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师资队伍
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向明

来源: 发布时间 2017-02-07 10:14:19 点击数:

向明,女,博士,教授,博士研究生导师

中国药理学会理事,中国药学会应用药理专业委员会委员,

中国抗炎免疫药理学会委员,湖北省药理学会常务理事,

世界中医药免疫专业委员会常务理事。

Frontiers in Pharmacology Review editor

 

研究方向抗炎免疫药理学,主要包括:研究基于天然免疫与获得性免疫相关联的自身免疫性疾病(T1DRAAIH等)及慢性炎症(胰腺炎、糖尿病肾病和胰岛素抵抗)发病机制;研究基于表观遗传和细胞代谢的免疫细胞功能转化机制;研究抗肿瘤免疫治疗的方式及机制;研究化学及中药新型免疫抑制剂的作用及机制。

 

科研经历

2010 年赴美国佐治亚医学院从事抗炎免疫抑制剂药理作用研究。

2004 年至2005年赴德国海德堡大学从事抗HCV感染基因疫苗及树突状细胞分化及功能研究。

1997 年至 1999 年赴意大利 CATANIA 大学从事自身免疫病发病和细胞因子抗体的作用及机制研究。

联系方式xiangming@mails.tjmu.edu.cn

 

发表文章:

1. Xiang M, Liu T, Tan W, Ren H, Li H, Liu J, Cao H, Cheng Q, Liu X, Zhu H, Tuo Y, Wang J, Zhang Y. Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on DCs-CD8+T cells communication. Hepatology. 2016 Dec 64(6):2135-2150. doi: 10.1002/hep.28825.

2. Liu X, Zhou Z, Cheng Q, Wang H, Cao H, Xu Q, Tuo Y, Jiang L, Zou Y, Ren H, Xiang M*. Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression. Cell Death Dis. 2017 Sep 7;8(9):e3033. doi: 10.1038/cddis.2017.424. (*corresponding author)

3. Cao H, Tuo L, Tuo Y, Xia Z, Fu R, Liu Y, Quan Y, Liu J, Yu Z, Xiang M*. Immune and Metabolic Regulation Mechanism of Dangguiliuhuang Decoction against Insulin Resistance and Hepatic Steatosis. Front Pharmacol. 2017 Jul 7;8:445. doi: 10.3389/fphar.2017.00445.

4. Xia F, Cao H, Du J, Liu X, Liu Y, Xiang M*. Reg3g overexpression promotes β cell regeneration and induces immune tolerance in nonobese-diabetic mouse model. J Leukoc Biol. 2016 Jun; 99(6):1131-40. doi: 10.1189/jlb.3A0815-371RRR.

5. Xu QQ, Fu R, Yin GX, Liu XL, Liu Y, Xiang M*. Microarray-based gene expression proling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. Gene.2016 Mar 10; 578(2):263-73. doi: 10.1016/j.gene.2015.12.039.

6. 许倩倩周仲实向明*。慢性胰腺炎恶性转化的相关信号通路研究进展。药学学报. 2016;51(2):174-81.

7. Liu X, Wang J, Wang H, Yin G, Liu Y, Lei X, Xiang M*. REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. Cancer Lett. 2015 Jun 28; 362(1): 45-60. doi: 10.1016/j.canlet.2015.03.014.

8. Cao H, Lu J, Du J, Xia F, Wei S, Liu X, Liu T, Liu Y, Xiang M*. TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice. Sci Rep. 2015 Oct 13;5:14593. doi: 10.1038/srep14593.

9.Wang J, Cao H, Wang H, Yin G, Du J, Xia F, Lu J, Xiang M*. Multiple mechanisms involved in diabetes protection by lipopolysaccharide in non-obese diabetic mice. Toxicol Appl Pharmacol. 2015 Jun 15;285 (3):149-58. doi:1016/j.taap. 2015. 04. 006.

10. Liu T, Cao H, Ji Y, Pei Y, Yu Z, Quan Y*, Xiang M*. Interaction of dendritic cells and T lymphocytes for the therapeutic effect of Dangguiliuhuang decoction to autoimmune diabetes. Sci Rep. 2015 Sep 11; 5:13982. doi: 10.1038/srep13982.

11. Cao H, Ji Y, Li W, Liu Y, Fu R, Xiang M*. Protective Effects of the Total Coumarin Fraction of Urtica dentata on Experimental Diabetic Nephropathy In Vitro and In Vivo. Planta Med. 2015 Oct; 81(15):1353-60. doi: 10.1055/s-0035-1557866.

12. Yin G, Du J, Cao H, Liu X, Xu Q, Xiang Ming*. Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis. Digest Dis Sci. 2015 Dec; 60(12):3656-68. doi: 10.1007/s10620-015-3787-5.

13. Wang J, Zhou H, Han Y, Liu X, Wang M, Wang X, Yin G, Li X, Xiang M*. SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer. J Mol Med. 2014 Jul 5; 92(12):1257-69. doi: 10.1007/s00109-014-1184-8.

14. Wang J, Xiang M*.Targeting potassium channels Kv1.3 and KC a 3.1: routes to selective immune modulators in autoimmune disorder treatment? Pharmacotherapy. 2013 May;33(5):515-28.

15. Wang J, Lu J, Lan Y, Zhou H, Li W, Xiang M*. Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways. J Ethnopharmacol. 2013 Mar 7;146(1):379-92.

16. Xiang M, Lu J, Zhang C, Lan Y, Zhou H, Li X, Peng W. Identification and quantification of total coumarins from Urtica dentata Hand and its roles in promoting immune tolerance via TLR4-mediated dendritic cell immaturation. Biosci. Biotechnol. Biochem. 2013 Jun 23;77(6):1200-6.

17. Xie S, Feng J, Yu C, Li Z, Wu Y, Cao Z, Li W, He X, Xiang M*, Han S. Identification of a new specific Kv1.3 channel blocker, Ctri9577, from the scorpion Chaerilus tricostatus. Peptides. 2012 Jul;36(1):94-9.

18. Lu J, Zeng Y, Hou W, Zhang S, Li L, Luo X, Xi W, Chen Z, Xiang M*. The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway. J Nutr Biochem. 2012; 23(11):1449-57.

19. Xiang M, Zhang S, Lu J, Li L, Hou W, Xie M, Zeng Y. Antilithic effects ofextracts from Urticadentata hand on calcium oxalate urinary stones in rats. J Huazhong Univ Sci Technol. 2011; 31(5): 673-677.

20. Luo X, Li L, Zhang S, Lu J, Zeng Y, Zhang H, Xiang M*. Therapeutic effects of total coumarins from Urtica dentata Hand on collagen-induced arthritis in Balb/c mice. J Ethnopharmacol. 2011; 138(2): 523-9.

21. Hou W, Xie S, Wang HJ, Su YY, Lu JL, Li LL, Zhang SS, Xiang M*. Intramuscular delivery of a naked DNA plasmid encoding proinsulin and pancreatic regenerating III protein ameliorates type 1 diabetes mellitus. Pharmacological Research. 2011; 634: 320-327.

22. Hou W, Su ZQ, Pi HF, Yao GM, Zhang P, Luo X, Xie SN, Xiang M*. Immunosuppressive constituents from Urtica dentata Hand. J Asian Nat Prod Res. 2010; 12(8): 707-13.

23. Xiang M, Hou W, Xie S, Zhang WD, Wang X. Immunosuppressive effects of an ethyl acetate extract from Urtica dentata Hand on skin allograft rejection. J Ethnopharmacol.  2009; 126: 57-63.

24. Zhang C, Zou X, Guan L, Xu J, Xiang M*. Prevention of Type 1 Diabetes by Immature Dendritic Cells Treated with an Ethanol Extract of Paecilomyceshepiali Chen Mycelium. Methods Find Exp Clin Pharmacol. 2008; 30(6): 421-429.

25. Zou X, Zhao Z, Wang Y, Su Z, Xiang M*. Diabetogenic T cells induce autoimmune diabetes in BALB/c mice. Chin Med Sci J. 2008; 23(2):88-94.

26. Xiang M, Zou X, Zhang C, Zhao Z, Xu J. Insulin administration confers diabetes-preventive properties to NOD mice derived dendritic cells. Immunopharmacol Immunotoxicol. 2007; 29(3-4): 451-64.

27. Zhang C, Zou X, Xiang M*. Immune tolerance induced by adoptive transfer of DCs in IDDM murine model. Acta Pharmacologica Sinica. 2007; 28(1): 98-104

28. Xiang M, Eisenbach C, Lupu C, Ernst E, Stremmel WEncke J. Induction of antigen-specific immune responses in vivo after vaccination with dendritic cells transduced with adenoviral vectors encoding hepatitis C virus NS3. Viral Immunology. 2006; 19(2): 210-219.

29. Xiang M, Zhang C, Zou X, Cai X, Peng J. Roles of dendritic cells and regulatory T cells in autoantigen-induced urine immune tolerance model. World Chinese Journal of Digestive. 2006; 14(7): 687-692.

30. Xiang M, Eisenbach C, Ernst E, Weigand K, Stremmel W, Encke J. Humoral and cellular immune responses elicited by immunization with genetically modified dendritic cells expressing HCVNS3. Hepatology. 2005; 42 (4) Suppl.1:248A

31. Nicoletti F, Zaccone P, Xiang M, Magro G, Di Mauro M, Di Marco R, Garotta G, Meroni P. Essential pathogenetic role for interferon (IFN-)gamma in concanavalin -induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein. Cytokine. 2000; 12(4): 315-23.

32. Nicoletti F, Di Marco R, Zaccone P, Xiang M, Magro G, Grasso S, Morrone S, Santoni A, Shoenfeld Y, Garotta G, Meroni P. Dichotomic effects of IFN-gamma on the development of systemic lupus erythematosus-like syndrome in MRL-lpr / lpr mice. Eur J Immunol. 2000; 30(2): 438-47.

33. Di Marco R, Xiang M, Zaccone P, Leonardi C, Franco S, Meroni P, Nicoletti F. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency. Autoimmunity. 1999; 31(2): 75-83.

34. Xiang M, Zaccone P, Di Marco R, Harris R, Magro G, Di Mauro M, Meroni PL, Garotta G, Nicoletti F. Failure of exogenously administered interferon-gamma or blockage of endogenous interleukin-4 with specific inhibitors to augment the incidence of autoimmune diabetes in male NOD mice. Autoimmunity. 1999; 30(2):71-80.

35. Xiang M, Zaccone P, Di Marco R, Magro G, Di Mauro M, Beltrami B, Meroni PL, Nicoletti F. Prevention by rolipram of concanavalin A-induced T-cell-dependent hepatitis in mice. Eur J Pharmacol. 1999; 367(2-3): 399-404.

发明专利:

1. 发明专利从红活麻中提取的新型免疫抑制剂及提取方法和应用(专利号:ZL 200910062442.8

2. 发明专利2H-1-苯并吡喃-2-酮在制备药物中的应用(专利申请公布号: CN105012295A

学术奖励:

1. “民族药红活麻的物质基础及药效学研究和应用”荣获2014年湖北省科技进步奖贰等奖。(第一完成人)

2. “民族药红活麻的物质基础及药效学研究”荣获2014年武汉市科技进步奖叁等奖。(第一完成人)

承担课题:

2017-2018: 国家自然科学基金“PID1基因介导胰岛素抵抗环境下肿瘤发生的机制及药物靶点研究”No 81673440

2015-2018: 国家自然科学基金当归六黄汤免疫调控胰岛素抵抗的作用机制及配伍研究 No 81473585

2013-2016:国家自然科学基金新型mcDC负调控T细胞免疫耐受、干预β细胞再生的作用机制及药物靶点研究” No 81273521

2013-2015:国家自然科学基金“RegIII信号通路与SOCS3甲基化协同调控胰腺炎症恶性转化的分子机制研究” No 91229114

2011-2013:国家自然科学基金红活麻总香豆素调节DC/Treg诱导免疫耐受防治RA的作用机制研究” No 81073124

 

编写教材:

1. 向明主编《药物毒理学》第四版 2015 中国医药科技出版社出版

2. 向明副主编《药学导论》第一版 2017 科学出版社

3. 向明副主编《临床药物治疗学》第四版 2016 人民卫生出版社出版

4. 向明参编《药理学》第八版 2016 人民卫生出版社出版

5. 向明参编《药理学》第四版 2015 中国医药科技出版社出版

6. 向明主编《临床药物治疗学图表解》2008 人民卫生出版社出版

7. 向明主译《Lippincott’s图解药理学》2006 中国医药科技出版社出版

 

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030