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师资队伍
杰出人才
博士后

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童擎一

来源: 发布时间 2018-12-11 19:03:42 点击数:

童擎一

童擎一,男,20099月至2014年6月在四川大学生物治疗国家重点实验室学习,获得医学博士学位,2014年7月至2018年5月在华中科技大学同济药学院从事博士后研究,2018年5月至今任同济药学院生物药学系讲师,目前承担《药理学》的理论和实验课程教学。在Nucleic Acids Research,Angewandte Chemie-International Edition, Organic Letters和Cellular Physiology and Biochemistry等学术期刊上发表SCI论文20余篇,其中第一作者/共同第一作者论文9篇(IF>10论文两篇,10>IF>5论文两篇)。主持国家自然科学基金青年基金一项,中国博士后科学基金面上项目一项,华中科技大学博士后科学基金和人才引进基金各一项,申请专利一项。

 

联系方式

邮箱qytong@hust.edu.cn tongqingyi@gmail.com

地址:武汉市硚口区航空路13号同济药学院2号楼4楼  邮编430030

 

研究方向

1. 肿瘤生物学:采用分子细胞生物学、分子生物学、遗传学及肿瘤模式动物等手段,研究肿瘤的分子病理机制,以期发现新的药物治疗靶点

2. 肿瘤药理学:基于癌症分子病理机制的探索,开发直接或间接靶向恶性肿瘤的药物或治疗新策略,并在临床前研究中利用体内外肿瘤模型评价其疗效和安全性

3. 新药筛选与活性评价技术平台构建:开发新的方法、技术,用来筛选和评价具有抗肿瘤、免疫调节、代谢调节等活性的新药

 

主持项目

1. 华中科技大学人才引进基金,2018/6-2020/12

2. 国家自然科学基金青年科学基金,批准号81503305,2016/01-2018/12

3. 博士后科学基金第58批面上项目,资助编号2015M582227,2014/08-2016/07

4. 华中科技大学博士后科学基金,项目号2006514110,2014/08-2016/07

 

主要学术论文(#Co-first author, *Correspondence author)

(1) Qingyi Tong#, Huijuan You#, Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo*, Yonghui Zhang*, ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia. Nucleic Acids Research, 2018, 46(7):3284–3297.

(2) Hucheng Zhu#, Chunmei Chen#, Qingyi Tong#, Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang*, Asperflavipine A, an unprecedented cytochalasan heterotetramer uniquely defined by a highly complicated tetradecacyclic ring system from Aspergillus flavipes QCS12, Angewandte Chemie-International Edition, 2017,129:5326–5330.

(3) Guangzheng Wei#, Chunmei Chen#, Qingyi Tong#, Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang, Hucheng Zhu*, and Yonghui Zhang*, Aspergilasines A–D: four merocytochalasans with new carbon skeletons from Aspergillus flavipes QCS12, Organic Letters, 2017, 19, 4399−4402.

(4) Qingyi Tong #, Yong Qing#, Dan Shu, Yang He, Yinglan Zhao, Yi Li, Zhengling Wang, Shiyuan Zhang, Zhihua Xing, Cheng Xu, Yuquan Wei, Wen Huang*, Xiaohua Wu*. Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and anti-angiogenesis. Cellular Physiology and Biochemistry, 2011, 27, 233–242.

(5) Qingyi Tong, Yong Qing*, Yang Wu, Xiaojuan Hu, Lei Jiang, Xiaohua Wu*, Dioscin inhibits colon tumor growth and angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways. Toxicology and Applied Pharmacology, 2014, 281, 166–173.

(6) Qingyi Tong, Qingbing Zhao, Yong Qing, Xiaojuan Hu, Lei Jiang, Xiaohua Wu*. Deltonin inhibits angiogenesis by regulating VEGFR2 and subsequent signaling pathways in endothelial cells. Steroids, 2015, 96, 30–36.

(7) Qingyi Tong#, Yang He#, Qingbing Zhao, Yong Qing*, Wen Huang*, Xiaohua Wu* Cytotoxicity and apoptosis-inducing effect of steroidal saponins from dioscorea zingiberensis wright against cancer cells. Steroids, 2012, 77, 1219–1227.

(8) Chunmei Chen#, Qingyi Tong#, Hucheng Zhu, Dongdong Tan, Jinwen Zhang, Yongbo Xue, Guangmin Yao, Zengwei Luo, Wang Jianping*, Wang Yanyan*, Zhang Yonghui*. Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales). Scientific Reports, 2016, 6:18711.

(9) Weiguang Sun#, Xintao Chen#, Qingyi Tong#, Hucheng Zhu#, Yan He, Liang Lei, Yongbo Xue,Guangmin Yao, Zengwei Luo, Jianping Wang, Hua Li ,Yonghui Zhang.Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune. Scientific Reports, 2016, 6:26418.

(10) Hucheng Zhu#, Chunmei Chen#, Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, and Yonghui Zhang*, Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged  Epicoccine Dimer Units from Aspergillus flavipes. Angewandte Chemie-International Edition, 2016, 2016, 55: 3486–3490.

(11) Hucheng Zhu#, Chunmei Chen#, Yongbo Xue#, Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, and Yonghui Zhang*, Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes. Angewandte Chemie-International Edition, 2015, 54: 13374–13378.

(12) Wenjing Wang, Fanrong Zeng, Qiong Bie, Chong Dai, Chunmei Chen, Qingyi Tong, Junjun Liu , Jianping Wang, Yuan Zhou, Hucheng Zhu*, and Yonghui Zhang*. Cytochathiazines A–C: Three Merocytochalasans with a 2H-1,4-Thiazine Functionality from Coculture of Chaetomium globosum and Aspergillus flavipes. Organic Letters, 2018, 20 (21), 6817–6821.

(13) Zhaodi Wu, Dongyan Li, Fanrong Zeng, Qingyi Tong, Yinyu Zheng, Junjun Liu, Qun Zhou, Xiao-Nian Li, Chunmei Chen, Yongji Lai, Hucheng Zhu∗, Yonghui Zhang∗ Brasilane sesquiterpenoids and dihydrobenzofuran derivatives from Aspergillus terreus [CFCC 81836]. Phytochemistry, 2018,156,159–166.

(14)FuqianWang#, Jie Jiang#, Song Hua#, Haoran MaHucheng Zhu, Qingyi TongLu Cheng, Xincai Hao,Geng Zhang*,Yonghui Zhang*.AspergilSecondary metabolites from endophytic fungus Chaetomium sp. induce colon cancer cell apoptotic death. Fitoterapia, 2017 121, 86–93.

(15) Yi Guo, Na Zhang, Chunmei Chen, Jinfeng Huang, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Qingyi Tong, Jinwen Zhang, Zengwei Luo, Yongbo Xue*, and Yonghui Zhang*.Tricyclic Polyprenylated Acylphloroglucinols from St John’s Wort, Hypericum perforatum. Journal of Natural Products, 2017, 80 (5), 1493–1504.

(16) Guangzheng Wei#, Dongdong Tan#, Chunmei Chen#, Qingyi Tong, Xiao-Nian Li, Jinfeng Huang, Junjun Liu, Yongbo Xue, Jianping Wang, Zengwei Luo, Hucheng Zhu*, and Yonghui Zhang*, Flavichalasines A–M, cytochalasan alkaloids from Aspergillus flavipes, Scientific Reports, 2017, 7: 42434.

(17) Hucheng Zhu#, Chunmei Chen#, Qingyi Tong, Xintao Chen, Jing Yang, Junjun Liu, Bin Sun, Jianping Wang, Guangmin Yao, Zengwei Luo, Yongbo Xue*, and Yonghui Zhang*, Hyperisampsins H−M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii, Scientific Reports, 2015, 5, 14772.

(18) Fuqian Wang, Qingyi Tong, Haoran Ma, Hongfeng Xu, Song Hu, Wei Ma, Yongbo Xue, Junjun Liu, Jianping Wang, Hongping Song, Jinwen Zhang*, Geng Zhang*, Yonghui Zhang*. Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death, Scientific Reports, 2015, 19; 5:9294.

(19) Chunmei Chen#, Hucheng Zhu#, XiaoNian Li, Jing Yang, Jianping WangGentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue*, Yonghui Zhang*, Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived Fungus Chaetomium globosum, Organic Letters, 2015, 17(3): 644-647.

(20) Xiaojuan Hu#, Xiaohua Wu#Yunfei Huang, Qingyi Tong, Shunichi Takeda, Yong Qing*, Berberine induces double-strand DNA breaks in Rev3 deficient cells, Molecular Medicine Reports, 2014, 9(5): 1883-1888.

(21) Shiyuan Zhang#, Yang He#, Qingyi Tong, Qianming Chen, Xiaohua Wu*, Wen Huang*, Deltonin induces apoptosis in MDAMB231 human breast cancer cells via reactive oxygen speciesmediated mitochondrial dysfunction and ERK/AKT signaling pathways, Molecular Medicine Reports, 2013, 7(3): 1038-1044.

(22) Yi Li #, Zhenling Wang #, Fang He, Yang Wu, Wen Huang, Yang He, Qingyi Tong, Yuquan Wei, Yong Qing, Li Yang*, Xiaohua Wu*, TP-58, a novel thienopyridine derivative, protects mice from concanavalinA-induced hepatitis by suppressing inflammation, Cellular Physiology and Biochemistry, 2012, 29(1-2): 31-40.

(23) Dan Shu#, Yong Qing #Qingyi TongYang He, Zhihua Xing, Yinglan Zhao, Yi Li, Yuquan Wei, Wen Huang*, Xiaohua Wu*, Deltonin isolated from Dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing Akt and mitogen activated protein kinase signals, Biological & Pharmaceutical Bulletin, 2011, 34(8): 1231-1239.

 

 

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030