辜良虎，男，博士，副教授。本硕均就读于华中科技大学，师从化学与化工学院龚跃法教授，获得理学本科和硕士学位，并被评为华中科技大学优秀毕业生。后赴德国马普煤炭研究所攻读博士学位，导师Alois Fürstner教授和Manuel Alcarazo教授。博士毕业后进入药明康德新药开发有限公司国内新药服务部从事新药开发服务。2018年11月加入同济药学院，主要研究兴趣为药物化学和人工光酶。
联系方式：gulianghu@hust.edu.cn
教育经历
09/2012 – 06/2016自然科学博士 德国多特蒙德工业大学（马普煤炭研究所）
09/2009 – 03/2012理学硕士 华中科技大学 化学与化工学院
09/2005 – 06/2009理学本科 华中科技大学 化学与化工学院
工作经历
11/2018-至今 副教授，华中科技大学 同济医学院药学院
09/2016-10/2018 高级研究员 药明康德新药开发有限公司 国内新药服务部
科研项目
1. 基于天然样品库的抗凝先导化合物发现及平台的建立-武汉武勤生物科技发展有限公司 （2025，主持）
2. 湖北省面上项目（2024，主持）
3. 国家自然科学基金青年科学基金项目，项目编号81903461，起止时间2020.01-2022.12，项目负责人。
4. 华中科技大学自主创新基金一项
代表论文
1. Discovery and enantioselective total synthesis of antitumor agent asperfilasin A via a regio- and diastereoselective Nazarov cyclization Fengqing Wang,1, Changxing Qi,1, Chunmei Chen,1, Qin Lia, Qingyi Tonga, Weiguang Suna, Zhengxi Hu, Minyan Wang,*, Hucheng Zhu,*,Lianghu Gu,* Yonghui Zhang,* Chinese Chemical Letters (2024), doi: https://doi.org/10.1016/j.cclet.2024.110252
2. Design, synthesis, and biological evaluation of β-carboline derivatives as ABCB1 inhibitors for reversing multidrug resistance. Yuanyuan Wang,1, Nanjin Ding,1, Yunpeng Zhao, Fengqing Wang, Wen Liu, Zhe Chen, Weiguang Sun,*Lianghu Gu,*Yonghui Zhang, European Journal of Medicinal Chemistry https://doi.org/10.1016/j.ejmech.2025.117390
3. Chaetoxylariones A–G: undescribed chromone-derived polyketides from co-culture of Chaetomium virescens and Xylaria grammica enabled via the molecular networking strategy Sitian Zhang,Lianghu Gu, Yongtong Lin , Hanxiao Zeng , Nanjin Ding , Jiangchun Wei , Xiaoxia Gu , Chang Liu , Weiguang Sun , Yuan Zhou *, Yonghui Zhang *, Zhengxi Hu Bioorganic Chemistry 147 (2024) 107329. (Q1, IF 4.5）
4. Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis Jie Yin 1, Longjie Ding 1, Si Yao , Jianzheng Huang , Yang Xiao , Yue Wang , Biqiong Zhang , Mewlude Rehmutulla ,Lianghu Gu*, Qingyi Tong *, Yonghui Zhang * Bioorganic Chemistry 153 (2024) 107820. (Q1, IF 4.5）
5. Maydistacins A−G, Terpestacin-type Sesterterpenoids with Antiinflammatory Activity from the Phytopathogenic Fungus Bipolaris Maydis Zhengyi Shi, Xueyan Duan, Fengqing Wang, Zhangrong Hou, Fei Song,Lianghu Gu,*Changxing Qi,* and Yonghui Zhang*J. Nat. Prod. 2024, 87, 68−76. (Q1, IF 3.4,）
6. Maydisens, Sesterterpenoids with Anti-MDR Activity from Bipolaris Maydis Yong Shen,† Nanjin Ding,†Lianghu Gu,† Mengru Yu, Qin Li, Weiguang Sun, Chunmei Chen,* Yonghui Zhang,* and Hucheng Zhu*J. Nat. Prod. 2024, 87, 2408−2420. (Q1, IF 3.4）
7. Isolation, absolute configurations and bioactivities of pestaphilones A–I: Undescribed methylated side chain containing-azaphilones from Pestalotiopsis oxyanthi Mengyi Deng, Xia Chen, Yuben Qiao, Zhengyi Shi, Jianping Wang, Hucheng Zhu, Lianghu Gu ***, Changxing Qi **, Yonghui Zhang *Phytochemistry 194 (2022) 113045. (Q1, IF 3.8,共通讯）
8. Xiaotan Yu, ‡ Xiaoxia Gu,‡ Yunpeng Zhao, Fengqing Wang, Weiguang Sun, Changxing Qi,*Lianghu Gu* and Yonghui Zhang* Collective synthesis of aspulvinone and its analogues by vinylogous aldol condensation of substituted tetronic acids with aldehydesRSC Adv., 2023, 13, 4859
9. Si Yao, Jie Yin, Wen Liu, Yang Li, Jianzheng Huang, Changxing Qi, Zhengxi Hu, Qingyi Tong(*),Lianghu Gu(*), Yonghui Zhang(*), A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma,Bioorganic Chemistry, 2022, 127, 106019 (DOI: https://doi.org/10.1016/j.bioorg.2022.106019).
10. Muyuan Yu, Fengqing Wang, Si Yao, Yi Zang, Chong Dai, Yu Liang, Mi Zhang,Lianghu Gu(*), Hucheng Zhu(*), Yonghui Zhang(*), Structural Elucidation and Total Synthesis of Trichodermotin A, A Natural α-Glucosidase Inhibitor from Trichoderma asperellum,Chinese Journal of Chemistry, 2022, 15, 2219−2225. (DOI: https://doi.org/10.1002/cjoc.202200296).
11. Si Yao, Runge Zhang, Jianping Wang,Lianghu Gu(*), Zhengxi Hu(*), Yonghui Zhang(*), A new diketopiperazine-type alkaloid from the endophytic fungus Penicillium expansum,Natural Product Research, 2022, online ahead of print. (DOI: 10.1080/14786419.2022.2099391).
12. Mengyi Deng, Xia Chen, Yuben Qiao, Zhengyi Shi, Jianping Wang, Hucheng Zhu, Lianghu Gu(*), Changxing Qi(*), Yonghui Zhang(*). Isolation, absolute configurations and bioactivities of pestaphilones A–I: undescribed methylated side chain containing-azaphilones from Pestalotiopsis oxyanthi,Phytochemistry, 2022, 194, 113045. (DOI: 10.1016/j.phytochem.2021.113045).
13. Mengsha Wei(#), Peng Zhou(#), Liping Huang, Yin, Jie; Qin Li, Chong Dai, Jianping Wang, Lianghu Gu(*), Qingyi Tong(*), Hucheng Zhu(*), Yonghui Zhang(*). Spectanoids A–H: eight undescribed sesterterpenoids from Aspergillus spectabilis,Phytochemistry, 2021, 191, 112910. (DOI: 10.1016/j.phytochem.2021.112910).
14. Mengting Liu(#), Lianghu Gu(#), Ling Shen, Xueke Zhang, Shuang Lin, Ying Ye, Jianping Wang, Zhengxi Hu(*), Yonghui Zhang(*). Bipolaquinones A–J, immunosuppressive meroterpenoids from a soil-derived Bipolaris zeicola,Journal of Natural Products, 2021, 84, 2427–2436. (DOI: 10.1021/acs.jnatprod.1c00327).
15. Fengqing Wang(#), Mengsha Wei(#), Xueyan Duan(#), Xiaorui Liu, Si Yao, Jianping Wang, Hucheng Zhu, Chunmei Chen(*), Lianghu Gu(*), Yonghui Zhang(*). Identification, synthesis and biological evaluation of pyrazine ring compounds from Talaromyces minioluteus (Penicillium minioluteum),Organic Chemistry Frontiers, 2020, 7, 3616–3624. (DOI: 10.1039/D0QO01030H).
16. Yu Liang, Qin Li, Mengsha Wei, Chunmei Chen, Weiguang Sun, Lianghu Gu(*), Hucheng Zhu(*), Yonghui Zhang(*). Structurally diverse vibralactones produced by the fungus Stereum hirsutum,Bioorganic Chemistry, 2020, 96, 103760. (DOI: 10.1016/j.bioorg.2020.103760).
17. Xueyan Duan(#), Xiaosheng Tan(#), Lianghu Gu(#), Junjun Li, Xincai Hao, Li Tao, Hao Feng, Yunfang Cao, Zhengyi Shi, Yulin Duan, Mengyi Deng, GangChen(*), Changxing Qi(*), Yonghui Zhang(*). New secondary metabolites with immunosuppressive activity from the phytopathogenic fungus Bipolaris maydis,Bioorganic Chemistry, 2020, 99, 103816. (DOI: 10.1016/j.bioorg.2020.103816).
18. Shuangshuang Xie(#), Changxing Qi(#), Yulin Duan, Xincai Hao, Yi Guo, Mengyi Deng, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao,Lianghu Gu(*), Yuan Zhou(*), Yonghui Zhang(*). Wilsonglucinols A−C, homoadamantane-type polycyclic polyprenylated acylphloroglucinols with unusual fused epoxy ring skeletons from Hypericum wilsonii, Organic Chemistry Frontiers,2020, 7, 464–471. (DOI: 10.1039/C9QO01158G).
19. Zhaodi Wu(#), Xiaotian Zhang(#), Chunmei Chen(#), Peng Zhou, Mi Zhang,Lianghu Gu, Zengwei Luo, Jianping Wang, Qingyi Tong(*), Hucheng Zhu(*), and Yonghui Zhang(*), Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from Aspergillus micronesiensis PG-1,Organic Letters, 2020 22(6), 2162-2166.
20. Yi Zang, Yihua Gong, Jiaojiao Gong, Junjun Liu, Chunmei Chen,Lianghu Gu, Yuan Zhou, Jianping Wang, Hucheng Zhu(*), and Yonghui Zhang(*), Fungal Polyketides with Three Distinctive Ring Skeletons from the Fungus Penicillium canescens Uncovered by OSMAC and Molecular Networking Strategies,The Journal of Organic Chemistry, 2020, 85(7), 4973-4980.
21. Weixi Gao, Chenwei Chai, Yan He, Fengli Li, Xincai Hao, Fei Cao,Lianghu Gu, Junjun Liu, Zhengxi Hu(*), Yonghui Zhang(*), Periconiastone A, an Antibacterial Ergosterol with a Pentacyclo[8.7.0.01,5.02,14.010,15]heptadecane System from Periconia sp. TJ403-rc01,Organic Letters, 2019, 21, 8469-8472.
华科之前的文章
1 L. Gu, Y. Zheng, E. Haldón, R. Goddard, E. Bill, W. Thiel, M. Alcarazo,α-Radical Phosphines: Synthesis, Structure and ReactivityAngew. Chem. Int. Ed.2017,56, 8790.（IF: 11.9）
2 L.Gu, L.M. Wolf, A.Zieliński, W.Thiel, M.Alcarazo,α‑Dicationic Chelating Phosphines: Synthesis and Application to the Hydroarylation of DienesJ. Am. Chem. Soc.2017,139, 4948.（IF: 13.8）
3 L. Gu,L. M. Wolf, W. Thiel, C. W. Lehmann, M. AlcarazoReductive Elimination of C6F5-C6F5from Pd(II) Complexes: Influence of α‑Dicationic Chelating PhosphinesOrganometallics,2018,37, 665.（IF: 3.8）
4 L. Gu, G. Gopakumar, P. Gualco, W. Thiel and M. AlcarazoBis- and Tris(pyrazolyl)borate/Methane-Stabilized PIII-Centered CationsChem. Eur. J.2014，20, 8575-8578.（IF: 5.3）
5 L. Gu, Y. Zhou, J. Zhang, Y. Gong*
A highly chemo- and enantioselective nitroaldol reaction of haloenals: preparation of chiral functionalized allylic alcoholsTetrahedron: Asymmetry2012,23, 124–129.（IF: 2.1）
6 J. Carreras, G. Gopakumar,L. Gu, A. Gimeno, J. Petuškova, W. Thiel, and M. Alcarazo
Polycationic Ligands in Gold Catalysis: Synthesis and Applications of Extremely π-Acidic CatalystsJ. Am. Chem. Soc.2013,135, 18815.（IF: 13.8）
7 E. H. Haldon, A. Kozma, H. Tinnermann,L. Gu, R. Goddard, M. Alcarazo*Synthesis and Reactivity of α-Cationic Phosphines: The Effect of Imidazolinium and Amidinium SubstituentsDalton Trans.,2016,45, 1872-1876（IF: 4.0）
8 J. Zhang, L. Liu, J. Duan,L. Gu, B. Chen T. Sun Y. Gong Stereoselective One‐Pot Sequential Dehydrochlorination/trans‐Hydrofluorination Reaction ofβ‐Chloro‐α,β‐unsaturated Aldehydes or Ketones: Facile Access to (Z)‐β‐Fluoro‐β‐arylenals/β‐Fluoro‐β‐arylenonesAdv. Synth. Catal.2017,359, 4348.（IF: 5.6）
9 M. Wei, Y. Zhou,L. Gu, F. Luo*, F. Zhang*Asymmetric organocatalytic Michael-Hemiacetalization reaction: access to chiral spirocis-δ-lactones by in situ oxidation of spiroδ-lactols.Tetrahedron Lett.,2013, 54,2546-2548.（IF: 2.2）
10 J. Zhang,L. Gu, Y. Gong*Direct Vinylogous Aldol Reaction Triggered by Tetrabutylammonium Fluoride: A Highly Regioselective and Diastereoselective Addition of Cyclic β-Haloenals to Aromatic AldehydesSynlett2012, 23,468–472.（IF: 2.1）
