朱虎成

朱虎成，博士，教授，博士生导师，药学院党委副书记，国家自然科学基金优秀青年基金及湖北省杰出青年基金获得者。主要从事药用植物和真菌来源活性天然药物的提取分离、结构鉴定及药理活性研究。主持国家自然科学基金优秀青年基金、面上项目，湖北省科技重大项目、省杰出青年基金等。以第一作者或通讯作者身份在Angew. Chem. Int. Ed.和Org. Lett.等学术期刊上发表SCI论文90余篇。现任天然药物化学与资源评价湖北省重点实验室副主任，湖北省药学会中药天然药专业委员会副主任委员。

联系方式

邮箱：zhuhucheng@hust.edu.cn

研究方向

药用植物和真菌来源活性天然药物的分离鉴定及药理活性研究

教育及工作经历

2024.1-至今，华中科技大学，同济药学院，党委副书记

2021.4-2023.12，华中科技大学，同济药学院，院长助理

2019.10-至今，华中科技大学，同济药学院，教授

2016.9-2019.9，华中科技大学，同济药学院，副教授

2014.7-2016.8，华中科技大学，同济药学院，博士后

2011.9-2014.6，华中科技大学，同济药学院，博士

2008.9-2011.6，西南大学，药学院，硕士

2004.9-2008.6，西南交通大学，生物工程系，本科

主持科研项目

国家自然科学基金面上项目，编号82173706，2022.1-2025.12（55万）

国家自然科学基金优秀青年基金，编号81922065，2020.1-2022.12（120万）

国家自然科学基金面上项目，编号21772048，2018.1-2021.12（66万）

国家自然科学基金青年项目，编号21502057，2016.1-2018.12（21万）

湖北省科技重大项目，编号2021ACA012，2021.7-2024.6（1000万）

湖北省杰出青年基金项目，编号2018CFA076，2018.3-2021.3（10万）

中国博士后科学基金特别资助，编号2016T90695，2016.1-2016.12（15万）

中国博士后科学基金面上项目，编号2015M572154，2015.7-2016.6（5万）

主要学术论文

[1] Hucheng Zhu^(#), Chunmei Chen^(#), Qingyi Tong^(#), Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang^(*), Asperflavipine A, A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System fromAspergillus flavipesQCS12,Angewandte Chemie-International Edition,2017, 56, 5242 –5246.

[2] Hucheng Zhu^(#), Chunmei Chen^(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, Yonghui Zhang^(*), Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units fromAspergillus flavipes,Angewandte Chemie International Edition, 2016, 55, 3486-3490.

[3] Hucheng Zhu^(#), Chunmei Chen^(#), Yongbo Xue^(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, Yonghui Zhang^(*), Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, fromAspergillus flavipes,Angewandte Chemie International Edition, 2015, 54, 13374-13378.

[4] Yi Guo^(#), Fang Huang^(#), Weiguang Sun, Yuan Zhou, Chunmei Chen, Changxing Qi, Jing Yang, Xiao-Nian Li, Zengwei Luo,Hucheng Zhu^(*), Xiaochuan Wang^(*), Yonghui Zhang^(*). Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort,Chemical Science,2021,12, 11438.

[5] Qin Li^(#), Mi Zhang^(#), Xiaotian Zhang^(#), Lanqin Li, Meijia Zheng, Jinbing Kang, Fei Liu, Qun Zhou, Xiaonian Li, Weiguang Sun, Junjun Liu, Chunmei Chen^(*),Hucheng Zhu^(*), Yonghui Zhang^(*). Talaroclauxins A and B: Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons fromTalaromyces stipitatus.Chinese Chemical Letters,2024, 35, 108193.

[6] Aimin Fu^(#), Chunmei Chen^(#), Qin Li^(#), Nanjin Ding, Jiaxin Dong, Yu Chen, MengshaWei, Weiguang Sun^(*),Hucheng Zhu^(*), Yonghui Zhang^(*). Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungusAspergillus nidulans.Chinese Chemical Letters,2023, 109100.

[7] Qin Li^(#), Meijia Zheng^(#), Fengli Li^(#), Yongqi Li, Chunmei Chen, Zijian Huang, Junjun Liu, Weiguang Sun^(*), Ying Ye^(*),Hucheng Zhu^(*), Yonghui Zhang^(*). Talarolactones A–G, α-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus, and Their Biosynthetic Pathways,Organic Letters, 2023, 25,1616–1621.

[8] Qin Li, Aimin Fu, Mengsha Wei, Yang Xiao, Jie Yin, Jianzheng Huang, Xiao-Nian Li, Qingyi Tong, Chunmei Chen^(*),Hucheng Zhu^(*), Yonghui Zhang^(*). Asperemestrins A−D, Emestrin Hybrid Polymers with Bridged Skeletons from the Endophytic FungusAspergillus nidulans,Organic Letters, 2022, 24, 6800–6804.

[9] Huaqiang Li^(#), Wenya Feng^(#), Xiaoxin Li, Xin Kang, Shan Yan, Menghang Chao, Shuyuan Mo, Weiguang Sun, Yuanyuan Lu, Chunmei Chen, Jianping Wang^(*),Hucheng Zhu^(*), and Yonghui Zhang^(*), Terreuspyridine: An Unexpected Pyridine-Fused Meroterpenoid Alkaloid with a Tetracyclic 6/6/6/6 Skeleton fromAspergillus terreus,Organic Letters, 2020 22, 7041-7046.

[10] Zhaodi Wu^(#), Xiaotian Zhang^(#), Chunmei Chen^(#), Peng Zhou, Mi Zhang, Lianghu Gu, Zengwei Luo, Jianping Wang, Qingyi Tong⁽*⁾,Hucheng Zhu⁽*⁾, and Yonghui Zhang⁽*⁾, Dimericchalasine A and Amichalasines D and E, Unexpected Cytochalasan Homodimer and Heterotrimers fromAspergillus micronesiensisPG-1,Organic Letters, 2020 22, 2162-2166.

[11] Qin Li^(#), Chunmei Chen^(#), Yan He, Danyingzi Guan, Li Cheng, Xincai Hao, Mengsha Wei, Yinyu Zheng, Chang Liu, Xiao-Nian Li, Qun Zhou,Hucheng Zhu^(*), and Yonghui Zhang^(*), Emeriones A−C, Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities fromEmericella nidulans,Organic Letters, 2019, 21, 5091-5095.

[12] Qin Li^(#), Chunmei Chen^(#), Mengsha Wei, Chong Dai, Li Cheng, Jiafeng Tao, Xiao-Nian Li, Jianping Wang, Weiguang Sun^(*),Hucheng Zhu^(*), and Yonghui Zhang^(*), Niduterpenoids A and B, Two Sesterterpenoids with a Highly Congested Hexacyclic 5/5/5/5/3/5 Ring System from the FungusAspergillus nidulans,Organic Letters, 2019, 21, 2290-2293.

[13] Zhaodi Wu^(#), Qingyi Tong^(#), Xiaotian Zhang, Peng Zhou, Chong Dai, Jianping Wang, Chunmei Chen^(*),Hucheng Zhu^(*), and Yonghui Zhang^(*),Amichalasines A–C, Three Cytochalasan Heterotrimers fromAspergillus micronesiensisPG-1,Organic Letters, 2019, 21, 1026-1030.

[14] Wenjing Wang, Fanrong Zeng, Qiong Bie, Chong Dai,Chunmei Chen, Qingyi Tong, Junjun Liu, Jianping Wang, Yuan Zhou,Hucheng Zhu^(*), Yonghui Zhang^(*), Cytochathiazines A−C, Three Merocytochalasans with a 2H-1,4-Thiazine Functionality from Coculture ofChaetomium globosumandAspergillus flavipes,Organic Letters, 2018, 20, 6817-6821.

[15] Zhengxi Hu^(#), Weiguang Sun^(#), Fengli Li^(#), Jiankun Guan^(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang^(*),Hucheng Zhu^(*), and Yonghui Zhang^(*),Fusicoccane-Derived Diterpenoids fromAlternaria brassicicola, Investigation of the Structure-Stability Relationship and Discovery of a IKKβ Inhibitor,Organic Letters, 2018, 20, 5198-5202.

[16] Yi Zang, Gregory Genta-Jouve, Yingyu Zheng, Qing Zhang, Chunmei Chen, Qun Zhou, Jianping Wang^(*),Hucheng Zhu^(*), Yonghui Zhang^(*). Griseofamines A and B, Two indole-tetramic acid alkaloids with 6/5/6/5 and 6/5/7/5 ring systems fromPenicillium griseofulvum,Organic Letters, 2018, 20, 2046-2050.

[17] Keliang Chen^(#), Xuwen Zhang^(#), Weiguang Sun^(#), Junjun Liu, Jing Yang, Chunmei Chen, Xiulan Liu, Limin Gao, Jianping Wang, Hua Li, Zengwei Luo, Yongbo Xue,Hucheng Zhu^(*), and Yonghui Zhang^(*), Manginoids A–G, Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System fromGuignardia mangiferae,Organic Letters, 2017, 19, 5956-5959.

[18] Guangzheng Wei^(#), Chunmei Chen^(#), Qingyi Tong^(#), Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang,Hucheng Zhu^(*), and Yonghui Zhang^(*), Aspergilasines A–D, four merocytochalasans with new carbon skeletons fromAspergillus flavipesQCS12,Organic Letters, 2017, 19, 4399-4402.

[19] Chunmei Chen^(#),Hucheng Zhu^(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue^(*), Yonghui Zhang^(*),Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived FungusChaetomium globosum,Organic Letters, 2015, 17, 644-647.

[20] Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue^(*), Yonghui Zhang^(*),Bioactive Acylphloroglucinols with Adamantyl Skeleton fromHypericum Sampsonii,Organic Letters, 2014, 16, 6322-6325.