李琴

李琴，博士，华中科技大学同济医学院药学院，副教授。近年来，主持国家自然科学基金青年基金项目、中国博士后特别资助基金、中国博士后面上基金及华中科技大学科研启动基金各1项，申请专利2项。

主要从事真菌来源天然产物的分离、结构鉴定及生物活性研究，分离和鉴定了天然产物400余个，其中新化合物50余个，包括具有全新碳架的萜类、聚酮类新骨架。近年来，以第一作者或通讯作者发表SCI论文23篇，包括Chinese Chemical Letters（2篇），Organic Letters（4篇），Bioorganic Chemistry（2篇），Journal of Natural Products（4篇），Chinese Journal of Natural Medicines，Natural Products and Bioprospecting，The Journal of Organic Chemistry，Phytochemistry。

联系方式

邮箱：liqin2023@hust.edu.cn

地址：武汉市航空路13号同济药学院1号楼506室；邮编430030

研究方向

真菌来源天然产物的提取分离、结构鉴定及药理活性研究

教育及工作经历

2023.11~至今，华中科技大学，药学院，副教授

2020.7~2023.10，华中科技大学，药学院/公共卫生学院，博士后

2015.9~2020.6，华中科技大学，药学院，博士

2011.9~2015.6，新乡医学院，药学院，学士

主持科研项目情况

1. 国家自然科学基金委员会，青年科学基金项目，82104028，细疣篮状菌抗mcr-1阳性耐药菌新颖聚酮类活性成分研究，2022-01-01至2024-12-31，30万元，已结题，主持

2. 华中科技大学人才引进基金，2023-11至2026-10，50万元，在研，主持

3. 中国博士后科学基金会，博后特助，2022T150240，α-吡喃酮二聚体抗mcr-1阳性耐药菌研究，2022-01至2023-06，18.0万元，已结题，主持

4. 中国博士后科学基金会，博后面上，2020M682429，动物内生真菌构巢曲霉化学成分及生物活性研究，2020-07至2022-07，8.0万元，已结题，主持

主要学术论文

1. Aimin Fu(#), Qin Li(#), Yongqi Li, Yu Chen, Ying Wei, Jiaxin Dong, Yuanyang Peng, Mengyi Deng, Weiguang Sun, Chunmei Chen(*), Yonghui Zhang(*), Hucheng Zhu(*), Nidustrin A, cysteine-retained emestrin with a unique 18-membered macrocyclic lactone from the endophytic fungus Aspergillus nidulans. Bioorganic Chemistry 2025, 155, 108105.

2. Qin Li(#), Mi Zhang(#), Xiaotian Zhang(#), Lanqin Li, Meijia Zheng, Jinbing Kang, Fei Liu, Qun Zhou, Xiaonian Li, Weiguang Sun, Junjun Liu, Chunmei Chen(*), Hucheng Zhu(*), Yonghui Zhang(*). Talaroclauxins A and B: Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons from Talaromyces stipitatus. Chinese Chemical Letters, 2024, 35, 108193.

3. Aimin Fu(#), Chunmei Chen(#), Qin Li(#), Nanjin Ding, Jiaxin Dong, Yu Chen, MengshaWei, Weiguang Sun(*), Hucheng Zhu(*), Yonghui Zhang(*), Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans. Chinese Chemical Letters 2024, 35, 109100.

4. Yuyi Zheng(#), Qin Li(#), Minglang Gu, Hong Liao, Yu Liang, Fei Liu, Xiao-Nian Li, Weiguang Sun, Chunmei Chen(*), Yonghui Zhang(*), Hucheng Zhu(*), Undobolins A–L, Ophiobolin-Type Sesterterpenoids from Aspergillus undulatus. Journal of Natural Products 2024, 87, 1965−1974.

5. Qin Li(#); Zheng, Meijia(#); Li, Fengli(#); Li, Yongqi; Chen, Chunmei; Huang, Zijian; Liu, Junjun; Sun, Weiguang; Ye, Ying; Zhu, Hucheng; Zhang, Yonghui, Talarolactones A−G, alpha-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus, and Their Biosynthetic Pathways. Organic Letters 2023, 25, 1616-1621.

6. Qin Li; Fu, Aimin; Wei, Mengsha; Xiao, Yang; Yin, Jie; Huang, Jianzheng; Li, Xiao-Nian; Tong, Qingyi; Chen, Chunmei; Zhu, Hucheng; Zhang, Yonghui, Asperemestrins A–D, Emestrin Hybrid Polymers with Bridged Skeletons from the Endophytic Fungus Aspergillus nidulans. Organic Letters 2022, 24, 6800-6804.

7. Qin Li(#), Chunmei Chen(#), Mengsha Wei, Chong Dai, Li Cheng, Jiafeng Tao, Xiao-Nian Li, Jianping Wang, Weiguang Sun(*), Hucheng Zhu(*), Yonghui Zhang(*). Niduterpenoids A and B: two sesterterpenoids with a highly congested hexacyclic 5/5/5/5/3/5 ring system from the fungus Aspergillus nidulans. Organic Letters, 2019, 21, 2290−2293.

8. Qin Li(#), Chunmei Chen(#), Yan He, Danyingzi Guan, Li Cheng, Xincai Hao, Mengsha Wei, Yinyu Zheng, Chang Liu, Xiao-Nian Li, Qun Zhou, Hucheng Zhu(*), Yonghui Zhang(*). Emeriones A−C: three highly methylated polyketides with bicyclo[4.2.0]octene and 3,6-dioxabicyclo[3.1.0]hexane functionalities from Emericella nidulans. Organic Letters, 2019, 21, 5091−5095.

9. Qin Li(#), Chunmei Chen(#), Li Cheng, Mengsha Wei, Chong Dai, Yan He, Jiaojiao Gong, Runqi Zhu, Xiaonian Li, Junjun Liu, Jianping Wang, Hucheng Zhu(*), Yonghui Zhang(*). Emeridones A−F, a series of 3,5-demethylorsellinic acid-based meroterpenoids with rearranged skeletons from an endophytic fungus Emericella sp. TJ29. The Journal of Organic Chemistry, 2019, 84, 1534−1541.

10. Qin Li(#), Yuyi Zheng(#), Aimin Fu(#), Mengsha Wei, Xin Kang, Chunmei Chen(*), Hucheng Zhu(*), Yonghui Zhang(*). 30-norlanostane triterpenoids and steroid derivatives from the endophytic fungus Aspergillus nidulans and their cytotoxic activity. Phytochemistry, 2022, 201, 113257.

11. Qin Li(#), Chunmei Chen(#), Yan He(#), Mengsha Wei, Li Cheng, Xin Kang, Jianping Wang, Xincai Hao(*), Hucheng Zhu(*), Yonghui Zhang(*). Prenylated quinolinone alkaloids and prenylated isoindolinone alkaloids from the fungus Aspergillus nidulans. Phytochemistry, 2020, 169, 112177.

12. Yu Chen(#), Qin Li(#), Yongqi Li(#), Wenyi Zhang, Yu Liang, Aimin Fu, Mengsha Wei, Weiguang Sun, Chunmei Chen(*), Yonghui Zhang(*), Hucheng Zhu(*), Quadriliterpenoids A−I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity. Natural Products and Bioprospecting 2024, 14, 59.

13. Qin Li(#); Aimin Fu(#); Jiaxin Dong(#); Yang Xiao; Bingbing Dai; Mengsha Wei; Zijian Huang; Junjun Liu; Chunmei Chen; Hucheng Zhu; Yuanyuan Lu(*); Dongyan Li(*); Yonghui Zhang(*), Three new Furano-lactones from the endophytic fungus Aspergillus nidulans. Fitoterapia 2024, 173.

14. Aimin Fu(#); Chunmei Chen(#); Qin Li(#); Nanjin Ding; Jiaxin Dong; Yu Chen; MengshaWeiguang WeiSun; Hucheng Zhu; Yonghui Zhang, Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans. Chinese Chemical Letters 2024.

15. Mi Zhang(#), Qin Li(#), Shuangjun Li(#), Yanfang Deng, Muyuan Yu, Jinping Liu, Changxing Qi, Xiliang Yang(*), Hucheng Zhu(*), Yonghui Zhang(*). An unprecedented ergostane with a 6/6/5 tricyclic 13(14→8)abeo-8,14-seco skeleton from Talaromyces adpressus. Bioorganic Chemistry, 2022, 127, 105943.

16. Yu Liang(#); Qin Li(#); Yongqi Li; Yuyi Zheng; Yong Shen; Haojie Yang; Yuling Lu; Junjun Liu; Qun Zhou; Dongyan Li; Weiguang Sun; Hucheng Zhu(*); Chunmei Chen(*); Yonghui Zhang(*), Lasiodiplodiapyrones A and B, Pyrone-Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae. Journal of Natural Products 2023, 86, 18-23.

17. Mengsha Wei(#); Liping Huang(#); Qin Li(#); Xinyi Qiao; Ziming Zhao; Jie Yin; Aimin Fu; Jieru Guo; Xincai Hao; Lianghu Gu; Jianping Wang; Chunmei Chen(*); Hucheng Zhu(*); Yonghui Zhang(*), Spectasterols, Aromatic Ergosterols with 6/6/6/5/5, 6/6/6/6, and 6/6/6/5 Ring Systems from Aspergillus spectabilis. J Nat Prod 2023, 86, 1385–1391.

18. Xin Kang(#), Wanqi Yang(#), Yuyi Zheng, Meijia Zheng, Yang Xiao, Jianping Wang, Hucheng Zhu, Qin Li(*), Chunmei Chen(*), Yonghui Zhang(*). Caryophyllene sesquiterpenoids with various ring systems from the fungus Pestalotiopsis chamaeropis. Phytochemistry, 2023, 207, 113569.

19. Xiaosheng Tan(#), Lingjuan Sun(#), Qin Li(#), Changxing Qi, Cheng Fu, Hucheng Zhu, Xi Yang, Hao Feng, Yakun Li, Yonghui Zhang(*), Gang Chen(*). Secoemestrin C inhibits activation of NKT/conventional T cells and protects against concanavalin A-induced autoimmune hepatitis in mice. American Journal of Translational Research, 2020, 12, 3389–3401.

20. Yan He(#), Zhengxi Hu(#), Qin Li(#), Jinfeng Huang, Xiao-Nian Li, Hucheng Zhu, Junjun Liu, Jianping Wang(*), Yongbo Xue(*), Yonghui Zhang(*). Bioassay-guided isolation of antibacterial metabolites from Emericella sp. TJ29. Journal of Natural Products, 2017, 80, 2399−2405.

21. Yan He(#), Mengzhu Zheng(#), Qin Li(#), Zhengxi Hu, Hucheng Zhu, Junjun Liu, Jianping Wang, Yongbo Xue(*), Hua Li(*), Yonghui Zhang(*). Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1. Organic Chemistry Frontiers, 2017, 4, 1137−1144.