李琴
联系方式
邮箱：liqin2023@hust.edu.cn
地址：武汉市航空路13号同济药学院1号楼414室；邮编430030
研究方向
真菌来源天然产物的提取分离、结构鉴定及药理活性研究
教育及工作经历
2023.11~至今，华中科技大学，药学院，讲师
2020.7~2023.10，华中科技大学，药学院/公共卫生学院，博士后
2015.9~2020.6，华中科技大学，药学院，博士
2011.9~2015.6，新乡医学院，药学院，学士
主持科研项目情况
[1] 国家自然科学基金委员会，青年科学基金项目，82104028，细疣篮状菌抗mcr-1阳性耐药菌新颖聚酮类活性成分研究，2022-01-01至2024-12-31，30万元，在研，主持
[2] 华中科技大学人才引进基金，2023-11至2026-10，15万元，在研，主持
[3] 中国博士后科学基金会，博后特助，2022T150240，α-吡喃酮二聚体抗mcr-1阳性耐药菌研究，2022-01至2023-06，18.0万元，已结题，主持
[4] 中国博士后科学基金会，博后面上，2020M682429，动物内生真菌构巢曲霉化学成分及生物活性研究，2020-07至2022-07，8.0万元，已结题，主持
主要学术论文
[1] Qin Li(#); Zheng, Meijia; Li, Fengli; Li, Yongqi; Chen, Chunmei; Huang, Zijian; Liu, Junjun; Sun, Weiguang; Ye, Ying; Zhu, Hucheng; Zhang, Yonghui, Talarolactones A−G, alpha-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus, and Their Biosynthetic Pathways.Organic Letters2023,25, 1616-1621.
[2] Qin Li; Fu, Aimin; Wei, Mengsha; Xiao, Yang; Yin, Jie; Huang, Jianzheng; Li, Xiao-Nian; Tong, Qingyi; Chen, Chunmei; Zhu, Hucheng; Zhang, Yonghui, Asperemestrins A–D, Emestrin Hybrid Polymers with Bridged Skeletons from the Endophytic Fungus Aspergillus nidulans.Organic Letters2022,24, 6800-6804.
[3] Qin Li(#), Mi Zhang(#), Xiaotian Zhang(#), Lanqin Li, Meijia Zheng, Jinbing Kang, Fei Liu, Qun Zhou, Xiaonian Li, Weiguang Sun, Junjun Liu, Chunmei Chen(*), Hucheng Zhu(*), Yonghui Zhang(*). Talaroclauxins A and B: Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons fromTalaromyces stipitatus.Chinese Chemical Letters,2024, 35, 108193.
[4] Qin Li(#), Chunmei Chen(#), Mengsha Wei, Chong Dai, Li Cheng, Jiafeng Tao, Xiao-Nian Li, Jianping Wang, Weiguang Sun(*), Hucheng Zhu(*), Yonghui Zhang(*). Niduterpenoids A and B: two sesterterpenoids with a highly congested hexacyclic 5/5/5/5/3/5 ring system from the fungusAspergillus nidulans.Organic Letters,2019, 21, 2290−2293.
[5] Qin Li(#), Chunmei Chen(#), Yan He, Danyingzi Guan, Li Cheng, Xincai Hao, Mengsha Wei, Yinyu Zheng, Chang Liu, Xiao-Nian Li, Qun Zhou, Hucheng Zhu(*), Yonghui Zhang(*).Emeriones A−C: three highly methylated polyketides with bicyclo[4.2.0]octene and 3,6-dioxabicyclo[3.1.0]hexane functionalities fromEmericella nidulans.Organic Letters,2019, 21, 5091−5095.
[6] Qin Li(#), Chunmei Chen(#), Li Cheng, Mengsha Wei, Chong Dai, Yan He, Jiaojiao Gong, Runqi Zhu, Xiaonian Li, Junjun Liu, Jianping Wang, Hucheng Zhu(*), Yonghui Zhang(*). Emeridones A−F, a series of 3,5-demethylorsellinic acid-based meroterpenoids with rearranged skeletons from an endophytic fungusEmericellasp. TJ29.The Journal of Organic Chemistry,2019, 84, 1534−1541.
[7] Qin Li(#), Yuyi Zheng(#), Aimin Fu(#), Mengsha Wei, Xin Kang, Chunmei Chen(*), Hucheng Zhu(*), Yonghui Zhang(*). 30-norlanostane triterpenoids and steroid derivatives from the endophytic fungusAspergillus nidulansand their cytotoxic activity.Phytochemistry,2022, 201, 113257.
[8] Qin Li(#), Chunmei Chen(#), Yan He(#), Mengsha Wei, Li Cheng, Xin Kang, Jianping Wang, Xincai Hao(*), Hucheng Zhu(*), Yonghui Zhang(*). Prenylated quinolinone alkaloids and prenylated isoindolinone alkaloids from the fungusAspergillus nidulans.Phytochemistry,2020, 169, 112177.
[9] Qin Li(#); Aimin Fu(#); Jiaxin Dong(#); Yang Xiao; Bingbing Dai; Mengsha Wei; Zijian Huang; Junjun Liu; Chunmei Chen; Hucheng Zhu; Yuanyuan Lu(*); Dongyan Li(*); Yonghui Zhang(*), Three new Furano-lactones from the endophytic fungus Aspergillus nidulans.Fitoterapia2024,173.
[10] Aimin Fu(#); Chunmei Chen(#);Qin Li(#); Nanjin Ding; Jiaxin Dong; Yu Chen; MengshaWeiguang WeiSun; Hucheng Zhu; Yonghui Zhang, Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans.Chinese Chemical Letters2024.
[11] Mi Zhang(#),Qin Li(#), Shuangjun Li(#), Yanfang Deng, Muyuan Yu, Jinping Liu, Changxing Qi, Xiliang Yang(*), Hucheng Zhu(*), Yonghui Zhang(*). An unprecedented ergostane with a 6/6/5 tricyclic 13(14→8)abeo-8,14-secoskeleton fromTalaromyces adpressus.Bioorganic Chemistry,2022, 127, 105943.
[12] Yu Liang(#);Qin Li(#); Yongqi Li; Yuyi Zheng; Yong Shen; Haojie Yang; Yuling Lu; Junjun Liu; Qun Zhou; Dongyan Li; Weiguang Sun; Hucheng Zhu(*); Chunmei Chen(*); Yonghui Zhang(*), Lasiodiplodiapyrones A and B, Pyrone-Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae.Journal of Natural Products2023,86, 18-23.
[13] Mengsha Wei(#); Liping Huang(#);Qin Li(#); Xinyi Qiao; Ziming Zhao; Jie Yin; Aimin Fu; Jieru Guo; Xincai Hao; Lianghu Gu; Jianping Wang; Chunmei Chen(*); Hucheng Zhu(*); Yonghui Zhang(*), Spectasterols, Aromatic Ergosterols with 6/6/6/5/5, 6/6/6/6, and 6/6/6/5 Ring Systems from Aspergillus spectabilis.J Nat Prod2023,86, 1385–1391.
[14] Xin Kang(#), Wanqi Yang(#), Yuyi Zheng, Meijia Zheng, Yang Xiao, Jianping Wang, Hucheng Zhu,Qin Li(*), Chunmei Chen(*), Yonghui Zhang(*). Caryophyllene sesquiterpenoids with various ring systems from the fungusPestalotiopsis chamaeropis.Phytochemistry,2023, 207, 113569.
[15] Xiaosheng Tan(#), Lingjuan Sun(#),Qin Li(#), Changxing Qi, Cheng Fu, Hucheng Zhu, Xi Yang, Hao Feng, Yakun Li, Yonghui Zhang(*), Gang Chen(*). Secoemestrin C inhibits activation of NKT/conventional T cells and protects against concanavalin A-induced autoimmune hepatitis in mice.American Journal of Translational Research,2020, 12, 3389–3401.
[16] Yan He(#), Zhengxi Hu(#),Qin Li(#), Jinfeng Huang, Xiao-Nian Li, Hucheng Zhu, Junjun Liu, Jianping Wang(*), Yongbo Xue(*), Yonghui Zhang(*). Bioassay-guided isolation of antibacterial metabolites fromEmericellasp. TJ29.Journal of Natural Products,2017, 80, 2399−2405.
[17] Yan He(#), Mengzhu Zheng(#),Qin Li(#), Zhengxi Hu, Hucheng Zhu, Junjun Liu, Jianping Wang, Yongbo Xue(*), Hua Li(*), Yonghui Zhang(*). Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1.Organic Chemistry Frontiers,2017, 4, 1137−1144.
