童擎一，博士，副教授，博士生导师。2014年6月毕业于四川大学生物治疗国家重点实验室，获医学博士学位。2014年7月到华中科技大学同济医学院药学院做博士后，2018年5月留校任讲师，2019年11月至今任副教授。承担本科生《药理学》，研究生《药学生物技术》、《应用药理学》等课程的理论和实验教学，参与的《药理学》分别获2022年国家级和2021年省级一流本科课程认定。已在Cell Discovery, Nucleic Acids Research，Angewandte Chemie-International Edition, Frontiers in Immunology，Organic Letters和Chinese Chemical Letters等学术期刊上发表SCI论文50余篇，其中一作和通讯（含共同）论文26篇，总引用近1200，H因子22。主持国自然面上和青年等基金项目9项，申请专利多项。作为参与人获2021年度湖北省科学技术奖一等奖1项。任中国药理学会会员、抗炎免疫药理专业青委会委员，湖北省毒理学会、药理学会理事，中国免疫学会会员、中医药免疫分会委员。Current Medical Science、医药导报、中国药师等杂志编委、审稿人。
研究方向
1.新药发现及前期研究：从病理出发，构建肿瘤、器官损伤、炎症等疾病模型，从新颖天然产物及其衍生物中筛选出活性分子，或从头设计并筛选出具有相关活性的小分子、嵌合分子（PROTAC、ADC）等，并系统研究它们的作用和机制。
2.活性天然产物的作用靶点研究：采用化学生物学、蛋白组学等技术在分子和细胞水平上研究活性天然产物的作用靶点，并在体外和体内疾病模型上对靶点进行确证。
联系方式
邮箱：qytong@hust.edu.cn
地址：武汉市硚口区航空路13号同济药学院2号楼413/转化医学楼1418
主持的科研项目
1. 国家自然科学基金面上项目，靶向DNA的新型菲啶酮衍生物抗胶质母细胞瘤研究,项目号82073886，2021/01-2024/12
2. 湖北省科技重大项目子课题，创新药物筛选技术研发与集成子课题,项目号2021ACA012，2021/07/01-2024/06/20
3. 湖北省中医药管理局面上项目，水仙来源的生物碱及其衍生物抗肿瘤研究,项目号ZY2023M063，2023/01/01-2024/12/31
4. 湖北省自然科学基金面上项目，小分子化合物ZYH005的抗癌作用靶点研究,项目号2019CFB428，2019/09-2021/08
5. 华中科技大学自主创新研究基金，新型菲啶酮衍生物抗肿瘤作用与机制研究,项目号2172019kfyXJJS166，2019/01-2021/12
6. 国家自然科学基金青年科学基金，葱莲生物碱类化合物的抗白血病作用及机理研究,项目号81503305，2016/01-2018/12
7. 中国博士后科学基金第66批面上项目，项目号2019M660125，2018/01-2019/12
8. 中国博士后科学基金第58批面上项目，项目号2015M582227，2014/08-2016/07
9. 华中科技大学博士后科学基金,项目号2006514110，2014/08-2016/07
参编教材
1.《药理研究方法学》2021中国医药科技出版社，编委
2.《药物毒理学》2019中国医药科技出版社 第四版，编委
主要学术论文(#Co-first author, *Correspondence author, Update on 230802)
1. Jie Yin, Ziming Zhao, Jianzheng Huang, Yang Xiao, Mewlude Rehmutulla, Biqiong Zhang, Zijun Zhang, Ming Xiang,Qingyi Tong*, Yonghui Zhang*.Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.Cell Discovery9, 77 (2023). https://doi.org/10.1038/s41421-023-00578-4（IF=33.5, Q1）
2. Qingyi Tong#, Huijuan You#, Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo*, Yonghui Zhang*, ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acidresistance in acute promyelocytic leukemia. Nucleic Acids Research, 2018,46(7):3284–3297.（IF=14.9, Q1）
3. Hucheng Zhu#, Chunmei Chen#,Qingyi Tong#, Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang*, Asperflavipine A, an unprecedented cytochalasan heterotetramer uniquely defined by a highly complicated tetradecacyclic ring system from Aspergillus flavipes QCS12, Angewandte Chemie-International Edition, 2017,56(19):5242–5246.（IF=16.6,Q1）
4. Yu Liang#, Biqiong Zhang#, Dongyan Li#, Xuanni Chen, Qiwei Wang, Benlong Shu, Qin Li,Qingyi Tong*, Chunmei Chen*, Hucheng Zhu*, Yonghui Zhang*, Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity, Bioorganic Chemistry 139(1):106736.（IF=5.1, Q1）
5. Nan Qiao#, Zhaohong An#, Zeyu Fu, Xingyu Chen,Qingyi Tong*, Yonghui Zhang*, Hong Ren*. Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke. European Journal of Pharmacology, 949 (2023), 175717. (IF 5.0)
6. Ping Hu#, Linzhen Hu#, Yizhan Chen#, Fuqian Wang, Yang Xiao, Zhou Tong, Hua Li, Ming Xiang,Qingyi Tong*, Yonghui Zhang*. Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia. Bioorganic Chemistry, 2023, 139, 106701.（IF=5.1, Q1）
7. Yi Kong#, Jian Jiang#, Yuqiong Huang, Xin Liu, Zilin Jin, Li Li, Fen Wei, Xinxin Liu, Jie Yin, Yonghui Zhang*,Qingyi Tong* and Hongxiang Chen*, Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis. Frontiers in Immunology, 13:1094375.（IF=7.3, Q1）
8. Yi Kong, Jian Jiang, Yuqiong Huang, Li Li, Xin Liu, Zilin Jin, Fen Wei, Xinxin Liu, Song Zhang, Xiaoru Duan, Yonghui Zhang*,Qingyi Tong*, Hongxiang Chen*,Endoplasmic reticulum stress in melanoma pathogenesis and resistance.Biomedicine & Pharmacotherapy.2022,155:113741.（IF=7.5, Q1）
9. Shuang Lin#, Jianzheng Huang#, Hanxiao Zeng,Qingyi Tong*, Xueke Zhang, Beiye Yang, Ying Ye, Jianping Wang, Zhengxi Hu*, Yonghui Zhang*.Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungus Stachybotrys chartarum. Chinese Chemical Letters. 2022 (33) 4587–4594（IF=9.1,Q1）
10. Xiaotian Zhang#, Zhaodi Wu#,Alan Bao, Ziming Zhao, Yu Chen, Huimin Zhao, Jianping Wang, Chunmei Chen,Qingyi Tong*, Hucheng Zhu*, Yonghui Zhang*. Asperflavipines C–E and aspermichalasine A: three cytochalasan heterotetramers and an unusual cytochalasan monomer from Aspergillus micronesiensis. Organic Chemistry Frontier, 2022,9, 2585-2592（IF=5.5,Q1）
11. Yulin Duan#, PingHu#, YiGuo, Pengfei Bu, Zhengyi Shi,Yunfang Cao, Yeting Zhang, Hong Hu,Qingyi Tong*, Changxing Qi*, Yonghui Zhang*. Kiiacylphnols A−H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim. Phytochemistry. 2022 (199) 113166.(IF=4.0,Q1）
12. Si Yao, Jie Yin, Wen Liu, Yang Li, Jianzheng Huang, Changxing Qi, Zhengxi Hu,Qingyi Tong*, Lianghu Gu*, Yonghui Zhang*. A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma. Bioorganic Chemistry, 2022, 127, 106019.（IF=5.1, Q1）
13. Beiye Yang#,Jianzheng Huang#,Shuang Lin,Qingyi Tong*, Zeyu Yao, Fengli Li, Ying Ye, Zhengxi Hu *, Yonghui Zhang*, Hyperbeanone A, a 5,6-seco-spirocyclic polycyclic polyprenylated acylphloroglucinol derivative with an unprecedented skeleton from Hypericum beanie. Organic Chemistry Frontiers, 2021,8, 6411-6418（IF=5.5, Q1）
14. Mengsha Wei#, Peng Zhou#, Liping Huang, Jie Yin, Qin Li, Chong Dai, Jianping Wang, Lianghu Gu*,Qingyi Tong*, Hucheng Zhu*,Yonghui Zhang*,Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis, Phytochemistry, 2021, 191 112910. (IF=4.0,Q1）
15. Jiaxiong Ming, Qianqian Xu, Limin Gao, Yanfang Deng, Jie Yin, Qun Zhou*,Qingyi Tong*, Yonghui Zhang*.Kinsenoside Alleviates 17α-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis.Pharmaceuticals, 2021,14(5):452.（IF=5.8,Q1）
16. Song Hu#, Jie Yin#, Shan Yan, Ping Hu, Jianzheng Huang, Geng Zhang, Fuqian Wang*,Qingyi Tong*, Yonghui Zhang*, Chaetocochin J, an epipolythiodioxopiperazine alkaloid, induces apoptosis and autophagy in colorectal cancer via AMPK and PI3K/AKT/mTOR pathways. Bioorganic Chemistry, 2021, 109, 104693.（IF=5.1, Q1）
17. Zhaodi Wu#; Xiaotian Zhang#, Chunmei Chen#, Peng Zhou, Mi Zhang, Lianghu Gu, Zengwei Luo, Jianping Wang,Qingyi Tong*, Hucheng Zhu*, Yonghui Zhang*, Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from Aspergillus micronesiensis PG-1. Organic Letters, 2020，22(6), 2162-2166.（IF=6.1, Q1）
18. Zhaodi Wu#,Qingyi Tong#, Xiaotian Zhang, Peng Zhou, Chong Dai, Jianping Wang, Chunmei Chen*, Hucheng Zhu*, and Yonghui Zhang*，Amichalasines A–C: Three Cytochalasan Heterotrimers from Aspergillus micronesiensis PG-1. Organic Letters 2019, 21 (4), 1026–1030.（IF=6.1, Q1）
19. Yi Guo#,Qingyi Tong#,Na Zhang, Xueyan Duan, Yunfang Cao, Hucheng Zhu, Shuangshuang Xie, Jing Yang, Jinwen Zhang, Yanfei Liu, Yongbo Xue* and Yonghui Zhang*, Highly-functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols fromHypericum perforatuminduce leukemia cell apoptosis. Organic Chemistry Frontiers, 2019,6, 817-824.（IF=5.5, Q1）
20. Guangzheng Wei#, Chunmei Chen#,Qingyi Tong#, Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang, Hucheng Zhu*, and Yonghui Zhang*,Aspergilasines A–D: four merocytochalasans with new carbon skeletons from Aspergillus flavipes QCS12, Organic Letters, 2017, 19, 4399−4402.（IF=6.1, Q1）
21. Qingyi Tong#, Yong Qing#, Dan Shu, Yang He, Yinglan Zhao, Yi Li, Zhengling Wang, Shiyuan Zhang, Zhihua Xing, Cheng Xu, Yuquan Wei, Wen Huang*, Xiaohua Wu*.Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and anti-angiogenesis.Cellular Physiology and Biochemistry, 2011, 27, 233–242.
22. Qingyi Tong,Yong Qing*, Yang Wu, Xiaojuan Hu, Lei Jiang, Xiaohua Wu*, Dioscin inhibits colon tumor growth and angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.Toxicology and Applied Pharmacology, 2014, 281, 166–173.
23. Qingyi Tong, QingbingZhao, Yong Qing, Xiaojuan Hu, Lei Jiang, Xiaohua Wu*.Deltonin inhibits angiogenesis by regulating VEGFR2 and subsequent signaling pathways in endothelial cells.Steroids, 2015, 96, 30–36.
24. Qingyi Tong#, YangHe#, Qingbing Zhao, Yong Qing*, Wen Huang*, Xiaohua Wu* Cytotoxicity and apoptosis-inducing effect of steroidal saponins from dioscorea zingiberensis wright against cancer cells. Steroids, 2012,77, 1219–1227.
25. Chunmei Chen#,Qingyi Tong#, Hucheng Zhu, Dongdong Tan, Jinwen Zhang, Yongbo Xue, Guangmin Yao, Zengwei Luo, Wang Jianping*, Wang Yanyan*, Zhang Yonghui*. Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales). Scientific Reports, 2016, 6:18711.
26. Weiguang Sun#, Xintao Chen#,Qingyi Tong#, Hucheng Zhu#, Yan He, Liang Lei, Yongbo Xue,Guangmin Yao, Zengwei Luo, Jianping Wang, Hua Li ,Yonghui Zhang.Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune. Scientific Reports, 2016, 6:26418.
