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师资队伍
杰出人才
博士后

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胡正喜

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胡正喜

胡正喜,博士,,湖北武汉人。中药与天然药物学系,主要从事药用植物与特殊生境来源的微生物中活性天然产物结构鉴定与生物功能研究。主持国家自然科学基金青年基金,中国博士后科学基金特别资助和面上项目(一等),华中科技大学2019年人才引进基金等。担任期刊Journal of Natural Products审稿人。第一作者或通讯作者在Organic LettersJournal of Organic ChemistryOrganic Chemistry FrontiersJournal of Natural ProductsPhytochemistryFrontiers in ChemistryOrganic & Biomolecular ChemistryMarine DrugsBioorganic & Medicinal ChemistryBioorganic ChemistryRSC AdvancesTetrahedronTetrahedron Letters等学术期刊上发表论文30

1. 联系方式

邮箱:hzx616@126.com

地址:武汉市硚口区航空路13号同济医学院药学院1号楼403 邮编430030

2. 研究方向

药用植物与特殊生境来源的微生物中活性天然产物结构鉴定与生物功能研究。

3. 教育与工作经历

2019/3~至今,华中科技大学,讲师

2016/7~2019/2,华中科技大学,博士后,合作导师:张勇慧教授王小川教授

2014/2~2016/6中国科学院昆明植物研究所,药物化学,联合培养博士,导师:孙汉董院士、张勇慧教授

2011/9~2016/6,华中科技大学,药物化学,博士,导师:张勇慧教授

2007/9~2011/6华中科技大学,中药学本科

4. 主持科研项目

1)华中科技大学人才引进基金,执行时间2019.3~2022.315万元

2国家自然科学基金青年项目,编号217020672018/01~2020/1225万元,在研,主持。

3)中国博士后科学基金特别资助项目,编号2018T11077715万,已结题,主持。

4)中国博士后科学基金面上项目(一等,编号2017M6104798万元,已结题,主持。

5. 主要学术论文(#Co-first author, *Corresponding author)

1. Weixi Gao(#), Yan He(#), Fengli Li, Chenwei Chai, Jinwen Zhang, Jieru Guo, Chunmei Chen, Jianping Wang, Hucheng Zhu, Zhengxi Hu(*), Yonghui Zhang(*). Antibacterial activity against drug-resistant microbial pathogens of cytochalasan alkaloids from the arthropod-associated fungus Chaetomium globosum TW1-1. Bioorganic Chemistry 2019, 83, 98104.

2. Beiye Yang, Qingyi Tong, Shuang Lin, Jieru Guo, Jinwen Zhang, Junjun Liu, Jianping Wang, Hucheng Zhu, Zhengxi Hu(*), Yonghui Zhang(*). Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp. Phytochemistry Letters 2019, 29, 186189.

3. Zhengxi Hu(#), Weiguang Sun(#), Fengli Li(#), Jiankun Guan(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang(*), Hucheng Zhu(*), Yonghui Zhang(*). Fusicoccane-Derived Diterpenoids from Alternaria brassicicola: Investigation of the Structure-Stability Relationship and Discovery of an IKKβ Inhibitor. Organic Letters 2018, 20, 5198–5202.

4. Fengli Li(#), Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu(#), Sitian Zhang, Shuang Lin, Junjun Liu, Weixi Gao, Jianping Wang, Zhengxi Hu(*), Yonghui Zhang(*). Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γ Agonistic Activity from Alternaria brassicicola. Organic Letters 2018, 20, 7982–7986.

5. Zheng-Xi Hu, Miao Liu, Wei-Guang Wang, Xiao-Nian Li, Kun Hu, Xing-Ren Li, Xue Du, Yong-Hui Zhang(*), Pema-Tenzin Puno(*), and Han-Dong Sun. 7α,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus. Journal of Natural Products 2018, 81, 106–116.

6. Beiye Yang(#), Weiguang Sun(#), Jianping Wang(#), Shuang Lin, Xiao-Nian Li , Hucheng Zhu, Zengwei Luo, Yongbo Xue, Zhengxi Hu(*), Yonghui Zhang(*). A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1. Marine Drugs 2018, 16, 110.

7. Zheng-Xi Hu, Hou-Chao Xu, Kun Hu, Miao Liu, Xiao-Nian Li, Xing-Ren Li, Xue Du, Yong-Hui Zhang(*), Pema-Tenzin Puno(*), Han-Dong Sun. Structurally diverse diterpenoids from Isodon pharicus. Organic Chemistry Frontiers 2018, 5, 2379–2389.

8. Mengting Liu(#), Weiguang Sun(#), Jianping Wang(#), Yan He, Jinwen Zhang, Fengli Li, Changxing Qi, Hucheng Zhu, Yongbo Xue, Zhengxi Hu(*), Yonghui Zhang(*). Bioactive secondary metabolites from the marine-associated fungus Aspergillus terreus. Bioorganic Chemistry 2018, 80, 525–530.

9. Qing Zhang, Beiye Yang, Fengli Li, Mengting Liu, Shuang Lin, Jianping Wang, Yongbo Xue, Hucheng Zhu, Weiguang Sun(*), Zhengxi Hu(*), Yonghui Zhang(*). Mycophenolic Acid Derivatives with Immunosuppressive Activity from the Coral-Derived Fungus Penicillium bialowiezense. Marine Drugs 2018, 16, 230.

10. Mengting Liu(#), Changxing Qi(#), Weiguang Sun(#), Ling Shen, Jianping Wang, Junjun Liu, Yongji Lai, Yongbo Xue, Zhengxi Hu(*), Yonghui Zhang(*). α-Glucosidase Inhibitors From the Coral-Associated Fungus Aspergillus terreus. Frontiers in Chemistry 2018, 6:422.

11. Weixi Gao, Weiguang Sun, Fengli Li, Chenwei Chai, Yan He, Jianping Wang, Yongbo Xue, Chunmei Chen, Hucheng Zhu, Zhengxi Hu(*), Yonghui Zhang(*). Armochaetoglasins A–I: Cytochalasan alkaloids from fermentation broth of Chaetomium globosum TW1-1 by feeding L-tyrosine. Phytochemistry 2018, 156, 106–115.

12. Fengli Li(#), Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu, Shuang Lin, Sitian Zhang, Weixi Gao, Junjun Liu, Guang Du, Jianping Wang, Hucheng Zhu, Changxing Qi(*), Zhengxi Hu(*), Yonghui Zhang(*). Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungus Alternaria brassicicola. Organic & Biomolecular Chemistry 2018, 16, 8751–8760.

13. Changxing Qi(#), Yuben Qiao(#), Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu, Zhengxi Hu(*), Yuan Zhou(*), Yonghui Zhang(*). New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus. Organic & Biomolecular Chemistry 2018, 16, 9046–9052.

14. Changxing Qi(#), Weixi Gao(#), Danyingzi Guan(#), Jianping Wang, Mengting Liu, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Yongji Lai(*), Zhengxi Hu(*), Qun Zhou(*), Yonghui Zhang(*). Butenolides from a marine-derived fungus Aspergillus terreus with antitumor activities against pancreatic ductal adenocarcinoma cells. Bioorganic & Medicinal Chemistry 2018, 26, 5903–5910.

15. Mengting Liu(#), Qun Zhou(#), Jianping Wang(#), Junjun Liu, Changxing Qi, Yongji Lai, Hucheng Zhu, Yongbo Xue, Zhengxi Hu(*), Yonghui Zhang(*). Anti-inflammatory butenolide derivatives from the coral-derived fungus Aspergillus terreus and structure revisions of aspernolides D and G, butyrolactone VI and 4’,8’’-diacetoxy butyrolactone VI. RSC Advances 2018, 8, 13040–13047.

16. Zhengxi Hu(#), Ye Wu(#), Shuangshuang Xie, Weiguang Sun, Yi Guo, Xiao-Nian Li, Junjun Liu, Hua Li, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*). Phomopsterones A and B, two functionalized ergostane-type steroids from the endophytic fungus Phomopsis sp. TJ507A. Organic Letters 2017, 19, 258–261.

17. Yan He(#), Zhengxi Hu(#), Weiguang Sun, Qin Li, Xiao-Nian Li, Hucheng Zhu, Jinfeng Huang, Junjun Liu, Jianping Wang, Yongbo Xue(*), Yonghui Zhang(*). Spiroaspertrione A, a bridged spirocyclic meroterpenoid, as a potent potentiator of oxacillin against methicillin-resistant Staphylococcus aureus from Aspergillus sp. TJ23. Journal of Organic Chemistry 2017, 82, 3125–3131.

18. Zheng-Xi Hu, Xiao-Nian Li, Yi-Ming Shi, Wei-Guang Wang, Xue Du, Yan Li, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun. Lanostane-type triterpenoids from Kadsura coccinea. Tetrahedron 2017, 73, 2931–2937.

19. Yan He(#), Zhengxi Hu(#), Qin Li(#), Jinfeng Huang, Xiao-Nian Li, Hucheng Zhu, Junjun Liu, Jianping Wang(*), Yongbo Xue(*), and Yonghui Zhang(*). Bioassay-Guided Isolation of Antibacterial Metabolites from Emericella sp. TJ29. Journal of Natural Products 2017, 80, 2399–2405.

20. Zheng-Xi Hu(#), Yi-Ming Shi(#), Wei-Guang Wang, Jian-Wei Tang, Min Zhou, Xue Du, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun. Structural Characterization of Kadcoccinin A: A Sesquiterpenoid with a Tricyclo[4.4.0.03,10]decane Scaffold from Kadsura coccinea. Organic Letters 2016, 18, 2284–2287.

21. Zheng-Xi Hu, Kun Hu, Yi-Ming Shi, Wei-Guang Wang, Xue Du, Yan Li, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun. Rearranged 6/6/5/6-Fused triterpenoid acids from the stems of Kadsura coccinea. Journal of Natural Products 2016, 79, 2590–2598.

22. Zheng-Xi Hu(#), Yi-Ming Shi(#), Wei-Guang Wang, Xiao-Nian Li, Xue Du, Miao Liu, Yan Li, Yong-Bo Xue, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun. Kadcoccinones A–F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea. Organic Letters 2015, 17, 4616–4619.

23. Zheng-Xi Hu(#), Yong-Bo Xue(#), Xiao-Bin Bi, Jin-Wen Zhang, Zeng-Wei Luo, Xiao-Nian Li, Guang-Min Yao, Jian-Ping Wang(*), Yong-Hui Zhang(*). Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii. Marine Drugs 2014, 12, 5563–5575.

24. Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue(*), Yingda Yang, Zengwei Luo, Guangmin Yao, Yonghui Zhang(*). Colletotrichumine A, a novel indole-pyrazine alkaloid with an unprecedented C16N3-type skeleton from cultures of Colletotrichum capsici. Tetrahedron Letters 2014, 55, 6093–6095.

25. Zhengxi Hu, Yongji Lai, Jinwen Zhang, Ye Wu, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*). Phytochemical and chemotaxonomic studies on Phyllanthus urinaria. Biochemical Systematics and Ecology 2014, 56, 6064.

26. Zhengxi Hu, Yongbo Xue, Guangmin Yao, Zengwei Luo, Yanyan Wang, Yonghui Zhang. Chemical constituents from the leaves of Premna microphylla Turcz. Journal of Chinese Pharmaceutical Sciences 2013, 22, 431–434.

27. 黄传俊, 刘梦婷, 胡正喜(*), 张勇慧(*). 植物来源内生真菌Bipolaris sp. TJ-1的次生代谢产物研究. 中国医院药学杂志 2018, 38, 19071910.


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