史琛，主任药师、博士生导师，曾在德国萨尔大学和马尔堡大学生物药学系访学。获湖北省自然科学基金青年A类项目资助（2026），入选湖北省医学青年拔尖人才（2023）及中国药学发展奖临床医药研究杰出青年学者（2022）。主持国家自然科学基金4项（面上项目3项，青年基金1项）、其他省部级项目17项；以通讯/第一作者在Adv Sci、Acta Pharm Sin B，J Control Release，Signal Transduct Target Ther、Pharmacol Res、eClinicalMedicine等国内外权威期刊发表SCI学术论文60余篇；授权发明专利3项，参编团体标准1部、指南共识10项，获批软件著作权2项。
（1）湖北省自然科学基金青年A类项目，2026AFA079，基于GSEA-GLM算法与类器官药敏测试系统的曲妥珠单抗耐药机制及干预策略研究，30万，2026-2029，在研，主持
（2）国家自然科学基金面上项目，NO.82474007，V-ATP酶介导巨噬细胞溶酶体酸化在MMAE类ADC药物诱发周围神经病变中的作用机制研究，2025.1-2028.12，在研，主持
（3）国家卫生健康委医药卫生科技发展研究中心“创新药物上市后临床研究科研专项”课题，基于真实世界数据的HER2-ADC药物多维度临床评估及临床应用前景研究，2024.1-2027.12，在研，主持
（4）国家重点研发计划“生物与信息融合（BT&IT融合）”重点专项，2023YFF1205000，基于靶标组学的复方用药AI药效评估与智能推荐系统的开发及应用，2023.11-2026.10，在研，课题骨干，分担100万经费
（5）国家自然科学基金面上项目，NO.82274026，Treg-Exo通过“CD39-CD73-腺苷轴”介导巨噬细胞选择性极化以促骨折愈合的作用及机制研究，2023.01-2026.12，在研，主持
（6）国家自然科学基金面上项目，NO.82073402，高仿生纳米系统靶向清除CAF及衰老CAF改善乳腺癌放疗抵抗的作用及机制研究，2021.01-2024.12，结题，主持
（7）教育部中国高校产学研创新基金资助高校科技/科研处，益生菌对口服阿片类药物的中重度癌痛患者肠道菌群肠道通透性和炎症因子的影响:一项开放标签、单臂、探索性临床研究，2023.01-2024.12，结题，主持
（8）国家自然科学基金青年项目，NO.81603037，基于“二次破坏”效应构建具磁-药协同作用的纳米载体及其抗三阴乳腺癌的研究，2017.01-2019.12，已验收，主持
（9）湖北省卫健委中医药科研项目面上项目，NO.ZY2021M007，粉防己碱协同FR-PLGA MNPs调控TASK-3通道抑制三阴乳腺癌细胞增殖的实验研究，2021.01-2022.12，已验收，主持
（11）湖北省自然科学基金面上项目，NO.2019CFB490，远程磁控释药纳米粒靶向阻断TASK-3通道治疗三阴乳腺癌的实验研究，2019.01-2020.12，已验收，主持
Light-Switched Mesenchymal Stem Cells for In Situ Exosome Amplification inCraniofacial Bone Defect Reconstruction；Advanced Science,2026,0:e75519.
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Exploring the diverse biomedical applications of programmable and multifunctional DNA nanomaterials. Journal of Nanobiotechnology 2023, 21:290.（IF=10.2）
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Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates. iScience.2023, 26(10): 107778.
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Efficacy and safety of semaglutide on weight loss in obese or overweight patients without diabetes: A systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 2022; 13: 935823.
Natural Product Alantolactone Targeting AKR1C1 Suppresses Cell Proliferation and Metastasis in Non-Small-Cell Lung Cancer. Front Pharmacol. 2022; 13: 847906.
Genetic and Clinical Factors Associated with Opioid Response in Chinese Han Patients with Cancer Pain: An Exploratory Cross-Sectional Study. Pain Ther. 2022; 11: 269-88.
Clinical Observation of the Effects of Oral Opioid on Inflammatory Cytokines and Gut Microbiota in Patients with Moderate to Severe Cancer Pain: A Retrospective Cohort Study. Pain Ther. 2022; 11: 667-81.
Application of information-intelligence technologies in pharmacy intravenous admixture services in a Chinese third-class a hospital. BMC Health Serv Res. 2022; 22: 1238.
Deng B. The fragility of liver glycogen from humans with type 2 diabetes: A pilot study. Int J Biol Macromol. 2022; 221: 83-90.
Knowledge, attitudes, and practices toward cancer pain management amongst healthcare workers (physicians, pharmacists, and nurses): a cross-sectional study from first-tier cities in China. Support Care Cancer. 2022; 30: 7261-9.
MicroRNA as an Important Target for Anticancer Drug Development. Front Pharmacol. 2021; 12: 736323.
Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study. J Clin Pharm Ther. 2021; 46: 1557-63.
Application of Quality Control Circle Activity in Improving Effectiveness of Drug Intervention in Lung Cancer Patients with Moderate to Severe Pain. Curr Med Sci. 2021; 41: 996-1003.
Remote-controllable bone-targeted delivery of estradiol for the treatment of ovariectomy-induced osteoporosis in rats. J Nanobiotechnology. 2021; 19: 248.
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Comprehensive Landscape of Heparin Therapy for COVID-19. Carbohydr Polym. 2021; 254: 117232.
Toxicities and Associated Factors in Patients Receiving Temozolomide-Containing Regimens: A 12-Year Analysis of Hospital Data. Drug Des Devel Ther. 2021; 15: 2151-9.
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Protective Effect of Yi Shen Pai Du Formula against Diabetic Kidney Injury via Inhibition of Oxidative Stress, Inflammation, and Epithelial-to-Mesenchymal Transition in db/db Mice. Oxid Med Cell Longev. 2021; 2021: 7958021.
Protective Effects and Mechanisms of Polyethylene Glycol Loxenatide Against Hyperglycemia and Liver Injury in db/db diabetic Mice. Front Pharmacol. 2021; 12: 781856.
Ultra-dispersed biomimetic nanoplatform fabricated by controlled etching agglomerated MnO2 for enhanced photodynamic therapy and immune activation. Chemical Engineering Journal. 2020; 397.
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Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields. RSC Adv. 2020; 10: 14471-81.
A multifunctional magnetic nanosystem based on "two strikes" effect for synergistic anticancer therapy in triple-negative breast cancer. J Control Release. 2020; 322: 401-15.
Analysis of Ornidazole Injection in Clinical Use at Post-marketing Stage by Centralized Hospital Monitoring System. Curr Med Sci. 2019; 39: 836-42.
Synthesis, purification, and anticancer effect of magnetic Fe3O4-loaded poly (lactic-co-glycolic) nanoparticles of the natural drug tetrandrine. Journal of Microencapsulation. 2019;36(4):356-370
Hyaluronic acid-coated and Olaparib-loaded PEI -PLGA nanoparticles for the targeted therapy of triple negative breast cancer. Journal of Microencapsulation. 2022;39(1):25-36
Drug-loaded poly(D,L -lactide-co-glycolide) microspheres as treatment for allergic contact dermatitis in mice model. Journal of Bioactive and Compatible Polymers (2017)
Clinical application analysis of andrographolide total ester sulfonate injection, a traditional Chinese medicine licensed in China. Journal of Huazhong University of Science and Technology (2017)
Inhibition of the cancer-associated TASK 3 channels by magnetically induced thermal release of Tetrandrine from a polymeric drug carrier, Journal of Controlled Release (2016)
A novel study on the mechanis5ms of drug release in PLGA-mPEG microspheres with fluorescent drug,J Biomater Sci Polym Ed (2016)
The effects of mPEG proportion and LA/GA ratio on degradation and drug release behaviors of PLGA-mPEG microparticles,Pharmazie (2016)
Multilayer Coating of Tetrandrine-loaded PLGA Nanoparticles: Effect of Surface Charges on Cellular Uptake Rate and Drug Release Profile,J Huazhong Univ Sci Technol［Med Sci］(2016)
Improved delivery of the natural anticancer drug tetrandrine, International Journal of Pharmaceutics；0378-5173；2015
ε-Polylysine and next-generation dendrigraft poly-L-lysine: chemistry, activity, and applications in biopharmaceuticals,Journal Journal of Biomaterials Science, Polymer Edition；0920-5063；2015
