张勇慧简历
二级教授，华中科技大学副校长，同济医学院党委书记，同济医学院药学院院长，国务院特殊津贴获得者，国家杰出青年科学基金获得者，教育部长江学者特聘教授，国家万人计划科技创新领军人才，国家重点研发计划首席科学家，国家重大新药创制专项课题组长，国家863计划项目负责人，“湖北省天然药物化学与资源评价重点实验室”主任，“武汉市天然药物工程技术中心”主任。获湖北省科技进步特等奖（已公示）及湖北省自然科学一等奖。2017年暑期，作为药学代表，参加了北戴河暑期专家休假活动，受到中央首长的亲切接见。
中国药学会理事，湖北省药学会副理事长，中国中药和天然药物专业委员会委员。国家科技奖励评审专家，教育部科技奖励评审专家，国家CFDA新药审评专家。国家级教学成果二等奖获得者，国家级一流本科专业建设点负责人，国家一流本科课程《天然药物化学》负责人。人民卫生出版社2022版《天然药物化学》副主编，Current Medical Science副主编，Acta Pharmaceutica Sinica B编委，药学进展、药学教育等编委。
主持国家“重大新药创制”专项课题3项，国家自然科学基金联合基金项目1项，国家自然科学基金项目7项等。申请专利38项（已授权21项），发表通讯作者SCI论文360余篇（IF>10论文13篇，IF 9～10论文11篇），文章总IF 1915，被引7586次。
主要从事天然药物化学研究，从华中地区药用植物及其内生真菌的次生代谢产物中分离和鉴定了活性天然产物超过8000个，新化合物超过4000个，有药用开发前景的化合物8个；其中金线莲苷获国家一类新药临床试验批准通知书，实现成果转化2.4亿，指导制定了云南省和福建省等金线莲地方特色食品安全标准。
诚挚欢迎国内外具有药物化学、药理、有机合成或生物合成等研究背景的科研工作者加入本课题组从事博士后研究，待遇从优！
E-mail：zhangyh@mails.tjmu.edu.cn
地址：武汉市航空路13号(邮编430030)
1.课题组主持的科研项目
2023.1-2026.12国家自然科学基金联合基金项目《湖北金丝桃属植物微生态圈中抗病毒药源分子的发现及形成机制研究》
2022.1-2026.12国家重点研发计划“合成生物学”重点专项《组合生物合成构建新骨架人工产物》
2022.1-2024.12湖北省科技重大项目《创新药物筛选技术研发与集成》
2018.1-2022.12国家杰出青年基金《天然药物化学》
2019.1-2020.12国家重大新药创制科技重大专项《化药1.1类抗肝纤维化新药金线莲苷临床前研究》
2018.1-2020.12湖北省技术创新专项重大项目《化药1.1类抗肝纤维化新药金线莲苷临床前研究》
2017.1-2021.12华中科技大学学术前沿青年团队
2014.1-2016.12国家高技术研究发展计划（863计划）《促肝细胞再生金线莲胶囊保健品的研究与开发》
2011.1-2013.12国家重大新药创制专项课题《糖尿病新药临床前研究》
2011.1-2013.12国家重大新药创制专项课题《中药6.1类治疗类风湿关节炎新药复方鹿角霜片临床前研究》
2.代表性论著
1.Zhenhua Guan, Nanyu Yao, Wenling Yuan, Yang Xiao, Mewlude Rehmutulla, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Qinyi Tong, Zheng Xiang(*), Ying Ye(*),Yonghui Zhang(*).Total Biosynthesis of Cotylenin Diterpene Glycosides as 14-3-3 Protein-Protein Interaction Stabilizers.Chemical Science,2024, DOI: 10.1039/D4SC05963H
2.Yulin Duan(#), Weiguang Sun(#), Yongqi Li(#), Zhengyi Shi, Lanqin Li, Yeting Zhang, Huang Kun, Zhiping Zhang, Changxing Qi(*),Yonghui Zhang(*). Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures.Acta Pharmaceutica Sinica B,2024, 14, 2642-2656.
3.Jie Yin, Ziming Zhao, Jianzheng Huang, Yang Xiao, Mewlude Rehmutulla, Biqiong Zhang, Zijun Zhang, Ming Xiang, Qingyi Tong(*),Yonghui Zhang(*). Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.Cell Discovery,2023, 9, 77.
4.Bingchuan Geng(#), Xing Chen(#), Jiangyang Chi(#), Fengli Li, Wai Yen Yim, Kan Wang, Chenghao Li, Minghui Xie, Peng Zhu, Zhengfeng Fan, Jiawei Shi, Zhengxi Hu(*),Yonghui Zhang(*), Nianguo Dong(*). Platelet membrane-coated alterbrassicene A nanoparticle inhibits calcification of the aortic valve by suppressing phosphorylation P65 NF-κB.Theranostics,2023, 13, 3781-3793.
5.Yuling Lu, Chunmei Chen, Hucheng Zhu, Zengwei Luo(*),Yonghui Zhang(*).Highly efficient and fast synthesis of di-iodinated succinimide derivatives from 1,6-enyne and I2 under air at room temperature.Green Chemistry,2022, 24, 8021−8028.
6.Ming Xiang(#), Tingting Liu(#), Cheng Tian(#), Kun Ma, Jing Gou, Rongrong Huang, Senlin Li, Qing Li, Chuanrui Xu, Lei Li, Chih-Hao Lee,Yonghui Zhang(*). Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cellsviathe PI3K-AKT-FoxO1 pathway.Pharmacological Research,2022, 177, 106092.
7.Yi Guo(#), Fang Huang(#), Weiguang Sun, Yuan Zhou, Chunmei Chen, Changxing Qi, Jing Yang, Xiaonian Li, Zengwei Luo, Hucheng Zhu(*), Xiaochuan Wang(*),Yonghui Zhang(*). Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort.Chemical Science,2021,12, 11438−11446.
8.Zhengxi Hu, Ying Ye(*),Yonghui Zhang(*). Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons.Natural Product Reports,2021, 38, 1775−1793.
9.Chunhua Zhao, Shan Yan, Qin Li, Hucheng Zhu, Zhiyu Zhong, Ying Ye, Zixin Deng,Yonghui Zhang(*). An Fe2+‐ and α‐ketoglutarate‐dependent halogenase acts on nucleotide substrates.Angewandte Chemie International Edition,2020, 59, 9478−9484.
10.Mengting Liu(#), Weiguang Sun(#), Ling Shen, Yan He, Junjun Liu, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Bipolarolides A–G, ophiobolin-derived sesterterpenes representing three new carbon skeletons fromBipolarissp. TJ403-B1.Angewandte Chemie International Edition,2019, 58, 12091−12095.
11.Qingyi Tong(#), Huijuan You(#), Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo(*),Yonghui Zhang(*). ZYH005, a novel DNA intercalator, overcomes all-transretinoic acid resistance in acute promyelocytic leukemia.Nucleic Acids Research,2018, 46, 3284−3297.
12.Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong(#), Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo,Yonghui Zhang(*). Asperflavipine A: A cytochalasan heterotetramer uniquely defined by a highly complex tetradecacyclic ring system fromAspergillus flavipesQCS12.Angewandte Chemie International Edition,2017, 56, 5242−5246.
13.Ying Tang(#), Yongbo Xue(#), Guang Du(#), Jianping Wang, Junjun Liu, Bin Sun, Xiao-Nian Li, Guangmin Yao, Zengwei Luo,Yonghui Zhang(*).Structural revisions of a class of natural products: scaffolds of aglycon analogues of fusicoccins and cotylenins isolated from fungi.Angewandte Chemie International Edition,2016, 55, 4069−4073.
14.Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao,Yonghui Zhang(*). Epicochalasines A and B: two bioactive merocytochalasans bearing caged epicoccine dimer units fromAspergillus flavipes.Angewandte Chemie International Edition,2016, 55, 3486−3490.
15.Ming Xiang, Tingting Liu, Wanyue Tan, Hongyu Ren, Hua Li, Junjun Liu, Hui Cao, Qi Cheng, Xiulan Liu, Hucheng Zhu, Yali Tuo, Jianping Wang,Yonghui Zhang(*). Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on DCs-CD8+T cells communication.Hepatology,2016, 64, 2135−2150.
16.Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-Guo Chen,Yonghui Zhang(*).Asperterpenes A and B, two unprecedented meroterpenoids fromAspergillus terreuswith BACE1 inhibitory activities.Chemical Science,2016, 7, 6563−6572.
17.Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo,Yonghui Zhang(*).Asperchalasine A, a cytochalasan dimer with an unprecedented decacyclic ring system, fromAspergillus flavipes.Angewandte Chemie International Edition,2015, 54, 13374−13378.
