万落生,华中科技大学教授,博、硕士研究生导师,中药与天然药物学系副主任。担任国家自然科学基金通讯评审专家、教育部学位论文评审专家、湖北省药品科技咨询专家、武汉市中药专业委员会委员。以第一或通讯作者身份在Angew. Chem. Int. Ed.、Org. Lett.、Chin. Chem. Lett.、Bioorg. Chem.、J. Nat. Prod.、Carbohyd. Polym.等领域权威学术期刊发表SCI论文30余篇,国家授权发明专利1项,主持国家自然科学基金面上项目2项、青年基金1项。
E-mail: wanluosheng@hust.edu.cn;
教育及工作经历
2024.01-至今,华中科技大学,教授,博士生、硕士生导师;
2017.11-2023.12,华中科技大学,副教授,博士生、硕士生导师;
2016.09-2017.11,华中科技大学,讲师,硕士生导师;
2013.07-2016.06,中国科学院昆明植物研究所,药学博士后;
2008.09-2013.06,华中科技大学,药理学博士;
2004.09-2008.06,华中科技大学,生物药学学士.
主要研究方向
1.中药药效物质基础及活性作用
2.创新中药的质量控制方法
教学
生药学(本科生专业课程主讲人)、国际传统药物与天然药物(本科生选修课程主讲人)、药学前沿(博士研究生课程主讲人)
科研项目与专利
1.以Kv1.3离子通道为靶点的大戟属植物抗银屑病药效物质基础研究,国家自然科学基金面上项目,59万元,主持人;
2.滇产三种黄杨属植物抗肿瘤作用及资源品质评价,国家自然科学基金青年项目,23万元,主持人;
3.黄连等三种鄂产高品质道地中药材规模化种植及精准扶贫示范研究,国家重点研发计划,745万元,主要参与人
4.二萜类化合物及制备方法和应用、二萜类化合物药学上可接受的衍生物、药物组合物及应用,CN202111202584.7.
近几年部分代表性论文(*corresponding author)
1. Xue Gong, Chen-Hao Yu, Xiao-Tian Zhang, Bin Deng, Jian-Hao Sun, Yu-Jing Yu, Zhengxi Hu, Meng-Ya Zhang*, Jun-Cheng Su*, Weiguang Sun*,Luo-Sheng Wan*.Eufischeramines A and B: Ingenane-type diterpenoid alkaloids fromEuphorbia fischerianawith potent anti-pulmonary fibrosis activity. Chin. Chem. Lett.2026,37:113232.(JCR Q1,中科院化学一区TOP)
2. Yuan XY, Gong X, Yuan SY, Meng WJ, Yu CH, Wang SJ, Zhang XT*, Su JC*,Wan Luo-Sheng*.Iridoid constituents from the flower buds and inflorescences ofBuddleja officinalisand their anti-pulmonary fibrosis activity.Phytochemistry2026,247:114890.(JCR Q2,中科院植物科学二区)
3. Wei SY, Huang Y, Yao J, Zhao P, Su JC,Wan Luo-Sheng*, Zhu GL*.Characterization of bridged guaiane-type sesquiterpenoids fromStellera chamaejasmeand their antifungal activities against phytopathogenic fungi.Bioorg. Chem.2026, 170: 109475.(JCR Q1,中科院有机化学一区)
4. Gong X, Zhang X, Yuan TT, Sun X, Hu Z, Su JC*, Sun W*,Wan Luo-Sheng*.Stelleroids A-C, Three Rearranged Guaiane Sesquiterpenoids with Caged Ring Systems fromStellera chamaejasme.Org. Lett.2025, 27:7991-7996.(JCR Q1,中科院化学一区)
5. Liu G, Sheng Q, Sun X, Meng F, Liu D, Yan L,Wan Luo-Sheng*, Zhou Y*.Base-Catalyzed Chemo-, Regio- and Stereoselective Addition of Quinazolinones to Trifluoromethylated Internal Alkynes for Access to N3-Vinylquinazolinones.Org. Lett.2025, 27:6088-6093.(JCR Q1,中科院化学一区)
6. Xia RF, Wei YR, Zhang CQ, Huang Y, Chen MS, Yuan XY, Zha HJ, Lai KD, Xia X,Wan Luo-Sheng*.Structurally diverse triterpenoids with antibacterial activities fromEuphorbia humifusa.Bioorg. Chem.2024, 127:106012.(JCR Q1,中科院有机化学一区)
7. Zhang X, Liu G, Sun X,Wan Luo-Sheng*, Zhou Y.A Metal-Free Direct Decarboxylative Fluoroacylation of Indole Carboxylic Acids with Fluorinated Acids.J. Org. Chem.2024,89:14591-14595.(JCR Q1,中科院有机化学二区)
8. Gong Y#, Liu R#, Zha H#, Dong D, Lu N, Yan H,Wan Luosheng*, Nian Y*.AnalgesicBuxusalkaloids with Enhanced Selectivity for the Low-Voltage-Gated Calcium Channel Cav3.2 over Cav3.1 through a New Binding Mode.Angew. Chem. Int. Ed.2024,63:e202313461.(JCR Q1,中科院化学一区)
9. Cai Q#, Zha HJ#, Yuan SY#, Sun X#, Lin X, Zheng XY, Qian YX, Xia RF, Luo YS, Shi Z, Su JC*,Wan Luo-Sheng*.Diterpenoids fromEuphorbia fischerianawith Kv1.3 Inhibitory Activity.J. Nat. Prod.2023,86:2379-2390.(JCR Q1,中科院药学一区)
10. XiaRF#, Su JC#, Yu J#, Zha HJ,Wu JL, Fu XN, Cai Q,Wan Luo-Sheng*.Anti-inflammatory lanostane triterpenoids with rearranged spirobi[indene] scaffold and their biogenetically related analogues fromEuphorbia maculata.Phytochemistry2023,211:113682.(JCR Q1,中科院植物科学二区)
11. Hu ZF#, Su JC#, Sun X#, Xia RF, Wu JL, Fu XN, Zhang BZ*, Chen JC*,Wan Luo-Sheng*.Brujavanoids A-U, structurally diverse apotirucallane-type triterpenoids fromBrucea javanicaand their anti-inflammatory effects.Bioorg. Chem.2022, 127:106012.(JCR Q1,中科院有机化学一区)
12. Xiang ZN#, Tong QL#, Su JC#, Hu ZF#, Zhao N, Xia RF, Wu JL, Chen C, Chen JC*,Wan Luo-Sheng*.Diterpenoids with Rearranged 9(10→11)-abeo-10,12-Cyclojatrophane Skeleton and the First (15S)-Jatrophane fromEuphorbia helioscopia: Structural Elucidation, Biomimetic Conversion, and Their Immunosuppressive Effects.Org. Lett.2022, 24:697-701.(JCR Q1,中科院化学一区)
13. Zhou CG, Xiang ZN, Zhao N, Sun X, Hu ZF, Wu JL, Xia RF, Chen C, Su JC*, Chen JC*,Wan Luo-Sheng*. Jatrophane Diterpenoids with Kv1.3 Ion Channel Inhibitory Effects fromEuphorbia helioscopia.J. Nat. Prod.2022,85:815-827.(JCR Q1,中科院药学一区)