齐昌兴简历
齐昌兴，博士，华中科技大学同济医学院药学院，副教授，2021年华中科技大学“学术新人奖”获得者。近年来，主持国家自然科学基金青年基金项目、中国博士后面上基金及华中科技大学科研启动基金各1项，申请专利2项（已授权1项），科学出版社《天然药物化学》第2版编委。
主要从事鄂西北产药用植物与丝状真菌来源天然产物的分离、结构鉴定及生物活性研究，分离和鉴定了天然产物900余个，其中新化合物600余个，包括具有全新碳架的PPAPs类、萜类、聚酮类新骨架化合物80余个，隶属于60余个不同的新骨架类型，发现具有药用开发潜力的先导化合物3个。近年来，以第一作者或通讯作者发表SCI论文43篇，包括Chemical Science（IF 9.9），Cell Communication and Signaling（IF 7.5），Organic Letters（IF 6.0），Organic Chemistry Frontiers（IF 5.4；4篇），The Journal of Organic Chemistry（IF 5.4；2篇），Journal of Natural Products（IF 4.8；6篇），Bioorganic Chemistry（IF 5.3；3篇），Frontiers in Pharmacology（IF 5.9），Phytochemistry（IF 4.0；6篇），Frontiers in Chemistry（IF 5.3），Organic Biomolecular & Chemistry（IF 3.9；5篇）。
1.联系方式
邮箱：qichangxing@hust.edu.cn
地址：武汉市硚口区航空路13号同济医学院药学院1号楼507室；邮编430030
2.研究方向
丝状真菌及鄂西北产金丝桃属药用植物来源天然产物的分离、结构鉴定及生物活性研究；天然抗排斥反应的免疫抑制剂研究；天然抗肿瘤活性分子及天然抗阿尔茨海默病活性分子研究。
3.教育与工作经历
2020.11至今，华中科技大学，药学院，副教授
2019.7~2020.11，华中科技大学，药学院，讲师
2017.6~2019.6，华中科技大学，药学院/基础医学院，博士后，合作导师：张勇慧教授、王小川教授
2018.7~2018.9，德国马尔堡大学，药物生物学研究所，访问学者，合作导师：李书明教授
2012.9~2017.6，华中科技大学，药学院，药物化学，博士，导师：张勇慧教授
2008.9~2012.6，湖北中医药大学，药学院，药学，本科
4.主持或参加科研项目情况
1）国家自然科学基金青年科学基金项目，烟色拟盘多毛孢中新颖azaphilone类化合物的发现及其靶向GOT1的抗胰腺癌活性研究，2021.01~2023.12.31，82003633，24万元，在研，主持
2）华中科技大学人才引进基金，2019.07~2022.07，15万元，结题，主持
3）中国博士后科学基金第63批面上项目，2018M632879，2018.07~2019.06，5万，结题，主持
5.主要学术论文
1) Yulin Duan, Pengfei Bu, Yi Guo, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Hankun Hu,Changxing Qi(*)and Yonghui Zhang(*). (±)-Walskiiglucinol A, a pair of rearranged acylphloroglucinol derivative enantiomers fromHypericum przewalskii,Organic & Biomolecular Chemistry,2022, 20, 4970−4975.
2) Xuebing Zhao(#), Yi Guo(#), Qianqian Xu(#), Zhengyi Shi, Ming Xiang, Hua Li, Yanyan Wang(*),Changxing Qi(*), Yonghui Zhang(*). (±)-Hyperpyran A: terpenoid-based bicyclic dihydropyran enantiomers with hypoglycemic activity fromHypericum perforatum(St. John's wort),Fitoterapia,2022, 161, 105221.
3) Yulin Duan, Yi Guo, Yanfang Deng, Pengfei Bu, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Weiguang Sun,Changxing Qi(*), Yonghui Zhang(*). Norprzewalsone A, a rearranged polycyclic polyprenylated acylphloroglucinol with a spiro[cyclopentane-1,3'-tricyclo[7.4.0.01,6]tridecane] core fromHypericum przewalskii. The Journal of Organic Chemistry, 2022, 87, 6824−6831.
4) Zhengyi Shi, Xiaosheng Tan, Hong Hu, Na Zhang, Yulin Duan, Yi Guo, Hao Feng, Lingjuan Sun, Gang Chen,Changxing Qi(*), Yonghui Zhang(*). Discovery of undescribed monoterpenoid polyprenylated acylphloroglucinols with immunosuppressive activities fromHypericum longistylum,Phytochemistry,2022, 198, 113173.
5) Yulin Duan(#), Ping Hu(#), Yi Guo, Pengfei Bu, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Qingyi Tong(*),Changxing Qi(*),Yonghui Zhang(*). Kiiacylphnols A−H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities fromHypericum przewalskiimaxim.Phytochemistry,2022, 199, 113166.
6) Zhengyi Shi, Hong Hu, Yi Guo, Yulin Duan, Yeting Zhang, Bo Tao, Pengfei Bu, Weiguang Sun(*),Changxing Qi(*), Yonghui Zhang(*). Discovery of 13,15-nor-polycyclic polyprenylated acylphloroglucinols fromHypericum longistylumwith anti-inflammatory activity.Organic & Biomolecular Chemistry,2022, 20, 1284−1291.
7) Yuben Qiao(#), Xiaosheng Tan(#), Qianqian Xu(#), Zijun Zhang, Qiaoxin Xu, Li Tao, Junjun Liu, Hucheng Zhu, Chunmei Chen, Ying Ye, Yuanyuan Lu, Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*). Asperosin A, a [4+2] diels–alder cycloaddition polyketide dimer fromAspergillus rugulosawith immunosuppressive activity,Organic Chemistry Frontiers,2022, 9, 2477−2485.
8) Shan Yan(#), Hao Feng(#), Lingjuan Sun(#), Zhengyi Shi, Hong Hu, Yulin Duan, Yi Guo, Xiaosheng Tan, Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*). Discovery of immunosuppressive lupane-type triterpenoids fromHypericum longistylum.Natural Products Research,2022, Epub ahead of print.
9) Mengyi Deng, Xia Chen, Yuben Qiao, Zhengyi Shi, Jianping Wang, Hucheng Zhu, Lianghu Gu(*),Changxing Qi(*), Yonghui Zhang(*). Isolation, absolute configurations and bioactivities of pestaphilones A–I: undescribed methylated side chain containing-azaphilones fromPestalotiopsis oxyanthi,Phytochemistry,2022, 194, 113045.
10) Shan Yan(#),Changxing Qi(#), Wei Song, Qianqian Xu, Lianghu Gu, Weiguang Sun(*),Yonghui Zhang(*).Discovery of GOT1 inhibitors from a marine-derivedAspergillus terreusthat act against pancreatic ductal adenocarcinoma,Marine Drugs,2021, 19, 588.
11) Beiye Yang(#),Changxing Qi(#), Zeyu Yao, Shuang Lin, Fengli Li, Weiguang Sun, Zhengxi Hu(*), Yonghui Zhang(*). Hybeanones A and B, two highly modified polycyclic polyprenylated acylphloroglucinols fromHypericum beanie,Chinese Journal of Chemistry,2021, 40, 53–58.
12) Yunfang Cao(#), Xiaosheng Tan(#), Ali Adhab Al Chnani, Pengkun Li, Zhengyi Shi, Hao Feng, Lingjuan Sun, Qiangbing Xia, Xi Yang, Yulin Duan, Yi Guo, Gang Chen(*),Changxing Qi(*), and Yonghui Zhang(*). Bioassay-Guided Isolation of an Abetiane-Type Diterpenoid fromPrunella vulgarisThat Protects against Concanavalin A‑Induced Autoimmune Hepatitis.Journal of Natural Products, 2021, 84, 2189−2199.
13) Yulin Duan(#), Yanfang Deng(#), Pengfei Bu, Yi Guo, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Zhengxi Hu(*),Changxing Qi(*), and Yonghui Zhang(*). Discovery of Bioactive Polycyclic Polyprenylated Acylphloroglucinols fromHypericum wilsonii.Bioorganic Chemistry, 2021, 115, 105246.
14) Qianqian Xu(#), Yuben Qiao(#), Zijun Zhang, Yanfang Deng, Tianqi Chen, Li Tao, Qiaoxin Xu, Junjun Liu, Weiguang Sun, Ying Ye, Yuanyuan Lu(*),Changxing Qi(*)and Yonghui Zhang(*). New Polyketides with Anti-Inflammatory Activity from the FungusAspergillus rugulosa.Frontiers in Pharmacology, 2021, 12, 700573.
15) Yulin Duan, Shuangshuang Xie, Pengfei Bu, Yi Guo, Zhengyi Shi, Yun Guo, Yunfang Cao, Weiguang Sun,Changxing Qi(*), and Yonghui Zhang(*). Hypaluton A, An Immunosuppressive 3,4-nor-Polycyclic Polyprenylated Acylphloroglucinol fromHypericum patulum.The Journal of Organic Chemistry, 2021, 86, 6478−6485.
16) Yulin Duan, Pengfei Bu, Shuangshuang Xie, Yi Guo, Zhengyi Shi,Changxing Qi(*), and Yonghui Zhang(*).(±)-Hyperzewalsins A−D, Four Pairs ofnor-MonocyclicPolyprenylated AcylphloroglucinolswithImmunosuppressive ActivityfromHypericum przewalskiiMaxim.Phytochemistry, 2021, 187, 112779.
17) Shuangshuang Xie(#), Yuan Zhou(#), Xiaosheng Tan(#), Weiguang Sun, Yulin Duan, Hao Feng, Lingjuan Sun, Yi Guo, Zhengyi Shi, Xincai Hao, Gang Chen(*),Changxing Qi(*), and Yonghui Zhang(*). Norwilsonnol A, An Immunosuppressive Polycyclic Polyprenylated Acylphloroglucinol with Spiro[5-oxatricyclo[6.4.0.03,7]dodecane-6',1-1',2'-dioxane] System fromHypericum wilsonii.Organic Chemistry Frontiers, 2021, 8, 2280−2286.
18) Mengyi Deng, Xia Chen, Zhengyi Shi, Shuangshuang Xie, Yuben Qiao, Gang Chen, Xiaosheng Tan(*), Yuanyuan Lu(*),Changxing Qi(*), and Yonghui Zhang(*). New Immunosuppressive Secondary Metabolites from the endophytic fungusAspergillussp.Fitoterapia, 2021, 151, 104882.
19) Yulin Duan(#), Yanfang Deng(#), Pengfei Bu, Shuangshuang Xie, Yi Guo, Zhengyi Shi, Yun Guo, Yunfang Cao,Changxing Qi(*), and Yonghui Zhang(*). Discovery ofNor-Bicyclic Polyprenylated Acylphloroglucinols Possessing Diverse Architectures with Anti-Hepatoma Activities fromHypericum patulum.Bioorganic Chemistry, 2021, 111, 104902.
20) Mengyi Deng, Xiaosheng Tan, Yuben Qiao, Weiguang Sun, Shuangshuang Xie, Zhengyi Shi, Yuanyuan Lu(*), Gang Chen(*),Changxing Qi(*), and Yonghui Zhang(*). New secondary metabolites from the endophytic fungusAspergillussp. fromTripterygium wilfordii.Natural Product Research, 2021, DOI: 10.1080/14786419.2020.1868464.
21) Sitian Zhang(#), Yan He(#), Fengli Li, Shuang Lin, Beiye Yang, Shuyuan Mo, Huaqiang Li, Jianping Wang,Changxing Qi(*), Zhengxi Hu(*), and Yonghui Zhang(*). Bioassay-Directed Isolation of Antibacterial Metabolites from an Arthropod-DerivedPenicillium chrysogenum.Journal of Natural Products, 2020, 83, 11, 3397–3403.
22)Na Zhang(#), Zhengyi Shi(#), Qianqian Xu(#), Weiguang Sun, Lianghu Gu, Shuangshuang Xie, Yi Guo, Yulin Duan, Kailin Zhang,Changxing Qi(*), and Yonghui Zhang(*). Longisglucinols A−C, Structurally Intriguing Polycyclic Polyprenylated Acylphloroglucinols with Anti-inflammatory Activity fromHypericum longistylum.Organic Letters, 2020, 22, 7926–7929.
23)Changxing Qi(#), Xiaosheng Tan(#), Zhengyi Shi, Hao Feng, Lingjuan Sun, Zhengxi Hu(*), Gang Chen(*), and Yonghui Zhang(*). Discovery of an Oxepine-Containing Diketopiperazine Derivative Active against Concanavalin A‑Induced Hepatitis.Journal of Natural Products, 2020, 83, 2672–2678.
24) Mengyi Deng(#), Li Tao(#), Yuben Qiao, Weiguang Sun, Shuangshuang Xie, Zhengyi Shi,Changxing Qi(*), Yonghui Zhang(*). New cytotoxic secondary metabolites against human pancreatic cancer cells from theHypericum perforatumendophytic fungusAspergillus terreus.Fitoterapia, 2020, 146, 104685.
25)Shuangshuang Xie(#), Xiaosheng Tan(#), Yaping Liu, Yulin Duan, Gang Chen, Hao Feng, Lingjuan Sun, Yingying Huang, Yi Guo, Zhengyi Shi, Yuan Zhou(*),Changxing Qi(*), and Yonghui Zhang(*). Hypersonins A−D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture fromHypericum wilsonii.Journal of Natural Products, 2020, 83, 1804–1809.
26)Shuangshuang Xie(#),Changxing Qi(#), Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Xu Yin, Weiguang Sun(*), Yuan Zhou(*), and Yonghui Zhang(*). Discovery of New Polycyclic Polyprenylated Acylphloroglucinols with Diverse Architectures as Potent Cyclooxygenase-2 Inhibitors.Organic Chemistry Frontiers, 2020, 7, 1349–1357.
27)Xueyan Duan(#), Xiaosheng Tan(#), Lianghu Gu(#), Junjun Liu, Xincai Hao, Li Tao, Hao Feng, Yunfang Cao, Zhengyi Shi, Yulin Duan, Mengyi Deng, Gang Chen(*),Changxing Qi(*), and Yonghui Zhang(*). New Secondary Metabolites with Immunosuppressive Activity from the Phytopathogenic FungusBipolaris maydis.Bioorganic Chemistry, 2020, 99, 103816.
28)Mengyi Deng, Yaping Liu, Yingying Huang, Xu Yin, Yuan Zhou, Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao,Changxing Qi(*), and Yonghui Zhang(*). New Bioactive Secondary Metabolites from theAnoectochilus roxburghiiendophytic fungusAspergillus versicolor.Fitoterapia, 2020, 143: 104532.
29)Qiong Bie(#), Chunmei Chen(#), Yihua Gong, Xinhang Wang, Weiguang Sun, Muyuan Yu, Jieru Guo, Junjun Liu,Changxing Qi(*), Hucheng Zhu(*), Yonghui Zhang(*). Dongtinganthracenes A−D: Bioxanthracene Derivatives fromPenicilliumsp. DT10 Derived from Wetland Soil Obtained from Dongting Lake.Phytochemistry, 2020, 173: 112295.
30)Shuangshuang Xie(#),Changxing Qi(#), Yulin Duan, Xincai Hao, Yi Guo, Mengyi Deng, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Lianghu Gu(*), Yuan Zhou(*), Yonghui Zhang(*). Wilsonglucinols A–C, Homoadamantane-Type Polycyclic Polyprenylated Acylphloroglucinols with Unusual Fused Epoxy Ring Skeletons fromHypericum wilsonii.Organic Chemistry Frontiers, 2020, 7, 464–471.
31)Yuben Qiao(#), Qianqian Xu(#), Wenya Feng, Li Tao, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Yuanyuan Lu, Jianping Wang,Changxing Qi(*), Yongbo Xue(*), and Yonghui Zhang(*). Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway.Journal of Natural Products, 2019, 82, 2925–2930.
32) Weiguang Sun(#), Shanshan Luan(#),Changxing Qi(#), Qingyi Tong, Shan Yan, Hua Li(*), and Yonghui Zhang(*). Aspulvinone O, A Natural Inhibitor of GOT1 Suppresses Pancreatic Ductal Adenocarcinoma Cells Growth by Interfering Glutamine Metabolism.Cell Communication and Signaling, 2019, 17: 111.
33)Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Mengyi Deng, Yunfang Cao, Yongbo Xue(*),Changxing Qi(*), and Yonghui Zhang(*). Przewalcyrones A–F, Epoxychromene-Containing Polycyclic Polyprenylated Acylphloroglucinols with Immunosuppressive Activity fromHypericum przewalskiiMaxim.Organic & Biomolecular Chemistry, 2019, 17, 8234–8242.
34)Changxing Qi, Qun Zhou, Weixi Gao, Mengting Liu, Chunmei Chen, Xiao-Nian Li, Yongji Lai, Yuan Zhou, Dongyan Li(*), Zhengxi Hu(*), Hucheng Zhu(*), and Yonghui Zhang(*). Anti-BACE1 and Anti-AchE Activities of Undescribed Spiro-Dioxolanecontaining Meroterpenoids from the Endophytic FungusAspergillus terreusThom.Phytochemistry, 2019, 165: 112041.
35) Mengting Liu(#), Yan He(#), Ling Shen(#), Weaam Hasan Al Anbari, Huaqiang Li, Jianping Wang,Changxing Qi(*), Zhengxi Hu(*), and Yonghui Zhang(*). Asperteramide A, an Unusual N-Phenyl-Carbamic Acid Methyl Ester Trimer Isolated from the Coral-Derived FungusAspergillus terreus.European Journal of Organic Chemistry, 2019, 2928–2932.
36)Changxing Qi(#)Yuben Qiao(#), Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu, Zhengxi Hu(*), Yuan Zhou(*), and Yonghui Zhang(*).New 3,5-Dimethylorsellinic Acid-Based Meroterpenoids with BACE1 and AchE Inhibitory Activities fromAspergillus terreus.Organic & Biomolecular Chemistry, 2018, 16, 9046–9052.
37) Fengli Li(#), Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu, Shuang Lin, Sitian Zhang, Weixi Gao, Junjun Liu, Guang Du, Jianping Wang, Hucheng Zhu,Changxing Qi(*), Zhengxi Hu(*), and Yonghui Zhang(*). Anti-Inflammatory Fusicoccane-Type Diterpenoids from the Phytopathogenic fungusAlternaria brassicicola.Organic & Biomolecular Chemistry, 2018, 16, 8751–8760.
38) Changxing Qi(#), Weixi Gao(#), Danyingzi Guan(#), Jianping Wang, Mengting Liu, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Yongji Lai(*), Zhengxi Hu(*), Qun Zhou(*), and Yonghui Zhang(*). Butenolides from a Marine-Derived FungusAspergillus terreuswith Antitumor Activities Against Pancreatic Ductal Adenocarcinoma Cells.Bioorganic & Medicinal Chemistry, 2018, 26, 5903–5910.
39) Changxing Qi(#), Mengting Liu(#), Qun Zhou(#), Weixi Gao, Chunmei Chen, Yongji Lai, Zhengxi Hu, Yongbo Xue, Jinwen Zhang, Dongyan Li, Xiao-Nian Li, Qing Zhang, Jianping Wang(*), Hucheng Zhu(*), and Yonghui Zhang(*). BACE1 Inhibitory Meroterpenoids fromAspergillus terreus.Journal of Natural Products,2018, 81, 1937–1945.
40) Changxing Qi, Weixi Gao, Jianping Wang, Mengting Liu, Jinwen Zhang, Chunmei Chen, Zhengxi Hu, Yongbo Xue, Dongyan Li, Qing Zhang, Yongji Lai(*), Qun Zhou(*), Hucheng Zhu(*), and Yonghui Zhang(*). Terrusnolides A–D, New Butenolides with Anti-inflammatory Activities from an EndophyticAspergillusfromTripterygium wilfordii.Fitoterapia, 2018, 130, 134–139.
41) Mengting Liu(#),Changxing Qi(#), Weiguang Sun(#), Ling Shen, Jianping Wang, Junjun Liu, Yongji Lai, Yongbo Xue, Zhengxi Hu and Yonghui Zhang. a-Glucosidase Inhibitors From the Coral-Associated FungusAspergillus terreus.Frontiers in Chemistry, 2018, 6, 422.
42) Changxing Qi(#), Qun Zhou(#),Yuan Zhou, Zengwei Luo, Chong Dai, Hucheng Zhu, Chunmei Chen, Yongbo Xue, Jianping Wang, Yafen Wang, Yaping Liu, Ming Xiang, Weiguang Sun, Jinwen Zhang(*), Yonghui Zhang(*). Kinsenoside: A Promising Bioactive Compound fromAnoectochilusSpecies.Current Medical science, 2018, 1, 11–18.
43) Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-Guo Chen, and Yonghui Zhang.Asperterpenes A and B, Two Unprecedented Meroterpenoids fromAspergillus terreuswith BACE1 Inhibitory Activities.Chemical Science, 2016, 7, 6563–6572.
