罗增伟,华中科技大学同济药学院副教授,博士。主要从事天然产物全合成和药物化学相关方面研究,主持或参与多项国家级科研项目。
Email: luozengwei@hust.edu.cn
工作经历:
2016.10至今 华中科技大学同济药学院 副教授
主持与参与的项目:
1. 国家自然科学基金《新型PTP1B抑制剂金线莲苷构效关系及降糖作用机制研究》,25万(No. 81102334,2012.01~2014.12),主持
2. 国家重大新药创制专项课题《化药一类降血糖新药KD10临床前研究》500万,2011.1-2013.12,参与
3. 国家自然科学基金《基于抑制Streptomyces 85E气生菌丝生成从照山白中寻找新颖蛋白激酶抑制剂先导化合物》,25万(No. 81001368, 2011.01~2013.12),参与
4. 国家自然科学基金《黄芫花中抗肿瘤二萜活性成分及抑制肿瘤侵袭转移作用机制研究》,35万(No.31070311, 2011.01~2013.12),参与
发表的文章:
1. Lu, Y., C. Chen, H. Zhu, Z. Luo, and Y. Zhang. "Highly Efficient and Fast Synthesis of Di-Iodinated Succinimide Derivatives from 1,6-Enyne and I2under Air at Room Temperature."Green Chemistry (2022).https://dx.doi.org/10.1039/d2gc02058k.
2. Tong, Q., H. You, X. Chen, K. Wang, W. Sun, Y. Pei, X. Zhao, M. Yuan, H. Zhu, Z. Luo, and Y. Zhang. "Zyh005, a Novel DNA Intercalator, Overcomes All-Trans Retinoic Acid Resistance in Acute Promyelocytic Leukemia."Nucleic Acids Research46, no. 7 (2018): 3284-97.https://dx.doi.org/10.1093/nar/gky202.
3. Chen, X., Z. Luo, Y. Chen, and Y. Zhang. "Silver(I)-Catalyzed Oxidative Cyclopropanation of 1,6-Enynes: Synthesis of 3-Aza-Bicyclo[3.1.0]Hexane Derivatives."Organic Letters24, no. 50 (2022): 9200-04.https://dx.doi.org/10.1021/acs.orglett.2c03619.
4. Lu, Y., J. Zhang, X. Duan, B. Yang, C. Zhao, L. Gu, C. Chen, H. Zhu, Y. Ye, Z. Luo, and Y. Zhang. "K2S2O8-Mediated Radical Cyclization of 1,6-Enyne for the Synthesis of DiiodonatedΓ-Lactams."Journal of Organic Chemistry88, no. 4 (2023): 2393-403.https://dx.doi.org/10.1021/acs.joc.2c02818.
5. Chen, X., C. Zhong, X. Duan, Z. Guan, L. Gu, Z. Luo, Y. Chen, and Y. Zhang. "A Removable Acyl Group Promoted the Intramolecular Dehydro-Diels-Alder Reaction of Styrene-Ynes: Highly Chemoselective Synthesis of Aryldihydronaphthalene Derivatives."Journal of Organic Chemistry (2022).https://dx.doi.org/10.1021/acs.joc.2c00180.
6. Chen, X., C. Zhong, Y. Lu, M. Yao, Z. Guan, C. Chen, H. Zhu, Z. Luo, and Y. Zhang. "Practical Access to Fluorescent 2,3-Naphthalimide Derivatives: Via Didehydro-Diels-Alder Reaction."Chemical Communications57, no. 42 (2021): 5155-58.https://dx.doi.org/10.1039/d1cc01437d.
7. Lu, Y., L. Chen, X. Chen, M. Yao, Z. Luo, and Y. Zhang. "Metal-Free Synthesis 6-Benzylphenanthridines Via Radical Addition/Cyclization of 2-Isocyanobiphenyls."Synthesis 52, no. 2 (2020): 290-96.https://dx.doi.org/10.1055/s-0039-1690218.
8. Lu, Y., X. Duan, X. Chen, M. Yao, C. Chen, H. Zhu, Z. Luo, and Y. Zhang. "A Mild Tetradehydro-Diels-Alder Reaction of Aryldiyne Compounds Affords Exclusively Linear Products." Organic and Biomolecular Chemistry20, no. 15 (2022): 3174-82.https://dx.doi.org/10.1039/d2ob00121g.
9. Wang, K., X. Chen, M. Yuan, M. Yao, H. Zhu, Y. Xue, Z. Luo, and Y. Zhang. "Silver-Mediated Cyanomethylation of Cinnamamides by Direct C(Sp3)-H Functionalization of Acetonitrile."Journal of Organic Chemistry83, no. 3 (2018): 1525-31.https://dx.doi.org/10.1021/acs.joc.7b02585.
10. Yuan, M., L. Chen, J. Wang, S. Chen, K. Wang, Y. Xue, G. Yao, Z. Luo, and Y. Zhang. "Transition-Metal-Free Synthesis of Phenanthridinones from Biaryl-2-Oxamic Acid under Radical Conditions."Organic Letters17, no. 2 (2015): 346-49.https://dx.doi.org/10.1021/ol503459s.