叶英,女,博士,副教授,博士生导师,博士毕业于日本北海道大学,师从真菌天然产物生物合成领域知名专家Hideaki Oikawa教授,后在美国密歇根大学天然产物领域著名专家David Sherman教授实验室从事博士后研究。
主要研究方向:微生物/真菌天然产物生物合成及合成生物学(综合运用生物信息学、天然产物化学、基因及蛋白操作、化学合成、计算化学等相关技术,欢迎具有相关学科背景或感兴趣的本科生及研究生咨询)。
联系方式: ying_ye@hust.edu.cn
教育背景
2014.10-2017.10博士,日本北海道大学,生物合成化学(Hideaki Oikawa教授)
2011.09-2014.03硕士,浙江大学,药学
2007.09-2011.06本科,武汉理工大学,制药工程
工作经历
2018.01-2019.09博士后,美国密歇根大学(Prof. David Sherman)
2019.09至今 副教授,华中科技大学,同济医学院药学院
主持及参与项目
国家自然科学基金面上项目,2023.01-2026.12,主持
国家重点研发计划合成生物学重点专项,2021-2026,子课题负责人
国家自然科学基金青年项目,2021.01-2023.12,主持
发表论文
1.Yuan, W.; Li, F.; Chen, Z.; …Ye, Y*(共同通讯).; Zhang, Y.*, AbnI: An α-ketoglutarate-dependent dioxygenase involved in brassicicene C-H functionalization and ring system rearrangement.Chin Chem Lett2024,35(5), 108788.
2. Li, F.; Lai, S.; Yuan, W.; Chen, Z.; …Liu, J.*; Ye, Y.*(共同通讯); Zhang, Y.*, Conformational Control in Diterpene Synthase TlnA: Elucidating the Mechanism of 5–8–6 Skeleton Formation through Ring Expansion.Organic Letters2024,26(8), 1734-1738.
3. Li, Q.; Zheng, M. J.; …Liu, J. J.; Sun, W. G.;* Ye, Y.*(共同通讯); Zhu, H. C.*; Zhang, Y. H.*, Talarolactones A-G, α-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus and Their Biosynthetic Pathways.Organic Letters2023,25(10), 1616-1621.
4. Qiao, Y. B., Xu, Q. X., Huang, Z. J., …,Liu, J. J. *,Ye, Y.*(共同通讯), Zhang Y. H.*, Genome mining reveals a new cyclopentane-forming sesterterpene synthase with unprecedented stereo-control.Organic Chemistry Frontiers,2022, 9, 5808-5818
5. Hu, Z. X.,Ye, Y.*(共同通讯), Zhang Y. H.*, Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons.Nat. Prod. Rep.,2021, 38 (10), 1775-1793. (IF 15.111)
6.Ye, Y.#; Du, L.#; Zhang, X. W.; Newmister, S. A.; McCauley, M., et al., Fungal-derived brevianamide assembly by a stereoselective semipinacolase.Nature Catalysis,2020, 3 (6), 497-+. (IF: 40.706)
7.Ye, Y.; Ozaki, T.; Umemura, M.; Liu, C.; Minami, A.; Igarashi, Y.; Oikawa, H.Heterologous Production of Asperipin-2a: Proposal for Sequential Oxidative Macrocyclization by a Fungi-Specific DUF3328 Oxidase.Org. Biomol. Chem.2019,17, 39-43.
8.Ye, Y.; Minami, A.; Igarashi, Y.; Izumikawa, M.; Umemura, M.; Nagano, N.; Machida, M.; Kawahara, T.; Shin-ya, K.; Gomi, K.; Oikawa, H. Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi,Angew. Chem. Int. Ed.,2016, 55,8072-8075. (IF: 16.823)
9.Ye, Y.; Minami, A.; Mandi, A.; Liu, C.; Taniguchi, T.; Kuzuyama, T.;Monde, K.; Gomi, K.; Oikawa, H. Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes,J. Am. Chem. Soc.,2015,137, 11846-11853. (IF: 16.383)