杨丛莲博士，女，华中科技大学药剂学系副教授，湖北省高层次人才，任中国抗癌协会纳米肿瘤专业委员会委员。
研究方向：药物新型递释系统在肿瘤疫苗和急性肺损伤中的应用研究
联系方式
邮箱：conglianyang@hust.edu.cn
地址：武汉市硚口区航空路13号同济药学院2号楼4楼邮编430030
教育背景与工作经历
2009年9月-2013年6月华中科技大学，生物药学基地班学士
2013年9月-2018年6月华中科技大学药剂学博士
2018年7月-2020年10月华中科技大学药学院博士后
2020年10月-2023年3月华中科技大学药学院讲师
2023年3月-至今华中科技大学药学院副教授
近五年代表性研究成果
Xiong Liu, Xiangjun Ou, Tiantian Zhang, Xiaonan Li, Qi Qiao, Liyuan Jia, Zhangxi Xu, Fangming Zhang, Tianyi Tian, Hongbing Lan,Conglian Yang*, Li Kong*, Zhiping Zhang*. In situ neutrophil apoptosis and macrophage efferocytosis mediated by Glycyrrhiza protein nanoparticles for acute inflammation therapy. Journal of Controlled Release 2024; 369: 215-230.
Hongbo Xu; Xianya Qin; Yuanyuan Guo; Siyu Zhao; Xingxing Feng; Runzan Zhang; Tianyi Tian; Li Kong*;Conglian Yang*; Zhiping Zhang*; Radiation-based immunogenic vaccine combined with a macrophage “checkpoint inhibitor” for boosting innate and adaptive immunity against metastatic colon cancers, Acta Pharmaceutica Sinica B, 2024, doi.org/10.1016/j.apsb.2024.02.015.
Xianya Qin#, Hongbo Xu#, Siyu Zhao#, Li Kong,Conglian Yang*, Zhiping Zhang*, A novel biosynthesized vaccine based on tumor cells for peritoneal metastasis treatment in colon cancer, Chemical Engineering Journal, 2024,484(15), 149224.
Xiong Liu, Qi Qiao, Xiaonan Li, Xiangjun Ou, Kexin Cui, Boning Niu,Conglian Yang*, Li Kong*, and Zhiping Zhang*, Apoptotic neutrophil-mediated inflammatory microenvironment regulation for the treatment of ARDS,Nano Today, 2023,52, 101946.
Xianya Qin#, Ting Yang#, Hongbo Xu, Runzan Zhang, Siyu Zhao, Li Kong,Conglian Yang*, Zhiping Zhang*, Dying tumor cells-inspired vaccine for boosting humoral and cellular immunity against cancer, Journal of Controlled Release, 2023,359,359-372.
Yang Li#; Dan Zhang#; Tianzi Shi; Yulin Yu; Yinmei Tian; Qi Xie; Jingyu Shi; Li Kong;Conglian Yang*; Zhiping Zhang*; De novo engineering of nanoformulation from traditional Chinese medicine mixtures for psoriasis, Nano Research, 2023,16(4): 5279-5291.
Conglian Yang; Li Kong*; Zhiping Zhang*; Bioreactor: Intelligent platform for drug delivery, Nano Today, 2022, 44, 101481.
Li Kong;Conglian Yang*; Zhiping Zhang*; Organism‐Generated Biological Vesicles In Situ: An Emerging Drug Delivery Strategy, Advanced Science, 2022, 10(2): e2204178
Jiali Li; Shichao Li; Yang Li; Guanjie Yuan; Yaqi Shen; Yang Peng; Li Kong;Conglian Yang*; Zhiping Zhang; Zhen Li*; A magnetic resonance nanoprobe with STING activation character collaborates with platinum-based drug for enhanced tumor immunochemotherapy, Journal of Nanobiotechnology, 2021, 19(1): 415
Qi Qiao; Xiong Liu; Ting Yang; Kexin Cu; Li Kong;Conglian Yang*; Zhiping Zhang*; Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design, Acta Pharmaceutica Sinica B. 2021;11(10): 3060-3091.
Conglian Yang; Kun Tu; Hanlu Gao; Liao Zhang; Yu Sun; Ting Yang; Li Kong; Defang Ouyang; Zhiping Zhang; The novel platinum (IV) prodrug with self-assembly property and structure-transformable character against triple-negative breast cancer, Biomaterials, 2020, 232: 119751.
Xue Jiang; Yu Sun; Lihuang Shang;Conglian Yang*; Li Kong; Zhiping Zhang*; Green tea extract-assembled nanoclusters for combinational photothermal and chemotherapy, Journal of Materials Chemistry B, 2019, 7(39): 5972-5982
已申请/已授权的发明专利
1、张志平；杨丛莲；一种二氯乙酸修饰的蒽环类化合物与其制备方法和应用, 2019-11-12,中国, ZL201711044597.X (已授权)
2、张志平；杨丛莲；一种修饰的铂类化合物及其制备方法与应用, 2020-10-16,中国, ZL201911330674.7 (已授权)
3、张志平；张娇；罗倩；杨丛莲；一种多功能可注射生物活性水凝胶及其制备方法和应用中国，2023-04-25,中国,ZL2022106556345 (已授权)
4、张志平；杨丛莲；李阳；孔丽；用于银屑病治疗的多组分载药中药蛋白纳米粒，2022-08-26,中国,申请号:2022110340907
5、张志平；杨丛莲；覃娴雅；杨婷；徐鸿博；孔丽；一种新型高免疫原性肿瘤全细胞疫苗及其制备与应用,2023-04-14,中国,申请号:202310397915X
主持和参与课题
(1)国家自然科学基金委员会,青年科学基金项目, 82104098,基于免疫原性死亡的肿瘤细胞构建DC囊泡疫苗及其机制研究, 2022-01-01至2024-12-31, 30万元,在研,主持
(2)湖北省自然科学基金,联合基金, 2023AFD152,中药植物外泌体装载NIR药物控制释放体系用于肿瘤协同治疗, 2023-07至2025-06, 10万元,在研,主持
(3)横向合作项目, 20232968,新型复合凝聚体透皮制剂，2023.11-2026.11, 170万元，在研，主持
(4)中国博士后科学基金会,中国博士后科学基金面上资助, 2018M642859,炎症微环境原位自重组策略在急性肺损伤中的研究, 2018-07至2020-06, 5万元,结题,主持
