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黎维勇

来源: 发布时间 2017-09-14 16:18:43 点击数:

黎维勇,男,19666月生,医学博士,主任药师,教授,硕士生导师、博士生导师,华中科技大学同济医学院附属协和医院药学教研室副主任,临床药学研究室副主任。国家自然科学基金审评专家,国家新药审评中心审评专家。

研究方向

临床药理

药代动力学和生物转化

药物制剂和生物效应

体内生物分析

基于代谢组学的药物不良反应机制和干预治疗

工作、研究与获奖情况:

近五年负责的课题:国家自然科学基金课题1项,湖北省自然科学基金课题1项,十二五、十三五重大新药创制课题各1项。


一.科研项目

1.华中科技大学同济医学院附属协和医院:临床药学研究室,2003.11-

1)纵向科研课题

国家自然科学基金课题,基于脂质代谢组学探究抗精神分裂症药物诱导新生糖尿病和胰岛素抵抗的缘由和作用研究(50.00万,2016.1-2019.12NO.81573509

‚湖北省自然科学基金课题。长期服用抗抑郁药诱发新生糖尿病和胰岛素抵抗的原因探究和机制研究(3.0万)。2015CFB446,2015,1~2016.1

ƒ十三五重大新药创制课题,2014ZX09101009,原创国家1.1类新药盐酸去甲乌药碱的试生产技术研究,2014/01~2016/12218.58万,在研、主持。

十二五重大新药创制课题,2011ZX09101-002-06,原创国家1.1类新药盐酸去甲乌药碱注射液的临床研究,2011/01~2013/12300.0万、已结题、主持。

十二五重大新药创制课题,2011ZX09302-002-01,创新生物药临床研究技术平台建设,2010/01~2013/12,1800,药代动力学技术平台建设负责人,已结题、参与。

国家自然科学基金面上项目,30271552,聚合物修饰的蓖麻毒素A链在肿瘤细胞内靶向释放,2003/01~2005/12,18.0万元,已结题、主持。

武汉市科委资助课题,适配分子介导的蓖麻毒素A链在肿瘤细胞内靶向释,2010/01~2011/128.0万、已结题、主持。

湖北省科委科研课题《肿瘤血管栓塞剂—白芨微球的研制与开发》(2002~2004)、《肿瘤热敏靶向脂质体的研制与开发》(2003~2005)、国家中医药管理局资助课题《榄香烯靶向纳米微乳冻干粉针的研制》(2005~2007)、湖北省自然科学基金《靶向肝星状细胞己酮可可碱纳米脂质体的研制和肝纤维化治疗》(2005ABA170)、华中科技大学医工交叉合作项目《高纯度蓖麻毒素A链的制备和靶向药物制剂的研制》(2004)和《蓖麻毒素A链肿瘤细胞靶向前药的研究》(2007,华中科技大学校内资助项目)、十一五重大新药创制“肿瘤靶向聚合物修饰的蓖麻毒素A链前药的研制”(2010~2011)等

2)新药临床安全性和药代评价

·生物制品1类新药“注射用鼠抗人T淋巴细胞CD25抗原单克隆抗体WuTac在健康志愿者和肾移植患者的耐受性和药代动力学研究”(武汉生物制品研究所);

·生物制品1类类新药“注射用重组人甲状旁腺激素在健康志愿者的耐受性和药代动力学研究”(北京双鹭制药有限公司);

·全球首创化学1.1类新药“巴替非班注射液在健康志愿者的耐受性和药代动力学研究”(百奥泰生物科技(广州)有限公司);

·3.1类新药“盐酸美普他酚片、注射液在中国健康志愿者的药代动力学研究”(浙江仙琚制药有限公司)

3)新药动物药代评价

·马来酸氟伏沙明缓释片在比格犬中的药代动力学试验研究(珠海丽珠);

·注射用三花冻干粉针比格犬药代动力学试验研究(珠海丽珠)

·埃索美拉唑肠溶胶囊beagle犬药代动力学研究(河南天方药业)

2中国食品药品监督管理局新药审评中心:2003.2~2003.11

国家新药审评中心审评三部,特聘外聘专家,从事进口药的技术审评。

3访问研究员

· 20001-20008:在加拿大BC肿瘤研究中心高级治疗部(Dr.Lawrence),参与肿瘤热敏靶向脂质体的研究(国家留学基金委资助)

· 20009-20016:在加拿大多伦多大学药学院药物化学实验室(Dr.Kotra)从事肝炎丙肝病毒蛋白酶抑制剂的设计与合成(国家留学基金委资助)。


学术和得奖

专利:①用于肿瘤动脉血管栓塞的白芨胶微球,专利号:031280625

②羟胺衍生物在神经退行性病变中的应用,专利申请号:201210194795.5


二.发表文章

SCI文章

1 Mingzhen Xu, Yang Ni, Shihong Li, Juan Du, Huqun Li, Ying Zhou, Weiyong Li, Hui Chen. Development and validation of a rapid LCMS/MS method forsimultaneous determination of netupitant and palonosetron inhuman plasma and its application to a pharmacokinetic study. Journal of Chromatography B. 2016; 1027: 187193. IF2.687

2. Mingzhen Xu#, Yang Ni#, Ying Zhou, Xiaomeng He, Huqun Li, Hui Chen*, Weiyong Li*. Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects. Eur J Drug Metab Pharmacokinet. 2016; 41(5): 541-548. IF1.68

3 Huqun Li, Maosheng Fang, Mingzhen Xu, Shihong Li, Juan Du, Weiyong Li*, Hui Chen. Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance.PLOS ONE, DOI:10.1371/journal.pone.0167930 Dec 14,2016.

4.Shihong Li, Mingzhen Xu, Huqun Li, Juan Du, Weiyong Li*. Pharmacokinetic Properties of Oral Lafutidine Tablets and the Effect of Food on its Pharmacokinetics in Healthy Chinese Subjects[J]. Advance in Therapy.DOI 10.1007/s12325-016-0383-9

5.Xu S#, Tao Z#, Hai B, Liang H, Shi Y, Wang T, Song W, Chen Y, OuYang J, Chen J, Kong F, Dong Y, Jiang SW, Li W, Wang P, Yuan Z, Wan X, Wang C, Li W, Zhang X, Chen K*. miR-424(322) reverses chemoresistance via T cell immune response activation by blocking the PD-L1 immune checkpoint. Nat Commun. 2016, 7: 11406. (IF=11.47)

6. Mingzhen Xu, Ying Zhou,Yang Ni,Xiao-Meng He, Huqun Li,Haseeb Sattar, Hui

Chen, Weiyong Li*. Tolerability and Pharmacokinetic Comparison of Oral, Intramuscular, and Intavenous Administration of Levosulpiride After Single and Multiple Dosing in Healthy Chinese Volunteers. Clinical Therapeutics, 2015, 37(11):2458-2467

7.Xiao-Meng He, Ying Zhou, Ming-Zhen Xu, Yang Li, Hu-Qun Li, Wei-Yong Li*,Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats.J Thorac Dis 2015;7(10):1725-1731.

8.Lixiu Yu, Ying Zhou, Xiaomeng He, Huqun Li, Hui Chen,Weiyong Li.Simultaneous determination of macitentan and its active metabolitein human plasma by liquid chromatography-tandem massspectrometry. Journal of Chromatography B, 1002 (2015) 358–363.

9 Mingzhen Xu, Yang Ni, Ying Zhou, Huqun Li,Hui Chen, Weiyong Li*. Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects.Eur J Drug Metab Pharmacokinet,DOI 10.1007/s13318-015-0291-4

10.Ying Zhou; Xiaomeng He; Huqun Li; Yang Ni; Mingzhen Xu; Haseeb Sattar; Hui Chen*; and Weiyong Li*,.Pharmacokinetics and Tolerability of Minodronic Acid Tablets in Healthy Chinese Subjects and Food and Age Effects on the Pharmacokinetics. Clinical Therapeutics2015 Apr 1;37(4):869-76. (IF=2.586)

11. Ni Y, Zhou Y, Xu M, He X, Li H, Haseeb S, Chen H*, Li W*.Simultaneous determination of phentermine and topiramate in human plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study. J Pharm Biomed Anal. 2015 Jan 24;107C:444-449. doi: 10.1016/j.jpba.2015.01.035 (IF=2.829)

12.Ying ZHOU , Xiao-meng HE , Hu-qun LI , Yang NI , Ming-zhen XU , Hui CHEN *, Wei-yong LI *,Pharmacokinetics and Tissue Distribution of Clevidipine and Its Metabolite in Dogs and Rats*.J Huazhong Univ Sci TechnolMed Sci34(6):856-860,2014.(IF=0.779)

13.Ying Zhou, Huqun Li, Xiaomeng He, Mengmeng Jia, Yang Ni, Mingzhen Xu, Hui Chen*,Weiyong Li*Simultaneous determination of clevidipine and its primary metabolitein dog plasma by liquid chromatographytandem mass spectrometry:Application to pharmacokinetic studyJournal of Pharmaceutical and Biomedical Analysis 100 (2014) 294299.(IF=2.829)

14.Wang T,liu Z,Guo S,Wu L, Li M,Yang J,Chen H,Li W,Wang L,Hu Z,Zhuang Q,Xu S,Wang L,liu J,YeZ,JiJYWangC, Chen K. The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer. Journal Oncotarget2014 Jun 15;5(11):3611-21.(IF=6.627)

15. Mengmeng Jia, Ying Zhou, Xiao-meng He, Hui Chen,Weiyong Li* et al. Development of a liquid chromatography-tandem mass spectrometry method for determination of butoconazole nitrate in human plasma and its application to a pharmacokinetic study. Journal of Huazhong  University of Science and Technology [Medical Sciences] .34(3):431-436, 2014.(IF=0.779)

16. Ying Zhou, Jie Li, Xiaomeng He, Mengmeng Jia, Mingzhou Liu, Huqun Li, Zhengjiang Xiong, Yue Fan, Weiyong Li*. Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous determination of amlodipine, atorvastatin and its metabolites ortho-hydroxy atorvastatin and para-hydroxy atorvastatin in human plasma and its application in a bioequivalence study, J Pharm Biomed Anal. 2013; 83:101-7. (IF=2.947)

17. Mengmeng Jia, Jie Li, Xiaomeng He, Mingzhou Liu, Ying Zhou, Yue Fan, Weiyong Li*. Simultaneous determination of iloperidone and its two active metabolites in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2013; 928:52-7. (IF=2.694)

18. Xiao-meng HE, Ying Zhou, Mengmeng Jia, Jie Li, Weiyong LI*. Pharmacokinetic and Pharmacodynamic Properties of Batifiban Coadministered with Antithrombin Agents in Chinese healthyVolunteers. Journal of Huazhong University of Science and Technology (Medical sciences). 2013; 33 (5):786-790.  (IF=0.779)

19. Liqiong Song, Wei Xia, Zhao Zhou, Yi Li, Jie Wei, Zhengzheng Wei, Bing Xu, Jie Shen, Weiyong Li, Shunqing Xu*. Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets. J Endocrinol, 2012; 215(2):303-11. (IF=3.548)

20.Zhenxing Mao, Wei Xia, Jun Wang, Tian Chen, Qianqian Zeng, Bing Xu, Weiyong Li, Xi Chen, Shunqing Xu*. Perfluorooctane sulfonate induces apoptosis in lung cancer A549 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. J Appl Toxicol, 2012; 13. (IF=2.478)

21. Tong Q, Li H, Li W, Chen H, Shu X, Lu X, Wang G. In vitro and in vivoanti-tumor effects of gemcitabine loaded with a new drug delivery system. J Nanosci Nanotechnol. 2011; 11(4):3651-8. (IF=1.987).

22. Qian Li, Jian Qiao, Li W.Y*. Safety, tolerability and pharmacokinetic study of recombinant human parathyroid hormone in Chinese healthy volunteers. Journal of Huazhong University of Science and Technology (Medicine Sciences). 2009; 29(4): 431-34. (IF=0.779)

23Hui Chen, Jian Qiao, Weiyong Li*. Safety, Pharmacokinetic and Pharmacodynamic Study of Batifiban Injection Following Single- and Multiple-Dose Administration to Healthy Chinese Subjects. Journal of Huazhong University of Science and Technology (Medical sciences). 2009; 29 (1):12-18.  (IF=0.779)

24Jian Qiao, Zhirong Tan, Weiyong Li*. Liquid chromatography/positive ion electrospray tandem mass spectrometry method for the quantification of hydrochloride meptazinol in human plasma: Application to a pharmacokinetic study. Journal of Chromatography B. 2009; 877(30): 3787-3791.IF=2.851

25. Tan, ZR; Ou-Yang, DS; Zhou, G; Chen, Y; Li, WY*; Fan, L; Zhou, HH. Validated LC-MS-MS Method for Quantitative Determination of Batifiban in Human Plasma and Its Application to a Pharmacokinetic Study. Chromatographia. 2009; 70 (3): 415-421.(IF=1.37)

26. Weiyong Li*, Jungang Deng, Jian Qiao. HPLC Determination of 4-hydroxy-anethole trithione in plasma via enzymatic hydrolysis and its application to bioequivalence study. Journal of Pharmaceutical and Biomedical Analysis. 2008; 47(3):612-617. (IF=2.73).

27. Qian J, Vossoughi D, Li W.Y. Combined transarterial chemoembolization and arterial administrayion of Bletilla striata in the treatment of liver tumor in rats. World Journal of Gastroenterology. 2003; 9(12): 2676-2680.(IF=2.433)

28. Annedi, S.C, Li W.Y, Samson, S, Kotral L.P. Design and synthesis of novel fluoropeptidomimetics as potential mimics of the transition state during peptide hydrolysis. J.org.chem. 2003; 68(3):1043-9. (IF=3.79).


参加国际会议:

Weiyong Li, Ying Zhou, Mengmeng Jia, et al. Pharmacokinetics and tissue distribution study of clevidipine and its metabolite in dogs and rats', Experimental Biology 2014 Annual Meeting scheduled April 26-30, in San Diego, CA.


中文文章

1.黄露,葛苗苗,舒成仁,卫乐乐,黎维勇(通讯作者), 盐酸美普他酚注射液在健康人体的药代动力学,中国临床药理学杂志2011 27卷第1期(总第135期)

2.方凯,黎维勇(通讯作者),马林,李茜,乔建,邓俊刚. 注射用鼠抗人T淋巴细胞CD25抗原单克隆抗体在健康受试者体内药代动力学与药效学,中国临床药理学杂志2011 27卷第6期(总第140期)

3.葛苗苗,方凯,黎维勇(通讯作者)等,注射用鼠抗人T淋巴细胞CD25抗原单克隆抗体在肾移植患者体内的药动学与药效学, 中国临床药理学杂志,2011,2710

4. 黄露 ,葛苗苗,黎维勇(通讯作者)等,盐酸美普他酚注射液在健康人体内的药代动力学 中国临床药理学杂志,2011,271):29~32.

5郭涛, 乔建, 邓俊刚, 李茜, 黎维勇(通讯作者)。富马酸卢帕他定片的人体药动学。中国医院药学杂志,20082819):1688-1692

6.郭涛乔建李茜邓俊刚黎维勇(通讯作者)。氯雷他定软胶囊人体相对生物利用度和生物等效性,中国医院药学杂志,20082818):1559-1562

7.方凯、黎维勇、郭文韬等。聚乙二醇修饰的蓖麻毒蛋白A链在荷瘤大鼠体内分布的研究。中国药学杂志,2007422):113115(通讯作者)

8.方凯、黎维勇、郭文韬等。聚乙二醇修饰的蓖麻毒蛋白A链在荷瘤大鼠体内分布的研究。中国药学杂志,2007422):113115(通讯作者)

9黎维勇、方凯、郭文韬等。聚乙二醇修饰的蓖麻毒蛋白A链的特性研究。中国医院药学杂志,2006268):915918

10. 黎维勇,方凯,宋波等。聚合物修饰的蓖麻毒素A链的免疫原性和毒性的研究。中国药学杂志,20054013):1026

11.宋波,戴垚,黎维勇等。蓖麻蛋白A链与单抗3G11偶联物的制备及体外生物活性研究。中国医院药学杂志,20052510):899901(通讯作者)

12.童强、王国斌、黎维勇等。血管内皮生长因子-阿霉素脂质体的制备及体外靶向杀伤肿瘤血管内皮细胞的研究。中华实验外科杂志2005223):313315

13黎维勇、黄璞、韩勇等。 两种盐酸噻氯匹定片的生物等效性评价。中国医院药学杂志,2006265):575577

14 黎维勇。脂质体的研究与脂质体产品的技术审评。药品技术审评论坛,200453234

15黎维勇,宋波,吴波。固相薇萃取气相色谱法测定大蒜素注射液的含量。中国药科大学学报,2005361):90~91

16黎维勇,宋波。高效液相色谱法测定大蒜素注射液中大蒜素的含量。 中国医院药学杂志,2005252):122~123

17黎维勇,宋波等。新型阿霉素热敏脂质体的研制。中国医院药学杂志。2005255439441

18黎维勇,谌辉等。白芨胶微球的研制与栓塞特性的研究。中国医院药学杂志,2005256493496

19黎维勇,杜端明,冯敢生等。白芨微球的研制及其肝动脉栓塞实验研究。同济医科大学学报。1999281):6264

20黎维勇,冯敢生等。5FU白芨微球家兔肾动脉栓塞后体内药代动力学实验研究。同济医科大学学报。2001305):501

21黎维勇,冯敢生等。氟尿嘧啶白芨微球对原发性肝癌患者肝动脉栓塞后体内药动学。中国医院药学杂志,20012111):643

22黎维勇,付艳丽等。依诺沙星长效植入制剂的研制及其在兔眼内的药代动力学。中国医院药学杂志,2003234207

23黎维勇,谌辉等。顺铂白芨胶微球的制备及理化性质的研究。中国药学杂志,2003237: 517520

24.钱骏,吴汉平,黎维勇等。白及在经肝动脉化疗栓塞术治疗大鼠肝细胞癌实验中的应用。中华放射学杂志。2005393):310312

25.钱骏,郑传胜,黎维勇等。白及在介入治疗ACI大鼠肝细胞癌实验中的比较研究。中华肝脏病杂志。2005132 143-144

26. 贾萌萌,李杰,周莹,黎维勇等.HPLC-MS/MS法同时测定人血浆中阿莫西林及克拉维酸钾的浓度.中国医院药学杂志. (2014) 34, 456-460.

27. 贾萌萌,何晓梦,周莹,黎维勇.高效液相色谱-质谱联用法测定人血浆中硝苯地平的浓度. 中国临床药理学杂志.30(6):75-78,2014.


三.学术荣誉及学术兼职

学术杂志评审和客座编辑: Journal of Chromatography B审稿专家; 中国医院药学杂志常务编委;中国临床药理学杂志编委。湖北省中药与天然药物专业委员会委员,武汉药学会副理事,武汉药学会药分专业委员会常委。

珠海润都制药股份有限公司:华中科技大学省部企业科技特派员

联系电话:0278572606313871475991E-mail:2621239868@qq.com


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