周宜荣，男，理学博士，副教授，博士生/硕士生导师，江苏句容人。华中科技大学同济医学院药学院药物化学系教师。目前以第一或通讯作者发表SCI论文20余篇，授权国家发明专利1项，其中Q1论文17篇，包括Angew 2篇，Chemical Science 1篇，JMC 2篇，EJMC 1篇，OL 5篇，JOC 2篇，ChemCatChem2篇，等，热点论文1篇，封面论文1篇，ESI高被引论文1篇，受编辑邀请，撰写相关领域研究综述2篇，共有4篇论文被国际同行点评，论文他引400余次，单篇最高他引100余次。
研究方向：手性含氟杂环药物分子设计合成及活性研究，中药有效成分靶点确证，重大疾病靶蛋白降解技术。
联系方式：zhouyirong@hust.edu.cn、zyrhust@126.com。
热忱欢迎对药物化学，有机合成化学感兴趣的同学加入实验室一起工作和学习！
工作经历
2019-至今 华中科技大学同济医学院药学院，副教授
2016-2018 德国弗莱堡大学(Freiburg University)，博士后(合作导师：有机与生物化学系主任Prof. Dr. BernhardBreit)
2015-2016 法国艾克斯-马赛大学(Aix-Marseille University)，博士后(合作导师：分子科学二所ISM2所长Prof. Dr. Jean Rodriguez, CNRS主任研究员Dr. YoannCoquerel)
2013-2015 江西师范大学，讲师
教育经历
2008–2013 华中科技大学化学化工学院，有机化学博士，导师：龚跃法教授
2004–2008 华中科技大学化学化工学院，应用化学学士
主持科研项目
国家自然科学青年基金：“不对称串联扩环反应合成手性八元杂环化合物研究” (21602089)
湖北省自然科学基金：“Martinelline和Chaetominine的合成及其构效关系研究”(2020CFB642)
江西省自然科学基金：“Martinelline和Martinellic Acid催化不对称合成研究”(20181BAB203004)；“甘油深度开发综合利用制备手性氨基醇药物”(20142BAB203009)
江西省教育厅青年基金：“多手性中心杂三环化合物的不对称合成研究” (GJJ150321)
荣誉奖励
2020入选第十批湖北省“百人计划”（创新人才项目）
2016Sino-German Postdoc Scholarship
2015法国马赛市政府优秀外国科技研究工作者奖
2014湖北省优秀博士学位论文
2013华中科技大学优秀毕业研究生(10%)
2012首届武汉市高校研究生化学学术报告竞赛三等奖
2012华中科技大学研究生国际交流基金，校三好研究生，校优秀论文奖
2011华中科技大学优秀论文奖
2009华中科技大学优秀研究生干部，化学与化工学院优秀学生共产党员
2008华中科技大学优秀毕业生(10%)
2007华中科技大学校三好学生(3%)，校一等奖学金(5%)
2006国家励志奖学金
2005华中科技大学新生奖学金，人民奖学金
代表性论文
[1] Yirong Zhou, Yunlong Wei, Jean Rodriguez,* Yoann Coquerel,* “Enantioselective Organocatalytic Four-Atom Ring Expansion of Cyclobutanones: Synthesis of Benzazocinones”，Angew. Chem. Int. Ed.2019,58, 456–460. (Hot paper,Selected as Inside Cover:Angew. Chem. Int. Ed.2019,58, 352,Highlightby Prof. B. List inSynfacts2019, 15(02), 0192)
[2] Yirong Zhou, Yuequan Zhu, Shaobai Yan, Yuefa Gong,* “Copper-Catalyzed Enantioselective Henry Reaction of Enals and Subsequent Iodocyclization: Stereoselective Construction of Chiral Azatricyclic Frameworks”，Angew. Chem. Int. Ed.2013,52, 10265–10269. (Highlightby Prof. H. Yamamoto inSynfacts2013,9(12), 1312)
[3] Yirong Zhou, Ali Nikbakht, Felix Bauer, Bernhard Breit,* “A rhodium catalyzed cycloisomerization and tandem Diels–Alder reaction for facile access to diverse bicyclic and tricyclic heterocycles”，Chem. Sci.2019, 10, 4805–4810. (Selected as 2019 Chemical Science HOT Article collection)
[4] Mengzhu Zheng, Junfeng Huo, Xiaoxia Gu, Yali Wang, Canrong Wu, Qingzhe Zhang, Wang Wang, Yang Liu, Yu Liu, Xuechen Zhou, Lixia Chen,* Yirong Zhou,*Hua Li,* “Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP”，J. Med. Chem.2021,64, 7839−7852.
[5] Yongdi Wu, Na Liu, Meifang Qi, Huihao Qiao, Xuelian Lu, Li Ma,Yirong Zhou,*Fang-Lin Zhang,* “Monodentate Transient Directing Group Assisted Ruthenium(II)-Catalyzed Direct ortho-C−H Imidation of Benzaldehydes for Diverse Synthesis of Quinazoline and Fused Isoindolinone”，Org. Lett.2021, 23, 3923−3927.(Highlightby Prof. P. Knochel inSynfacts2021,17(07), 0784)
[6] Mengzhu Zheng, Yang Liu, Canrong Wu, Kaiyin Yang, Qiqi Wang,Yirong Zhou,*Lixia Chen,* Hua Li,* “Novel PROTACs for degradation of SHP2 protein”，Bioorg. Chem.2021,110, 104788.
[7] Weiguang Sun, Yanli Wu, Mengzhu Zheng, Yueying Yang, Yang Liu, Canrong Wu,Yirong Zhou,*Yonghui Zhang,* Lixia Chen,* Hua Li,* “Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor”，J. Med. Chem.2020,63, 8146−8156.
[8] Dandan Liu, Jiansheng Wang, Wenqin Liu, Fang-Lin Zhang,Yirong Zhou,*“Synthesis of Polycyclic Spiro Pyrrolidone Derivatives via DBU-Catalyzed Diastereoselective Vinylogous Aldol-Michael Cascade Reaction”，ChemCatChem2020,12, 3212–3215.
[9] Guanghua Kuang, Guangyuan Liu, Xingxing Zhang, Naihao Lu, Yiyuan Peng,* Qiang Xiao,*Yirong Zhou,*“Directing-Group-Assisted Transition-Metal-Catalyzed Direct C–H Oxidative Annulation of Arenes with Alkynes for Facile Construction of Various Oxygen Heterocycles”，Synthesis2020,52, 993–1006.（Invited review）
[10] Guangyuan Liu, Xingxing Zhang, Guanghua Kuang, Naihao Lu, Yang Fu, Yiyuan Peng,* Qiang Xiao,*Yirong Zhou,*“Phosphine-Free Ru-Catalyzed Regio- and Stereoselective Addition of Benzoic Acids to Trifluoromethylated Alkynes toward Facile Access to Trifluoromethyl Group-Substituted (E)‑Enol Esters”，ACS Omega2020,5, 4158−4166.
[11] Beichen Hu,#Yirong Zhou,#Dejuan Sun,#Yueying Yang, Yang Liu, Xingzhou Li,* Hua Li,* Lixia Chen,* “PROTACs: New method to degrade transcription regulating proteins”，Euro. J. Med. Chem.2020,207112698. (#Co-first author)
[12] Canrong Wu, Mengzhu Zheng, Yueying Yang, Xiaoxia Gu, Kaiyin Yang, Mingxue Li, Yang Liu, Qingzhe Zhang, Peng Zhang, Yali Wang, Qiqi Wang, Yang Xu,Yirong Zhou,*Yonghui Zhang,* Lixia Chen,* Hua Li,* “Furin: A Potential Therapeutic Target for COVID-19”,iScience2020,23, 101642.
[13] Guangyuan Liu, Guanghua Kuang, Xingxing Zhang, Naihao Lu, Yang Fu, Yiyuan Peng,Yirong Zhou,*“Iridium-Catalyzed Regioselective Synthesis of Trifluoromethylated Isocoumarins through Annulation of Benzoic Acids with Trifluoromethylated Alkynes”，Org. Lett.2019, 21, 3043−3047.
[14] Huihao Qiao, Bing Sun, Qinqin Yu, Yi-Yong Huang,Yirong Zhou,*Fang-Lin Zhang,* “Palladium-Catalyzed Direct Ortho-C−H Selenylation of Benzaldehydes Using Benzidine as a Transient Directing Group”，Org. Lett.2019, 21, 6914−6918.
[15] Feng Li,#Yirong Zhou,#Heng Yang, Ziqi Wang, Qinqin Yu, Fang-Lin Zhang,* “Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C−H Methoxylation and Chlorination of Benzaldehydes”，Org. Lett.2019, 21, 3692−3695. (#Co-first author)
[16] Feng Li,#Yirong Zhou,#Heng Yang, Dandan Liu,Bing Sun,Fang-lin Zhang,* “Assembly of Diverse Spirocyclic Pyrrolidines via Transient Directing Group Enabled Ortho-C(sp2)−H Alkylation of Benzaldehydes”，Org. Lett.2018,20, 146−149. (#Co-first author,ESI高被引论文)
[17] Yirong Zhou, Bernhard Breit,* “Rhodium-Catalyzed Asymmetric N@H Functionalization of Quinazolinones with Allenes and Allylic Carbonates: The First Enantioselective Formal Total Synthesis of (-)-Chaetominine”，Chem. Euro. J.2017, 23, 18156–18160. (Highlightby Prof. H. Yamamoto in Synfacts2018,14(02), 0173)
[18] Yirong Zhou,*Jianjun Yuan, Qin Yang, Qiang Xiao,* Yiyuan Peng,* “Directing-Group-Assisted Transition-Metal-Catalyzed Direct Intermolecular C-H Amidation and Amination of Arenes”，ChemCatChem2016,8, 2178–2192.（Invited review）
[19] Yirong Zhou, Chunyan Zhang, Jianjun Yuan, Qin Yang, Qiang Xiao,* Yiyuan Peng,* “Synthesis of 3-trifluoromethylindoles via Rh-catalyzed regioselective oxidative coupling of acetanilides with trifluoromethylated alkynes”，Tetrahedron: Lett.2016,57, 3222–3225.
[20] Yirong Zhou,*Qin Yang,Jian Shen, Xin Chen, Yiyuan Peng,* Yuefa Gong,J. Org. Chem.“Merging Asymmetric Henry Reaction with Organocatalytic Cascade Reaction for the Construction of a Chiral Indolizidine Alkaloid Skeleton”，2015,80, 1446−1456.
[21] Yirong Zhou, Qiang Liu, Yuefa Gong,* “Organocatalytic asymmetric Michael addition of ethyl nitroacetate to enones using natural amino acids-derived C1-symmetric chiral primary–secondary diamines”，Tetrahedron: Lett.2013,54, 3011–3014.
[22] Yirong Zhou, Qiang Liu, Yuefa Gong,* “Camphor-derived C1-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones”，Org. Biomol. Chem.2012,10, 7618–7627.
[23] Yirong Zhou, Yuefa Gong,* “Asymmetric Copper(II)-Catalysed Nitroaldol (Henry) Reactions Utilizing a Chiral C1-Symmetric Dinitrogen Ligand”，Eur. J. Org. Chem.2011, 6092–6099.
[24] Yirong Zhou, Junfang Dong, Fanglin Zhang,* Yuefa Gong,* “Synthesis of C1-Symmetric Chiral Secondary Diamines and Their Applications in the Asymmetric Copper(II)-Catalyzed Henry (Nitroaldol) Reactions”，J. Org. Chem.2011,76, 588–600. (citations over100times)
发明专利
周宜荣，张春艳，杨琴，彭以元，“一种3位三氟甲基取代吲哚的制备方法”，2018, ZL 201510527880.2.
