余旭，博士，教授，博士生导师，华中科技大学同济医学院药学院药物分析系。
2013年6月博士毕业于武汉大学化学与分子科学学院分析化学专业，导师：庞代文教授、张志凌教授。2013年7月-2015年6月在美国宾夕法尼亚州立大学生物医学工程系从事博士后研究，合作导师：Si-Yang Zheng教授，现为美国卡耐基梅隆大学生物医学工程系教授。2015年7月-2017年6月在以色列希伯来大学纳米科学与技术中心从事博士后研究。合作导师：Itamar Willner院士，以色列科学院院士，欧洲科学院院士，德国科学院院士，中国科学院外籍院士。2017.07-2019.11在西安交通大学生命与科学技术学院任副教授，特聘研究员。2019年12月-2026年2月，华中科技大学同济医学院药学院，副教授。2026年2月至今，华中科技大学同济医学院药学院，教授。迄今在Adv. Sci., ACS Nano, Adv. Funct. Mater., Bioact. Mater., Small, Small Methods, Chem. Sci., Anal. Chem.等期刊发表SCI论文90余篇，其中以一作/共一/共通讯作者发表SCI论文60余篇（IF > 10, 23篇），5篇论文被选为封面文章。多篇论文分别被Chem. Rev., Chem. Soc. Rev., Nat. Comm., Acc. Chem. Res.等期刊文章引用和报道，产生了一定的影响力。论文被引用3400余次，H指数31 (google scholar)，其中9篇论文被引用超过100次，最高被引用325次。受邀担任ACS Nano, Adv. Funct. Mater., Nano Lett., Small, Small Science, Anal. Chem., Chem. Sci., ACS Sens., Lab Chip等多个期刊审稿人。申请国家发明专利7项，获授权发明专利5项，实现专利转让2项。
研究方向：
1.仿生微流控芯片“液体”活检、单细胞分析
2.纳米药物载体、纳米酶的合成与应用
3.精准药物分析
科研项目：
1.国家自然科学基金面上项目：基于仿生微流控芯片的细胞外囊泡无偏向俘获与精准分析，50万，2026.1-2029.12，主持。
2.国家自然科学基金面上项目：基于凝胶微流控芯片的肿瘤外泌体多维度分析，60万，2022.1-2025.12，主持。
3.国家自然科学基金青年项目：三维仿生微纳结构集成微流控芯片用于循环肿瘤细胞高灵敏检测，27万，2019.1-2021.12，主持。
4.湖北省面上项目：基于膜亲和多肽的细胞外囊泡富集及肿瘤标志物多维度分析，8万，2021-2023，主持。
5.湖北省陈孝平科技发展基金会青年科学专项基金：细胞膜伪装的三金属离子修饰金属有机框架纳米酶在肿瘤治疗中的应用研究，7万，2025.6-2026.6，主持。
6.横向课题：基于纳米酶的牙周疾病治疗与机制研究，42万，2025.10-2028.10，主持。
7.横向课题：仿生微流控芯片互作蛋白捕获效率检测，4.2万，2025.1-2026.1，主持。
8.横向课题：互作蛋白检测，4.5万，2025.4-2026.4，主持。
9.横向课题：一种中药活性成分的提取，3万，2023-2024，主持。
10.横向课题：基于多机制效应的金属有机框架纳米材料的构建及在增强前列腺癌免疫治疗中的应用研究，30万，2025.11-2026.11，主持。
11.南开大学重点实验室开放基金：李斯特菌生物代谢标志物传感材料与传感器件，0.5万，2021.6-2022.6，主持。
12.华中科技大学新进教师科研启动经费，50万，2019.12-2022.12，主持。
13.中央高校基本业务费：基于微纳界面的肿瘤外泌体多组分微流控分析，15万，2018.1-2020.12，主持。
14.西安交通大学青年拔尖人才计划B类，100万，2017.9-2019.11，主持。
发表文章：
Journal Articles (2020-present)
92. Meng-Meng Pan, Wei-Hu Ye, Run-Ze Zhang, Jin-Xuan Hu, Yuchen Xie, Min Wang, Haibin Xia, Huiping Chen, Yang Yang*, Li Xu*, Xu Yu*, Liang-Wen Chen*, Engineering Smart Bimetallic Ionic-Site MOF Nanozyme Nanocomposites for Microenvironment-Responsive Dynamic Therapy of Periapical Periodontitis,ACS Nano, 2026, 20, 7652-7669. (IF: 16.1).
新闻报道：治疗：牙周炎
ACS Nano |智能双金属离子位点MOF纳米酶复合材料：微环境响应动态治疗根尖周炎
华中科技大学、武汉大学等团队ACS Nano：智能双金属离子位点MOF纳米酶复合材料，微环境响应动态治疗根尖周炎
[ACS Nano]精准抗菌+炎症调控+骨再生，纳米酶技术攻克根尖周炎治疗痛点
91.Yu-Ying Cai, Lin-Jiao Yang, Meng-Meng Pan, Nefise Nurtay, Yan-Ping Yu, Minjie Xie, Ming Jiang, Yao Wang*, Xu Yu*, Li Xu*,PtCu-bimetallic modified MOF nanozyme composites for alleviating acute liver injury via reactive oxygen species elimination and inflammation regulation,Journal of Controlled Release, 2026, 393, 114774.(IF: 11.5).
新闻报道：J. Control. Release | Pt/Cu双金属MOF纳米酶复合物用于ROS清除和炎症调节，有效缓解急性肝损伤
90. Wan-Chun Luo#, Shengbo Kang#, Lina Bao#, Jin-Tao Zhang, Linjiao Yang, Hong Chen, Ning Li, Qinfang Li, Kun Huang*, Xu Yu*, Yirong Zhou*, Li Xu*, A Near-infrared Fluorescence Probe with Photothermal-Assisted BBB Penetration for Enhanced Brain Imaging of α-Synuclein Aggregates,Analytical Chemistry, 2026, DOI: https://doi.org/10.1021/acs.analchem.6c00118. (IF: 6.7)
89. Yi-Zhong Liang, Lina Bao, Li Xu*, Xu Yu*, Cysteine carbon dots/Au3+system for dual-mode detection of epinephrine and discrimination of different catecholamines with PCA,Analytical and Bioanalytical Chemistry,2026, DOI:https://doi.org/10.1007/s00216-026-06371-y.(IF: 3.8).
88. Yiyi Shi, Meng-Meng Pan, Yan Wei, Wanchun Luo, Ying Ma, Liyun Ma, Ming Jiang, Feng Liu*, Xu Yu*, Li Xu*, MOF-based nanozyme incorporated composite film with prominent antibacterial activity and multiple functionalities for fruit preservation,Food Chemistry, 2026, 508, 14836. (IF: 9.8).
87. Ying Ma, Xiang-Lan He, Jia-Qi Du, Meng-Meng Pan, Ming Wang, Ming Jiang, Xu Yu*, Li Xu*, Multistage Cascade-Hierarchical Nucleic Acid Amplification for Label-Free Ultrasensitive Electrochemical Sensing of Tumor-Associated Extracellular Vesicles,Analytical Chemistry, 2026, 98, 2214-2224. (IF: 6.7).
新闻报道：Analytical Chemistry｜华中科技大学同济医学院药学院余旭/徐丽团队：级联-分层核酸扩增用于肿瘤细胞外囊泡的无标记超灵敏电化学传感
86. Jintao Zhang, Ying Ma, Linyu Feng, Minjie Xie, Yao Wang, Linjiao Yang, Yuying Cai, Xu Yu*, Li Xu*, Rational design of near-infrared carbon dots activated by mitochondrial viscosity in the living Parkinson's disease mouse,Chemical Engineering Journal, 2026, 528, 172529. (IF: 13.2).
85. Yiyi Shi, Ying Ma, Lina Bao, Meng-Meng Pan, Ming Jiang, Xu Yu*, Li Xu*, All-in-one colorimetric-photothermal-electrochemical platform based on Fe-doped carbon dots nanozyme with enhanced peroxidase-like activity for flexible analysis of acetylcholinesterase,Biosensors and Bioelectronics, 2026, 93, 118153. (IF: 10.5).
84. Yunfan Li, Peilong Li, Jiajie Zhan, Yuying Cai, Hao Ning, Longju Yi, Xu Yu*, Huai Zheng*, Feng Liu*, 3D-printed microfluidic integrated magnetic robot for biofluid analysis,Biosensors and Bioelectronics, 2026, 293, 118178. (IF: 10.5).
83. Rui Zhang, Zhe Xu, Meiqi Gu, Penghui Xiang, Yifei Li, Fei Xin, Yuying Cai, Yuchen Xie, Xu Yu, Li He*, Chengla Yi*, Construction of Silver-Ion Functionalized Metal-Organic Framework with levofloxacin Nanocomposites and Its Multi-Mechanism Synergistic Antibacterial Performance,Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 733, 139249. (IF: 5.4).
82. Lin-Jiao Yang, Yu-Ying Cai, Nefise Nurtay, Meng-Meng Pan, Chuanjie Zhang, Xuan Hu, Xi-Tian Peng, Yingxin Wei, Ming Jiang, Xiao-Wei Wu*, Li Xu*, Xu Yu*, Three-in-one: Biomimetic Trimetallic Ionic-Site Nanozyme Composite as a Redox Homeostasis Disruptor for Ferroptosis/Cuproptosis/Pyroptosis Co-Activated Nanocatalytic Therapy,Small, 2025, 21, e09285. (IF: 12.1).
81.Wan-Chun Luo, Jin-Tao Zhang, Li-Na Bao, Lin-Jiao Yang, Zi-Ke Yang, Ming Jiang, Xu Yu*, Li Xu*, A ratiometric fluorescence probe based on curcumin and supramolecular deep eutectic solvent for in vivo imaging cerebral pH,Chemical Engineering Journal, 2025, 2025, 167986. (IF: 13.2).
80. Lin-Jiao Yang#, Meng-Meng Pan#, Haofan Hu#, Furong Liu#, Ming Jiang, Shangwu Ning, Xiaoping Chen, Zhanguo Zhang*, Xu Yu*, Li Xu*, Bioinspired Dual-Ionic-Site Single-Atom Nanozymes for Synergistic Ferroptosis/Cuproptosis and Enhanced Immune Checkpoint Blockade Therapy,Small, 2025, 2501076. (#Equal contribution, IF: 12.1).
新闻报道：Small︱华中科技大学徐丽/陈孝平院士团队合作揭示双离子位点单原子纳米酶协同激活铁死亡/铜死亡及免疫治疗肝癌
Small：用于协同铁死亡/铜死亡和增强免疫检查点阻断疗法的生物启发双离子位点单原子纳米酶
79. Yanping Yu, Ping Li, Lina Bao, Furong Liu, Ziran Zeng, Zhi Li, Le Wang, Feng Liu, Ming Jiang, Minjie Xie, Zhanguo Zhang, Luqin Si, Xu Yu*, Li Xu*, An Injectable, Self-Adaptive Hydrogel with Metallic-Functionalized Metal Organic Frameworks for Enhanced Wound Healing in Dynamic Infectious and Inflammatory Microenvironment,Small Methods, 2025, 2500015. (IF: 9.1).
新闻报道：华中科技大学余旭、徐丽：一种负载金属离子功能化金属有机框架化合物可注射、自适应水凝胶，可在动态细菌感染和炎症微环境下促进伤口愈合
78. Liyun Ma#, Zhi Li#, Yiyi Shi, Yuchen Xie, Ming Jiang, Xu Yu*, Li Xu*, Two Birds With One Stone: A Novel Nanocomposite Combining Silicon Nanoparticles and Carbon-Doped Titania as the Fluorescence Probe and Visible Light Photocatalyst for Simultaneous Detection and Removal of Oxytetracycline,Advanced Science,2025, 12, 2410306.(IF: 14.1).
77. Le Wang, Zhou Gong, Ming Wang*, Yi-Zhong Liang, Jing Zhao, Qi Xie, Xiao-Wei Wu, Qin-Ying Li, Cong Zhang, Li-Yun Ma, Si-Yang Zheng, Xu Yu*, Li Xu*, Rapid and unbiased enrichment of extracellular vesicles via meticulously engineered peptide,Bioactive Materials, 2025, 43, 292-304. (IF: 20.3).
新闻报道：多肽用于细胞外囊泡快速富集
华中科技大学同济医学院药学院徐丽教授团队：通过精心设计的肽实现细胞外囊泡（EVs）的快速和无偏富集
华中科技大学同济医学院药学院徐丽：通过精心设计的肽实现细胞外囊泡的快速和无偏富集
76. Yong-Li Song#, Xiang-Lan He#, Yarong Guo, Li-Yun Ma, Ming Jiang, Li Xu*, Xu Yu*, Qi Mei*, Highly sensitive flow cytometry biosensor with a high signal-to-background ratio for FEN1 analysis via solid-phase interface-mediated primer exchange reaction amplification,Analytical Chemistry2025, 97, 464-472. (IF: 6.7).
新闻报道：Analytical Chemistry：基于固相界面介导的引物交换反应与流式细胞术的高灵敏、高信噪比FEN1生物传感器
75. Liyun Ma#, Zhi Li#, Yuying Cai, Linjiao Yang, Yuchen Xie, Ming Jiang*, Xu Yu*, Li Xu*, Highly efficient degradation of sulindac under visible light irradiation by a novel titanium based photocatalyst,Journal of Colloid and Interface Science, 2025, 680,191-201. (IF: 9.4).
74. Jintao Zhang, Jiaqi Du, Minjie Xie, Hong Chen, Wanchun Luo, Na Jiang, Xi Li, Kun Huang, Xu Yu*, Li Xu*, A solvatochromic carbon dot with turn-on red emissive fluorescence for multi-mode detection of amyloids, Sensors and Actuators B: Chemical, 2025, 433, 137537. (IF: 8.0)
73. Xiang-Lan He, Yong-Li Song, Li-Yun Ma, Ming Jiang, Li Xu*, Xu Yu*, An ultra-sensitive fluorescence biosensor with rolling circle amplification and CRISPR/Cas12a one-pot system for FEN1 detection,Talanta, 2025, 283,127159. (IF: 5.6).
72.Li He, Zhi Li, Meiqi Gu, Yifei Li, Chengla Yi*, Ming Jiang*, Xu Yu*, and Li Xu*, Intelligent carbon dots with switchable photo-activated oxidase-mimicking activity and pH responsive antioxidant activity adaptive to the wound microenvironment for selective antibacterial therapy,Advanced Science, 2024, 11, 2406681. (IF: 14.3).
新闻报道：华中科技大学易成腊/徐丽团队Adv. Sci.：具有可切换光激活氧化酶活性和pH响应抗氧化活性智能碳点用于选择性抗菌治疗
71.Lina Bao, Wanchun Luo, Qinying Li, Yu Zhang, Zitong Zhang, Xi Li, Le Wang, Jin-Tao Zhang, Kun Huang*, Xu Yu*, Li Xu*, Chiral carbon dots based on ternary carbon sources: a multifunctional therapeutic agent for Cu2+-induced Alzheimer's disease,Carbon, 2024, 228, 119333.(IF: 10.5).
70. Jia-Qi Du, Wan-Chun Luo, Jin-Tao Zhang, Qin-Ying Li, Li-Na Bao, Ming Jiang, Xu Yu*, Li Xu*, Machine Learning-Assisted fluorescence/fluorescence colorimetric sensor array for discriminating amyloid fibrils,Sensors and Actuators B: Chemical, 2024, 136173.(IF: 8.0).
69. Qin-Ying Li, Li-Yun Ma, Li Li, Jin-Tao Zhang, Xi Li, Yu Zhang, Ming Jiang, Wan-Chun Luo, Lin-Jiao Yang, Zhi Li, Kun Huang*, Xu Yu*, Li Xu*, The carbon dots based on Nile red: The preparation and application to probe α-synuclein fibrils,Sensors and Actuators B: Chemical, 2024, 412, 135785. (IF: 8.0).
68. Wan-Chun Luo, Li-Na Bao, Yu Zhang, Zi-Tong Zhang, Xi Lia, Meng-Meng Pan, Jin-Tao Zhang, Kun Huang*, Xu Yu*, Li Xu*, A Ru3+-Functionalized-NMOF Nanozyme as an Inhibitor and Disaggregater for β-Amyloid Aggregates,Journal of Materials Chemistry B, 2024, 12, 12239-12250. (IF: 6.1).
67. Jintao Zhang, Wan-Chun Luo, Yu Zhang, Xi Li, Ming Jiang, Kun Huang*, Xu Yu*, Li Xu*, Red emissive fluorescent carbon dots based on ternary carbon source for imaging α-synuclein fibrils,Journal of Colloid and Interface Science, 2024, 670, 576-584.(IF: 9.4).
66. Yong-Li Song, Xiang-Lan He, Meng-Meng Pan, Ming Wang, Ming Jiang, Li Xu*, Xu Yu*, An ultrasensitive biosensor with suppressed background signals for FEN1 detection in a homogeneous reaction via cascade primer exchange reaction and CRISPR/Cas12a system,Sensors and Actuators B: Chemical, 2024, 403, 135194. (IF: 8.0).
65. Zhi Li, Meng-Meng Pan, Yan-Ping Yu, Li-Na Bao, Lin-Jiao Yang, Yong-Li Song, Ming Wang, Lu-Qin Si, Xu Yu*, Ming Jiang*, Li Xu*, Polymer nanoparticles crosslinked by polyethyleneimine and hydroquinone with the selective antibacterial, antibiofilm and antioxidative activity to promote infected wound healing,Sustainable Materials and Technologies, 2024, 39, e00817. (IF: 8.6).
64. Wan-Chun Luo, Ming Jiang, Li Li, Li-Na Bao, Xu Yu*, Li Xu*, Deep Eutectic Solvent-Assisted Preparation of Resveratrol-Based Carbon Dots with High Biocompatibility for in situ Screening Inhibitors on Amyloid Protein Aggregation and Scavenging Reactive Oxygen Species,Sensors and Actuators B: Chemical, 2024, 400, 134901. (IF: 8.0).
63. Yundi Chen, Le Wang, Xu Yu, Wenjun Mao, Yuan Wan*,Ultrasonication Outperforms Electroporation for Extracellular Vesicle Cargo Depletion,Extracellular Vesicle, 2024, 4, 100052.
62. Qin-Ying Li#, Xu Yu#, Xi Li, Li-Na Bao, Yu Zhang, Min-Jie Xie, Ming Jiang, Ya Qian Wang, Kun Huang*, Li Xu*, Silicon-carbon dots loaded mesoporous silica nanocomposites (mSiO2@SiCDs): an efficient dual inhibitor of Cu2+-mediated oxidative stress and Aβ aggregation for Alzheimer’s disease,ACS Applied Materials & Interfaces, 2023, 15, 47, 54221-54233.(#Equal contribution, IF: 9.5).
61. Yong-Li Song, Xiang-Lan He, Yong Li, Ming Wang, Ming Jiang, Li Xu*, Xu Yu*, Homogeneous detection of viral nucleic acid via selective recognition proximity ligation and signal amplification with T7 transcription and CRISPR/Cas12a system,Analytica Chimica Acta, 2023, 1280, 341881. (IF: 6.2).
60. Meng-Meng Pan, Ming Wang, Linjiao Yang, Yongli Song, Ming Jiang, Xu Yu*, Li Xu*, Construction of Metal Organic Framework-Derived Fe-N-C Oxidase Nanozyme for Rapid and Sensitive Detection of Alkaline Phosphatase,Nanomaterials, 2023, 13, 2496. (IF: 5.3).
59. Meng‐Meng Pan#, Puze Li#, Yan‐Ping Yu, Ming Jiang, Xiangliang Yang, Pei Zhang, Jing Nie*, Jun Hu*, Xu Yu*, Li Xu*, Bimetallic ions functionalized Metal‐Organic‐Framework nanozyme for tumor microenvironment regulating and enhanced photodynamic therapy for hypoxic tumor，Advanced Healthcare Materials, 2023, 2300821. (#Equal contribution, IF: 10.0).
58.Qin-Ying Li#, Xu Yu#, Xi Li, Li-Na Bao, Yu Zhang, Shi-lin Wang, Ming Jiang, Kun Huang*, Li Xu*, Congo red-derived carbon dots: simultaneously as fluorescence probe for protein aggregates, inhibitor for protein aggregation and scavenger of free radicals,Small, 2023, 2205634.(#Equal contribution, IF: 13.3).
新闻报道：华中科技大学徐丽教授/黄昆教授《Small》：刚果红衍生碳点-Aβ42蛋白聚集的成像剂、抑制剂和活性氧清除剂
Small:刚果红衍生的碳点：同时作为蛋白质聚集物的荧光探针、蛋白质聚集抑制剂和自由基清除剂
57. Yan-Ping Yu, Meng-Meng Pan, Ming Jiang, Xu Yu*, Xi Li*, Facile synthesis of self-assembled three-dimensional flower-like Cu-MOF and its pyrolytic derivative Cu-N-C450for diverse applications,Journal of Environmental Chemical Engineering, 2023, 11, 109400. (IF: 7.7).
56. Li Li, Wan-Chun Luo, Ming Jiang, Xu Yu*, Xi Li*, Turn-on fluorescence probing of amyloid fibrils by the proto-berberine alkaloids and the study of their interactions,International Journal of Biological Macromolecules,2023, 231, 123319. (IF: 8.2).
55. Song Huang#, Le Wang#, Ming Wang, Jing Zhao, Cong Zhang, Li-Yun Ma, Ming Jiang, Li Xu*, Xu Yu*, Highly sensitive detection of extracellular vesicles on ZnO nanorods integrated microarray chips with cascade signal amplification and portable glucometer readout,Sensors and Actuators B: Chemical, 2023, 375, 132878. (#Equal contribution, IF:8.4).
54. Yi-Fan Wang#, Xu Yu#, Zhi Li, Meng-Meng Pan, Ming Jiang*, Li Xu*, Multicolor fluorescence regulation of N doped silicon quantum dots and the multiple applications,Sensors and Actuators B: Chemical,2023, 376, 132978. (#Equal contribution, IF:8.4).
53. Xiao Lei#, Li-Jun Ma#, Si-Nan Yu, Tian-Ling Ren*, Shi-Feng Li, Jun Yuan, Lei Ye, Xu Yu, Feng Liu*, Ultrahigh sensitive, sensing-actuating integrated, and multi-functional intelligent skin based on electromechanical-hydraulic coupling,Chemical Engineering Journal, 2023, 454, 140548.(#Equal contribution, IF: 15.1).
52. Zhi Li, Xu Yu, Ming Jiang*, Li Xu*, Fluorescent silicon-doped polymer dots: preparation and its multiple applications as antibacterial, solid fluorescence and reducing agents,Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 659, 130827. (IF: 5.2).
51. Ya-Qian Wang, Li Li, Jin Yin, Xu Yu, Xiaowei Wu*, Li Xu, Xu Yu, Turn on fluorescence detection of curcumin in food matrices by the novel fluorescence sensitizer,Analytica Chimica Acta, 2023, 1254, 341094. (IF: 6.2).
50. Yi-Fan Wang, Zhi Li, Ming Jiang, Xu Yu*, Li Xu*, “Two-in-one” sulfur and nitrogen co-doped fluorescent silicon nanoparticles: Simultaneous as the fluorescent probe and photocatalyst for in-situ real time visual monitoring and degradation of tetracycline antibiotics,Science of The Total Environment, 2022, 846, 157470.(IF: 10.753).
49. Meng‐Meng Pan, Yu Ouyang, Yong‐Li Song, Lu‐Qin Si, Ming Jiang, Xu Yu*, Li Xu*, Itamar Willner*, Au3+‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O2•−and •OH Generating Nanozymes and Their Antibacterial Functions,Small, 2022, 18, 2200548. (Feature as inside back cover story, IF: 15.153).
48. Yi-Fan Wang, Meng-Meng Pan, Yong-Li Song, Zhi Li, Le Wang, Ming Jiang, Xu Yu*, Li Xu*, Beyond the fluorescence labelling of novel nitrogen-doped silicon quantum dots: the reducing agent and stabilizer for preparing hybrid nanoparticles and antibacterial applications,Journal of Materials Chemistry B, 2022,10, 7003. (IF: 7.571).
47. Qin-Ying Li, Liyun Ma, Li Li, Shilin Wang, Xi Li, Cong Zhang, Yu Zhang, Ming Jiang, Hui Wang, Kun Huang*, Xu Yu*, Li Xu*, Array-based sensing of amyloidogenic proteins and discrimination of cancer by using different oxidants doped carbon nanodots as fluorescent probes,Chemical Engineering Journal, 2022, 430, 132696. (IF: 16.744).
新闻报道：Che. Eng. J.：不同氧化剂掺杂的碳纳米点荧光探针材料及其基于阵列的淀粉样蛋白检测和癌症鉴别
46. Le Wang, Song Huang, Qin-Ying Li, Li-Yun Ma, Cong Zhang, Feng Liu, Ming Jiang, Xu Yu*, Li Xu*, Bioinspired Three-Dimensional Hierarchical Micro/Nano-Structured Microdevice for Enhanced Capture and Effective Release of Circulating Tumor Cells,Chemical Engineering Journal, 2022, 435, 134762. (IF: 16.744).
45. Yi-Fan Wang, Li Li, Ming Jiang, Xin Yang, Xu Yu*, Li Xu*, One-pot synthesis of boron and nitrogen co-doped silicon-carbon dots for fluorescence enhancement and on-site colorimetric detection of dopamine with high selectivity,Applied Surface Science, 2022, 573, 151457. (IF: 7.392).
44. Meng-Meng Pan#, Dongliang Feng#, Yu Ouyang, Dachi Yang*, Xu Yu*, Li Xu*, Itamar Willner*, MOF-Templated Synthesis of Cobalt-Doped Zinc Oxide Superparticles for Detection of the 3-Hydroxy-2-Butanone Microbial Biomarker,Sensors and Actuators B: Chemical, 2022, 358, 131482. (#Equal contribution, IF: 9.221).
43. Qin-Ying Li, Ya-Qian Wang, Ming Jiang, Yuanyuan Cui,Xu Yu*, Li Xu*, Hydrophilic silicon nanoparticles as a turn-off and colorimetric fluorescent probe for curcuminoids detection in food samples and cell imaging,Food Chemistry, 2022, 366, 130629. (IF: 9.231).
42. Xuanqi Guo, Lijun Ma, Weiguang Wu, Shifeng Li, Xiao Lei, Xi Wu, Xu Yu*, Feng Liu*, Ultra-Sensitive Flexible Piezoresistive Pressure Sensor Prepared by Laser-Assisted Copper Template for Health Monitoring,Sensors and Actuators A: Physical, 2022, 334, 113325. (IF: 4.291).
41. Ya-Qian Wang, Qin-Ying Li, Ming Jiang, Xin Yang, Xiaowei Wu, Xu Yu*, Li Xu*, A palmatine-based fluorescent sensor for sensitive fluorometric and smartphone-assisted on-site fluorescent colorimetric detection of water in organic solvents,Microchemical Journal, 2022, 107598. (IF: 5.304).
40. Le Wang, Meng-Meng Pan, Li Xu*, Xu Yu*, Si-Yang Zheng*,Recent Advances of Emerging Microfluidic Chips for Exosome Mediated Cancer Diagnosis,Smart Materials in Medicine, 2021, 2, 158-171.
39. Li-Yun Ma, Qin-Ying Li, Xu Yu, Ming Jiang, Li Xu*, Recent developments in the removal of metal-based engineered nanoparticles from the aquatic environments by adsorption,Chemosphere, 2021, 291, 133089. (IF: 8.943).
38. Zhao Xu, Cong Zhang, Xu Yu, Heng Zheng*, Li Xu*, Microwave-assisted solid-phase synthesis of nitrogen-doping carbon dot with good solvent compatibility and its sensing of sunitinib,Analytical and Bioanalytical Chemistry, 2021, 413, 6435-6447. (IF: 4.478).
37. Meng-Meng Pan, Yi-Fan Wang, Le Wang, Xu Yu*, Li Xu*，Recent advances in visual detection for cancer biomarkers and infectious pathogens,Journal of Materials Chemistry B, 2021, 9, 35-52. (IF:7.571).
36. Si Qin, Xu Yu, Li Xu*, Amplified fluorescence detection and adsorption of Au3+by the fluorescent melamine formaldehyde microspheres incorporated with N and S co-doped carbon dots,Journal of Hazardous Materials, 2021, 405, 123978. (IF: 14.224).
35. Qin-Ying Li, Le Wang, Xu Yu, Li Xu*, Highly efficient removal of silver nanoparticles by sponge-like hierarchically porous thiourea-formaldehyde resin from Water.Journal of Hazardous Materials, 2020, 400, 123184. (IF: 14.224).
34. Yi-Fan Wang, Meng-Meng Pan, Xu Yu*, Li Xu*, The Recent Advances of Fluorescent Sensors Based on Molecularly Imprinted Fluorescent Nanoparticles for Pharmaceutical Analysis.Current Medical Science, 2020, 40, 407-421. (Invited review, IF: 1.273).
33. Feng Chen#, Jing Xue#, Jin Zhang, Min Bai, Xu Yu, Chunhai Fan and Yongxi Zhao*. Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding.Journal of the American Chemical Society, 2020, 142, 6, 2889-2896. (#Equal contribution, IF: 16.383).
32. Min Bai#, Feng Chen#, Xiaowen Cao, Yue Zhao, Jing Xue, Xu Yu, Chunhai Fan, and Yongxi Zhao*. Intracellular Entropy-driven Multi-bit DNA Computing for Tumor Progression Discrimination.Angewandte Chemie International Edition, 2020, 59, 13267-13272. (#Equal contribution, IF: 16.823).
Journal Articles (2010-2019)
31. Xu Yu, Na Wu, Feng Chen, Jin Wei, Yongxi Zhao*, Engineering Microfluidic chip for Circulating Tumor Cells: From Enrichment, Release to Single Cell Analysis.Trends in Analytical Chemistry, 2019, 117, 27-38. (IF: 14.908).
30. Yiqiu Xia, Yizhu Chen, Yeming Tang, Gong Cheng, Xu Yu, Hongzhang He, Guohong Cao, Huaguang Lu, Zhiwen Liu, Si-Yang Zheng*, A Smartphone-based Point-of-care Microfluidic Platform Fabricated with ZnO Nanorod Template for Colorimetric Virus Detection,ACS Sensors, 2019, 4, 12, 3298-3307. (IF: 9.618).
29. Na Wu, Feng Chen, Yue Zhao, Xu Yu, Jing Wei, Yongxi Zhao*, Functional and Biomimetic DNA Nanostructures on Lipid Membranes.Langmuir, 2018, 34, 14721-14730. (IF: 4.331)
28. Hengbo Huang, Jing Qin, Gen Wang, Zehua Guo, Xu Yu, Yongxi Zhao, Jing Wei*, Synthesis of Spiny Metal-phenolic Coordination Crystals as a Sensing Platform for Sequence-Specific Detection of Nucleic Acid,CrystEngComm, 2018, 20, 7626-7630. (IF: 3.756).
27. Xu Yu, Yiqiu Xia, Yi Tang, Wen-Long Zhang, Yin-Ting Yeh, Huaguang Lu, and Si-Yang Zheng*, A nanostructured microfluidic immunoassay platform for highly sensitive detection of infectious pathogen.Small, 2017, 13, 1700425. (Feature as inside front cover story, IF: 15.153,[Nanowerk]Nanostructured microfluidics platform detects infectious pathogens).
26. Wei-Hai Chen#, Xu Yu#, Alessandro Cecconello, Yang Sung Sohn, Rachel Nechushtaib, Itamar Willner*, Stimuli-Responsive Release of Loads from Metal-Organic-Framework Nanoparticles Using pH- and Metal-Ion Dependent DNAzymes as Locks,Chemical Science, 2017, 8, 5769-5780. (#Equal contribution, IF: 9.969).
25. Wei-Hai Chen#, Xu Yu#, Wei-Ching Liao, Y ang Sung Sohn, Alessandro Cecconello, Anna Kozell, Rachel Nechushtai, Itamar Willner*, ATP-Responsive Aptamer-Based Metal Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs,Advanced Functional Materials, 2017, 27, 1702102. (#Equal contribution, Feature as inside back cover story, IF: 19.924).
24. Xu Yu, Yuwei Hu, Jason S. Kahn, Alessandro Cecconello, and Itamar Willner*, Orthogonal dual-triggered shape-memory DNA-based hydrogels,Chemistry-A European Journal, 2016, 22, 14504-14507. (IF: 5.02).
23. Xu Yu, Gong Cheng, Si-Yang Zheng*, Synthesis of self-assembled multifunctional nanocomposite catalysts with highly stabilized reactivity and magnetic recyclability.Scientific Reports, 2016, 6, 25459. (IF: 4.996).
22. Xu Yu, Zhi-Ling Zhang, Si-Yang Zheng*, Highly sensitive DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization,Biosensors and Bioelectronics, 2015, 66, 520-526.(IF: 12.545).
21. Xu Yu, Gong Cheng, Ming-Da Zhou, Si-Yang Zheng*, On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics.Langmuir, 2015, 31, 3982-3992. (IF: 4.331).
20. Shibin He#, Xu Yu#, Xiangwu Wang, Junjun Tan, Shihan Yan, Pu Wang, Bi-Hai Huang, Zhi-Ling Zhang*, Lijia Li*, Fast magnetic isolation of simple sequence repeat markers in microfluidic channels.Lab on a Chip, 2014, 14, 1410-1414. (#Equal contribution,IF: 7.517).
19. Xu Yu, Cong-Ying Wen, Zhi-Ling Zhang*, Dai-Wen Pang, Control of magnetic field distribution by using nickel powder@PDMS pillars in microchannels.RSC Advances, 2014, 4, 17660-17666. (IF: 4.036).
18. Xu Yu, He-Shun Xia, Zuo-Dong Sun, Yi Lin, Kun Wang, Jing Yu, Hao Tang, Dai-Wen Pang, Zhi-Ling Zhang*, On-chip dual detection of cancer biomarkers directly in serum based on self-assembled magnetic bead patterns and quantum dots.Biosensors and Bioelectronics, 2013, 41, 129-136. (IF: 12.545).
17. Xu Yu, Xuan Feng, Jun Hu, Zhi-Ling Zhang*, Dai-Wen Pang, Controlling the magnetic field distribution on the micrometer scale and generation of magnetic bead patterns for microfluidic applications.Langmuir, 2011, 27, 5147-5156. (IF: 4.331).
16. Margarita Vázquez-González, Wei-Ching Liao, Rémi Cazelles, Shan Wang, Xu Yu, Vitaly Gutkin, Itamar Willner*, Cu2+-Modified Carbon Nitride Nanoparticles or Cu2+-Modified Carbon Dots as Heterogeneous Catalysts.ACS Nano, 2017, 11, 3247-3253. (IF: 18.027).
15. Yiqiu Xia, Yi Tang, Xu Yu, Yuan Wan, Yizhu Chen, Huaguang Lu, Si-Yang Zheng*, Label-Free Virus Capture and Release by a Microfluidic Device Integrated with Porous Silicon Nanowire Forest.Small, 2017, 1603135. (Feature as inside front cover story, IF: 15.153).
14. Jing Xue, Feng Chen, Min Bai, Xu Yu, Jing Wei, Ping Huang, Yongxi Zhao*, DNA-Mediated Assembly of Gold Nanoparticles and Its Applications in Bioanalysis.ChemNanoMat, 2017, 3, 725-735. (IF: 3.82).
13. Yi Tang, Xu Yu, Hao Chen, Youxiang Diao*, An immunoassay-based reverse-transcription loop-mediated isothermal amplification assay for the rapid detection of avian influenza H5N1 virus viremia,Biosensors and Bioelectronics, 2016, 86, 255-261. (IF: 12.545).
12. Pei-Lin Guo, Man Tang, Shao-Li Hong, Xu Yu, Dai-Wen Pang, Zhi-Ling Zhang*, Combination of dynamic magnetophoretic separation and stationary magnetic trap for highly sensitive and selective detection of Salmonella typhimurium in complex matrix.Biosensors and Bioelectronics, 2015, 74, 628-636. (IF: 12.545).
11. Gong Cheng, Si-Jie Hao, Xu Yu, Si-Yang Zheng*, Nanostructured microfluidic digestion system for rapid high-performance proteolysis,Lab on a Chip, 2015, 15, 650-654. (IF: 7.517).
10. Ling-Hong Xiong, Ran Cui, Zhi-Ling Zhang, Xu Yu, Zhixiong Xie, Yun-Bo Shi, Dai-Wen Pang*, Uniform fluorescent nanobioprobes for pathogen detection.ACS Nano. 2014, 8, 5116-5124.(IF: 18.027).
9. Gong Cheng, Xu Yu, Ming-Da Zhou, Si-Yang Zheng*, Preparation of magnetic graphene composites with hierarchical structure for selective capture of phosphopeptides.Journal of Materials Chemistry B, 2014, 2, 4711-4719. (IF: 7.571).
8. Bin Deng, Yu Tian, Xu Yu, Jian Song, Feng Guo, Yuxiu Xiao*, Zhiling Zhang*, Laminar flow mediated continuous single-cell analysis on a novel poly (dimethylsiloxane) microfluidic chip.Analytica Chimica Acta, 2014, 820, 104-111. (IF: 6.911).
7. Yin-Ting Yeh, Merisa Nisic, Xu Yu, Yiqiu Xia, Si-Yang Zheng*, Point-of-care microdevices for blood plasma analysis in viral infectious diseases.Annals of Biomedical Engineering, 2014, 42, 2333-2343. (IF: 4.219).
6. Rui-Qiao Zhang, Shu-Lin Liu, Wei Zhao, Wan-Po Zhang, Xu Yu, Yong Li, An-Jun Li, Dai-Wen Pang, Zhi-Ling Zhang*, A simple point-of-care microfluidic immunomagnetic fluorescence assay for pathogens.Analytical Chemistry, 2013, 85, 2645-2651. (IF: 8.008).
5. Sha Yao, Yun Shu, Yu-Jun Yang, Xu Yu, Dai-Wen Pang, Zhi-Ling Zhang*, Picoliter droplets developed as microreactors for ultrafast synthesis of multi-color water-soluble CdTe quantum dots.Chemical Communications, 2013, 49, 7114-7116. (Feature as inside back cover story, IF: 6.065).
4. Hongwei Liu, Yingying Jing, Xu Yu, Dai-Wen Pang, Zhi-Ling Zhang*, Construction of CdSe/ZnS quantum dot microarray in a microfluidic chip.Science China Chemistry, 2012, 55, 543-549. (IF: 10.138).
3. Er-Qun Song, Jun Hu, Cong-Ying Wen, Zhi-Quan Tian, Xu Yu, Zhi-Ling Zhang, Yun-Bo Shi, Dai-Wen Pang*, Fluorescent-magnetic-biotargeting multifunctional nanobioprobes for detecting and isolating multiple types of tumor cells.ACS Nano, 2011, 5, 761-770. (IF: 18.027).
2. Xuan Feng, Ying Yi, Xu Yu, Dai-Wen Pang, Zhi-Ling Zhang*, Generation of water-ionic liquid droplet pairs in soybean oil on microfluidic chip.Lab on a Chip, 2010, 10, 313-319. (IF: 7.517).
1. Beibei Chen, Shujing Heng, Hanyong Peng, Bin Hu*, Xu Yu, Zhi-Ling Zhang, Dai-Wen Pang, Xin Yue, Ying Zhu, Magnetic solid phase microextraction on a microchip combined with electrothermal vaporization-inductively coupled plasma mass spectrometry for determination of Cd, Hg and Pb in cells.Journal of Analytical Atomic Spectrometry, 2010, 25, 1931-1938. (IF: 4.351).
获奖及荣誉：
2025华中科技大学药学院优秀工作个人
2024华中科技大学药学院优秀工作个人
2022华中科技大学同济医学院招生宣传先进个人
2022华中科技大学药学院优秀工作个人
2021湖北省高层次人才
2020华中科技大学华中学者
2018中国分析测试协会科学技术奖（CAIA）一等奖：核酸信号放大生物分析新方法
2017西安交通大学“青年拔尖人才计划”B类
2012武汉大学学术创新奖
学术兼职：
2024-今第二届药物分析技术分会青年委员
2026-今中国分析测试协会分析药学分会委员
2021-2026湖北省科技厅入库专家
2023-2027湖北省细胞外囊泡学会（ESEV）理事
2023-2026湖北省武汉市江夏实验室兼职研究员
2026-今《Research》(IF: 10.9)青年编委
2020-2026《Current Medical Science》青年编委
2022-2023《Nanomaterials》(IF: 5.3)客座编辑（Guest Editor）
毕业学生去向（Alumni）：
潘梦梦（协带）2020级博士 武汉大学人民医院检验科主管技师
宋勇丽2020级博士 河南省人民医院药学部主管药师
王乐（协带）2021级博士 华中科技大学附属同济医院药学部主管药师
黄淞2020级硕士 重庆市大坪医院（第三军医大学大坪医院）临床药师
余燕平2022级硕士 华中科技大学附属协和医院重庆医院药师
研究生招生方向：
药物分析学，分析化学，材料化学
联系方式：
邮箱：xuyu@hust.edu.cn; yuxu@whu.edu.cn
地址：湖北省武汉市航空路13号华中科技大学同济医学院药学院2号楼，430030。
