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师资队伍
杰出人才
博士后

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张煜

来源: 发布时间 2017-02-07 10:21:23 点击数:

导师:张煜

职称及职务:讲师,硕士生导师

研究方向:炎症反应和代谢综合征的分子交谈机制

邮箱:yuzhang@hust.edu.cn

地址:武汉市航空路13号同济医学院药学院二号楼604室

教育及工作经历:

2014至今 华中科技大学药学院,讲师

2009-2014 武汉大学,理学博士(导师:舒红兵 院士)

2005-2009 兰州大学,理学学士

主持科研项目:

湖北省自然科学基金青年基金:《Betatrophin对糖尿病中NF-kB激活的调节机制研究》,项目批准号2015CFB245

国家自然科学基金青年基金:《Betatrophin对TNFa或IL-1b诱导NF-kB活化的负调控机制研究》,项目批准号31500706

发表论文:

1. Zhang, Y., Lei, C.Q., Hu, Y. H., Xia, T., Li, M., Zhong B., Shu, H.B*. Kruppel-like factor 6 is a co-activator of NF-kappaB that mediates p65-dependent transcription of selected downstream genes.The Journal of Biological Chemistry(2014), 289: 12876-12885

2. Lei, C. Q., Zhong, B.,Zhang, Y., Zhang, J., Wang, S., and Shu, H. B*. Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1.Immunity(2010), 33, 878-889

3. Chen, R., Li, M.,Zhang, Y., Zhou, Q., and Shu, H.B*. The E3 ubiquitin ligase MARCH8 negatively regulates IL-1beta-induced NF-kappaB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.Proceedings of the National Academy of Sciences of the United States of America(2012), 109, 14128-14133

4. Hu, M. M., Yang, Q., Zhang, J., Liu, S. M.,Zhang, Y., Lin, H., Huang, Z. F., Wang, Y. Y., Zhang, X. D., Zhong, B., and Shu, H.B*. TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3.Proceedings of the National Academy of Sciences of the United States of America(2014), 111, 1509-1514

5. Hu, Y. H.,Zhang, Y., Jiang, L. Q., Wang, S., Lei, C. Q., Sun, M. S., Shu, H. B., and Liu, Y. WDFY1 mediates TLR3/4 signaling by recruiting TRIF.EMBO reports(2015),16, 447-455

6. Zhong, B.,Zhang, Y., Tan, B., Liu, T. T., Wang, Y. Y., and Shu, H. B*. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation.Journal of Immunology(2010), 184, 6249-6255

7. Lei, C. Q.,Zhang, Y., Xia, T., Jiang, L. Q., Zhong, B., and Shu, H.B*. FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3.The Journal of Biological Chemistry(2013), 288, 12596-12604

8. Lei, C. Q.,Zhang, Y., Li, M., Jiang, L. Q., Zhong, B., Kim, Y. H., and Shu, H. B*. ECSIT Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral Responses.Journal of Innate Immunity.(2015), 7,153-164

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030