陈红
研究方向：
1.急性肾损伤和糖尿病肾病的机制研究
2.多肽药物在肾脏疾病中治疗作用研究
3.糖尿病及代谢综合征的机制研究
联系方式：hongchen2017@hust.edu.cn
工作与教育经历：
2019/11-至今，华中科技大学，药学院，副教授
2017/08-2019/11，华中科技大学，药学院，讲师
2014/07-2017/07，华中科技大学，公共卫生学院，博士后
2009/09-2014/06，华中科技大学，药学院，博士
2004/09-2009/06，沈阳药科大学，药学院，学士
主持科研项目：
1. 国家自然科学基金面上项目，32371171，UTX-TRPM6依赖性的镁离子稳态在急性肾损伤中的作用机制研究
2. 湖北省自然科学基金面上项目，组蛋白去甲基化酶UTX对肥胖相关性肾病的调控作用研究
3. 2022年度湖北省生物靶向湖北省重点实验室开放基金
4. 国家自然科学基金青年项目，31500941，脂肪因子Apelin对急性肾损伤的保护机制研究
5. 华中科技大学自主创新基金面上项目，ELA多肽在急性肾损伤中的作用研究
6. 中国博士后科学基金第九批特别资助项目，2016T90692，H3K27甲基化在糖尿病肾病中的作用机制研究
7. 中国博士后科学基金面上项目，2015M572149，Apelin对缺血再灌注型急性肾损伤的保护机制研究
参编教材：
《药学分子生物学》人民卫生出版社第六版，编委
《药学分子生物学》学习指导与习题集人民卫生出版社第六版，编委
代表性研究成果：
1. Yang C, Xu H, Yang D, Xie Y, Xiong M, Fan Y, Liu X, Zhang Y, Xiao Y, Chen Y, Zhou Y, Song L, Wang C, Peng A, Petersen RB,Chen H*, Huang K*, Zheng L*. A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury.Nature communications(Accepted). IF= 17.694
2. Xiong M#,Chen H#, Fan Y, Jin M, Yang D, Chen Y , Zhang Y, Petersen R, Su H, Peng A, Wang C, Zheng L*, Huang K*. Tubular Elabela-APJ axis attenuates ischemia-reperfusion induced acute kidney injury and the following AKI-CKD transition by protecting renal microcirculation.Theranostics2023; 13(10):3387-3401. IF= 12.4
3. Chen Hong, Liu Chong, Wang Qian, Xiong Mingrui, Zeng Xia, Yang Dong, Xie Yunhao, Su Hua, Zhang Yu, Huang Yixue, Chen Yuchen, Yue Junqiu, Liu Chengyu, Wang Shun, Huang, Kun*, Zheng Ling*, Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver,Nature communications, 2022 Jul 4;13(1):3835. (IF=17.694)被Natural Review Nephrology评选为Research Highlight
4. Yang Chen#, Zhang Yu#, Zeng Xia, Chen Huijing, Chen Yuchen, Yang Dong, Shen Ziwei, Wang Xiaomu, Liu Xiuran, Xiong Mingrui,Chen Hong*and Huang Kun*, Kidney injury molecule-1 is a potential receptor for SARS-CoV-2.JMol Cell Biol, 2021 Jul 6;13(3):185-196. (IF=8.185)
5. Wang Chao#, Xiong Mingrui#, Yang Chen, Yang Dong, Zheng Jiaojiao, Fan Yu, Wang Shun, Gai Yongkang, Lan Xiaoli,Chen Hong*, Zheng Ling*, Huang Kun*, PEGylated and acylated Elabela analogues show enhanced receptor binding, prolonged stability, and remedy of acute kidney injury.J Med Chem, 2020 Dec 24;63(24):16028-16042. (IF=8.039)
6. Chen Hong#,Huang Yixue#, Zhu Xiuqin, Liu Chong, Yuan Yangmian, Su Hua, Zhang Chun, Liu Chengyu, Xiong Mingrui, Qu Yannan, Yun Peng, Zheng Ling*, Huang Kun *, Histone demethylase UTX is a therapeutic target for diabetic kidney disease,The Journal of Physiology,2019, 597(6):1643-1660. (IF=6.228)
7. Chen Hong, Liu Chengyu, Cheng Cheng, Zheng Ling, Huang Kun*, Effects of apelin peptides on diabetic complications,Curr Protein Pept Sci, 2018, 19(2):179-189. (IF=3.118)
8. Chen Hong,Wang Lin, Wang Wenjun, Cheng Cheng, Zhang Yu, Zhou Yu, Wang Congyi, Miao Xiaoping, Wang Jiao, Wang Chao, Li Jianshuang, Zheng Ling, Huang Kun*, ELABELA and an ELABELA fragment protect against AKI.J Am Soc Nephrol,2017 Sep; 28(9):2694-2707. (IF=14.978)
9. Chen Hong, Wan Danyang, Wang Lin, Peng Anlin, Xiao Hongdou, Petersen R.Bobert, Liu Chengyu,Zheng Ling*, Huang Kun*, Apelin protects against acute renal injury by inhibiting TGF-b1,BBA - Molecular Basis of Disease,2015 Jul; 1852(7):1278-87. (IF=6.633)
10. Chen Hong,Li Jianshuang, Jiao Lihua, Petersen R.Bobert, Li Jiong, Peng Anlin, Zheng Ling*, Huang Kun*, Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse,The Journal of Physiology, 2014, 592, 505-521. (IF=6.228)
11. Chen Hong#, Zheng Chenghong#, Zhang Xin, Li Jianshuang, Li Jiong, Zheng Ling*, Huang Kun*, Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice,Peptides, 2011, 32, 1634-1639. (IF=3.867)
