万落生，教授，博、硕士研究生导师。国家自然科学基金通讯评审专家、教育部学位论文评审专家。主持国家自然科学基金面上项目2项、青年基金1项。在Angew. Chem. Int. Ed.、Org. Lett.、J. Nat. Prod.、Bioorg. Chem.、Carbohydr. Polym.、J. Ethnopharmacol.等领域权威期刊发表论文40余篇。
E-mail:wanluosheng@hust.edu.cn;
教育及工作经历
2024.01-至今，华中科技大学，教授，博、硕士生导师；
2017.11-2023.12，华中科技大学，副教授，硕士生导师；
2016.09-2017.11，华中科技大学，讲师，硕士生导师；
2013.07-2016.06，中国科学院昆明植物研究所，药学博士后；
2008.09-2013.06，华中科技大学，药理学博士；
2004.09-2008.06，华中科技大学，生物药学学士.
研究方向
中药药效物质基础与中药质量标准
科研项目与专利
1. 两种黄杨科植物抗神经病理性疼痛的活性生物碱研究，国家自然科学基金面上项目，批准号：32370421，50万元，项目负责人；
2. 以Kv1.3离子通道为靶点的大戟属植物抗银屑病药效物质基础研究，国家自然科学基金面上项目，批准号：31870330，59万元，项目负责人；
3. 滇产三种黄杨属植物抗肿瘤作用及资源品质评价，国家自然科学基金青年项目，批准号：81403050，23万元，项目负责人；
4. 黄连等三种鄂产高品质道地中药材规模化种植及精准扶贫示范研究，750万元，项目参与人；
5. 二萜类化合物及制备方法和应用、二萜类化合物药学上可接受的衍生物、药物组合物及应用，ZL 2021 1 1202584.7.
社会学术兼职
1. 湖北省药品科技咨询专家；
2. 武汉市中药委员会委员
部分代表性论文(*corresponding author, #first author)
1. Gong Y#, Liu R#, Zha H#, Dong D, Lu N, Yan H,Wan Luosheng*, Nian Y*. AnalgesicBuxusalkaloids with Enhanced Selectivity for the Low-Voltage-Gated Calcium Channel Cav3.2 over Cav3.1 through a New Binding Mode.Angew. Chem. Int. Ed. Engl.2024, 63: e202313461.(JCR Q1, IF: 16.6)
2. Cai Q#, Zha HJ#, Yuan SY#, Sun X#, Lin X, Zheng XY, Qian YX, Xia RF, Luo YS, Shi Z, Su JC*,Wan Luo-Sheng*. Diterpenoids fromEuphorbia fischerianawith Kv1.3 Inhibitory Activity.J. Nat. Prod.2023, 86: 2379-2390.(JCR Q1, IF: 5.1)
3. Xia RF#, Su JC#, Yu J#, Zha HJ, Wu JL, Fu XN, Cai Q,Wan Luo-Sheng*. Anti-inflammatory lanostane triterpenoids with rearranged spirobi[indene] scaffold and their biogenetically related analogues fromEuphorbia maculata.Phytochemistry2023, 211:113682.(JCR Q1, IF: 3.8)
4. Hu ZF#, Su JC#, Sun X#, Xia RF, Wu JL, Fu XN, Zhang BZ*, Chen JC*,Wan Luo-Sheng*. Brujavanoids A-U, structurally diverse apotirucallane-type triterpenoids fromBrucea javanicaand their anti-inflammatory effects.Bioorg. Chem.2022, 127: 106012.(JCR Q1, IF: 5.1)
5. Xiang ZN#, Tong QL#, Su JC#, Hu ZF#, Zhao N, Xia RF, Wu JL, Chen C, Chen JC*,Wan Luo-Sheng*. Diterpenoids with Rearranged 9(10→11)-abeo-10,12-Cyclojatrophane Skeleton and the First (15S)-Jatrophane fromEuphorbia helioscopia: Structural Elucidation, Biomimetic Conversion, and Their Immunosuppressive Effects.Org. Lett.2022, 24: 697-701.(JCR Q1, IF: 5.2)
6. Zhou CG, Xiang ZN, Zhao N, Sun X, Hu ZF, Wu JL, Xia RF, Chen C, Su JC*, Chen JC*,Wan Luo-Sheng*. Jatrophane Diterpenoids with Kv1.3 Ion Channel Inhibitory Effects fromEuphorbia helioscopia.J. Nat. Prod.2022, 85: 815-827.(JCR Q1, IF: 5.1)
7. Pan J#, Su JC#, Liu YH, Deng B, Hu ZF, Wu JL, Xia RF, Chen C, He Q, Chen JC*,Wan Luo-Sheng*. Stelleranoids A-M, guaiane-type sesquiterpenoids based on [5,7] bicyclic system fromStellera chamaejasmeand their cytotoxic activity.Bioorg. Chem.2021, 115: 105251.(JCR Q1, IF: 5.1)
8. Xiang ZN, Su JC, Liu YH, Deng B, Zhao N, Pan J, Hu ZF, Chen FH, Cheng BY, Chen JC*,Wan Luo-Sheng*. Structurally diverse alkaloids fromBuxus sempervirenswith cardioprotective activity.Bioorg. Chem.2021, 109: 104753.(JCR Q1, IF: 5.1)
9. Xiang Z, Xie H, Tong Q, Pan J,Wan Luosheng*, Fang J*, Chen J*. Revealing hypoglycemic and hypolipidemic mechanism ofXiaokeyinshuiextract combination on streptozotocin-induced diabetic mice in high sucrose/high fat diet by metabolomics and lipidomics.Biomed. Pharmacother.2021, 135: 111219.(JCR Q1, IF: 7.5)
10. Zhou J, Pan J, Xiang Z, Wang Q, Tong Q, Fang J,Wan Luosheng*, Chen J*. Xiaokeyinshui extract combination, a berberine-containing agent, exerts anti-diabetic and renal protective effects on rats in multi-target mechanisms.J. Ethnopharmacol.2020, 262: 113098.(JCR Q1, IF: 5.4)
11. Wang YL, Xiang ZN, Yuan Y, Zhou JW, Tian LY, Chen JC*,Wan Luo-Sheng*. Triterpenoid alkaloids fromBuxus rugulosaand their cytotoxic activities.Phytochem. Lett.2020, 36: 86-90.
12. Yuan Y, Wang QY, Zhang J, Nie J, Zhou CG, Yi WQ,Wan Luo-Sheng*, Chen JC*. A new bile acid from the traditional chinese medicineshedan.J. Asian Nat. Prod. Res.2019, PMID: 31535572.
13. Wang Q, Zhou J, Xiang Z, Tong Q, Pan J,Wan Luosheng*, Chen J*. Anti-diabetic and renoprotective effects of Cassiae Semen extract in the streptozotocin-induced diabetic rats.J. Ethnopharmacol.2019, 2019: 111904.(JCR Q1, IF: 5.4)
14. Xiang ZN, Yi WQ, Wang YL, Shao LD, Zhang CQ, Yuan Y, Pan J,Wan Luo-Sheng*, Chen JC*. Buxaustroines A-N, a Series of 17(13→18)abeo-Cycloartenol Triterpenoidal Alkaloids fromBuxus austro-yunnanensisand Their Cardioprotective Activities.J. Nat. Prod.2019, 82: 3111-3120.(JCR Q1, IF: 5.1)
15. Wan Luo-Sheng#, Nian Y#, Peng XR, Shao LD, Li XN, Yang J, Zhou M*, and Qiu MH*, Pepluanols C–D, Two Diterpenoids with Two Skeletons fromEuphorbia peplus.Org. Lett.2018, 20: 3074-3120.(JCR Q1, IF: 5.2)
16. Gong Y, Zhang J, Gao F, Zhou J, Xiang Z, Zhou C,Wan Luosheng*, Chen J*. Structure features and in vitro hypoglycemic activities of polysaccharides from different species ofMaidong.Carbohydr. Polym.2017, 173: 215-222.(JCR Q1, IF: 11.2)
17. Bai ST, Zhu GL, Peng XR, Dong JR, Yu MY, Chen JC,Wan Luo-Sheng*, Qiu MH*. Cytotoxicity of Triterpenoid Alkaloids fromBuxus microphyllaagainst Human Tumor Cell Lines.Molecules2016, 21: 1125.
18. Wan Luo-Sheng#, Nian Y#, Ye CJ#, Shao LD, Peng XR, Geng CA, Zuo ZL, Li XN, Yang J, Zhou M*, Qiu MH*. Three Minor Diterpenoids with Three Carbon Skeletons fromEuphorbia peplus.Org. Lett.2016, 18: 2166-2169.(JCR Q1, IF: 5.2)
19. Wan Luo-Sheng, Shao LD, Fu L, Xu J, Zhu GL, Peng XR, Li XN, Li Yan, Qiu MH*. One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction.Org. Lett.2016, 18: 496-499.(JCR Q1, IF: 5.2)
20. Wan Luo-Sheng, Chu R, Peng XR, Zhu GL, Yu MY, Li L, Zhou L, Lu SY, Dong JR, Zhang ZR, Li Y, Qiu MH*. Pepluane and Paraliane Diterpenoids fromEuphorbia pepluswith Potential Anti-inflammatory Activity.J. Nat. Prod.2016, 79: 1628-1634.(JCR Q1, IF: 5.1)
21. Wan Luo-Sheng, Min QX, Wang YL, Yue YD, Chen JC*. Xanthone Glycoside Constituents ofSwertia kouitchensiswith α-Glucosidase Inhibitory Activity.J. Nat Prod.2013, 76: 1248-1253.(JCR Q1, IF: 5.1)
22. Wan Luo-Sheng, Liu TT, Lin XJ, Min QX, Chen JC*, Two New Chiratane-Type Triterpenoids fromSwertia kouitchensis.Molecules2013, 18: 8518-8523.
23. Wan Luo-Sheng, Chen CP, Xiao ZQ, Wang YL, Min QX, Yue Y, Chen J*. In vitro and in vivo anti-diabetic activity ofSwertia kouitchensisextract.J. Ethnopharmacol.2013, 147: 622-630.(JCR Q1, IF: 5.4)
