,15万,已结题

4)中国博士后科学基金面上项目(一等),编号2017M610479,光轮层炭壳菌中新颖抗糖尿病活性次生代谢产物的研究,2017/07–2018/06,8万元,已结题

6.主要学术论文(#Co-first author, *Corresponding author)

1.Mengting Liu(#), Weiguang Sun(#), Ling Shen, Yan He, Junjun Liu, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). Bipolarolides A–G: Ophiobolin-Derived Sesterterpenes with Three New Carbon Skeletons fromBipolarissp. TJ403-B1.Angewandte Chemie International Edition2019,58, 12091–12095. (中科院一区, IF = 12.959)

2.Fengli Li, Shuang Lin, Sitian Zhang, Xincai Hao, Xiao-Nian Li, Beiye Yang, Junjun Liu, Jianping Wang,Zhengxi Hu(*), and Yonghui Zhang(*). Alterbrassinoids A–D: Fusicoccane-Derived Diterpenoid Dimers Featuring Different Carbon Skeletons fromAlternaria brassicicola.Organic Letters2019,21, 8353–8357. (中科院一区, IF = 6.091)

3.Weixi Gao(#), Chenwei Chai(#), Yan He, Fengli Li, Xincai Hao, Fei Cao, Lianghu Gu, Junjun Liu,Zhengxi Hu(*), and Yonghui Zhang(*). Periconiastone A, an Antibacterial Ergosterol with a Pentacyclo[8.7.0.01,5.02,14.010,15]heptadecane System fromPericoniasp. TJ403-rc01.Organic Letters2019,21, 8469–8472. (中科院一区, IF = 6.091)

4.Zhengxi Hu(#), Weiguang Sun(#), Fengli Li(#), Jiankun Guan(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang(*), Hucheng Zhu(*), Yonghui Zhang(*). Fusicoccane-Derived Diterpenoids fromAlternaria brassicicola: Investigation of the Structure-Stability Relationship and Discovery of an IKKβInhibitor.Organic Letters2018,20, 5198–5202. (中科院一区, IF = 6.091)

5.Fengli Li(#), Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu(#), Sitian Zhang, Shuang Lin, Junjun Liu, Weixi Gao, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γAgonistic Activity fromAlternaria brassicicola.Organic Letters2018,20, 7982–7986. (中科院一区, IF = 6.091)

6.Zhengxi Hu(#), Ye Wu(#), Shuangshuang Xie, Weiguang Sun, Yi Guo, Xiao-Nian Li, Junjun Liu, Hua Li, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*). Phomopsterones A and B, two functionalized ergostane-type steroids from the endophytic fungusPhomopsissp. TJ507A.Organic Letters2017,19, 258–261. (中科院一区, IF = 6.091)

7.Zheng-Xi Hu(#), Yi-Ming Shi(#), Wei-Guang Wang, Jian-Wei Tang, Min Zhou, Xue Du, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun. Structural Characterization of Kadcoccinin A: A Sesquiterpenoid with a Tricyclo[4.4.0.03,10]decane Scaffold fromKadsura coccinea.Organic Letters2016,18, 2284–2287. (中科院一区, IF = 6.091)

8.Zheng-Xi Hu(#), Yi-Ming Shi(#), Wei-Guang Wang, Xiao-Nian Li, Xue Du, Miao Liu, Yan Li, Yong-Bo Xue, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun. Kadcoccinones A–F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons fromKadsura coccinea.Organic Letters2015,17, 4616–4619. (中科院一区, IF = 6.091)

9.Zheng-Xi Hu, Hou-Chao Xu, Kun Hu, Miao Liu, Xiao-Nian Li, Xing-Ren Li, Xue Du, Yong-Hui Zhang(*), Pema-Tenzin Puno(*), Han-Dong Sun.Structurally diverse diterpenoids fromIsodon pharicus.Organic Chemistry Frontiers2018,5, 2379–2389.(中科院一区, IF = 5.155)

10.Changxing Qi(#), Xiaosheng Tan(#), Zhengyi Shi, Hao Feng, Lingjuan Sun,Zhengxi Hu(*), Gang Chen(*), Yonghui Zhang(*). Discovery of an Oxepine-Containing Diketopiperazine Derivative Active against Concanavalin A‑Induced Hepatitis.Journal of Natural Products2020, DOI: 10.1021/acs.jnatprod.0c00558.

11.Huaqiang Li, Runge Zhang, Fei Cao, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). Proversilins A−E, Drimane-Type Sesquiterpenoids from the EndophyticAspergillus versicolor.Journal of Natural Products2020,83, 2200−2206.

12.Fengli Li(#), Shuang Lin(#), Sitian Zhang, Lifen Pan, Chenwei Chai, Jun-Cheng Su, Beiye Yang, Junjun Liu, Jianping Wang(*),Zhengxi Hu(*), Yonghui Zhang(*). Modified Fusicoccane-Type Diterpenoids fromAlternaria brassicicola.Journal of Natural Products2020,83, 1931−1938.

13.Shuang Lin(#), Huimin Yu(#), Beiye Yang, Fengli Li, Xia Chen, Huaqiang Li, Sitian Zhang, Jianping Wang, Youcai Hu,Zhengxi Hu(*), Yonghui Zhang(*). Reisolation and Configurational Reinvestigation of Cottoquinazolines E–G from an Arthropod-Derived Strain of the FungusNeosartorya fischeri.Journal of Natural Products2020,83, 169–173.

14.Ling Shen(#), Mengting Liu(#), Yan He(#), Weaam Hasan Al Anbari, Huaqiang Li, Shuang Lin, Chenwei Chai, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). Novel Antimicrobial Compounds as Ophiobolin-Type Sesterterpenes and Pimarane-Type Diterpene FromBipolarisSpecies TJ403-B1.Frontiers in Microbiology2020,11, 856.

15.Fengli Li(#), Weiguang Sun(#), Sitian Zhang(#), Weixi Gao, Shuang Lin, Beiye Yang, Chenwei Chai, Huaqiang Li, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungusPenicilliumsp. TJ403-2.Chinese Chemical Letters2020,31, 197–201.

16.Shuang Lin(#),Yan He(#), Fengli Li, Beiye Yang, Mengting Liu, Sitian Zhang, Junjun Liu, Huaqiang Li, Changxing Qi, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). Structurally diverse and bioactive alkaloids from an insect-derived fungusNeosartorya fischeri.Phytochemistry2020,175, 112374.

17.Fengli Li, Lifen Pan, Shuang Lin, Sitian Zhang, Huaqiang Li, Beiye Yang, Junjun Liu, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). Fusicoccane-derived diterpenoids with bridgehead double-bond-containing tricyclo[9.2.1.03,7]tetradecane ring systems fromAlternaria brassicicola.Bioorganic Chemistry2020,100, 103887.

18.Weixi Gao(#), Chenwei Chai(#), Xiao-Nian Li(#), Weiguang Sun, Fengli Li, Chunmei Chen, Jianping Wang, Hucheng Zhu, Yanyan Wang(*),Zhengxi Hu(*), Yonghui Zhang(*). Two anti-inflammatory chlorinated azaphilones fromChaetomium globosumTW1-1 cultured with 1-methyl-L-tryptophan and structure revision of chaephilone C.Tetrahedron Letters2020,61, 151516.

19.Huaqiang Li(#), Qianqian Xu(#), Weiguang Sun, Runge Zhang, Jianping Wang, Yongji Lai(*),Zhengxi Hu(*), Yonghui Zhang(*). 21-Epi-taichunamide D and (±)-versicaline A, three unusual alkaloids from the endophyticAspergillus versicolorF210.Tetrahedron Letters2020,61, 152219.

20.Shuang Lin , Xueke Zhang , Ling Shen , Shuyuan Mo , Junjun Liu , Jianping Wang ,Zhengxi Hu(*), Yonghui Zhang(*). A new abietane-type diterpenoid and a new long-chain alkenone from fungusDaldiniasp. TJ403-LS1.Natural Product Research2020, DOI: 10.1080/14786419.2020.1789638.

21.Yan He(#), Weiguang Sun(#), Qin Li, Hucheng Zhu,Zhengxi Hu(*), Jinwen Zhang(*).Wortmannolol Induces Breast Cancer Cell Death In Vitro and In Vivo by Targeting Phosphoinositide 3-Kinaseα.ChemistrySelect2020,5, 2214–2218.

22.Mengting Liu(#), Weiguang Sun(#), Ling Shen, Xincai Hao, Weaam Hasan Al Anbari, Shuang Lin, Huaqiang Li, Weixi Gao, Jianping Wang,Zhengxi Hu(*), and Yonghui Zhang(*). Bipolaricins A–I, Ophiobolin-Type Tetracyclic Sesterterpenes from a PhytopathogenicBipolarissp. Fungus.Journal of Natural Products2019,82, 2897–2906.

23.Huaqiang Li, Dan Xu, Weiguang Sun, Beiye Yang, Fengli Li, Mengting Liu, Jianping Wang, Yongbo Xue,Zhengxi Hu(*), Yonghui Zhang(*). HPLC-DAD-Directed Isolation of Linearly Fused Prenylated Indole Alkaloids from a Soil-DerivedAspergillus versicolor.Journal of Natural Products2019,82, 2181–2188.

24.Beiye Yang(#), Yan He(#), Shuang Lin, Jinwen Zhang, Huaqiang Li, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). Antimicrobial Dolabellanes and Atranones from a Marine-Derived Strain of the Toxigenic FungusStachybotrys chartarum.Journal of Natural Products2019,82, 1923–1929.

25.Changxing Qi, Qun Zhou, Weixi Gao, Mengting Liu, Chunmei Chen, Xiao-Nian Li, Yongji Lai, Yuan Zhou, Dongyan Li(*),Zhengxi Hu(*), Hucheng Zhu(*), Yonghui Zhang(*). Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungusAspergillus terreusThom.Phytochemistry2019,165, 112041–112048.

26.Jiaojiao Gong, Chunmei Chen, Shuyuan Mo, Junjun Liu, Wenjing Wang, Yi Zang, Huaqiang Li, Chenwei Chai, Hucheng Zhu,Zhengxi Hu(*), Jianping Wang(*), Yonghui Zhang(*). Fusaresters A–E, newγ-pyrone-containing polyketides from fungusFusariumsp. Hungcl and structure revision of fusariumin D.Organic & Biomolecular Chemistry2019,17, 5526–5532.

27.Mengting Liu(#), Yan He(#), Ling Shen(#), Weaam Hasan Al Anbari, Huaqiang Li, Jianping Wang, Changxing Qi(*),Zhengxi Hu(*), and Yonghui Zhang(*). Asperteramide A, an UnusualN-Phenyl-Carbamic Acid Methyl Ester Trimer Isolated from the Coral-Derived FungusAspergillusterreus.European Journal of Organic Chemistry2019,18, 2928–2932.

28.Meng-Ting Liu(#), Yan He(#),LingShen,Zheng-Xi Hu(*), Yong-Hui Zhang(*). Bipolarins A–H, eight new ophiobolin-type sesterterpenes withantimicrobial activity from fungusBipolarissp. TJ403-B1.Chinese Journal of Natural Medicines2019,17, 935–944.

29.Fengli Li(#), Ying Tang(#), Weiguang Sun, Jiankun Guan, Yuanyuan Lu, Sitian Zhang, Shuang Lin, Jianping Wang,Zhengxi Hu(*), Yonghui Zhang(*). New cytotoxic tricycloalternarenes from fungusAlternaria brassicicola.Bioorganic Chemistry2019,92, 103279.

30.Weixi Gao(#), Yan He(#), Fengli Li, Chenwei Chai, Jinwen Zhang, Jieru Guo, Chunmei Chen, Jianping Wang, Hucheng Zhu,Zhengxi Hu(*), Yonghui Zhang(*). Antibacterial activity against drug-resistant microbial pathogens of cytochalasan alkaloids from the arthropod-associated fungusChaetomiumglobosumTW1-1.Bioorganic Chemistry2019,83, 98–104.

31.Beiye Yang, Qingyi Tong, Shuang Lin, Jieru Guo, Jinwen Zhang, Junjun Liu, Jianping Wang, Hucheng Zhu,Zhengxi Hu(*), Yonghui Zhang(*). Cytotoxic butenolides and diphenyl ethers from the endophytic fungusPestalotiopsissp.Phytochemistry Letters2019,29, 186–189.

32.Zheng-Xi Hu, Miao Liu, Wei-Guang Wang, Xiao-Nian Li, Kun Hu, Xing-Ren Li, Xue Du, Yong-Hui Zhang(*), Pema-Tenzin Puno(*), Han-Dong Sun. 7α,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts ofIsodon pharicus.Journal of Natural Products2018,81, 106–116.

33.Beiye Yang(#), Weiguang Sun(#), Jianping Wang(#), Shuang Lin, Xiao-Nian Li , Hucheng Zhu, Zengwei Luo, Yongbo Xue,Zhengxi Hu(*), Yonghui Zhang(*). A New Breviane Spiroditerpenoid from the Marine-Derived FungusPenicilliumsp. TJ403-1.Marine Drugs2018,16, 110.

34.Mengting Liu(#), Weiguang Sun(#), Jianping Wang(#), Yan He, Jinwen Zhang, Fengli Li, Changxing Qi, Hucheng Zhu, Yongbo Xue,Zhengxi Hu(*), Yonghui Zhang(*). Bioactive secondary metabolites from the marine-associated fungusAspergillus terreus.Bioorganic Chemistry2018,80, 525–530.

35.Qing Zhang, Beiye Yang, Fengli Li, Mengting Liu, Shuang Lin, Jianping Wang, Yongbo Xue, Hucheng Zhu, Weiguang Sun(*),Zhengxi Hu(*), Yonghui Zhang(*). Mycophenolic Acid Derivatives with Immunosuppressive Activityfrom the Coral-Derived FungusPenicillium bialowiezense.Marine Drugs2018,16, 230.

36.Mengting Liu(#), Changxing Qi(#), Weiguang Sun(#), Ling Shen, Jianping Wang, Junjun Liu, Yongji Lai, Yongbo Xue,Zhengxi Hu(*), Yonghui Zhang(*).α-Glucosidase Inhibitors from the Coral-Associated FungusAspergillus terreus.Frontiers in Chemistry2018,6, 422.

37.Weixi Gao, Weiguang Sun, Fengli Li, Chenwei Chai, Yan He, Jianping Wang, Yongbo Xue, Chunmei Chen, Hucheng Zhu,Zhengxi Hu(*), Yonghui Zhang(*). Armochaetoglasins A–I: Cytochalasan alkaloids from fermentation broth ofChaetomium globosumTW1-1 by feedingL-tyrosine.Phytochemistry2018,156,106–115.

38.Fengli Li(#), Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu, Shuang Lin, Sitian Zhang, Weixi Gao, Junjun Liu, Guang Du, Jianping Wang, Hucheng Zhu, Changxing Qi(*),Zhengxi Hu(*), Yonghui Zhang(*). Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungusAlternaria brassicicola.Organic & Biomolecular Chemistry2018,16, 8751–8760.

39.Changxing Qi(#), Yuben Qiao(#), Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu,Zhengxi Hu(*), Yuan Zhou(*), Yonghui Zhang(*). New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities fromAspergillus terreus.Organic & Biomolecular Chemistry2018,16, 9046–9052.

40.Changxing Qi(#), Weixi Gao(#), Danyingzi Guan(#), Jianping Wang, Mengting Liu, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Yongji Lai(*),Zhengxi Hu(*), Qun Zhou(*), Yonghui Zhang(*). Butenolides from a marine-derived fungusAspergillus terreuswith antitumor activities against pancreatic ductal adenocarcinoma cells.Bioorganic & Medicinal Chemistry2018,26, 5903–5910.

41.Mengting Liu(#), Qun Zhou(#), Jianping Wang(#), Junjun Liu, Changxing Qi, Yongji Lai, Hucheng Zhu, Yongbo Xue,Zhengxi Hu(*), Yonghui Zhang(*). Anti-inflammatory butenolide derivatives from the coral-derived fungusAspergillus terreusand structure revisions of aspernolides D and G, butyrolactone VI and 4’,8’’-diacetoxy butyrolactone VI.RSC Advances2018,8, 13040–13047.

42.Yan He(#),Zhengxi Hu(#), Weiguang Sun, Qin Li, Xiao-Nian Li, Hucheng Zhu, Jinfeng Huang, Junjun Liu, Jianping Wang, Yongbo Xue(*), Yonghui Zhang(*). Spiroaspertrione A, a bridged spirocyclic meroterpenoid, as a potent potentiator of oxacillin against methicillin-resistantStaphylococcus aureusfromAspergillussp. TJ23.Journal of Organic Chemistry2017,82, 3125–3131.

43.Zheng-Xi Hu, Xiao-Nian Li, Yi-Ming Shi, Wei-Guang Wang, Xue Du, Yan Li, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun. Lanostane-type triterpenoids fromKadsura coccinea.Tetrahedron2017,73, 2931–2937.

44.Yan He(#),Zhengxi Hu(#), Qin Li(#), Jinfeng Huang, Xiao-Nian Li, Hucheng Zhu, Junjun Liu, Jianping Wang(*), Yongbo Xue(*), and Yonghui Zhang(*). Bioassay-Guided Isolation of Antibacterial Metabolites fromEmericellasp. TJ29.Journal of Natural Products2017,80, 2399–2405.

45.Zheng-Xi Hu, Kun Hu, Yi-Ming Shi, Wei-Guang Wang, Xue Du, Yan Li, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun. Rearranged 6/6/5/6-Fused triterpenoid acids from the stems ofKadsura coccinea.Journal of Natural Products2016,79, 2590–2598.

46.Zheng-Xi Hu(#), Yong-Bo Xue(#), Xiao-Bin Bi, Jin-Wen Zhang, Zeng-Wei Luo, Xiao-Nian Li, Guang-Min Yao, Jian-Ping Wang(*), Yong-Hui Zhang(*). Five New Secondary Metabolites Produced by a Marine-Associated Fungus,Daldinia eschscholzii.Marine Drugs2014,12, 5563–5575.

47.Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue(*), Yingda Yang, Zengwei Luo, Guangmin Yao, Yonghui Zhang(*). Colletotrichumine A, a novel indole-pyrazine alkaloid with an unprecedented C16N3-type skeleton from cultures ofColletotrichum capsici.Tetrahedron Letters2014,55, 6093–6095.

48.Zhengxi Hu, Yongji Lai, Jinwen Zhang, Ye Wu, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*). Phytochemical and chemotaxonomic studies onPhyllanthus urinaria.Biochemical Systematics and Ecology2014,56, 60–64.

49.Zhengxi Hu, Yongbo Xue, Guangmin Yao, Zengwei Luo, Yanyan Wang, Yonghui Zhang. Chemical constituents from the leaves ofPremna microphyllaTurcz.Journal of Chinese Pharmaceutical Sciences2013,22, 431–434.

50.黄传俊,刘梦婷,胡正喜(*),张勇慧(*).植物来源内生真菌Bipolarissp. TJ-1的次生代谢产物研究.中国医院药学杂志2018,38,1907–1910.

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