郭翼，博士，中药与天然药物学系。主要从事药用植物及微生物来源的新颖天然产物挖掘、复杂天然产物的结构鉴定及其生物活性研究。重点研究具有抗阿尔茨海默病、抗肿瘤以及影响糖脂代谢的天然活性分子。近年来共分离鉴定新化合物160余个，新骨架化合物30个，其中包括2个具有药用开发潜力的先导化合物。
联系方式
邮箱：guoyi_tjmu@hust.edu.cn
地址：武汉市硚口区航空路13号同济医学院药学院1号楼；邮编430030
研究方向：挖掘药用植物及微生物来源的天然活性分子。
教育和工作经历
2025/2~至今，华中科技大学药学院，副教授
2022/9~2025/1，华中科技大学药学院，讲师
2020/7~2022/8，华中科技大学药学院/公共卫生学院，博士后，合作导师：张勇慧教授/刘烈刚教授
2014/9~2020/6，华中科技大学药学院，药物化学，博士，导师：张勇慧教授
2010/9~2014/6，中南民族大学药学院，药学，学士
主持或参加科研项目
1.国家自然科学基金委员会，青年项目，32100321，贯叶连翘中多靶点抗阿尔茨海默病有效成分的发现及其作用机制研究，2022-01-01至2024-12-31，30万元，结题，主持
2.湖北省科技厅，面上项目，2024AFB809，金丝桃属药用植物间苯三酚类成分抗神经退行性疾病活性研究，2024-03至2026-03，5万元，在研，主持
3.华中科技大学人才引进基金，2022-09至2025-09，15万元，在研，主持
4.国家自然科学基金委员会，联合基金项目，U22A20380，湖北金丝桃属植物微生态圈中抗病毒药源分子的发现及形成机制研究，2023-01-01至2026-12-31，255万元，在研，参与
5.国家自然科学基金委员会，面上项目，22477036，国家一类新药金线莲苷的生物合成研究，2025-01-01至2028-12-31，50万元，在研，参与
6.国家自然科学基金委员会，面上项目，31972865，四川石杉内生真菌聚多曲霉新颖生物碱及其抗AD活性和作用机制研究，2020-01-01至2023-12-31，58万元，结题，参与
7.国家自然科学基金委员会，面上项目，31770379，藤黄科植物中多靶点抗痴呆症天然先导化合物及其作用机制研究，2018-01-01至2021-12-31，60万元，结题，参与
代表性论文(#Co-first author, *Correspondence author)
1.Yi Guo#, Qianqian Xu#, Bo Tao, Xinye Huang, Yunfang Cao, Weiguang Sun, Changxing Qi*, Hucheng Zhu*, Yonghui Zhang*. Hyperatins A–D, highly oxidized polycyclic polyprenylated acylphloroglucinols fromHypericum perforatumL. with hypoglycemic potential in liver cells.Phytochemistry2024, 221 (March). 114047.
2.Yi Guo#, Fang Huang#, Weiguang Sun, Yuan Zhou, Chunmei Chen, Changxing Qi, Jing Yang, Xiao Nian Li, Zengwei Luo, Hucheng Zhu*, Xiaochuan Wang*, and Yonghui Zhang*. Unprecedented Polycyclic Polyprenylated Acylphloroglucinols with Anti-Alzheimer’s Activity from St. John’s Wort.Chemical Science2021,12(34), 11438–11446.
3.Yi Guo, Yunfang Cao, Changxing Qi, Qingyi Tong, Chunmei Chen, Jing Yang*, Hucheng Zhu*, and Yonghui Zhang*. Polycyclic Polyprenylated Acylphloroglucinols with Immunosuppressive Activity fromHypericum perforatumand Absolute Configurations Assignment of Previously Reported Analogues.Bioorganic Chemistry2021,114(May), 105144.
4.Yi Guo#, Qingyi Tong#, Na Zhang, Xueyan Duan, Yunfang Cao, Hucheng Zhu, Shuangshuang Xie, Jing Yang, Jinwen Zhang, Yanfei Liu, Yongbo Xue*, and Yonghui Zhang*. Highly Functionalized Cyclohexanone-Monocyclic Polyprenylated Acylphloroglucinols fromHypericum perforatumInduce Leukemia Cell Apoptosis.Organic Chemistry Frontiers2019,6(6), 817–824.
5.Yi Guo#, Na Zhang#, Xueyan Duan#, Yunfang Cao, Yongbo Xue*, Zengwei Luo, Hucheng Zhu, Chunmei Chen, Jianping Wang, and Yonghui Zhang*. Hyperforatins L–U: Prenylated Acylphloroglucinols with a Terminal Double Bond fromHypericum perforatumL. (St John’s Wort).Phytochemistry2019,164(April), 41–49.
6.Yi Guo, Na Zhang, Weiguang Sun, Xueyan Duan, Qing Zhang, Qun Zhou, Chunmei Chen, Hucheng Zhu, Zengwei Luo, Junjun Liu, Xiao Nian Li, Yongbo Xue*, and Yonghui Zhang*. Bioactive Polycyclic Polyprenylated Acylphloroglucinols fromHypericum perforatum.Organic and Biomolecular Chemistry2018,16(43), 8130–8143.
7.Yi Guo,Na Zhang, Chunmei Chen, Jinfeng Huang, Xiao Nian Li, Junjun Liu, Hucheng Zhu, Qingyi Tong, Jinwen Zhang, Zengwei Luo, Yongbo Xue*, and Yonghui Zhang*. Tricyclic Polyprenylated Acylphloroglucinols from St John’s Wort,Hypericum perforatum.Journal of Natural Products2017,80(5), 1493–1504.
其他学术论文(#Co-first author, *Correspondence author)
1.Zhao, Xuebing#,Yi Guo#, Qianqian Xu, Zhengyi Shi, Ming Xiang, Hua Li, Yanyan Wang*, Changxing Qi*, and Yonghui Zhang*. (±)-Hyperpyran A: Terpenoid-Based Bicyclic Dihydropyran Enantiomers with Hypoglycemic Activity fromHypericum perforatum(St. John’s Wort).Fitoterapia2022,161(May), 105221.
2.Duan, Yulin,Yi Guo, Yanfang Deng, Pengfei Bu, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Weiguang Sun, Changxing Qi*, and Yonghui Zhang*. Norprzewalsone A, a Rearranged Polycyclic Polyprenylated Acylphloroglucinol with a Spiro[cyclopentane-1,3′-tricyclo[7.4.0.01,6]tridecane] Core fromHypericum przewalskii.Journal of Organic Chemistry2022, 2–9.
3.Duan, Yulin#, Ping Hu#,Yi Guo, Pengfei Bu, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Qingyi Tong*, Changxing Qi*, and Yonghui Zhang*. Kiiacylphnols A−H, Eight Undescribed Polycyclic Polyprenylated Acylphloroglucinols with Anticancer Activities fromHypericum przewalskiiMaxim.Phytochemistry2022,199(November), 113166.
4.Shi, Zhengyi, Hong Hu,Yi Guo, Yulin Duan, Yeting Zhang, Bo Tao, Pengfei Bu, Weiguang Sun*, Changxing Qi*, and Yonghui Zhang*. Discovery of 13,15-nor-Polycyclic Polyprenylated Acylphloroglucinols fromHypericum Longistylumwith Anti-Inflammatory Activity.Organic & Biomolecular Chemistry2022,20(6), 1284–91.
5.Duan, Yulin, Pengfei Bu,Yi Guo, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Hankun Hu*, Changxing Qi*, and Yonghui Zhang*.(±)-Walskiiglucinol A, a Pair of Rearranged Acylphloroglucinol Derivative Enantiomers fromHypericum Przewalskii.Organic & Biomolecular Chemistry2022,20(24), 4970–4975.
6.Zhang, Na, Zhengyi Shi,Yi Guo, Shuangshuang Xie, Yuben Qiao, Xiao Nian Li, Yongbo Xue*, Zengwei Luo, Hucheng Zhu, Chunmei Chen, Linzhen Hu, and Yonghui Zhang*. The Absolute Configurations of Hyperilongenols A-C: Rare 12,13-seco-Spirocyclic Polycyclic Polyprenylated Acylphloroglucinols with Enolizable β,β′-Tricarbonyl Systems fromHypericum longistylumOliv.Organic Chemistry Frontiers2019,6(9), 1491–1502.
7.Duan, Yulin, Shuangshuang Xie,Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Mengyi Deng, Yunfang Cao, Yongbo Xue*, Changxing Qi*, and Yonghui Zhang*. Przewalcyrones A-F, Epoxychromene-Containing Polycyclic Polyprenylated Acylphloroglucinols with Immunosuppressive Activity fromHypericum przewalskiiMaxim.Organic and Biomolecular Chemistry2019,17(35), 8234–8242.
发明专利
1.张勇慧，薛永波，郭翼，朱虎成，王小川。“贯叶连翘提取物及其制法和制备抗阿尔兹海默病药的应用”，已授权，2020-7-10，ZL201810556307.8
2.张勇慧，薛永波，郭翼，张娜，张锦文。“贯叶连翘次生代谢产物中具有乙酰胆碱酯酶抑制作用化合物及分离制备和用途”，已授权，2020-5-19，ZL201710277708.5
