阮汉利女，医学博士，三级教授，博士生/硕士生导师。现任华中科技大学同济药学院中药与天然药物学系主任、天然药物化学与资源评价湖北省重点实验室副主任。兼任世界中医药学联合会中药化学专业委员会常务理事、湖北省药学会中药和天然药物专委会常务委员。主持多项国家和省部级科研项目，发表学术论文170余篇，主编、副主编和参编多部本科生国家统编教材。国家精品课程和国家级一流本科课程《天然药物化学》主讲教师之一、湖北省一流本科课程《波谱解析》负责人、华中科技大学《天然药物化学》课程责任教授。
联系方式：华中科技大学同济医学院药学院1号楼409，阮汉利；邮编430030；Email: ruanhl@hust.edu.cn;ruanhl@mails.tjmu.edu.cn
硕士/博士研究生招生方向：药物化学（天然药物化学方向）、中药与天然药物学
研究方向：天然药物活性成分的提取分离、结构鉴定和活性研究
承担课程：主讲本科生《天然药物化学》、《天然药物化学实验》、《波谱解析》及研究生《结构解析》、《中药化学成分提取分离新技术》等课程
教育经历：
2001.9-2004.7：华中科技大学同济医学院药学院，获得药理学博士学位
1996.9-1999.7：同济医科大学药学院，获药物化学专业硕士学位
1985.9-1989.7：中国药科大学中药系，获理学学士学位
2014.1-2014.6：德国马尔堡大学，访问学者
2007.7-10;2008.7-10：德国杜塞尔多夫大学，访问学者
2005.9-2006.9：德国图宾根大学及杜塞尔多夫大学，访问学者
工作经历：
2014.11-今：华中科技大学同济药学院教授，硕士、博士生导师，中药与天然药物学系主任
2011.3-2014.11：华中科技大学同济药学院教授，硕士、博士生导师，天然药物化学与中药学系副主任；天然药物化学课程群负责人
2009.11-2011.2：华中科技大学同济药学院教授，硕士、博士生导师
2002.7-2009.10：华中科技大学同济药学院副教授，硕士生导师
1997.1-2002.6：华中科技大学同济医学院药学院讲师
1992.12-1996.12：同济医科大学药学院助教
主持科研项目情况：
国家自然科学基金面上项目，三种蟹甲草属植物及其内生真菌抗AD次生代谢产物及机制，22077041，2021.01-2024.12，63万。
国家自然科学基金面上项目，基于多靶点机制的三种五味子属植物及其内生真菌抗AD活性成分研究，31770380，2018.01-2021.12，60万。
国家自然科学基金面上项目，三种核桃属植物PIN1靶向抗肿瘤萘醌类成分及作用机制，21572073，2016.01-2019.12，77.4万。
国家自然科学基金面上项目，金山五味子治疗阿尔茨海默症活性成分及机制，31270394，2013.01-2016.12，80万。
湖北省卫生健康委员会中医药科研项目，兴山五味子抗阿尔茨海默症物质基础研究，2021.01-2022.12，5万。
武汉市科技攻关项目，野核桃中新型凋亡诱导剂YHT-2和YHT-3抗肿瘤成药性评价，2013.01-2015.12，30万。
国家自然科学基金面上项目，换锦花抗AD活性成分及作用机制研究，81072547，2011.1-2013.12，32万。
科技部国际合作重点项目，石蒜属植物中化学成分治疗阿尔茨海默症的临床前研究，2010DFA32430，2010.7-2013.6，89万。
国家自然科学基金面上项目，野核桃青果皮抗肿瘤活性成分及作用机制研究，30873361，2009.1-2011.12，31万。
湖北省自然科学基金项目，野核桃果皮诱导肿瘤细胞Trail基因表达活性成分研究，2006ABA125，2006.1-2007.12，4万。
中德合作PPP项目，生物信息学、分子生物学与化学相结合研究Aspergillus中次生代谢物的生物合成，2009.1-2009.12。
中德合作PPP项目，生物信息学、分子生物学与化学相结合研究真菌Aspergillus fisherianus中次生代谢物的生物合成，2007.1-2008.12。
湖北省科技攻关项目，筒鞘蛇菰抗炎镇痛作用的研究与开发，2004AA302B10，2004.1-2006.12，3万。
武汉市科技局青年科技晨光计划，湖北大戟抗肿瘤活性成分研究，20025001022，2002.1-2005.12，5万。
发表学术论文（*通讯作者）：
* Jin-Ling Chang,#Yu-Tian Gan,#Yin-Hui Zhou, Xiao-Gang Peng, Zuo-Ye Xie, Xianggao Meng, Shu-Ming Li,Han-Li Ruan*. Asperustins A−J, Austocystins with Immunosuppressive and Cytotoxic Activities fromAspergillus ustusNRRL 5856.Journal of Natural Products, 2024, ASAP, https://doi.org/10.1021/acs.jnatprod.3c01243.
* Fangfang Duan, Chunlun Qin, Zihuan Sang, Xiaoyi Wei,Hanli Ruan*. Lignans and [11]-chaetoglobosins fromPseudeurotium bakeriand their immunosuppressive activity.Organic & Biomolecular Chemistry, 2024, 22, 2271–2278.
* Jin-Ling Chang, Jiao Pei, Yin-Hui Zhou, Qian-Xi Ouyang, Chun-Lun Qin, Jia-Yun Hu, Xiang-Gao Meng,Han-Li Ruan*. Diaporaustalides A-L, Austalide Meroterpenoids from a Plant EndophyticDiaporthesp.Journal of Natural Products, 2024, 87, 141–151.
* Fangfang Duan, Xiaogang Peng, Lin Liu, Xianggao Meng, An Jin*,Hanli Ruan*.Chaepseubakerins A–J, ten undescribed cytotoxic [11]-chaetoglobosins from an endophytic fungusPseudeurotium bakeri.Phytochemistry,2024, 218: 113939.
* Jinling Chang, Qianxi Ouyang, Xiaogang Peng, Jiao Pei, Linlin Zhang, Yutian Gan, andHanli Ruan*. Peniandrastins A-H: Andrastin-Type Meroterpenoids with Immunosuppressive Activity from aPenicilliumsp.Bioorganic Chemistry, 2023, 139: 106745.
* Zhou, Ming, Jia Zhou, Xiaogang Peng, Fangfang Duan, Ying Gao, Xianggao Meng, andHanli Ruan*. Isomeric Eremophilane Lactones from the Whole Plant ofParasenecio Albusand Their Cytotoxic and Immunosuppressive Activities.Phytochemistry,2023, 214: 113821.
* Jin-Ling Chang, Yu-Tian Gan, Xiao-Gang Peng, Qian-Xi Ouyang, Jiao Pei, andHan-Li Ruan*.Peniandranoids A–E: Meroterpenoids with Antiviral and Immunosuppressive Activity from aPenicilliumsp.Journal of Natural Products,2023, 86 (1): 66–75.
* Fangfang Duan, Ying Gao, Xiaogang Peng, Xianggao Meng, Jinling Chang, Yutian Gan, Qianxi Ouyang,Hanli Ruan*. [11]-chaetoglobosins with cytotoxic activities fromPseudeurotium bakeri.Bioorganic Chemistry, 2022, 127: 106011.
* Xiaogang Peng, Junjun Liu, Chunlun Qin, Qian Wu, Wanpeng Li, Fatemeh Mohammadipanah,Hanli Ruan*. Ergochaeglobosins A-E, Unprecedented Heterodimers of Cytochalasan and Ergosterol fromChaeglobosin globosumP2-2-2.Chinese Journal of Chemistry,2022,40: 1909–1916.
* Xiaogang Peng, Jinling Chang, Ying Gao, Fangfang Duan,Hanli Ruan*.Thiocytochalasins A−D, four sulfur-containing cytochalasans from an endophytic fungusPhoma multirostrataXJ-2-1.Chinese Chemical Letters,2022, 33(10): 4572–4576.
* Ying Gao, Jia Zhou, Xianggao Meng, Qianxi Ouyang, Yutian Gan,Hanli Ruan*. Ilyomycins A−K, radicicol-type resorcylic acid lactones as potential immunosuppressants from a soil-derivedIlyonectriasp.Bioorganic Chemistry, 2022, 123, 105796.
* Ying Gao, Fangfang Duan, Jinling Chang, Xianggao Meng,Hanli Ruan*. Resorcylic acid lactones from aPodosporasp. that induce apoptosis in activated T cells through MAPKs/AKT pathway.Bioorganic Chemistry, 2022, 118: 105482.
* Xiaogang Peng, Shuang Zhou, Junjun Liu, Ying Gao, Jinling Chang andHanli Ruan*. (±)-Usphenethylones A–C, three pairs of heterodimeric polyketide enantiomers fromAspergillus ustus3.3904.Organic & Biomolecular Chemistry, 2022, 20(3): 694–700.
* Ying Gao, Ruihua Mao, Ye Liu, Ming Zhou,Hanli Ruan*. Cytochalasan Alkaloids as TRAIL Sensitizers from an Endophytic FungusChaetomiumsp.Planta Medica, 2022, 88 (14), 1293–1298.
* An Jin, Fangfang Duan, Jinling Chang, Si Liu,Hanli Ruan*. Chlorinated bisabolene sesquiterpenoids from the whole plant ofParasenecio rubescens.Fitoterapia, 2022, 156, 105093.
* Lin Liu,Hanli Ruan*. An overview of natural austalides: Structure, bioactivity and synthesis.Phytochemistry Letters, 2022, 47, 81–92.
* 金岸，刘思，李港，阮汉利*.矢镞叶蟹甲草中1个新的8-O-3′型新木脂素.中草药,2022, 53 (2): 329–333.
* Lin Liu, Fang-Fang Duan, Ying Gao, Xiao-Gang Peng, Jin-Ling Chang, Juan Chen, andHan-Li Ruan*.Aspersteroids A–C, Three Rearranged Ergostane-type Steroids fromAspergillus ustusNRRL 275.Organic Letters, 2021,23 (24): 9620−9624.
* Fang-Fang Duan, Ying Gao, Jun-Jun Liu, Lin Liu, Xiao-Gang Peng, andHan-Li Ruan*.Pseudeurglobosins A-F, Six Rearranged [11]-Chaetoglobosins with Immunosuppressive Activities fromPseudeurotium BakeriP1-1-1.Organic Chemistry Frontiers,2021, 8(24), 7015–7024.
* Ming Zhou, Fangfang Duan, Ying Gao, Xiaogang Peng, Xianggao Meng, andHanli Ruan*.Eremophilane Sesquiterpenoids from the Whole Plant ofParasenecio albuswith Immunosuppressive Activity.Bioorganic Chemistry,2021, 115: 105247.
* Fang-Fang Duan, Lin Liu, Ying Gao, Xiao-Gang Peng, Xiang-Gao Meng,Han-Li Ruan*.[11]-Chaetoglobosins fromPseudeurotium bakeriInduce G2/M Cell Cycle Arrest and Apoptosis in Human Cancer Cells.Journal of Natural Products,2021, 84(7): 1904–1914.
* Ying Gao, Fang-Fang Duan, Lin Liu, Xiao-Gang Peng, Xiang-Gao Meng, andHan-Li Ruan*.Hypothemycin-Type Resorcylic Acid Lactones with Immunosuppressive Activities from aPodosporasp.Journal of Natural Products, 2021, 84(2), 483–494.
* Lin, Yi, Jingjing Liang, Xiaogang Peng, andHanli Ruan*.Phenolic Constituents from the Fresh Pericarps ofJuglans sigillata.Natural Product Research,2021, 35(8): 1242–1248.
* Lin, Yi, Xiaogang Peng, Juan Chen, Jia Zhou, andHanli Ruan*Triterpenoids from the Fresh Pericarps ofJuglans Hopeiensis.Natural Product Research,2021, 35(2): 228–235.
* Xiao-Gang Peng, Junjun Liu, Ying Gao, Fang Cheng, Jin-Ling Chang, Juan Chen, Fang-Fang Duan andHan-Li Ruan*.Pchaeglobolactone A, Spiropchaeglobosin A, and Pchaeglobosals A and B: Four Rearranged Cytochalasans fromChaetomium globosumP2-2-2.Organic Letters, 2020, 22(24), 9665–9669.
* Juan Chen, Xiao-Gang Peng, Junjun Liu, Ying Gao, Ming Zhou, Jia Zhou, Jian Song, andHan-Li Ruan*.Incarnolides A and B, Two Schinortriterpenoids with a Tricyclo[9.2.1.02,8]tetradecane-Bridged System fromSchisandra incarnata.Organic Letters,2020, 22(3): 1071–1075.
* Jin-Ling Chang, Hong-Zhe Xu, Jia Zhou, Ming Zhou, Xuke Zhang, Yuanqiang Guo andHan-Li Ruan*.Antimicrobial Furancarboxylic Acids from aPenicilliumsp.Journal of Natural Products,2020, 83 (12): 3606–3613.
* Jia Zhou, Ying Gao, Jin-Ling Chang, Heng-Yi Yu, Juan Chen, Ming Zhou, Xiang-Gao Meng, andHan-Li Ruan*Resorcylic Acid Lactones from anIlyonectriasp.Journal of Natural Products,2020, 83(5): 1505–1514.
* Xiaogang Peng, Yangzhou He, Ying Gao, Fangfang, Duan, Juan Chen, andHan-Li Ruan*.Cytochalasins from an endophytic fungusPhoma multirostrataXJ-2-1 with cell cycle arrest and TRAIL-resistance-overcoming activities.Bioorganic Chemistry,2020, 104, 104317.
* Xiaogang Peng, Fangfang Duan, Yangzhou He, Ying Gao, Juan Chen, Jinling Chang andHanli Ruan*. Ergocytochalasin A, a polycyclic merocytochalasan from an endophytic fungusPhoma multirostrataXJ-2-1.Organic & Biomolecular Chemistry, 2020, 18, 4056–4062.
* Ming Zhou, Xiaogang Peng, Jia Zhou, Yie Liu, Xianggao Meng,Hanli Ruan*. Triterpenoids from the stems and leaves ofSchisandra incarnata.Phytochemistry, 2020, 177, 112448.
* Ying Gao, Jia Zhou,Hanli Ruan*. Trichothecenes from an Endophytic FungusAlternariasp. sb23.Planta Medica,2020,86 (13/14): 976–982.
* Xiaogang Peng, Yi Lin, Jingjing Liang, Ming Zhou, Jia Zhou,Hanli Ruan*.Triterpenoids from the barks ofJuglans hopeiensis.Phytochemistry,2020. 170, 112201.
* Yi Lin, Xiaogang Peng,Hanli Ruan*.Diarylheptanoids from the fresh pericarps ofJuglans hopeiensis.Fitoterapia,2019, 136, 104165.
* Jing-Jing Liang, Jia Zhou, Jian Song, andHan-Li Ruan*. Anthraquinone and Naphthoquinone Derivatives from the Pericarps ofJuglans sigillata.Chemistry of Natural Compounds, 2019, 55(3): 435-439.
* Aiqian Li#, Zhifeng Du#, Mei Liao, Yulin Feng,Hanli Ruan*and Hongliang Jiang*.Discovery and Characterisation of Lycorine-Type Alkaloids inLycorisSpp. (Amaryllidaceae) Using UHPLC-QTOF-MS.Phytochemical Analysis, 2019, 30: 268–277.
* Wenming Wu &Hanli Ruan*Triterpenoids and lignans from the stems ofSchisandra glaucescens.Natural Product Research, 2019, 33(3), 328–334.
* Ming Zhou, Jia Zhou, Junjun Liu, Jing-Jing Liang, Xiao-Gang Peng, Fang-Fang Duan, andHan-Li Ruan*. Parasubindoles A-G, Seven Eremophilanyl Indoles from the Whole Plant ofParasenecio albus.The Journal of Organic Chemistry, 2018, 83 (19), 12122–12128.
* Jian Song, Ming Zhou, Jia Zhou, Jing-Jing Liang, Xiao-Gang Peng, Junjun Liu, andHan-Li Ruan*. Schincalactones A and B, Two 5/5/6/11/3 Fused Schinortriterpenoids with a 13-Membered Carbon Ring System fromSchisandra incarnate.Organic Letters, 2018, 20 (8), 2499-2502.
* Ye Liu, Heng-Yi Yu, Hong-Zhe Xu, Jun-Jun Liu, Xiang-Gao Meng, Ming Zhou, andHan-Li Ruan*. Alkaloids with Immunosuppressive Activity from the Bark ofPausinystalia yohimbe.Journal of Natural Products, 2018, 81 (8), 1841–1849.
* Jingjing Liang, Xiaogang Peng, Jia Zhou, Ming Zhou &Hanli Ruan*Diarylheptanoids from the fresh pericarps ofJuglans sigillata.Natural Product Research, 2018, 32(20), 2457-2463.
* Jian Song, Ye Liu, Ming Zhou, Hui Cao, Xiao-Gang Peng, Jing-Jing Liang, Xiao-Ya Zhao, Ming Xiang,Han-Li Ruan*. Spiroschincarins A–E: Five Spirocyclic Nortriterpenoids from the Fruit ofSchisandra incarnata.Organic Letters, 2017, 19 (5), 1196–1199.
* Ye Liu, Heng-Yi Yu, Yan-Mei Wang, Tian Tian, Wen-Ming Wu, Ming Zhou, Xiang-Gao Meng,Han-Li Ruan*. Neuroprotective Lignans from the Fruits ofSchisandra bicolorvar.tuberculata.Journal of Natural Products, 2017, 80 (4), 1117–1124.
* Ye Liu, Tian Tian, Heng-Yi Yu, Ming Zhou,Han-Li Ruan*. Nortriterpenoids from the stems and leaves ofSchisandra viridis.Fitoterapia, 2017, 118: 38-41.
* An Jin, Wen-Ming Wu,Han-Li Ruan*.Sesquiterpenoids and monoterpenoid coumarins fromParasenecio rubescens.Rsc Advances, 2017, 7(9), 5167–5176.
* Ye Liu,Yan-Mei Wang, Wen-Ming Wu, Jian Song,Han-Li Ruan*. Triterpenoids and lignans from the fruit ofSchisandra sphenanthera.Fitoterapia, 2017, 116:10–16.
* Ming Zhou, Ye Liu, Jian Song, Xiao-Gang Peng, Qi Cheng, Hui Cao, Ming Xiang, andHan-Li Ruan*,Schincalide A, a Schinortriterpenoid with a Tricyclo[5.2.1.01,6]decane-Bridged System from the Stems and Leaves ofSchisandra incarnate.Organic Letters, 2016, 18 (18), 4558–4561.
* Wen-Ming Wu, Xu Chen, Ye Liu, Yan-Mei Wang, Tian Tian, Xiao-Ya Zhao, Juan Li,Han-Li Ruan*. Triterpenoids from the branch and leaf ofAbies fargesii.Phytochemistry, 2016,130, 301–312.
* Heng-Yi Yu, Juan Li, Ye Liu, Wen-Ming Wu,Han-Li Ruan*. Triterpenoids from the fruit ofSchisandra glaucescens.Fitoterapia, 2016, 113, 64–68.
* Wen-Ming Wu, Ye Liu, Xu Chen, An Jin, Ming Zhou, Tian Tian,Han-Li Ruan*, Diterpenoids from the branch and leaf ofAbies fargesii.Fitoterapia, 2016, 110: 123-128.
* 毛瑞华，吴文明，方伟，阮汉利*.海洋真菌Aspergillus fumigatus次生代谢产物研究.天然产物研究与开发, 2016, 28: 1857–1863.
* 毛瑞华,钟志宏,吴文明,刘叶,阮汉利*.鄂西大蓟茎叶化学成分研究.中草药, 2016, 47(13): 2236–2240.
* Tian Tian, Ye Liu, Heng-Yi Yu, Yun-Yun Zhu, Xiao-Ya Zhao,Han-Li Ruan* Dibenzocyclooctadiene Lignans from the Fruits ofSchisandra viridis.Chemistry of Natural Compounds, 2015,51 (6):1046–1048.
* An Jin, Wen-Ming Wu, Heng-Yi Yu, Ming Zhou, Ye Liu, Tian Tian, andHan-Li Ruan* Bisabolane-Type Sesquiterpenoids from the Whole Plant ofParasenecio rubescens.Journal of Natural Products, 2015,78 (8): 2057–2066.
* Yun-Yun Zhu, Xue Li, Heng-Yi Yu, Yu-Fang Xiong, Peng Zhang, Hui-Fang Pi,Han-Li Ruan*Alkaloids from the bulbs ofLycoris longitubaand their neuroprotective and acetylcholinesterase inhibitory activities.Archives of Pharmacal Research, 2015, 38(5): 604–613.
* Yuan Gan, Yang Zhang, Aiqian Li, Chengwu Song, Chang Chen, Yong Xu,Hanli Ruan*, Hongliang*. Jiang, A Novel Four-step Approach for Systematic Identification of Naphthoquinones inJuglans cathayensisDode using Various Scan Functions of Liquid Chromatography-Tandem Mass Spectrometry along with Data Mining Strategies.Phytochemical Analysis,2015, 26(6): 413–422.
Zhenzhong Chen, Ling Tong, Yuanli Feng, Jizhou Wu, Xiaoya Zhao,Hanli Ruan, Huifang Pi, Peng Zhang, Ursane-type nortriterpenes with a five-membered A-ring fromRubus innominatus.Phytochemistry,2015, 116, 329–336.
* Heng-Yi Yu, Zu-Yu Chen, Bin Sun, Junjun Liu, Fan-Yu Meng, Ye Liu, Tian Tian, An Jin, andHan-Li Ruan*, Lignans from the Fruit ofSchisandra glaucescenswith Antioxidant and Neuroprotective Properties.Journal of Natural Products, 2014, 77 (6): 1311–1320.
* An Jin, Xue Li, Yun-Yun Zhu, Heng-Yi Yu, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Four New Compounds from the Bulbs ofLycoris aureawith Neuroprotective Effects against CoCl2and H2O2-induced SH-SY5Y Cell Injuries.Archives of Pharmacal Research, 2014, 37: 315–323.
* Wen-Ming Wu, Yun-Yun Zhu, Hao-ran Li, Heng-Yi Yu, Peng Zhang, Hui-Fang Pi,Han-Li Ruan*Two new alkaloids from the bulb ofLycoris sprengeri.Journal of Asian Natural Products Research, 2014, 16(2): 192–199.
Ke Jiao, Huo-Yun Li, Peng Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu Two new ent-kaurane diterpenoids from the aerial parts ofIsodon excisoides.Chinese Chemical Letters,2014, 25(1): 131–133.
Ling Tong, Tu Chen, Zhenzhong Chen, Peng Zhang, Huifang Pi,Hanli Ruan, Jizhou. Wu, Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae.Journal of Ethnopharmacology,2014, 155 (3), 1553–1560.
Juan Li, Hang Chang, Wenyu Zhao, Huifang Pi, Hanli Ruan, Peng. Zhang, New Alkaloids fromAconitum vaginatum.Helvetica Chimica Acta,2014, 97 (5), 689–693.
* Heng-Yi Yu, Xiao-Qiong Zhang, Xue Li, Fan-Bo Zeng,Han-Li Ruan*.2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma Model.Journal of Natural Products, 2013, 76(5): 889−895.
* Juan Li, Jia-Xiang Sun, Heng-Yi Yu, Zu-Yu Chen, Xiao-Ya Zhao,Han-Li Ruan*Diarylheptanoids from the root bark ofJuglans cathayensis.Chinese Chemical Letters, 2013, 24: 521–523.
* Xue Li, Heng-Yi Yu, Zhuo-Yi Wang, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Neuroprotective Compounds from the Bulbs ofLycoris radiate.Fitoterapia,2013, 88: 82–90.
Ke Jiao, Huo-Yun Li, Peng Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu Three new ursane-type triterpenoids from the aerial parts ofIsodon excisoides.Journal of Asian Natural Products Research,2013, 15(9): 962–968.
Kun Yang, Ling Tong, Chunxia Chen, Peng Zhang, Huifang Pi,Hanli Ruan, Jizhou. Wu, Therapeutic effects of extracts from Radix Toddaliae Asiaticae on collagen-induced arthritis in Balb/c mice.Journal of Ethnopharmacology,2013, 146 (1), 355–362.
* Heng-Yi Yu, Cui Hao, Fan-Yu Meng, Xue Li, Zu-Yu Chen, Xi Liang,Han-Li Ruan*Neuroprotective Lignans from the Stems ofSchisandra glaucescens.Planta Medica2012, 78: 1962–1966.
* Jia-Xiang Sun, Xiao-Ya Zhao, Xiao-Fang Fu, Heng-Yi Yu, Xue Li, Shu-Ming Li,Han-Li Ruan*Three new naphthalenyl glycosides from the root bark ofJuglans cathayensis.Chemical and Pharmaceutical Bulletin2012, 60: 785–789.
Kathrin Mundt, Beate Wollinsky,Han-Li Ruan, Tianjiao Zhu and Shu-Ming Li, Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.Chembiochem,2012, 13(17): 2583–2592 (This paper was selected as issue cover).
* Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Heng-Yi Yu, Shu-Ming Li, andHan-Li Ruan*. Schiglautone A, a New Tricyclic Triterpenoid with a Unique 6/7/9-Fused Skeleton from the Stems ofSchisandra glaucescens.Organic Letters,2011, 13 (6): 1502–1505.
* Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*. Triterpenoids from the Stems ofSchisandra glaucescens.Helvetica Chimica Acta, 2011, 94(10):1778–1785.
* Heng-Yi Yu, Xue Li, Fan-Yu Meng, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Naphthoquinones from the root barks ofJuglans cathayensisDode.Journal of Asian Natural Products Research, 2011,13 (7): 581–587.
Lujun Li, Yue Zhang, Peng Zhang, Huifang Pi,Hanli Ruan,Jizhou Wu. Appraisal of anti-inflammatory and free radical scavenging activities of ethanol extract ofIlex ficoideaHemsl andIlex centrochinensisS.Y. Hu.Environmental Toxicology and Pharmacology,2011, 32(2), 122–127.
Yue Zhang, Lu-Jun Li, Peng Zhang, Hui-Fang Pi,Han-Li Ruan,Ji-Zhou Wu. Three New E-Secoursane Triterpenoid Saponins from the Leaves ofIlex dunniana.Helvetica Chimica Acta,2011, 94(12): 2207–2214.
Chunxia Chen, Peng Zhang, Huifang Pi,Hanli Ruan, Zehua Hu, Jizhou Wu. Extracts of Arisaema rhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice.Journal of Ethnopharmacology,2011, 133: 573–582.
Lu-Jun Li, Yue Zhang, Peng Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu. Flavans from the leaf ofIlex centrochinensis.Journal of Asian Natural Products Research,2011, 13(4): 367–372.
Lu-Jun Li, Yue Zhang, Peng Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu. Two new 5,8-quinoflavans from the leaf ofIlex centrochinensis.Journal of Asian Natural Products Research,2011, 13(4): 341–345.
* 陈超，胡钰，孙家祥，皮慧芳，张鹏，阮汉利*.野核桃叶化学成分研究.中草药, 2011，42(11), 2177–2180.
张悦,李陆军,张鹏,皮慧芳,阮汉利,吴继洲.冬青属两种植物的抗炎作用及自由基清除能力研究.华中科技大学学报(医学版), 2011, 40(1), 71–74.
* 张悦，阮汉利*，张勇慧，皮慧芳，吴继洲鄂西大蓟根的化学成分的研究.天然产物研究与开发，2010, 22(1): 58–59.
Han-Li Ruan, Edyta Stec and Shu-Ming Li. Production of diprenylated indole derivatives by tandem incubation of two recombinant dimethylallyltryptophan synthases.Archives of Microbiology2009, 191: 791–795.
* Hui-fang Pi, Peng Zhang,Han-li Ruan*, Yong-hui Zhang, Han-dong Sun, Ji-zhou Wu. A new triterpenoid from the leaves and stems ofFritillaria hupehensis.Journal of Asian Natural Products Research, 2009,11 (9): 779–782.
Nicola Steffan, Alexander Grundmann, Shamil Afiyatullov,Hanli Ruanand Shu-Ming Li FtmOx1, a non-heme Fe(II) and a-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen inAspergillus fumigatus.Organic & Biomolecular Chemistry, 2009, 7(19): 4082–4087.
Jiu-liang Zhang, Hui Wang, Hui-fang Pi,Han-li Ruan, Peng Zhang, Ji-zhou Wu. Structural analysis and antitussive evaluation of five novel esters of verticinone and bile acids.Steroids, 2009, 74(4-5), 424–434.
Xue-Feng Zhou, Lan Tang, Peng Zhang, Xiao-Ya Zhao, Hui-Fang Pi, Yong-Hui Zhang,Han-Li Ruan, Yonghong Liu, Ji-Zhou Wu. The interleukin-18 inhibitory activities of echinocystic acid and its saponins fromImpatiens pritzelliivar.hupehensis.Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 2009, 64(5/6), 369–372.
Xue-Feng Zhou, Peng Zhang, Hui-Fang Pi, Yong-Hui Zhang,Han-Li Ruan, Hui Wang, Ji-Zhou Wu. Triterpenoids from the Roots ofActinidia chinensis.Chemistry & Biodiversity, 2009, 6(8), 1202–1207.
徐仿周,张鹏,张勇慧,阮汉利,皮慧芳,吴继洲.湖北贝母总生物碱平喘作用及其机理的研究.时珍国医国药,2009, 20(6): 1335–1337.
徐仿周,陈昶,阮汉利,张勇慧,皮慧芳,吴继洲.湖北贝母有效部位提取工艺的研究时珍国医国药,2009, 20(5): 1033–1034.
Han-Li Ruan,Wen-Bing Yin,Ji-Zhou Wu, Shu-Ming Li.Reinvestigation of a Cyclic Dipeptide N-Prenyltransferase Reveals Rearrangement of N-1 Prenylated Indole Derivatives.ChemBioChem, 2008, 9: 1044–1047.
* Hui-Fang Pi, Zhi-Hong Zhong,Han-Li Ruan*,Peng Zhang, Yong-Hui Zhang, Ji-Zhou Wu. A new hopane triterpenoid fromSaxiglossum angustissimum.Chinese Chemical Letters, 2008, 19: 835–836.
* Yi-xiu Li,Han-li Ruan*, Xue-feng Zhou, Yong-hui Zhang, Hui-fang Pi, Ji-zhou Wu. Cytotoxic Diarylheptanoids from Pericarps ofJuglans CathayensisDode.Chemical Research in Chinese Universities,2008, 24(4): 427–429.
Yonghui Zhang, Xiliang Yang, Peng Zhang, Xuefeng Zhou,Hanli Ruan, Huifang Pi, Jizhou Wu, Handong Sun. Cytotoxic alkaloids from the bulbs ofFritillaria hupehensis.Chemistry & Biodiversity,2008, 5(2): 259–266.
Peng Zhang, Juan Li, Guoxin Zhang, Huifang Pi, Yonghui Zhang, Hanli Ruan, Jizhou Wu. Analysis of hupehenine in the total alkaloids from Fritillaria hupehensis by HPLC-ELSD. Journal of Huazhong University of Science and Technology, Medical Sciences, 2008, 28(1): 118–120.
* Han-Li Ruan*, Xue-Feng Zhou, Yong-Hui Zhang, Hui-Fang Pi, Ji-Zhou Wu, Han-Dong Sun. Ferulic acid esters fromEuphorbia hylonoma.Fitoterapia,2007, 78(1), 72–73.
* Hui Fang Pi, Peng Zhang, Tian Zhu,Han Li Ruan,*Yong Hui Zhang, Han Dong Sun, Ji Zhou Wu. A new cycloartane triterpenoid from the leaves and stems ofFritillaria hupehensis.Chinese Chemical Letters,2007, 18(4): 418–420.
Wen-Bing Yin,Han-Li Ruan, Lucia Westrich, Alexander Grundmann, Shu-Ming Li.CdpNPT, an N-prenyltransferase fromAspergillus fumigatus: overproduction, purification and biochemical characterization.ChemBioChem,2007, 8(10): 1154–1161.
Yonghui Zhang, Jinyan Cai,Hanli Ruan, Huifang Pi, Jizhou Wu. Antihyperglycemic activity of kinsenoside, a high yielding constituent fromAnoectochilus roxburghiiin streptozotocin diabetic rats.Journal of Ethnopharmacology,2007, 114(2): 141–145.
Xuefeng Zhou, Xiaoya Zhao, Lan Tang, Yonghui Zhang,Hanli Ruan,Huifang Pi, Jun Qiu, Jizhou Wu.Immunomodulatory activity of the rhizomes ofImpatiens pritzelliivar.hupehensison collagen-induced arthritis mice.Journal of Ethnopharmacology,2007, 109(3): 505–509.
Yong-Hui Zhang, Xi-Liang Yang, Xue-Feng Zhou,Han-Li Ruan, Hui-Fang Pi, Ji-Zhou Wu, Han-Dong Sun. Alkaloids fromFritillaria hupehensis.Chinese Journal of Chemistry,2007, 25(11): 1728–1731.
Fang-zhou Xu, Chang Chen, Yong-hui Zhang,Han-li Ruan, Hui-fang Pi, Peng Zhang, Ji-zhou Wu. Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent.Acta Pharmacologica Sinica,2007, 28(10): 1591–1596.
Yong-Hui Zhang, Xi-Liang Yang, Xue-Feng Zhou,Han-Li Ruan, Hui-Fang Pi, Ji-Zhou Wu, Han Dong Sun, Tetsuro Fujita. A new veratramine alkaloid from the bulbs ofFritillariahupehensis.Chinese Chemical Letters,2007, 18(2): 175–177.
Xue-Feng Zhou, Lan Tang, Yong-Hui Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu. Nitrogenous compounds fromImpatiens pritzelliivar.hupehensis(Balsaminaceae).Biochemical Systematics and Ecology,2007, 35(5): 308–310.
Fang-Zhou Xu, Chang Chen, Yong-Hui Zhang,Han-Li Ruan, Hui-Fang Pi, Peng Zhang, Ji-Zhou Wu. Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent.Acta Pharmacologica Sinica,2007, 28(10): 1591–1596.
Xue-Feng Zhou, Xiao-Ya Zhao, Lan Tang,Han-Li Ruan, Yong-Hui Zhang, Hui-Fang Pi, Wei-Lie Xiao, Han-Dong Sun, Ji-Zhou Wu*. Three new triterpenoid saponins from the rhizomes ofImpatiens pritzelliivar.hupehensis.Journal of Asian Natural Products Research,2007, 9(4): 379–385.
Hui-Fang Pi,Han-Li Ruan, Yong-Hui Zhang, Ji-Zhou Wu.Two new steroidal alkaloids from bulbs ofFritillaria lichuanensis.Journal of Asian Natural Products Research,2006,8(3):253–257.
Hui-Fang Pi,Han-Li Ruan, Yong-Hui Zhang, Lei-Ming Niu, Ji-Zhou Wu. Steroidal alkaloids from bulbs ofFritillaria lichuanensis.Journal of Asian Natural Products Research,2006, 8(1-2): 133–136.
Yong-hui Zhang,Han-li Ruan, Hui-fang Pi, Jin-yan Cai, Ji-zhou Wu. A new steroidal alkaloid from bulbs ofFritillaria HupehensisHsiao et K.C. Hsia.Chemical Research of Chinese Universities, 2004, 20 (6): 804–806.
Yong-Hui Zhang，Han-Li Ruan，Hui-Fang Pi，Ji-Zhou Wu，Tetsuro Fujita. Structural elucidation of fritillahupehin from bulbs ofFritillaria HupehensisHsiao et K. C. Hsia.Journal of Asian Natural Products Research,2004, 6(1): 29–34.
Han-li Ruan, Yong-hui Zhang, Ji-zhou Wu. Two new diterpenoid dimers, fritillebinide D and E, from bulbs ofFritillaria ebeiensis.Journal of Asian Natural Products Research,2002,4(4): 309–314.
Han-li Ruan, Yong-hui Zhang, Ji-zhou Wu.Structure of a novel diterpenoid ester, fritillahupehin, from bulbs ofFritillaria hupehensisHsiaoetK. C. Hsia.Fitoterapia,2002: 73(4): 288–291.
Ji-zhou Wu,Han-li Ruan, Nian-huan Yao.Structures of Two Diterpenoid Dimers from Bulbs ofFritillaria ebeiensis.Journal of Asian Natural Products Research,2000, 2(3): 161–167.
Ji-zhou Wu, Yu-ping Wen,Han-li Ruan. Structural Elucidation of TwoEnt-kauran Dimers from Bulbs ofFritillariaebeiensisvar.purpurea.Journal of Asian Natural Products Research,2000, 2(3): 213–218.
Ji-zhou Wu,Han-li Ruan, Chun-lan Zeng. Structures of Two New Diterpenoid Dimers from Bulbs ofFritillaria ebeiensis.Journal of Asian Natural Products Research,1999, 1: 251–257.
专利申请：
1. 2004100607538湖北贝母中提取的单体生物碱在制备镇咳祛痰平喘药物中的应用
2. 2004100607542浙贝乙素及其衍生物在制备镇咳祛痰平喘药物中的应用
3. 2004100607523浙贝乙素及其衍生物在制备抗肿瘤药物中的应用
4. 2006100190270浙贝乙素和胆汁酸的衍生物及药物组合物
5. 2008100487229浙贝乙素胆汁酸酯及其制备方法和应用
6. 2009100611697用于预防或治疗痴呆症的组合物
7. KR 2010104064Lycoris aureaextracts for preventing and treating dementia, Repub. Korean
8. 2010105959577两个萘醌类化合物在制备抗肿瘤类药物中的应用
9. WO 2012/026641 A1 Composition for preventing or treating dementia
10. 2012104169575 一种木脂素类化合物及其制备方法和应用
11. 2012104179007 一种木脂素类化合物及其在防治阿尔茨海默症中的应用
12. 2013100756654 具有神经保护作用的石蒜科生物碱类化合物
13. 2013100764684 具有神经保护作用的石蒜伦碱类化合物
14. 2013100764665 一个具有神经保护作用的石蒜碱类化合物
15. 2013106738541 一种用于预防和治疗阿尔茨海默症的药物及其制备方法
编写教材：
主编《天然药物化学》(医药科技出版社，2021年7月出版)；（全国普通高等医学院校“十四五”药学类专业规划教材）；
主编《天然药物化学》(医药科技出版社，2016年1月出版)；（全国药学类专业“十三五”规划教材）；
副主编《天然药物化学题库》(人民卫生出版社，2019年)；
副主编《天然药物化学》(医药科技出版社，2015年8月出版)；
参编《波谱解析》第3版(人民卫生出版社，2023年出版)；
参编《中药化学》(中国中医药出版社，2017年8月出版)；（全国中医药行业高等教育十三五规划教材）；
参编《波谱解析》第2版(人民卫生出版社，2016年出版)；
参编《波谱解析》(中医药出版社，2014年出版)；
副主编《天然药物化学》(高等教育出版社，2010年5月出版)；
参编《波谱解析》(人民卫生出版社，2011年7月出版)；
参编《天然药物化学》(医药科技出版社，2008年8月出版)；
参编《天然药物化学图表解》(人民卫生出版社，2008年10月出版)；
参编《天然药物化学学习指导》(人卫出版社，2005年2月出版)；
参编《天然药物化学习题集》第二版(人卫出版社，2007年8月出版)；
参编《药物计量学》(医药科技出版社，2006年4月出版)。
专著：
副主编《华中地区常见常用药用植物图鉴》(科学出版社，2021；ISBN 978-7-03-067197-4)。
参编《鄂西常用药用植物图鉴》(湖北科学技术出版社，2020；ISBN 978-7-5706-1178-2)。
参加会议：
2023.9.23−2023.9.26，真菌中的二羟基苯甲酸内酯类成分及其生物活性研究,中国化学会第十四届全国天然有机化学学术会议,武汉香格里拉大酒店, (会议报告)
2022.9.23−2022.9.25，Study on the Chemical Constituents and Biological Activities of SeveralSchisandraPlants,世界著名科学家来鄂讲学武汉论坛暨食品安全与健康国际研讨会,武汉欧亚会展国际酒店, (会议报告)
2021.10.8−11，世界中医药学会联合会中药化学专业委员会第九届学术年会，兰州，中国
2016.9.25−28,中国化学会第十一届全国天然有机化学学术会议，上海，中国
2014.11.21−23,中国化学会第十届全国天然有机化学学术会议，广州，中国
2014.10.20−24, 28th International Symposium on the Chemistry of Natural Products and the 8th International Conference on Biodiversity (ISCNP28 & ICOB8), Shanghai, China
2012.8.23−26,韩国首尔the 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy (第7届中日韩三国生药学联合学术研讨会)交流论文Diarylheptanoids from the root bark ofJuglans cathayensisDode
2011.8.10−12,昆明野核桃根皮化学成分研究，第十届全国药用植物及植物药学术研讨会PP159
2010.10.24−26.Zongfang Wang, Hengyi Yu, Hanli Ruan*, Huifang Pi, Peng Zhang, Jizhou Wu.Five new compounds fromJuglans cathayensisthe 5th JSP-CCTCNM-KSP Joint Symposium.Tokushima-Japan.
2008.3.4.Nicola Steffan, Inge Unsöld, Alexander Grundmann, Wen-Bing Yin, Anika Kremer, Hanli Ruan, Shu-Ming Li.Evolution of aromatic prenyltransferases in the biosynthesis of indole derivatives.7thColloquium of SPP 1152: Evolution of Metabolic Diversity,Halle (Saale), Germany.
2007.6.22.Wen-Bing Yin, Han-Li Ruan, Lucia Westrich, Alexander Grundmann and Shu-Ming Li. CdpNPT, an N-prenyltransferase fromAspergillus fumigatus: Overproduction, purification and biochemical characterization.Tag des Wissenschaftlichen Nachwuchses“, HHU Düsseldorf.
2007.10.4−6. Wen-Bing Yin, Han-Li Ruan, Lucia Westrich, Alexander Grundmann and Shu-Ming Li.CdpNPT, a tryptophan-containing cyclic dipeptide N1-prenyltransferase fromAspergillus fumigatus. VAAM International Workshop: Biology of Bacteria Producing Natural Products,European Academy Otzenhausen, Germany.
2007. 12. 4−5:江西南昌交流论文A new Diarylheptanoid fromJuglans cathayensisDode第九届全国中药和天然药物学术研讨会
2000.3.17−19：中国昆明交流论文Diterpenoids from the bulbs ofFritillaria ebeiensisvar. purpurea。UNESCO Regional Symposium on Chemistry of Medicinal Plants.
1997.10.28−31：日本京都交流论文Structures of Six Novel Diterpenoids fromFritillaria ebeiensis. International Symposium on Natural Medicines, Kyoto, Japan.
获奖情况：
2003年被评为华中科技大学“三育人积极分子”。2001-2002学年获华中科技大学教学质量优秀二等奖。1999、2000、2001、2015、2017、2018、2019、2021年考核优秀。2005年湖北省自然科学三等奖（排名第二）。2005年华中科技大学优秀博士学位论文。2009和2010年指导本科生论文获湖北省大学本科生毕业论文一等奖。
