项光亚,男,1968年生,湖北黄梅人,博士,教授,博士生导师,教育部新世纪优秀人才支持计划入选者。现任教育部高等学校药学教学指导委员会药学(大)教学指导分委员会委员,中国药学会湖北省药物制剂专业委员会主任委员。1990年毕业于华东师范大学化学系,1995年毕业于武汉大学获硕士学位;2000年毕业于同济医科大学获博士学位。先后在德国蒂宾根大学和美国俄亥俄州立大学分别进行为期一年进修访问。现主要从事靶向药物传递系统和药物合成研究。
主要讲授的课程包括《有机化学》、《生物偶联技术》、《药学文献检索与利用》等,曾多次荣获华中科技大学教学质量奖,荣获过2004年华中科技大学“三育人奖”、2011年华中科技大学第二届研究生导师“师表奖”、2016年获华中科技大学“优秀班主任”、2017年获华中科技大学“师德先进个人”等荣誉称号。近年来,参编的教材包括人民卫生出版社出版的有机化学(第七版和第八版副主编),有机化学学习指导(第三版,第四版)等以及中国医药科技出版社出版的《有机化学》(主编,2016年)《药学文献检索与利用》(第二版,副主编)等近十本教材。教学研究方面,曾主持过校级省级教学研究项目多项,获得过华中科技大学优秀教学成果奖二等奖一次(第二),一等奖一次(第一),此外还多次指导国家大学生创新科研训练计划项目,主持教育部“质量工程”药学国家特色专业建设以及参与建设生物药学创新人才培养试验区建设。科学研究方面,近年来先后主持了国家级、省部级科研项目十多项,发表论文六十余篇,其中在包括《Acta biomaterialia》、《Angew. Chem. Int. Ed》、《Chemical Engineering Journal》、《Acta Pharmaceutica Sinica B》、《Nanomedicine: Nanotechnology, Biology, and Medicine》、《Theranostics》、《Bioactive Materials》、《Theranostics》等国际著名刊物发表的SCI收录论七十余篇。
研究方向:
1.纳米给药系统研究;
2.药物合成新技术;
3.纳米医学影像
承担的主要课题
1.教育部留学回国人员科研启动基金“叶酸-冠醚偶联物的合成研究”(主持,2003-2005);
2.国家自然科学基金“叶酸-酶偶联物的制备及生物活性和体内分布”(主持,2004-2006);30300430
3.华中科技大学医工、医理交叉科研基金重点项目叶酸化壳聚糖纳米粒的研制(主持,2004-2006)
4.华中科技大学医科重点科研基金项目“叶酸化壳聚糖量子点荧光探针的制备及其对叶酸受体表达阳性肿瘤细胞的标记与成像研究”(主持,2007-2008)
5.国家自然科学基金:叶酸靶向荧光/磁共振多功能脂质体纳米探针的制备及性能研究(主持,2008-2010)30772669
6.教育部新世纪优秀人才支持计划“叶酸靶向脂质体的研究”(主持,2009-2011)
7.华中科技大学资助创新基金“叶酸/肿瘤归巢肽双重靶向脂质体研究”(主持,2009-2011)
8.武汉市科技攻关计划项目“盐酸巴尼地平的研制”(2010-2011)
9.湖北省自然科学基金重点项目“以PAMAM为载体的靶向荧光磁共振肿瘤诊断显像剂研究”(2011-2013)
9.国家自然科学基金项目“针对肿瘤组织和肿瘤血管的多靶点阿霉素脂质体给药系统研究”(主持,2011-2013)81072596
10.华中科技大学创新交叉重点团队项目“肿瘤糖脂代谢关键调控分子挖掘及其抑制剂研究”(主持,2016-2018,2016JCTD109)
11.国家自然科学基金项目,新型脂包被顺铂/磷酸钙Bmi1 siRNA纳米粒抑制肝癌干细胞并协同治疗肝癌的研究,国家自然科学基金(81673368,2017-2020)
12.国家自然科学基金项目,顺铂/过氧化钙纳米系统综合调控肿瘤微环境逆转肿瘤耐药的研究,国家自然科学基金(81973257,2020-2023)
13.国家自然科学基金项目,内外兼修剿灭肿瘤:CaO2-PROTAC纳米粒降解EGFR协同克服肺癌耐药的实验研究,国家自然科学基金(82173759,2021-2025)
发表的部分论文列表:
◆Chen, Yan; Fang, Lei; Zhou, Weixin; Chang, Jinghan; Zhang, Xiaojuan; He, Chuanchuan; Chen, Chen; Yan, Ruicong; Yan, Yakai; Lu, Yao; Xu, Chuanrui*;Xiang, Guangya*,Nitric oxide-releasing micelles with intelligent targeting for enhanced anti-tumor effect of cisplatin in hypoxia,Journal of Nanobiotechnology,2021,19(1):246
◆Zhang, Xiaojuan#; He, Chuanchuan#; Chen, Yan; Chen, Chen; Yan, Ruicong; Fan, Ting; Gai, Yongkang; Yang, Tan*; Lu, Yao*;Xiang, Guangya*, Cyclic reactions- mediated self-supply of H2O2and O2for cooperative chemodynamic/starvation cancer therapy,Biomaterials, 2021,275:120987
◆Zhao, Pengxuan, Deng, Youbin,Xiang, Guangya*,Liu, Yani, Nanoparticle- Assisted Sonosensitizers and Their Biomedical Applications,International Journal of Nanomedicine, 2021,16:4615-4630
◆Ting Fan, Wenping Ye, Pengxuan Zhao, Weixin Zhou, Yan Chen, Chuanchuan He,
Xiaojuan Zhang, Ruicong Yan, Chen Chen, Jun Luo, Tan Yang, Xiang Ma,Guangya Xiang*, Yao Lu*,pH-responsive core-shell nanogels induce in situ antigen production for cancer treatment,Chemical Engineering Journal,2021,426:130839
◆He, Chuanchuan#; Zhang, Xiaojuan#; Chen, Chen; Liu, Xiaoguang; Chen, Yan; Yan, Ruicong; Fan, Ting; Gai, Yongkang; Lee, Robert J.; Ma, Xiang; Luo, Jun;Lu, Yao*; Yang, Tan*; Xiang, Guangya*,A solid lipid coated calcium peroxide nanocarrier enables combined cancer chemo/chemodynamic therapy with O-2/H2O2self-sufficiency,Acta Biomaterialia,2021,122: 354-364
◆He, Chuanchuan; Zhang, Xiaojuan;Xiang, Guangya*,Nanoparticle facilitated delivery of peroxides for effective cancer treatments,Biomaterial Science,2020,8(20):5574-5582
◆Zhao, Pengxuan; Zhang, Yuebao; Li, Wenqing;Jeanty, Christopher ;Xiang, Guangya*; Dong, Yizhou*,Recent advances of antibody drug conjugates for clinical applications,Acta Pharmaceutic Sinica B,2020,10(9):1589-1600
◆Chen, Yan; Chen, Chen; Zhang, Xiaojuan; He, Chuanchuan; Zhao, Pengxuan; Li, Minsi; Fan, Ting; Yan, Ruicong; Lu, Yao; Lee, Robert J.; Khan, Muhammad Waseem; Sarfraz, Muhammad;Ma, Xiang*; Yang, Tan*; Xiang, Guangya*, Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects,Acta Pharmaceutica Sinica B, 2020,10(6):1106-1121
◆Chen, Yan ; Lu, Yao ;Lee, Robert J.;Xiang, Guangya*,Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications,International Journal of Nanomedicine,2020:15 3099-3120
◆Zhao, Pengxuan#; Hou, Xucheng#; Yan, Jingyue; Du, Shi; Xue, Yonger; Li, Wenqing;Xiang, Guangya*; Dong, Yizhou*,Long-term storage of lipid-like nanoparticles for mRNA delivery,Bioactive materials,2020,5(2):358-363
◆Liu, Xiaoguang; Dong, Xiuxiu; He, Chuanchuan; Zhang, Xiaojuan;Xiang, Guangya*; Ma, Xiang*,New polyazamacrocyclic 3-hydroxy-4-pyridinone based ligands for iron depletion antitumor activity,Bioorganic chemistry,2020,96:103574
◆Zhang, Xiaojuan#; He, Chuanchuan#; Yan, Ruicong ; Chen, Yan ; Zhao, Pengxuan ; Li, Minsi; Fan, Ting ; Yang, Tan ;Lu, Yao ;Luo, Jun* ; Ma, Xiang* ; Xiang, Guangya*,HIF-1 dependent reversal of cisplatin resistance via anti-oxidative nano selenium for effective cancer therapy,Chemical Engineering Journal,2020,380:122540
◆Zhang, Xiaojuan# ;He Chuanchuan#; Liu, Xiaoguang; Chen, Yan; Zhao, Pengxuan ; Chen, Chen; Yan, Ruicong; Li, Minsi; Fan, Ting; Altine, Bouhari; Yang, Tan; Lu, Yao ; Lee, Robert J. ;Gai, Yongkang*;Xiang, Guangya*,One-pot synthesis of a microporous organosilica-coated cisplatin nanoplatform for HIF-1-targeted combination cancer therapy,Theranostics,2020,10(7):2918-2929
◆Li, Minsi ; Zhao, Pengxuan; Fan, Ting; Chen, Yan; Zhang, Xiaojuan; He, Chuanchuan; Yang, Tan; Lee, Robert J.; Khan, Muhammad Waseem; Raza, Shahid Masood;Ma, Xiang*; Lu, Yao* ; Xiang, Guangya*,Biocompatible co-loading vehicles for delivering both nanoplatin cores and siRNA to treat hepatocellular carcinoma,International Journal of Pharmaceuticals,2019,572:118769
◆Zhao, Pengxuan; Li, Minsi; Chen, Yan; He, Chuanchuan; Zhang, Xiaojuan; Fan, Ting; Yang, Tan; Lu, Yao; Lee, Robert J; Ma, Xiang;Luo, Jun*; Xiang, Guangya*,Selenium-doped calcium carbonate nanoparticles loaded with cisplatin enhance efficiency and reduce side effects,International Journal of Pharmaceutics,2019,570:118638
◆He, Chuanchuan#;Zhang, Xiaojuan# ;Yan, Ruicong;Zhao, Pengxuan;Chen, Yan; Li, Minsi;Chen, Chen;Fan, Ting; Lu, Yao; Wang, Chen; Wu, Fan;Lee, Robert J.*; Yang, Tan*; Xiang, Guangya*,Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment,Biomaterial Science,2019,7(10): 4260-4272
◆Khan, Muhammad Waseem ; Zhao, Pengxuan; Khan, Asifullah; Raza, Faisal ; Raza, Shahid Masood ; Sarfraz, Muhammad ; Chen, Yan ; Li, Minsi ; Yang, Tan;Ma, Xiang* ; Xiang, Guangya*,Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity,International Journal of Nanomedicine, 2019, 14:3753-3771;
◆Li, Weijie ;Yan, Ruicong ; Liu, Yong;He, Chuanchuan;Zhang, Xiaojuan;Lu, Yao; Khan, Muhammad Waseem;Xu, Chuanrui ;Yang, Tan* ; Xiang, Guangya*,Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo,Drug Delivery,2019, 26(1): 794-802;
◆Gai, Yongkang ; Sun, Lingyi ; Lan, Xiaoli ;Zeng, Dexing* ; Xiang, Guangya*; Ma, Xiang*, Synthesis and Evaluation of New Bifunctional Chelators with Phosphonic Acid Arms for Gallium-68 Based PET Imaging in Melanoma,Biocojugate Chemistry,2018,29(10): 3483-3494
◆Yang, Tan ; Chen, Yuyuan ; Zhao, Pengxuan ; Xue, Huiying ; You, Jia ; Li, Bin ; Liu, Yong ; He, Chuanchuan; Zhang, Xiaojuan ; Fan, Lingling;Lee, Robert J.; Li, Lei ; Ma, Xiang ;Xu, Chuanrui*; Xiang, Guangya*, Enhancing the therapeutic effect via elimination of hepatocellular carcinoma stem cells using Bmi1 siRNA delivered by cationic cisplatin nanocapsules,Nanomedicien-Nanotechnology Biology and Medicine,2018,14(7): 2009-2021
◆Sarfraz, Muhammad ; Afzal, Attia ; Yang, Tan ; Gai, Yongkang; Raza, Shahid Masood ; Khan, Muhammad Waseem ; Cheng, Yao ;Ma, Xiang* ; Xiang, Guangya*,Development of Dual Drug Loaded Nanosized Liposomal Formulation by A Reengineered Ethanolic Injection Method and Its Pre-Clinical Pharmacokinetic Studies,Pharmaceutics, 2018,10:3
◆Lu, Yao ; Yang, Yannan ; Gu, Zhengying ; Zhang, Jun ; Song, Hao ;Xiang, Guangya* ; Yu, Chengzhong*, Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and Co-delivery platform for enhanced cancer immunotherapy,Biomatreials, 2018,175: 82-92
◆Zhao, Pengxuan; Li, Minsi; Wang, Yao; Chen, Yan; He, Chuanchuan; Zhang, Xiaojuan; Yang, Tan; Lu, Yao; You, Jia;Lee, Robert J*; Xiang, Guangya*,Enhancing anti-tumor efficiency in hepatocellular carcinoma through the autophagy inhibition by miR-375/sorafenib in lipid-coated calcium carbonate nanoparticles.,Acta Biomaterialia,2018,72:248-255
◆Cheng, Yao; Zhao, Pengxuan; Wu, Shuangping; Yang, Tan; Chen, Yan; Zhang, Xiaojuan; He, Chuanchuan; Zheng, Chao; Li, Kelin;Ma, Xiang*; Xiang, Guangya*,Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma,International Journal of Pharmaceutics,2018,545(1-2):261-273
◆Chen, Y; Cheng, Y; Zhao, PX; Zhang, SS; Li, MS; He, CC; Zhang, XJ; Yang, T; Yan, RC; Ye, P;Ma, X*; Xiang, GY*,Co-delivery of doxorubicin and imatinib by pH sensitive cleavable PEGylated nanoliposomes with folate-mediated targeting to overcome multidrug resistance,International Journal of Pharmaceutics,2018,542(1-2):266-279
◆Pengxuan Zhao#, Shuangping Wu, Yao Cheng, Jia You, Yan Chen, Minsi Li, Chuanchuan He, Xiaojuan Zhang, TanYang, Yao Lu, Robert J. Lee,Xingxing He*, Guangya Xiang*, MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma,Nanomedicine: Nanotechnology, Biology, and Medicine,2017,13(8):2507-2516.
◆Yannan Yang#, Yao Lu#, Prasanna Lakshmi Abbaraju, Jun Zhang, Min Zhang,Guangya Xiang,* andChengzhong Yu*,Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy,Angew. Chem. Int. Ed., 2017, 56:8446-8450
◆Muhammad Sarfraz#, Attia Afzal1#, Shahid Masood Raza, Sajid Bashir, Asadullah Madni, Muhammad Waseem Khan,Xiang Ma*,Guangya Xiang*,Liposomal co-delivered oleanolic acid attenuates doxorubicin induced multi-organ toxicity in hepatocellular carcinoma,Oncotarget,2017,8(29):47136-47153
◆Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min1, Weiguang Sun,Lixia Chen*, Guangya Xiang* and Hua Li*,Benserazide, a dopadecarboxylase inhibitor,suppresses tumor growth by targeting hexokinase,Journal of Experimental & Clinic Cancer Research, 2017,36:58
◆Zhongping Hu, Shasha Zhang, Weicheng Zhou,Xiang Ma*, Guangya Xiang*,Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ Inhibitors,Bioorganic & Medicinal Chemistry Letters,2017,27:1854-1858
◆Tan Yang#,Ling Xu#,Bin Li,Weijie Li,Xiang Ma,Lingling Fan,Robert J Lee,Chuanrui Xu*,Guangya Xiang*,Antitumor activity of a folate receptor-targeted immunoglobulin G-doxorubicin conjugate,Internatioal Journal of Nanomedicine,2017,12:2505-2515
◆Yongkang Gai#, Lingyi Sun#, Wenqi Hui, Qin Ouyang, Carolyn J. Anderson,Guangya Xiang*, Xiang Ma*, and Dexing Zeng*,New Bifunctional Chelator p‑SCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET Imaging,Inorganic Chemistry,2016,55(14):6892-6901(IF=4.82)
◆Yao Lu, Yuhua Wang, Lei Miao, Matthew Haynes,Guangya Xiang*, Leaf Huang*, Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: A combination nanomedicine approach,Cancer Letters,2016,379(1):32–38(IF=5.992)
◆Yongkang Gai,Guangya Xiang, Xiang Ma, Wenqi Hui, Qin Ouyang, Lingyi Sun, Jiule Ding, Jing Sheng, and Dexing Zeng*,Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes,Bioconjugate Chemistry,2016,27:515-520(IF=4.513)
◆ Lu, Yao; Miao, Lei; Wang, Yuhua; Xu, Zhenghong; Zhao, Yi; Shen, Youqing;Xiang, Guangya*; Huang, Leaf*,Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model,Molecular Therapy,2016,24(2):364-374(IF=6.938)
◆ Yang, Tan; Zhao, Pengxuan; Rong, Zhao; Li, Bin; Xue, Huiying; You, Jia; He, Chuanchuan; Li, Weijie; He, Xingxing; Lee, Robert J;Ma, Xiang*;Guangya Xiang*,Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375,Theranostics,2016,6(1):142-154(IF=8.854)
◆ Gai, YK;Hu, ZP ; Rong, Z;Ma, X*;Xiang, GY*,A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm,Molecules,2015,20(10):19393-19405(IF=2.416)
◆ Zhang, Wendian; Peng, Fangqi; Zhou, Taotao; Huang, Yifei; Zhang, Li; Ye, Peng; Lu, Miao; Yang, Guang; Gai, Yongkang; Yang, Tan;Ma, Xiang*; Xiang, Guangya*,Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes,International Journal of Nanomedicine, 2015,10:4825-4836.(IF=4.195)
◆ Yifei Huang#,Tan Yang#, Wendian Zhang,Yao Lu,Peng Ye,Guang Yang,Bin Li,Shibo Qi,Yong Liu,Xingxing He,Robert J Lee,Chuanrui Xu*,Guangya Xiang*,A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo,International Journal of Nanomedicine,2014:9 4581–4595(IF=4.195)
◆ Guang Yang, Tan Yang, Wendian Zhang, Miao Lu,Xiang Ma,*, and Guangya Xiang*,In Vitro and in Vivo Antitumor Effects of Folate-Targeted Ursolic Acid Stealth Liposome,J. Agric. Food Chem.2014,62:2207-2215(IF=3.107)
◆ Peng Ye,Wendian Zhang,Tan Yang,Yao Lu,Miao Lu,Yongkang Gai,Xiang Ma*,Guangya Xiang*,Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting,International Journal of Nanomedicine,2014,9:2167-2178(IF=4.195)
◆ Bin Zhao,Xianmei Shang*, Ling Xu, Wendian Zhang,Guangya Xiang*,Novel mixed ligand di-n-butyltin(IV) complexes derived from acylpyrazolones and fluorinated benzoic acids: Synthesis, characterization, cytotoxicity and the induction of apoptosis in Hela cancer cells,European Journal of Medicinal Chemistry,2014,76:87-97(IF=3.432)
◆ Zhi-Gang Cheng,Xu-Yong Dai, Li-Wei Li, Qiong Wan,Xiang Ma,* and Guang-Ya Xiang*,Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance,Molecules,2014,19:1344-1352(IF=2.095)
◆ Miao Lu, Wendian Zhang, Yongkang Gai, Tan Yang, Peng Ye, Guang Yang,Xiang Ma* and Guangya Xiang,Folate–PEG functionalized silica CdTe quantum dots as fluorescent probes for cancer cell imaging,New Journal of Chemistry, 2014,38:4519-4526(IF=3.159)
◆ Tan Yang, Bin Li, Shibo Qi, Yong Liu, Yongkang Gai, Peng Ye, Guang Yang, Wendian Zhang, Peng Zhang, Xingxing He, Weijie Li, Zhiping Zhang, Guangya Xiang*, Chuanrui Xu*, Co-delivery of Doxorubicin and Bmi1 siRNA by Folate Receptor Targeted Liposomes Exhibits Enhanced Anti-Tumor Effects in vitro and in vivo,Theranostics,2014,4(11):1096-1111(IF=7.827)
◆ Chang Yang, Lun Ma, Jason Maley, Ramaswami Sammynaiken, Renfei Feng,Guangya Xiang∗, and Wei Chen∗,Photoluminescence and X-Ray Excited Luminescence from Glutathione-Stabilized Gold Nanoparticles,Journal of Biomedical Nanotechnology,2013,9:1827–1836(IF=7.578)
◆ Changqin Xiao, Minqiong Tang, Jian Li, Chen-ru Yin,Guangya Xiang∗, Li Xu∗,Determination of sildenafil, vardenafil and aildenafil in human plasmaby dispersive liquid–liquid microextraction-back extraction based onionic liquid and high performance liquid chromatography-ultravioletdetection,Journal of Chromatography B,2013,931:111-116(IF=2.694)
◆ Chang Yang,Lun Ma,Xiaoju Zou,Guangya Xiang∗,Wei Chen∗,Surface plasmon-enhanced Ag/CuS nanocomposites for cancer treatment,Cancer Nano,2013,4:81-89
◆Xianmei Shang*, Nan Ding,Guangya Xiang*,Novel di-n-butyltin(IV) derivatives: Synthesis, high levels of cytotoxicity in tumor cells and the induction of apoptosis in KB cancer cells,European Journal of Medicinal Chemistry,2012,48:305-312(IF=3.432)
◆ Yao Lu, Nan Ding, Chang Yang, Lei Huang, Jian Liu, andGuangya Xiang∗,Preparation and in vitro evaluation of a folate-linked liposomal curcumin formulation,Journal of Liposome Research, 2012,22(2):110-119(IF=1.533)
◆ Ye, L; Huang, YF; Li;Xiang, GY;Xu, L∗,Nonaqueous capillary electrophoresis of imatinib mesylate and related substances,JOURNAL OF SEPARATION SCIENCE2012,35(16):2108-2113(IF=2.594)
◆ Jian Li, Yifei Huang, Lei Huang, Lei Ye, Zhou Zhou,Guangya Xiang∗, Li Xu∗, Determination of imatinib mesylate and compounds by field amplified sample stacking with large volume sample injection capillary electrophoresis,Journal of Pharmaceutical and Biomedical Analysis, 2012,70:26-31(IF=2.829)
◆ Chang Yang, Wei Chen, Brian Quang Bui, andGuangya Xiang∗,Recent Progress on the Liposomes Loaded with Quantum Dots,Rev. Nanosci. Nanotechnol, 2012, 1(4):1-14
◆ Nan Ding,Yao Lu,Robert J Lee,Chang Yang,Lei Huang,Jian Liu,Guangya Xiang∗,Folate receptor targeted fluorescentparamagnetic bimodal liposomes for tumor imaging,International Journal of Nanomedicine,2011,6:2513-2520(IF=4.195)
◆Xiaolan Qu,Chang Yang,Jing Zhang,Nan Ding,Yao Lu,Lei Huang,Guangya Xiang∗,In-vitro evaluation of a folate-bovine serum albumin doxorubicin conjugate,Journal of Drug Targeting, 2010 ,18(5): 351-61. (IF=2.723)
◆ Chang Yang, Nan Ding, Yibing Xu, Xiaolan Qu, Jing Zhang1, Chaoyang Zhao, Liang Hong, Yao Lu,Guangya Xiang*, Folate receptor–targeted quantum dot liposomes as fluorescence probes,Journal of Drug Targeting, 2009, 17(7): 502-511(IF=2.723)
◆Guangya Xiang*,Jun Wu,Yanhui Lu,Zhilan Liu,Robert J Lee,Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes,International Journal of Pharmaceuticals,2008,356:29-36 (IF=3.785)
◆ Qi Zhang,Guang Ya Xiang*, Youjiu Zhang, Yang, Keya,Fan, Wo,Lin Jialiang,Zeng Fanbo,Wu Jizhou,Increase of Doxorubicin Sensitivity for Folate Receptor Positive Cells when given as the Prodrug N-(phenylacetyl) doxorubicin in Combination with Folate-conjugated PGA,Journal of Pharmaceutical Sciences,2006,2006, 95(10):2266-75. (IF=3.007)
联系方式
通信方式:武汉市华中科技大学同济医学院药学院,430030
eMail:gyxiang1968@hotmail.com,youjti@mails.tjmu.edu.cn
主要合作实验室
美国俄亥俄州立大学药学院Robert Lee教授实验室
美国北卡罗莱纳州立大学教堂山分校药学院Leaf Huang实验室
美国匹兹堡大学放射医学中心曾德兴教授实验室
美国华盛顿大学(西雅图)Rodeny Ho教授实验室
美国NIH陈小元教授实验室
澳大利亚昆士兰大学余承忠教授实验室
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