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师资队伍
杰出人才
博士后

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齐昌兴

来源: 发布时间 2019-09-03 09:54:28 点击数:

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齐昌兴,博士,男,湖北孝感人。中药与天然药物学系,主要从事植物与真菌来源天然产物的分离、结构鉴定及生物活性研究,研究重点为天然来源抗阿尔茨海默病、抗器官移植后排斥反应、抗自身免疫性肝炎及抗胰腺导管癌先导化合物的发现以第一作者或通讯作者在Chemical ScienceJournal of Natural ProductsPhytochemistryFrontiers in ChemistryOrganic & Biomolecular ChemistryBioorganic & Medicinal Chemistry等学术期刊上发表论文十余篇。

1. 联系方式

邮箱:qichangxing@hust.edu.cn

地址:武汉市硚口区航空路13号同济医学院药学院1号楼507 邮编430030

2. 研究方向

植物与真菌来源天然产物的分离、结构鉴定及生物活性研究

3. 教育与工作经历

2019/7~至今,华中科技大学,讲师

2017/6~2019/6,华中科技大学,博士后,合作导师:张勇慧教授、王小川教授

2018/7~2018/9德国马尔堡大学访问学者,合作导师:李书明教授

2012/9~2017/6,华中科技大学,药物化学,博士,导师:张勇慧教授

2008/9~2012/6湖北中医药大学,药学,本科

4. 主持或参加科研项目情况

1) 中国博士后科学基金面上项目,批准号:2018M632879,杂色曲霉中杂萜类成份及其抗阿尔茨海默病活性的研究,2019/01–2021/125万元,在研,主持

2) 国外合作项目/中德合作科研项目(PPP),批准号:留金欧[2018]6046,学号2018019400192018/012019/12,在研,参与

3) 国家自然科学基金面上项目,批准号:81773597,黄柄曲霉产细胞松弛素二聚体黄柄霉素A的生物合成研究,2018/012021/1248万元,在研,参与

4) 国家自然科学基金面上项目,批准号:31770379,藤黄科植物中多靶点抗痴呆症天然先导化合物及其作用机制研究,2018/012021/1260万元,在研,参与

5) 国家自然科学基金面上项目,批准号:31670354,石蒜内生真菌抗阿尔茨海默病活性次生代谢产物的研究,2017/012020/1262万元,在研,参与

5. 主要学术论文

1) Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-Guo Chen, and Yonghui Zhang. Asperterpenes A and B, Two Unprecedented Meroterpenoids from Aspergillus terreus with BACE1 Inhibitory Activities. Chemical Science, 2016, 7, 65636572. (IF 9.063) (ISSN 2041-6520)

2) Changxing Qi(#) Yuben Qiao(#), Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu, Zhengxi Hu, Yuan Zhou, and Yonghui Zhang. New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus. Organic & Biomolecular Chemistry, 2018, 16, 9046. (IF 3.423) (ISSN 1477-0520)

3) Mengting Liu(#), Changxing Qi(#), Weiguang Sun(#), Ling Shen, Jianping Wang, Junjun Liu, Yongji Lai, Yongbo Xue, Zhengxi Hu and Yonghui Zhang. α-glucosidase inhibitors from the coral-associated fungus Aspergillus terreus. Frontiers in Chemistry, 2018, 6, 422. (IF 4.155) (ISSN 2296-2646)

4) Changxing Qi(#), Weixi Gao(#), Danyingzi Guan(#), Jianping Wang, Mengting Liu, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Yongji Lai, Zhengxi Hu, Qun Zhou, and Yonghui Zhang. Butenolides from a Marine-Derived Fungus Aspergillus terreus with Antitumor Activities Against Pancreatic Ductal Adenocarcinoma Cells. Bioorganic & Medicinal Chemistry, 2018, 26, 59035910. (IF 2.881) (ISSN 0968-0896)

5) Changxing Qi, Weixi Gao, Jianping Wang, Mengting Liu, Jinwen Zhang, Chunmei Chen,  Zhengxi Hu, Yongbo Xue, Dongyan Li, Qing Zhang, Yongji Lai, Qun Zhou, Hucheng Zhu, and Yonghui Zhang. Terrusnolides A-D, new butenolides with anti-inflammatory activities from an endophytic Aspergillus from Tripterygium wilfordii. Fitoterapia, 2018, 130, 134139. (IF 2.642) (ISSN 0367-326X)

6) Changxing Qi(#), Qun Zhou(#), Yuan Zhou, Zengwei Luo, Chong Dai, Hucheng Zhu, Chunmei Chen, Yongbo Xue, Jianping Wang, Yafen Wang, Yaping Liu, Ming Xiang, Weiguang Sun, Jinwen Zhang, Yonghui Zhang. Kinsenoside: A Promising Bioactive Compound from Anoectochilus Species. Current Medical science, 2018, 1, 1118. (IF 0.948) (ISSN 2523-899X)

7) Changxing Qi(#), Mengting Liu(#), Qun Zhou(#), Weixi Gao, Chunmei Chen, Yongji Lai, Zhengxi Hu, Yongbo Xue, Jinwen Zhang, Dongyan Li, Xiao-Nian Li, Qing Zhang, Jianping Wang, Hucheng Zhu, and Yonghui Zhang. BACE1 Inhibitory Meroterpenoids from Aspergillus terreus. Journal of Natural Products, 2018, 81, 19371945. (IF 3.885) (ISSN 1520-6025)

8) Changxing Qi, Qun Zhou, Weixi Gao, Mengting Liu, Chunmei Chen, Xiao-Nian Li, Yongji Lai, Yuan Zhou, Dongyan Li(*), Zhengxi Hu(*), Hucheng Zhu(*), and Yonghui Zhang(*), Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom, Phytochemistry, 2019, 165, 112014. (IF 3.186) (ISSN 0031-9422)

9) Fengli Li(#), Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu, Shuang Lin, Sitian Zhang, Weixi Gao, Junjun Liu, Guang Du, Jianping Wang, Hucheng Zhu, Changxing Qi(*), Zhengxi Hu(*), and Yonghui Zhang(*). Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungus Alternaria brassicicola. Organic & Biomolecular Chemistry, 2018, 16, 8751–8760. (IF 3.423) (ISSN 1477-0520)

10) Mengting Liu(#), Yan He(#), Ling Shen(#), Weaam Hasan Al Anbari, Huaqiang Li, Jianping Wang, Changxing Qi(*), Zhengxi Hu(*), Yonghui Zhang(*), Asperteramide A, an Unusual N-Phenyl-Carbamic Acid Methylester Trimer Isolated from the Coral-Derived Fungus Aspergillus terreus, European Journal of Organic Chemistry, 2019, 2928–2932. (IF 2.882) (ISSN 1099-0690)

11) Weiguang Sun(#), Shanshan Luan (#), Changxing Qi(#), Qingyi Tong, Shan Yan, Hua Li(*), Yonghui Zhang(*), Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism, Cell Communication and Signaling, 2019, 17, 111. (IF 5.111) (ISSN 1478-811X)

12) Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Mengyi Deng, Yunfang Cao, Yongbo Xue(*), Changxing Qi(*), Yonghui Zhang(*), Przewalcyrones A–F, epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum przewalskii Maxim., Organic & Biomolecular Chemistry, 2019, Accept. (IF 3.423) (ISSN 1477-0520)

13) Yuben Qiao(#), Qianqian Xu(#), Wenya Feng, Li Tao, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Yuanyuan Lu, Jianping Wang, Changxing Qi(*), Yongbo Xue(*), Yonghui Zhang(*), Asperpyridone A, an unusual pyridone alkaloid exerts hypoglycemic activity through the insulin signaling pathway, Journal of Natural Products, 2019, Accept. (IF 3.885) (ISSN 1520-6025)

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