张志平，入选万人计划科技创新领军人才，华中科技大学同济药学院、国家纳米药物工程技术研究中心教授，附属同济医院双聘教授，博士生导师。2007年获新加坡国立大学博士，2010年哈佛医学院博士后。主要研究方向：1）仿生递送系统在肿瘤、急性呼吸窘迫综合征中的研究；2）新型药用辅料与自组装递送系统在肿瘤疫苗、核酸药物递送等方面的研究。发表文章90余篇，他引6000余次，高被引文章7篇，h因子43。近五年以通讯作者发表SCI收录文章40余篇（影响因子大于10的29篇），包括本领域主流刊物Journal of Controlled Release、Advanced Science、ACS Nano、Advanced Functional Materials、Nano Today、Nano Letter、Small、Biomaterials、Acta Pharmaceutica Sinica B等。申请专利15件，授权11件。主持国家自然科学基金6项，参与承担国家重大科学研究计划等项目等。曾获世界生物材料大会颁发的“Young Scientist”奖、中国药学会青年药剂学奖、华中科技大学2013年度“学术新人奖”、2015年“十佳青年教工”、2016年“知心导师”、2020年度“三育人”称号等。目前担任Journal of Controlled Release、Acta Pharmaceutica Sinica B、Asian Journal of Pharmaceutical Sciences和Current Medical Science编委；任中国药学会药剂专委会委员，中国颗粒学会第八届理事会理事，中国抗癌协会纳米肿瘤专业委员会委员，中国生物物理学会纳米生物物理专业委员会委员，湖北省药学会理事会理事、制药工程专委会副主任委员等。
联系方式：zhulinyulaoliu@msn.com
承担的主要科研项目
1）2024-2027，嵌套式凝聚体的构建及其介导的时序靶向策略用于ARDS的治疗，国家自然科学基金82373816
2）2022-2025，中性粒细胞凋亡小体介导的“御敌、策反、歼敌”策略在ARDS治疗中的研究，国家自然科学基金82173760
3）2019-2022，细胞衍生的生物矿化囊泡在急性肺损伤治疗中的研究，国家自然科学基金81872810
4）2017-2020，基于肿瘤微环境原位自组装多肽纳米纤维的化疗联合免疫治疗研究，国家自然科学基金81673374
5）2014-2017，基于红细胞膜包被聚合物纳米粒的“功能鸡尾酒”癌症免疫治疗研究，国家自然科学基金81373360
6）2019-2024，细胞孕育高仿生药物研究，华中科技大学，学术前沿青年团队，300万元
7）2017-2019，一氧化氮供体与阿杜丁-阿霉素前药协同抑制耐药肿瘤的关键技术研究，武汉市科技计划攻关
8）2012-2016，肝癌治疗的新型纳米药物治疗，国家重大科学研究计划(973)，2012CB932500
发明专利情况
1）一种具有P-糖蛋白抑制功能的抗肿瘤前药，ZL201210475046.X
2）一种具有抗癌活性的化合物及抗癌组合物，ZL201410417939.8
3）一种具有抗肿瘤作用的化合物、其制备方法及应用，ZL201410621102.5
4）一种二氯乙酸修饰的蒽环类化合物与其制备方法和应用，ZL201711044597.X
5）一种具有P-糖蛋白抑制功能的抗肿瘤前药及制备方法，ZL201810078390.2
6）肿瘤细胞纳米金囊泡、免疫纳米金囊泡及制备方法与应用，ZL201810207398.4
7）一种修饰的铂类化合物及其制备方法与应用，ZL201911330674.7
8）缓控释制剂及制法与制备原位肿瘤免疫联合治疗药物应用，ZL202010725637.2
9）用于调控表观遗传与免疫检查点的药物组合脂质体制剂，zl202110589914.6
10）一种可注射生物活性水凝胶及其制备方法和应用，ZL2022106556345
11）一种具有高效基因转染效率的阳离子脂质体及制备与应用，ZL202111403326.5
12）甘草蛋白载药纳米粒子用于制备治疗银屑病药物的应用，CN2022110340907
13）一种搭载细胞内生成dsRNA的纳米囊泡、制备与应用，CN202211711080.2
14）一种新型高免疫原性肿瘤全细胞疫苗及其制备与应用，CN202310397915.X
发表文章情况（*通讯作者）
2024
1. Yulin Yu, Yinmei Tian, Yang Li, Xianya Qin, Xiaonan Li, Qian Hu, Chuansheng Fu, Boning Niu, Conglian Yang, Li Kong,Zhiping Zhang*. Self-generated double-stranded RNA for enhancing tumor immunotherapy and metastasis inhibition.Nano Today, 2024, 55: 102173.
2. Xianya Qin, Hongbo Xu, Siyu Zhao, Li Kong, Conglian Yang*,Zhiping Zhang*. A novel biosynthesized vaccine based on tumor cells for peritoneal metastasis treatment in colon cancer.Chemical Engineering Journal, 2024, in press.
3. Xiaonan Li, Qi Qiao, Xiong Liu, Qian Hu, Yulin Yu, Xianya Qin, Tianyi Tian, Yinmei Tian, Xiangjun Ou, Boning Niu, Conglian Yang, Li Kong,* andZhiping Zhang*. Engineered Biomimetic Nanovesicles Based on Neutrophils for Hierarchical Targeting Therapy of Acute Respiratory Distress Syndrome.ACS Nano2024, 18, 1658−1677.
4. Hongbo Xu, Xianya Qin, Yuanyuan Guo, Siyu Zhao, Xingxing Feng, Runzan Zhang, Tianyi Tian, Li Kong*, Conglian Yang*,Zhiping Zhang*. Radiation-induced immunogenic vaccine combined with macrophage “checkpoint inhibitor” for boosting innate and adaptive immunity against metastatic colon cancers.Acta Pharmaceutica Sinica B, 2024, in press.
5. Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo*,Zhiping Zhang*. Biofunctional coacervate-based artificial protocells with membrane-like and cytoplasm-like structures for the treatment of persistent hyperuricemia.Journal of Controlled Release2024; 365: 176–192.
2023
1. Lihuan Shang#, Qi Xie#, Conglian Yang, Li Kong,* and Zhiping Zhang*. Extracellular Vesicles Facilitate the Transportation of Nanoparticles within and between Cells for Enhanced Tumor Therapy.ACS Applied Materials & Interfaces2023; 15: 42378-42394.
2. Xiong Liu, Qi Qiao, Xiaonan Li, Xiangjun Ou, Kexin Cui, Boning Niu, Conglian Yang*, Li Kong*,Zhiping Zhang*. Apoptotic neutrophil-mediated inflammatory microenvironment regulation for the treatment of ARDS.Nano Today2023; 52: 101946
3. Xianya Qin#, Ting Yang#, Hongbo Xu, Runzan Zhang, Siyu Zhao, Li Kong, Conglian Yang*,Zhiping Zhang*. Dying Tumor Cells-inspired Cancer Vaccine for Boosting Humoral and Cellular Immunity against Cancer.Journal of Controlled Release2023; 359: 359-372.
4. Runzan Zhang, Xianya Qin, Junyu Lu, Hongbo Xu, Siyu Zhao, Xiaonan Li, Conglian Yang, Li Kong, Yuanyuan Guo*,Zhiping Zhang*. Chemodynamic/Photothermal Synergistic Cancer Immunotherapy Based on Yeast Microcapsule-Derived Au/Pt Nanoparticles.ACS Applied Materials & Interfaces2023; 15: 24134-24148.
5. Jiao Zhang, Qian Luo, Qian Hu, Tiantian Zhang, Jingyu Shi, Li Kong, Dehao Fu,Conglian Yang,Zhiping Zhang*.An injectable bioactive dressing based on platelet-rich plasma and nanoclay:Sustained release of deferoxamine to accelerate chronic wound healing.Acta Pharmaceutica Sinica B,2023, 13(10): 4318-43336.
6.Yulin Yu, Yang Li, Yinmei Tian, Qian Hu, Xiaonan Li, Jingyao Tu, Han Liu, Conglian Yang,Li Kong andZhiping Zhang*.Boosting B Cell and Macrophage-Mediated HumoralImmunity with Fusion Nanovesicles for Triple-NegativeBreast Cancer Combined Therapy. Advanced Healthcare Materials2023;12(6): 2202209.
7. Yang Li#, Dan Zhang#, Tianzi Shi, Yulin Yu, Yinmei Tian, Qi Xie, Jingyu Shi, Li Kong, Conglian Yang*andZhiping Zhang*. De novo engineering of nanoformulation from traditional Chinesemedicine mixtures for psoriasis.Nano Research2023; 16: 5279-5291.
8. Li Kong, Conglian Yang* andZhiping Zhang*.Organism-Generated Biological Vesicles In Situ: AnEmerging Drug Delivery Strategy.Advanced Science2023;10(2): 2204178.
9. Yixuan Zhou#, Xingxing Feng#, Hongbo Xu, Jing Guo, Conglian Yang, Li Kong*,Zhiping Zhang*. The application of naturalproduct-delivering micro/nano systems in the treatment of inflammatory bowel disease.Journal of Materials Chemistry B2023;11(2): 244-260.
2022
1. Qi Qiao, Xiong Liu, Kexin Cui, Xiaonan Li, Tianyi Tian, Yulin Yu, Boning Niu, Li Kong, Conglian YangandZhiping Zhang*. Hybrid Biomimetic Nanovesicles to Drive HighLung Biodistribution and Prevent CytokineStorm for ARDS Treatment.ACS Nano2022; 16(9):15124-15140.
2.Dan Zhang, Pengran Liu, Xianya Qin, Lu Cheng, Fuqian Wang, Xin Xiong,Chuanqi Huang andZhiping Zhang*. HSA-templated self-generation of goldnanoparticles for tumor vaccine delivery andcombinational therapy.Journal of Materials Chemistry B2022; 10(42):8750-8759.
3. Xingxing Feng, Qi Xie, Hongbo Xu, Tiantian Zhang, Xiaonan Li, Yinmei Tian, Hongbing Lan, Li Kong*andZhiping Zhang*.Yeast Microcapsule Mediated Natural Products Delivery for TreatingUlcerative Colitis through Anti-Inflammatory and Regulation ofMacrophage Polarization.ACS Applied Materials & Interfaces2022;14(27): 31085-31098.
4. Qi Xie, Shichao Li, Xingxing Feng, Jingyu Shi, Yang Li, Guanjie Yuan, Conglian Yang, Yaqi Shen*, Li Kong* andZhiping Zhang*. All-in-One Approaches for Triple-negative Breast Cancer Therapy: Metal-phenolic Nanoplatform for MR Imaging-guided Combinational Therapy.Journal of Nanobiotechnology2022;20: 226.
5. Lihuan Shang, Xue Jiang, Ting Yang, Hongbo Xu, Qi Xie,Mei Hu, Conglian Yang, Li Kong*,Zhiping Zhang*. Enhancing cancer chemo-immunotherapy by biomimetic nanogel with tumor targeting capacity and rapid drug-releasing in tumor microenvironment.Acta Pharmaceutica Sinica B2022;12(5): 2550-2567.
6. Conglian Yang, Li Kong*,Zhiping Zhang*. Bioreactor: Intelligent platform for drug delivery.Nano Today2022;44: 101481.
2021
1. Lihuan Shang, Ting Yang, Conglian Yang, Zhen Li*, Li Kong*,Zhiping Zhang*.Metalions-mediated self-assembly of nanomedicine for combinationaltherapy against triple-negative breast cancer.Chemical Engineering Journal2021;425: 131420.
2. Xianya Qin, Conglian Yang, Hongbo Xu, Runzan Zhang, Dan Zhang, Jingyao Tu, Yuanyuan Guo, Boning Niu, Li Kong, andZhiping Zhang*. Cell-Derived Biogenetic Gold Nanoparticles for Sensitizing Radiotherapy and Boosting Immune Response against Cancer.Small2021;17(50):2103984.
3. Qi Qiao, Xiong Liu, Ting Yang, Kexin Cui, Li Kong, Conglian Yang,Zhiping Zhang*. Nanomedicine for acute respiratory distress syndrome: The latest application,targeting strategy, and rational design.Acta pharmaceutica Sinica B2021; 11(10): 3060-3091.
4.Kun Tu#, Yulin Yu#, Yi Wang, Ting Yang, Qian Hu, Xianya Qin, Jingyao Tu, Conglian Yang, Li Kong,Zhiping Zhang*.Combination of Chidamide-Mediated Epigenetic Modulation with Immunotherapy: Boosting Tumor Immunogenicity and Response to PD-1/PD-L1 Blockade.ACS Applied Materials & Interfaces2021;13(33): 39003-39017.
5. Mei Hu, Jiao Zhang, Li Kong, Yulin Yu, Qian Hu, Ting Yang, Yi Wang, Kun Tu, Qi Qiao, Xianya Qin,Zhiping Zhang*. Immunogenic Hybrid Nanovesicles of Liposomes and Tumor-Derived Nanovesicles for Cancer Immunochemotherapy.ACS Nano2021; 15(2): 3123-3138.
6. Jiali Li#, Xue Jiang#, Lihuan Shang, Li Zhen, Conglian Yang, Yan Luo, Daoyu Hu, Yaqi Shen*,Zhiping Zhang*. L-EGCG-Mn nanoparticles as a pH-sensitive MRI contrast agent.Drug Delivery2021; 28(1): 126-135.
7. Qian Hu, Jingyu Shi, Jiao Zhang, Yi Wang, Yuanyuan Guo*,Zhiping Zhang*. Progress and Prospects of Regulatory Functions Mediated by Nitric Oxide on Immunity and Immunotherapy.Advanced Therapeutics2021; 4(8): 2100032.
2020
1. Jingyao Tu, Kun Tu, Haoran Xu, Lei Wang, Xianglin Yuan, Xianya Qin, Li Kong, Qian Chu*,Zhiping Zhang*. Improving tumor hypoxia and radiotherapy resistance via in situ nitric oxide release strategy.European Journal of Pharmaceutics and Biopharmaceutics2020;150:96-107.
2. Mei Hu, Jiao Zhang, Yulin Yu, Kun Tu, Ting Yang, Yi Wang, Qian Hu, Li Kong,Zhiping Zhang*. Injectable Liquid Crystal Formation System for Reshaping Tumor Immunosuppressive Microenvironment to Boost Antitumor Immunity: Postoperative Chemoimmunotherapy.Small2020;16(50):2004905.
3. Qian Hu, Lihuan Shang, Mengmeng Wang, Kun Tu, Mei Hu, Yulin Yu, Mingwang Xu, Li Kong, Yuanyuan Guo*,Zhiping Zhang*.Co-Delivery of Paclitaxel and Interleukin-12 Regulating Tumor Microenvironment for Cancer Immunochemotherapy.Advanced Healthcare Materials2020;9(10): 1901858.
4.Kun Tu#, Huan Deng#, Li Kong, Yi Wang, Ting Yang, Qian Hu, Mei Hu, Conglian Yang,Zhiping Zhang*.Reshaping Tumor Immune Microenvironment through Acidity-Responsive Nanoparticles Featured with CRISPR/Cas9-Mediated Programmed Death-Ligand 1 Attenuation and Chemotherapeutics-Induced Immunogenic Cell Death.ACS Applied Materials & Interfaces2020;12: 16018-16030.
5. Yang Conglian, Tu Kun, Gao Hanlu, Zhang Liao, Sun Yu, Yang Ting, Kong Li, Ouyang Defang*,Zhang, Zhiping*. The novel platinum(IV) prodrug with self-assembly property and structure transformable character against triple-negative breast cancer.Biomaterials2020; 232: 119751.
6. Deng Huan#, Tan Songwei#, Gao Xueqin, Zou Chenming, Xu Chenfeng, Tu Kun, Song Qingle, Fan Fengjuan, Huang Wei,Zhang Zhiping*. Cdk5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity.Acta Pharmaceutica Sinica B2020; 10(2): 358-373.
2019
1. Chenfeng Xu, Yulin Yu, Yu Sun, Li Kong, Conglian Y ang, Mei Hu, Ting Y ang, Jiao Zhang, Qian Hu andZhiping Zhang*. Transformable Nanoparticle-Enabled Synergistic Elicitation and Promotion of Immunogenic Cell Death for Triple-Negative Breast Cancer Immunotherapy.Advanced Functional Materials2019;29(45): 1905213.
2. Xiaomeng Hu, Tingting Wu, Xianya Qin, Y an Qi, Qi Qiao, Conglian YangandZhiping Zhang*.Tumor Lysate-Loaded Lipid Hybrid Nanovaccine Collaborated with an Immune Checkpoint Antagonist for Combination Immunotherapy.Advanced Healthcare Materials2019; 8(1):1800837.
3. Dan Zhang, Xianya Qin, Tingting Wu, Qi Qiao, Qingle Song,Zhiping Zhang*. Extracellular vesicles based self-grown gold nanopopcorn for combinatorialchemo-photothermal therapy.Biomaterials2019;197: 220-228.
4.Dan Zhang, Tingting Wu, Xianya Qin, Qi Qiao, Lihuan Shang,Qingle Song, Conglian Yang,Zhiping Zhang*. Intracellularly Generated Immunological Gold Nanoparticles for Combinatorial Photothermal Therapy and Immunotherapy against Tumor.Nano Letters2019;19(9):6635-6646.
5. Huan Deng#, Wei Huang#,Zhiping Zhang*. Nanotechnology based CRISPR/Cas9 system delivery for genome editing: Progress and prospect.Nano Research2019;12(10):2437-2450.
6. Tingting Wu , Qi Qiao , Xianya Qin , Dan Zhang ,Zhiping Zhang*. Immunostimulatory cytokine and doxorubicin co-loaded nanovesicles for cancer immunochemotherapy.Nanomedicine: Nanotechnology, Biology and Medicine2019;18:66-77.
7. Chenfeng Xu, Yu Sun, Yulin Yu, Mei Hu, Conglian Yang,Zhiping Zhang*. A sequentially responsive and structure-transformable nanoparticle with a comprehensively improved ‘CAPIR cascade’ for enhanced antitumor effect.Nanoscale2019;11(3):1177-1194.
8. Xue Jiang#, Yu Sun#, Lihuang Shang, Conglian Yang*, Kong Li,Zhiping Zhang*. Green tea extract-assembled nanoclusters for combinational photothermal and chemotherapy.Journal of Materials Chemistry B2019;7(39):5972-5982.
2018
1. Yongdan Zhao, Qingle Song, Yijia Yin, Tingting Wu, Xiaomeng Hu, Xueqin Gao, Gao Li, Songwei Tan andZhiping Zhang*.Immunochemotherapymediated by thermosponge nanoparticles for synergistic anti-tumor effects.Journal of Controlled Release2018;269: 322-336.
2. Conglian Yang#, Tingting Wu#, Yan Qi,Zhiping Zhang*. Recent Advances in the Application of Vitamin E TPGS for Drug Delivery.Theranostics2018; 8(2):464-485.
3.Huan Deng,Zhiping Zhang*. The application of nanotechnology in immune checkpoint blockade for cancer treatment.Journal of Controlled Release2018; 290:28-45.
4. Chenfeng Xu, Yu Sun, Yan Qi, Yulin Yu, Yangzhou He, Mei Hu, Qian Hu, Tingting Wu, Dan Zhang, Lihuan Shang, Huan Deng andZhiping Zhang*. Selective self-induced stimulus amplification prodrug platform for inhibiting multidrug resistance and lung metastasis.Journal of Controlled Release2018;284:224-239.
5. Conglian Yang, Yuting Qin, Kun Tu, Chenfeng Xu, Zhen Li*,Zhiping Zhang*. Star-shaped polymer of β‑cyclodextrin-g-vitamin E TPGS for doxorubicin delivery and multidrug resistance inhibition.Colloids Surf. B Biointerfaces2018;169:10-19.
6. Yu Sun, Yuling Bao, Xue Jiang, Songwei Tan*, Mingxing Yin, Conglian Yang, Liping Zhou,Zhiping Zhang*. pH-sensitive micelles with charge-reversible property for tumor growth inhibition and anti-metastasis.Journal of Materials Chemistry B2018; 6(3): 458-468.
7. Yijia Yin, Qian Hu, Chenfeng Xu, Qi Qiao, Xianya Qin, Qingle Song, Yang Peng*, Yongdan Zhao,Zhiping Zhang*. Co-delivery of Doxorubicin and Interferon‑γ by Thermosensitive Nanoparticles for Cancer Immunochemotherapy.Molecular Pharmaceutics2018; 15(9): 4161-4172.
8. Tingting Wu, Dan Zhang, Qi Qiao, Xianya Qin, Conglian Yang, Miao Kong, Huan Deng,Zhiping Zhang*. Biomimetic Nanovesicles for Enhanced Antitumor Activity of Combinational Photothermal and Chemotherapy.Molecular Pharmaceutics2018; 15(3): 1341-1352.
9. Yan Qi, Xianya Qin, Conglian Yang, Tingting Wu, Qi Qiao, Qingle Song,Zhiping Zhang*. Micelle system based on molecular economy principle for overcoming multidrug resistance and inhibiting metastasis.Molecular Pharmaceutics2018; 15(3): 1005-1016.
10. Conglian Yang, Tingting Wu, Yuting Qin, Yan Qi, Yu Sun, Miao Kong, Xue Jiang, Xianya Qin, Yaqi Shen*,Zhiping Zhang*. A facile doxorubicin-dichloroacetate conjugate nanomedicine with high drug loading for safe drug delivery.International Journal of Nanomedicine2018; 13: 1281-1293.
