余旭，博士，副教授，博士生导师，华中科技大学同济药学院药物分析系。
2013年博士毕业于武汉大学化学与分子科学学院，分析化学专业，导师：张志凌教授、庞代文教授。曾在美国宾夕法尼亚州立大学（生物医学工程系，合作导师：Si-Yang Zheng教授）和以色列希伯来大学（纳米科学与技术中心，合作导师：Itamar Willner院士）从事博士后研究。2017.09-2019.11在西安交通大学生命与科学技术学院任副教授，特聘研究员。2019.12-今，华中科技大学同济医学院药学院，副教授。致力于生命分析化学和材料科学交叉领域的研究，努力创新，注重实验研究与理论探索及实际应用相结合，在微流控芯片、生物传感器、纳米材料、分析新方法等方面取得了一系列创新研究成果。在Adv. Funct. Mat., Small, Chem. Sci., Chem. Eng. J., Trends Anal. Chem., Lab Chip等国内外核心（权威）期刊发表论文57篇，其中以第一/共一/通讯作者发表SCI论文30篇（IF >10, 10篇），5篇文章被选为封面文章，多篇论文分别被Chem. Rev., Chem. Soc. Rev., Nat. Comm., Acc. Chem. Res.等综述引用和报道。论文被引用2000余次，H指数23（google scholar）。获国家授权发明专利2项，申请国家发明专利3项。ACS Nano, Biosens. Bioelectron., Lab Chip, Anal. Chim. Acta, Analyst等多个期刊审稿人。
研究方向：
1.纳米生物医学传感：微流控芯片、“液体”活检、单细胞分析
2.纳米药物载体、纳米酶抗菌和抗肿瘤治疗
3.药物分析
科研项目：
1.国家自然科学基金面上项目：基于凝胶微流控芯片的肿瘤外泌体多维度分析，60万，2022-2025，主持。
2.湖北省面上项目：基于膜亲和多肽的细胞外囊泡富集及肿瘤标志物多维度分析，8万，2021-2023，主持。
3.华中科技大学新进教师科研启动经费，50万，2019-2022，主持。
4.国家自然科学基金青年项目：三维仿生微纳结构集成微流控芯片用于循环肿瘤细胞高灵敏检测，27万，2019-2021，主持，已结题。
5.南开大学重点实验室开放基金：李斯特菌生物代谢标志物传感材料与传感器件，0.5万，2021-2022，主持。
6.西安交通大学青年拔尖人才计划B类，100万，2017-2019，主持。
7.中央高校基本业务费：基于微纳界的肿瘤外泌体多组分微流控分析，15万，2018-2020，主持，已结题。
发表文章：
Journal Articles (2020-present)
57.Qin-Ying Li#,Xu Yu#, Xi Li, Li-Na Bao, Yu Zhang, Shi-lin Wang, Ming Jiang, Kun Huang*, Li Xu*, Congo red-derived carbon dots: simultaneously as fluorescence probe for protein aggregates, inhibitor for protein aggregation and scavenger of free radicals,Small, 2023, 2205634.(#Equal contribution, IF:15.153).
华中科技大学徐丽教授/黄昆教授《Small》：刚果红衍生碳点-Aβ42蛋白聚集的成像剂、抑制剂和活性氧清除剂
Small:刚果红衍生的碳点：同时作为蛋白质聚集物的荧光探针、蛋白质聚集抑制剂和自由基清除剂
56. Yan-Ping Yu, Meng-Meng Pan, Ming Jiang,Xu Yu*, Xi Li*, Facile synthesis of self-assembled three-dimensional flower-like Cu-MOF and its pyrolytic derivative Cu-N-C450for diverse applications,Journal of Environmental Chemical Engineering, 2023, 11, 109400. (IF:7.968).
55. Li Li, Wan-Chun Luo, Ming Jiang,Xu Yu*, Xi Li*, Turn-on fluorescence probing of amyloid fibrils by the proto-berberine alkaloids and the study of their interactions,International Journal of Biological Macromolecules,2023, 231, 123319. (IF:8.025).
54. Song Huang#, Le Wang#, Ming Wang, Jing Zhao, Cong Zhang, Li-Yun Ma, Ming Jiang, Li Xu*,Xu Yu*, Highly sensitive detection of extracellular vesicles on ZnO nanorods integrated microarray chips with cascade signal amplification and portable glucometer readout,Sensors and Actuators B: Chemical, 2023, 375, 132878. (#Equal contribution, IF:9.221).
53. Yi-Fan Wang#,Xu Yu#, Zhi Li, Meng-Meng Pan, Ming Jiang*, Li Xu*, Multicolor fluorescence regulation of N doped silicon quantum dots and the multiple applications,Sensors and Actuators B: Chemical,2023, 376, 132978. (#Equal contribution, IF:9.221).
52. Xiao Lei#, Li-Jun Ma#, Si-Nan Yu, Tian-Ling Ren*, Shi-Feng Li, Jun Yuan, Lei Ye,Xu Yu, Feng Liu*, Ultrahigh sensitive, sensing-actuating integrated, and multi-functional intelligent skin based on electromechanical-hydraulic coupling,Chemical Engineering Journal, 2023, 454, 140548.(#Equal contribution, IF:16.744)
51. Zhi Li, Xu Yu, Ming Jiang*, Li Xu*, Fluorescent silicon-doped polymer dots: preparation and its multiple applications as antibacterial, solid fluorescence and reducing agents,Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 659, 130827. (IF:5.518).
50. Yi-Fan Wang, Zhi Li, Ming Jiang,Xu Yu*, Li Xu*, “Two-in-one” sulfur and nitrogen co-doped fluorescent silicon nanoparticles: Simultaneous as the fluorescent probe and photocatalyst for in-situ real time visual monitoring and degradation of tetracycline antibiotics,Science of The Total Environment, 2022, 846, 157470.(IF:10.753).
49. Meng‐Meng Pan, Yu Ouyang, Yong‐Li Song, Lu‐Qin Si, Ming Jiang,Xu Yu*, Li Xu*, Itamar Willner*, Au3+‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O2•−and •OH Generating Nanozymes and Their Antibacterial Functions,Small, 2022, 18, 2200548. (Feature as inside back cover story, IF:15.153).
48. Yi-Fan Wang, Meng-Meng Pan, Yong-Li Song, Zhi Li, Le Wang, Ming Jiang,Xu Yu*, Li Xu*, Beyond the fluorescence labelling of novel nitrogen-doped silicon quantum dots: the reducing agent and stabilizer for preparing hybrid nanoparticles and antibacterial applications,Journal of Materials Chemistry B, 2022,10, 7003. (IF:7.571).
47. Qin-Ying Li, Liyun Ma, Li Li, Shilin Wang, Xi Li, Cong Zhang, Yu Zhang, Ming Jiang, Hui Wang, Kun Huang*,Xu Yu*, Li Xu*, Array-based sensing of amyloidogenic proteins and discrimination of cancer by using different oxidants doped carbon nanodots as fluorescent probes,Chemical Engineering Journal, 2022, 430, 132696. (IF:16.744).
Che. Eng. J.：不同氧化剂掺杂的碳纳米点荧光探针材料及其基于阵列的淀粉样蛋白检测和癌症鉴别
46. Le Wang, Song Huang, Qin-Ying Li, Li-Yun Ma, Cong Zhang, Feng Liu, Ming Jiang,Xu Yu*, Li Xu*, Bioinspired Three-Dimensional Hierarchical Micro/Nano-Structured Microdevice for Enhanced Capture and Effective Release of Circulating Tumor Cells,Chemical Engineering Journal, 2022, 435, 134762. (IF:16.744).
45. Yi-Fan Wang, Li Li, Ming Jiang, Xin Yang,Xu Yu*, Li Xu*, One-pot synthesis of boron and nitrogen co-doped silicon-carbon dots for fluorescence enhancement and on-site colorimetric detection of dopamine with high selectivity,Applied Surface Science, 2022, 573, 151457. (IF:7.392).
44. Meng-Meng Pan#, Dongliang Feng#, Yu Ouyang, Dachi Yang*,Xu Yu*, Li Xu*, Itamar Willner*, MOF-Templated Synthesis of Cobalt-Doped Zinc Oxide Superparticles for Detection of the 3-Hydroxy-2-Butanone Microbial Biomarker,Sensors and Actuators B: Chemical, 2022, 358, 131482. (#Equal contribution, IF:9.221).
43. Qin-Ying Li, Ya-Qian Wang, Ming Jiang, Yuanyuan Cui,Xu Yu*, Li Xu*, Hydrophilic silicon nanoparticles as a turn-off and colorimetric fluorescent probe for curcuminoids detection in food samples and cell imaging,Food Chemistry, 2022, 366, 130629. (IF: 9.231).
42. Xuanqi Guo, Lijun Ma, Weiguang Wu, Shifeng Li, Xiao Lei, Xi Wu,Xu Yu*, Feng Liu*, Ultra-Sensitive Flexible Piezoresistive Pressure Sensor Prepared by Laser-Assisted Copper Template for Health Monitoring,Sensors and Actuators A: Physical, 2022, 334, 113325. (IF:4.291).
41. Ya-Qian Wang, Qin-Ying Li, Ming Jiang, Xin Yang, Xiaowei Wu,Xu Yu*, Li Xu*, A palmatine-based fluorescent sensor for sensitive fluorometric and smartphone-assisted on-site fluorescent colorimetric detection of water in organic solvents,Microchemical Journal, 2022, 107598. (IF: 5.304).
40. Le Wang, Meng-Meng Pan, Li Xu*,Xu Yu*, Si-Yang Zheng*,Recent Advances of Emerging Microfluidic Chips for Exosome Mediated Cancer Diagnosis,Smart Materials in Medicine, 2021, 2, 158-171.
39. Li-Yun Ma, Qin-ying Li,Xu Yu, Ming Jiang, Li Xu*, Recent developments in the removal of metal-based engineered nanoparticles from the aquatic environments by adsorption,Chemosphere, 2021, 291, 133089. (IF: 8.943).
38. Zhao Xu, Cong Zhang,Xu Yu, Heng Zheng*, Li Xu*, Microwave-assisted solid-phase synthesis of nitrogen-doping carbon dot with good solvent compatibility and its sensing of sunitinib,Analytical and Bioanalytical Chemistry, 2021,413, 6435-6447. (IF: 4.478).
37. Meng-Meng Pan, Yi-Fan Wang, Le Wang,Xu Yu*, Li Xu*，Recent advances in visual detection for cancer biomarkers and infectious pathogens,Journal of Materials Chemistry B, 2021, 9, 35-52. (IF:7.571).
36. Si Qin,Xu Yu, Li Xu*, Amplified fluorescence detection and adsorption of Au3+by the fluorescent melamine formaldehyde microspheres incorporated with N and S co-doped carbon dots,Journal of Hazardous Materials, 2021, 405, 123978. (IF: 14.224).
35. Qin-Ying Li, Le Wang,Xu Yu, Li Xu*, Highly efficient removal of silver nanoparticles by sponge-like hierarchically porous thiourea-formaldehyde resin from Water.Journal of Hazardous Materials, 2020, 400, 123184. (IF: 14.224).
34. Yi-Fan Wang, Meng-Meng Pan,Xu Yu*, Li Xu*, The Recent Advances of Fluorescent Sensors Based on Molecularly Imprinted Fluorescent Nanoparticles for Pharmaceutical Analysis.Current Medical Science, 2020, 40, 407-421. (Invited review, IF: 1.273).
33. Feng Chen#, Jing Xue#, Jin Zhang, Min Bai,Xu Yu, Chunhai Fan and Yongxi Zhao*. Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding.Journal of the American Chemical Society, 2020, 142, 6, 2889-2896. (#Equal contribution, IF: 16.383).
32. Min Bai#, Feng Chen#, Xiaowen Cao, Yue Zhao, Jing Xue,Xu Yu, Chunhai Fan, and Yongxi Zhao*. Intracellular Entropy-driven Multi-bit DNA Computing for Tumor Progression Discrimination.Angewandte Chemie International Edition, 2020, 59, 13267-13272. (#Equal contribution, IF: 16.823).
Journal Articles (2010-2019)
31.Xu Yu, Na Wu, Feng Chen, Jin Wei, Yongxi Zhao*, Engineering Microfluidic chip for Circulating Tumor Cells: From Enrichment, Release to Single Cell Analysis.Trends in Analytical Chemistry, 2019, 117, 27-38. (IF: 14.908).
30. Yiqiu Xia, Yizhu Chen, Yeming Tang, Gong Cheng,Xu Yu, Hongzhang He, Guohong Cao, Huaguang Lu, Zhiwen Liu, Si-Yang Zheng*, A Smartphone-based Point-of-care Microfluidic Platform Fabricated with ZnO Nanorod Template for Colorimetric Virus Detection,ACS Sensors, 2019, 4, 12, 3298-3307. (IF: 9.618).
29. Na Wu, Feng Chen, Yue Zhao,Xu Yu, Jing Wei, Yongxi Zhao*, Functional and Biomimetic DNA Nanostructures on Lipid Membranes.Langmuir, 2018, 34, 14721-14730. (IF: 4.331)
28. Hengbo Huang, Jing Qin, Gen Wang, Zehua Guo,Xu Yu, Yongxi Zhao, Jing Wei*, Synthesis of Spiny Metal-phenolic Coordination Crystals as a Sensing Platform for Sequence-Specific Detection of Nucleic Acid,CrystEngComm, 2018, 20, 7626-7630. (IF: 3.756).
27.Xu Yu, Yiqiu Xia, Yi Tang, Wen-Long Zhang, Yin-Ting Yeh, Huaguang Lu, and Si-Yang Zheng*, A nanostructured microfluidic immunoassay platform for highly sensitive detection of infectious pathogen.Small, 2017, 13, 1700425. (Feature as inside front cover story, IF:15.153,[Nanowerk]Nanostructured microfluidics platform detects infectious pathogens).
26. Wei-Hai Chen#,Xu Yu#, Alessandro Cecconello, Yang Sung Sohn, Rachel Nechushtaib, Itamar Willner*, Stimuli-Responsive Release of Loads from Metal-Organic-Framework Nanoparticles Using pH- and Metal-Ion Dependent DNAzymes as Locks,Chemical Science, 2017, 8, 5769-5780. (#Equal contribution, IF: 9.969).
25. Wei-Hai Chen#,Xu Yu#, Wei-Ching Liao, Y ang Sung Sohn, Alessandro Cecconello, Anna Kozell, Rachel Nechushtai, Itamar Willner*, ATP-Responsive Aptamer-Based Metal Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs,Advanced Functional Materials, 2017, 27, 1702102. (#Equal contribution, Feature as inside back cover story, IF: 19.924).
24.Xu Yu, Yuwei Hu, Jason S. Kahn, Alessandro Cecconello, and Itamar Willner*, Orthogonal dual-triggered shape-memory DNA-based hydrogels,Chemistry-A European Journal, 2016, 22, 14504-14507. (IF: 5.02).
23.Xu Yu, Gong Cheng, Si-Yang Zheng*, Synthesis of self-assembled multifunctional nanocomposite catalysts with highly stabilized reactivity and magnetic recyclability.Scientific Reports, 2016, 6, 25459. (IF: 4.996).
22.Xu Yu, Zhi-Ling Zhang, Si-Yang Zheng*, Highly sensitive DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization, Biosensors and Bioelectronics, 2015, 66, 520-526.(IF: 12.545).
21.Xu Yu, Gong Cheng, Ming-Da Zhou, Si-Yang Zheng*, On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics.Langmuir, 2015, 31, 3982-3992. (IF: 4.331).
20. Shibin He#,Xu Yu#, Xiangwu Wang, Junjun Tan, Shihan Yan, Pu Wang, Bi-Hai Huang, Zhi-Ling Zhang*, Lijia Li*, Fast magnetic isolation of simple sequence repeat markers in microfluidic channels.Lab on a Chip, 2014, 14, 1410-1414. (#Equal contribution,IF: 7.517).
19.Xu Yu, Cong-Ying Wen, Zhi-Ling Zhang*, Dai-Wen Pang, Control of magnetic field distribution by using nickel powder@PDMS pillars in microchannels.RSC Advances, 2014, 4, 17660-17666. (IF: 4.036).
18.Xu Yu, He-Shun Xia, Zuo-Dong Sun, Yi Lin, Kun Wang, Jing Yu, Hao Tang, Dai-Wen Pang, Zhi-Ling Zhang*, On-chip dual detection of cancer biomarkers directly in serum based on self-assembled magnetic bead patterns and quantum dots.Biosensors and Bioelectronics, 2013, 41, 129-136. (IF: 12.545).
17.Xu Yu, Xuan Feng, Jun Hu, Zhi-Ling Zhang*, Dai-Wen Pang, Controlling the magnetic field distribution on the micrometer scale and generation of magnetic bead patterns for microfluidic applications.Langmuir, 2011, 27, 5147-5156. (IF: 4.331).
16. Margarita Vázquez-González, Wei-Ching Liao, Rémi Cazelles, Shan Wang,Xu Yu, Vitaly Gutkin, Itamar Willner*, Cu2+-Modified Carbon Nitride Nanoparticles or Cu2+-Modified Carbon Dots as Heterogeneous Catalysts.ACS Nano, 2017, 11, 3247-3253. (IF: 18.027).
15. Yiqiu Xia, Yi Tang,Xu Yu, Yuan Wan, Yizhu Chen, Huaguang Lu, Si-Yang Zheng*, Label-Free Virus Capture and Release by a Microfluidic Device Integrated with Porous Silicon Nanowire Forest.Small, 2017, 1603135. (Feature as inside front cover story, IF:15.153).
14. Jing Xue, Feng Chen, Min Bai,Xu Yu, Jing Wei, Ping Huang, Yongxi Zhao*, DNA-Mediated Assembly of Gold Nanoparticles and Its Applications in Bioanalysis.ChemNanoMat, 2017, 3, 725-735. (IF: 3.82).
13. Yi Tang,Xu Yu, Hao Chen, Youxiang Diao*, An immunoassay-based reverse-transcription loop-mediated isothermal amplification assay for the rapid detection of avian influenza H5N1 virus viremia,Biosensors and Bioelectronics, 2016, 86, 255-261. (IF: 12.545).
12. Pei-Lin Guo, Man Tang, Shao-Li Hong,Xu Yu, Dai-Wen Pang, Zhi-Ling Zhang*, Combination of dynamic magnetophoretic separation and stationary magnetic trap for highly sensitive and selective detection of Salmonella typhimurium in complex matrix.Biosensors and Bioelectronics, 2015, 74, 628-636. (IF: 12.545).
11. Gong Cheng, Si-Jie Hao,Xu Yu, Si-Yang Zheng*, Nanostructured microfluidic digestion system for rapid high-performance proteolysis,Lab on a Chip, 2015, 15, 650-654. (IF: 7.517).
10. Ling-Hong Xiong, Ran Cui, Zhi-Ling Zhang,Xu Yu, Zhixiong Xie, Yun-Bo Shi, Dai-Wen Pang*, Uniform fluorescent nanobioprobes for pathogen detection.ACS Nano. 2014, 8, 5116-5124.(IF: 18.027).
9. Gong Cheng,Xu Yu, Ming-Da Zhou, Si-Yang Zheng*, Preparation of magnetic graphene composites with hierarchical structure for selective capture of phosphopeptides.Journal of Materials Chemistry B, 2014, 2, 4711-4719. (IF: 7.571).
8. Bin Deng, Yu Tian,Xu Yu, Jian Song, Feng Guo, Yuxiu Xiao*, Zhiling Zhang*, Laminar flow mediated continuous single-cell analysis on a novel poly (dimethylsiloxane) microfluidic chip.Analytica Chimica Acta, 2014, 820, 104-111. (IF: 6.911).
7. Yin-Ting Yeh, Merisa Nisic,Xu Yu, Yiqiu Xia, Si-Yang Zheng*, Point-of-care microdevices for blood plasma analysis in viral infectious diseases.Annals of Biomedical Engineering, 2014, 42, 2333-2343. (IF: 4.219).
6. Rui-Qiao Zhang, Shu-Lin Liu, Wei Zhao, Wan-Po Zhang,Xu Yu, Yong Li, An-Jun Li, Dai-Wen Pang, Zhi-Ling Zhang*, A simple point-of-care microfluidic immunomagnetic fluorescence assay for pathogens.Analytical Chemistry, 2013, 85, 2645-2651. (IF: 8.008).
5. Sha Yao, Yun Shu, Yu-Jun Yang,Xu Yu, Dai-Wen Pang, Zhi-Ling Zhang*, Picoliter droplets developed as microreactors for ultrafast synthesis of multi-color water-soluble CdTe quantum dots.Chemical Communications, 2013, 49, 7114-7116. (Feature as inside back cover story, IF: 6.065).
4. Hongwei Liu, Yingying Jing,Xu Yu, Dai-Wen Pang, Zhi-Ling Zhang*, Construction of CdSe/ZnS quantum dot microarray in a microfluidic chip.Science China Chemistry, 2012, 55, 543-549. (IF: 10.138).
3. Er-Qun Song, Jun Hu, Cong-Ying Wen, Zhi-Quan Tian,Xu Yu, Zhi-Ling Zhang, Yun-Bo Shi, Dai-Wen Pang*, Fluorescent-magnetic-biotargeting multifunctional nanobioprobes for detecting and isolating multiple types of tumor cells.ACS Nano, 2011, 5, 761-770. (IF: 18.027).
2. Xuan Feng, Ying Yi,Xu Yu, Dai-Wen Pang, Zhi-Ling Zhang*, Generation of water-ionic liquid droplet pairs in soybean oil on microfluidic chip.Lab on a Chip, 2010, 10, 313-319. (IF: 7.517).
1. Beibei Chen, Shujing Heng, Hanyong Peng, Bin Hu*,Xu Yu, Zhi-Ling Zhang, Dai-Wen Pang, Xin Yue, Ying Zhu, Magnetic solid phase microextraction on a microchip combined with electrothermal vaporization-inductively coupled plasma mass spectrometry for determination of Cd, Hg and Pb in cells.Journal of Analytical Atomic Spectrometry, 2010, 25, 1931-1938. (IF: 4.351).
获奖及荣誉：
2022《Nanomaterials》(IF:5.719)客座编辑(Guest Editor)
2022华中科技大学基础医学院招生宣传先进个人
2021华中科技大学药学院招生宣传先进个人
2021湖北省高层次人才
2020《Current Medical Science》青年编委
2018中国分析测试协会科学技术奖（CAIA）一等奖：核酸信号放大生物分析新方法
2012武汉大学学术创新奖,二等奖，武汉大学
研究生招生方向：
药物分析，分析化学
联系方式：
邮箱：xuyu@hust.edu.cn; yuxu@whu.edu.cn
地址：湖北省武汉市航空路13号华中科技大学同济医学院药学院2号楼，430030。
