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张玉

来源: 发布时间 2019-07-12 10:24:05 点击数:

张玉,男,1968年生,主任药师,博士硕士生导师;现任武汉协和医院党委书记、湖北省重大疾病精准用药临床研究中心主任、湖北省第二届医学领军人才工程培养对象暨湖北名医工作室负责人、药学教研室主任、临床药学研究室主任。中国药学会医院药学专业委员会主任委员;中华医学会临床药学分会副主任委员;中国药理学会药物基因组分会常委;湖北省药学会医院药学专业委员会主任委员;湖北省医学会临床药学分会主任委员;湖北合理用药管理专家委员会主任委员;《中国医院药学杂志》主编。1991年同济医科大学药学院药学本科毕业,2002年获药物化学硕士学位,2012年获药理学博士学位。

研究方向:

药物制剂及其生物效应;

新药开发及其研制;

植物多糖活性物质及其作用机制;

植物多糖肝靶向及肝靶向载体可行性研究。

研究及获奖情况:

近五年负责的课题:国家自然基金课题5项,省自然基金重点项目2项,省科技攻关计划3项,湖北省支撑计划1项,省自然科学基金1项,省中医药中西医结合科研课题1项,市攻关计划2项,校基金5项;横向课题11项;在权威期刊发表论文四十余篇,其中SCI论文20余篇,参编全英教材《The Clinical Diagnosis and Treatment for New Coronavirus Pneumonia》;参编《药物流行病学》、《药物利用研究——理论、方法与应用》,共计10万字;主译《临床药物手册》第十一版,共156万字。

参与湖北省科研课题“菝葜治疗妇科盆腔慢性炎性包块的药理及有效成分研究”,并获湖北省科技进步二等奖、武汉市科技进步三等奖。2010年以第二负责人完成的项目《当归多糖铁复合物治疗铁代谢障碍性贫血的研究》获湖北省科技进步二等奖。2016年以第一负责人完成的项目《移植患者精准免疫抑制治疗的临床药学关键技术》获湖北省科技进步一等奖。

一、参与及在研科研项目:

1.双氯芬酸钠缓释栓剂变更药品规格的研究。横向课题,2020.9-2022.3,40万,第一负责人。

2.Dectin-1介导的香菇多糖体内吸收代谢机制研究。国家自然科学基金,55万,2020.01-2023.12,第二负责人。

3.Dectin-1介导的香菇多糖体内吸收代谢机制研究。中国医疗手牵手工程。100万,2020.1-2023.12,第一负责人。

4.天然多糖体内检测方法的建立和药代动力学机制研究。省自然基金重点项目,500万,第一负责人。

5.中药复方多糖提取工艺及降糖降脂功效研究。横向课题。2018.06-2020.06,第一负责人。

6.生血宁片通过调节EPO表达改善肾性贫血的作用及分子机制研究。横向课题,2018.03-2019.09,第一负责人。

7.中药复方多糖提取工艺、降糖降脂功效及新剂型的关键技术研究。湖北省技术创新专项重大项目。2017.01-2018.12,第一负责人。

8.当归多糖调节机体糖脂代谢紊乱的分子机制研究。武汉市科技计划,2016.08-2018.08,第一负责人。

9.药用植物多糖的绿色提取工艺、结构鉴定及新剂型的关键技术研发。湖北省科技支撑计划项目2014BKB088, 2014.1-2015.12,第一负责人。

10.香菇多糖抗肿瘤构效关系及诱导肿瘤细胞凋亡的分子机制研究。国家自然科学基金, 2014.01-2017.12,第二负责人。

11.香菇多糖非免疫途径抗肿瘤作用的分子机制研究。武汉市科技攻关, 2013.01-2014.12,第一负责人。

12.当归多糖作为铁调素抑制剂参与机体铁代谢的分子机制研究。国家自然科学基金,2013.01-2016.12,第一负责人。

13.香菇多糖药用研究。横向课题, 2011.06-2013.06,第一负责人。

14.当归多糖特异性肝靶向的分子机理研究。国家自然科学基金,2011.01-2013.12,第一负责人。

15.当归多糖作为肝靶向给药系统载体的可行性研究。华中科技大学自然重点项目,2010.10-2012.09,第一负责人。

16.当归多糖抑制hepcidin表达的分子机制研究。国家自然科学基金,2010.01-2010.12,第一负责人。

17.湖北道地植物多糖及其铁复合物开放铁释放通道调节铁代谢的作用研究。省自然基金重点项目。2008.10-2011.09,第一负责人。

18.当归多糖铁口服液的研制与开发.市科技攻关计划。2008.01-2009.12,第一负责人。

19.药学实验教材建设与改革。中华医学会医学教育科研课。2007.12-2008.12,第一负责人。

20.当归多糖铁协同补血的血细胞调控分子生物学机理研究。省中医药中西医结合科研课题。2007.01—2008.12,第一负责人。

21.当归多糖铁协同补血的血细胞调控分子生物学机理研究.省自然科学基金. 2007.01—2008.12,第一负责人。

22.新型补铁剂当归多糖铁的研制。省科技攻关计划。2005.07—2006.12,第一负责人。

猪苓多糖与rIL-2结合物长循环脂质体及抗瘤活性研究。省科技攻关计划。2003.07—2004.12,第一负责人。

二、论文代表作(第一作者或通讯作者)

1.Identification of the core active structure of a Dendrobium officinale polysaccharide and its protective effect against dextran sulfate sodium induced colitis via alleviating gut microbiota dysbiosis.Food Research International.2020,137,109641.

2.Advances in tracking of polysaccharides in vivo: Labeling strategies, potential factors and applications based on pharmacokinetic characteristics.International Journal of Biological Macromolecules.2020,163,1403–1420.

3.A multifunctional magnetic nanosystem based on “two strikes” effect for synergistic anticancer therapy in triple-negative breast cancer.Journal of Controlled Release.2020, 322:401-415

4.The important role of polysaccharides from a traditional Chinese medicineLung Cleansing and Detoxifying Decoction against the COVID-19 pandemic.Carbohydrate Polymers. 2020, 240:116346.

5.Pharmacy administration and pharmaceutical care practice in a module hospital during the COVID-19 epidemic.Journal of the American Pharmacists Association.2020, 60:431-438.

6.Ultra-dispersed biomimetic nanoplatform fabricated by controlled etching agglomerated MnO2for enhanced photodynamic therapy and immune activation.Chemical Engineering Journal.2020, 397:125478

7.Dendrobium officinale polysaccharide protected CCl4-induced liver fibrosis through intestinal homeostasis and the LPS-TLR4-NF-kB signaling pathway.Front Pharmacol.2020, 11

8.Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection.International Journal of Pharmaceutics.2020, 577, 118996

9.Cost-Effectiveness of Zoledronic Acid Versus Oral Alendronate for Postmenopausal Osteoporotic Women in China.Frontiers in Pharmacology. 2020, 11:456.

10.Prediction of tacrolimus dosage in the early period after heart transplantation: a population pharmacokinetic approach.Pharmacogenomics.2019, 20(1):21-35.

11.A comparative study on the structures of Grifola frondosa polysaccharides obtained by different decolourization methods and their in vitro antioxidant activities.Food & Function.2019,10,6720-6731

12.Purification, structural elucidation and anti-inflammatory activity in vitro of polysaccharides from Smilax china L.International Journal of Biological Macromolecules, 2019, 139, 233-243.

13.A “turn-on” near-infrared fluorescent probe with high sensitivity for detecting reduced glutathione based on red shift in vitro and in vivo.Dyes and Pigments,2020, 172, 107837

14.Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer.Carbohydrate Polymers,2019,219:143-154

15.Oral administration of Angelica sinensis polysaccharide protects against pancreatic islets failure in type 2 diabetic mice: Pancreatic β-cell apoptosis inhibition.Journal of Functional Foods.54 (2019): 361-370

16.A sensitive and rapid radiolabelling method for the in vivo pharmacokinetic study of lentinan.Food Funct.,2018, 9, 3114-3125

17.Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism.Journal of Functional Foods.January 2018, Pages 261-271

18.Pharmacokinetics, biodistribution and receptor mediated endocytosis of a natural Angelica sinensis polysaccharide.Artificial Cells, Nanomedicine, and Biotechnology.2017 1:1-10.

19.Investigation of the transport and absorption of Angelica sinensis polysaccharide through gastrointestinal tract both in vitro and in vivo.Drug Delivery.2017 Nov;24(1):1360-1371.

20.Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation,Oxidative Medicine and Cellular Longevit,Volume 2017,13 pages

21.Protective effects of Angelica sinensis polysaccharide against hyperglycemia and liver injury in multiple low-dosestreptozotocininduced type 2 diabetic BALB/c mice.Food & Function.2016, 7, 4889-4897

22.Filicinic acid based meroterpenoids with anti-Epstein–Barr virus activities from Hypericum japonicum,Org. Lett.2016, 18:2272−2275

23.(±)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum,Sci. Rep.2016, 6, 27588. DOI: 10.1038/srep27588

24.(±)-Japonicols A–D, acylphloroglucinol-based meroterpenoid enantiomers with anti-KSHV activities from Hypericum japonicum,J. Nat.Prod. 2016, 79, 1322−1328

25.A new megastigmane sesquiterpenoid from Zanthoxylum schinifolium Sieb. et Zucc., Molecules2016, 21, 383. DOI:10.3390/molecules21030383.

26.Two new bioactive α-pyrones from Hypericum japonicum, Molecules 2016, 21, 515.

27.Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice.Sci. Rep.2016,6:26229

28.Polysaccharide from Lentinus edodes combined with oxaliplatin possesses the synergy and attenuation effect in hepatocellular carcinoma.Cancer letters.2016,377:117-125

29.Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels.Carbohydrate Polymers.2016

30.The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice.Food & Function.2016,7:1033-1039

31.Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice.International Immunopharmacology. 2016,31:140-148

32.Induction of apoptosis in S180 tumour bearing mice by polysaccharide from Lentinus edodes via mitochondria apoptotic pathway.Journal of functional foods. 2015,15:151-159.

33.Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors.Food & Function.2015,6:902-909

34.The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia.Food & Function,2014,5:1381-1388.

35.Structural differences and conformational characterization of five bioactive polysaccharides from Lentinus Edodes.Food Research International,2014,62:223-232.

36.Alkali-Soluble Polysaccharide, Isolated from Lentinus edodes, Induces Apoptosis and G2/M Cell Cycle Arrest in H22Cells Through Microtubule Depolymerization.Phytotherapy Research,2014,12:1837-1845

37.Structure and inducing tumor cell apoptosis activity of polysaccharide isolated from Lentinus edodes.Journal of Agricultural and Food Chemistry,2013,61(41):9849-9858.

38.Polysaccharide Isolated from Angelica sinensis Inhibits Hepcidin Expression in Rats with Iron Deficiency Anemia.Journal of Medical Food,2012,15 (10):923–929.

39.Study to establish the role of JAK2 and SMAD1/5/8 pathways in the inhibition of hepcidin by polysaccharides from Angelica sinensis.Journal of Ethnopharmacology, 2012, 144(10):433-440

40.Inhibitory effect of polysaccharides isolated from Angelica sinensis on hepcidin expression.Journal of Ethnopharmacology,2011, 134(3):944-948

41.A comparison study between different molecular weight polysaccharides derived from Lentinus edodes and their antioxidant activities in vivo,Journal of Pharmaceutical Biology.2011,49(12):1298-1305

42.Structure,Chain comformation and antitumor activity of a novel polysaccharide from Lentinus edodes.Fitoterapia,2010, 81(8):1163-1170

43.Molecular Weight and Proposed Structure of the Angelica sinensis Polysaccharide-iron Complex.Chinese Journal of Chemistry,2008,26(6):1-7

44.Effect of Angelica sinensis Polysaccharide-iron Complex on Iron Deficiency Anemia Rats.Chinese Journal of Integrative Medicine,2007,13(4):297-300

45.Preparation and Identification of Angelica sinensis Polysaccharide-iron Complex.Chemical Research in Chinese Universities,2005,21(6): 668-672

46.新型冠状病毒感染肺炎重症患者的营养支持及监护建议[J].中国医院药学杂志, 2020, 40(5):1-3

47.方舱医院290名新型冠状病毒肺炎患者用药现状分析与建议[J].中国医院药学杂志, 2020, 40(网络首发)

48.方舱医院线上药学服务模式的实践与探讨[J].中国医院药学杂志, 2020, 40(8):876-879.

49.地红霉素肠溶微丸胶囊的生物等效性,中国医院药学杂志, 2007, (6)

50.氟康唑口服液人体相对生物利用度和生物等效性,中国医院药学杂志,2007,(4)

51.正交试验优化当归多糖铁的合成条件研究,中成药,2007,(4)

52.泮托拉唑钠肠溶微丸胶囊人体相对生物利用度和生物等效性研究,中国医院药学杂志,2006,(10)

53.右旋布洛芬混悬剂人体相对生物利用度,医药导报,2006,,(11)

54.醇析水提法提取金银花多糖,中国医院药学杂志,2006,(1)

55.双氯芬酸锌的结构鉴定,中国医院药学杂志,2005,(11)

56.正交试验法优选双氯芬酸锌缓释片处方,中草药,2006,(3)

57.放射免疫分析法测定重组人白细胞介素-2含量,中国中药杂志,2006,(9)

三、获奖情况:

1993年、1998年获院先进工作者称号;

1997年、1998年连续两年考核优秀;

2003-2010年每年获华中科技大学优秀党员;

2006年获湖北省科技进步二等奖(第三负责人);

2010年获湖北省科技进步二等奖(第二负责人);

2016年获湖北省科技进步一等奖(第一负责人)。

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通讯地址:华中科技大学同济医学院附属协和医院邮政编码430022

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