张勇慧简历
二级教授，国务院特殊津贴获得者，同济医学院副院长，药学院院长，教育部“长江学者”特聘教授，国家杰出青年科学基金获得者，国家万人计划“科技创新领军人才”，科技部“科技创新领军人才”，国家自然科学基金创新群体骨干，湖北省自然科学基金创新群体负责人，教育部“新世纪优秀人才支持计划”、“湖北省杰出青年科学基金”获得者，“湖北省天然药物化学与资源评价重点实验室”主任，“武汉市天然药物工程技术中心”主任。2017年暑期，作为药学代表，参加了北戴河暑期专家休假活动，受到刘云山、赵乐际等中央首长的亲切接见。
中国药学会理事，中国中药和天然药物专业委员会委员，中国医药生物技术协会生物制药技术分会常务委员，湖北省药学会副秘书长、常务理事，湖北省中药和天然药物专业委员会主任委员，武汉市药学会副理事长。国家科技奖励评审专家，教育部科技奖励评审专家，国家CFDA新药审评专家，国家CFDA化妆品审评专家，国家重大新药创制专项“十二五”《糖尿病新药临床前研究》课题组长。湖北省药学一级重点学科负责人，中药学湖北省品牌专业负责人，人民卫生出版社2016版《天然药物化学》副主编。Current Medical Science（影响因子2.6）副主编，Acta Pharmaceutica Sinica B（影响因子14.9）编委，药学进展编委。
主持国家“重大新药创制”专项课题3项，国家高技术研究发展计划（863计划）1项，国家自然科学基金项目7项，多项省市级科研项目及企业合作项目。申请专利23项（已授权16项），发表论文390余篇，其中SCI收录论文290余篇，副主编或参加编写国家级教材或配套教材10部。2021年获湖北省自然科学一等奖，2018年获华中科技大学三育人奖，2011年获湖北省科技进步二等奖。
主要从事天然药物生物活性成分及创新药物研究，分离和鉴定了天然产物3271个，其中新化合物1828个，包括具有全新碳架的PPAPs、细胞松弛素、萜类、聚酮等200个，隶属于120个不同的新骨架类型。其中21个化合物被Nat. Prod. Rep.评为热点化合物（Hot off the press），有药用开发前景的天然产物或衍生物8个，在复杂天然产物的结构鉴定及活性研究、微量天然产物活性筛选及作用靶点确证、活性化合物深入药理及作用机制研究等方面取得了较好的成绩。申请专利36项，授权专利21项。发表通讯作者SCI论文335篇（IF 10以上论文11篇；IF 5~10论文105篇），文章总IF 1561，被引4602次（他引3586），H-index 34，包括Hepatology1篇（IF 17.3）、Angew. Chem. Int. Ed.6篇（IF 16.8）、Nat. Prod. Rep.1篇（IF 15.1）、Nucleic Acids Res.1篇（IF 19.2）、Chem. Sci.2篇（IF 9.9）、Org. Lett.25篇（IF 6.0）、Brit. J. Pharmacol.2篇（IF 9.4）、Chinese Chem. Lett.9篇（IF 8.4）、Chem. Commun.1篇（IF 6.0）、Org. Chem. Front.15篇（IF 5.4）、Bioorg. Chem.20篇（IF 5.3）、Front. Pharmacol.2篇（IF 5.9）、Mar. Drugs8篇（IF 6.0）、J. Org. Chem.11篇（IF 4.1）、J. Nat. Prod.34篇（IF 4.8）、Phytochemistry29篇（IF 4.0）等。
诚挚欢迎国内外具有天然药物化学、药理、药物化学、有机合成或生物合成等研究背景的科研工作者加入本课题组从事博士后研究，待遇从优！
E-mail：zhangyh@mails.tjmu.edu.cn
地址：武汉市航空路13号(邮编430030)
1.课题组主持的科研项目
2022.1-2026.12国家重点研发计划“合成生物学”重点专项《组合生物合成构建新骨架人工产物》1972万，（项目编号：2021YFA0910500）
2022.1-2024.12湖北省科技重大项目《创新药物筛选技术研发与集成》1000万，（项目编号：2021ACA012）
2018.1-2022.12国家杰出青年基金《天然药物化学》400万元（项目编号：81725021）
2019.1-2020.12国家重大新药创制科技重大专项《化药1.1类抗肝纤维化新药金线莲苷临床前研究》290万元（项目编号：2019ZX09201001-001-003）
2018.1-2020.12湖北省技术创新专项重大项目《化药1.1类抗肝纤维化新药金线莲苷临床前研究》200万元（项目编号：2018ACA115）
2017.1-2021.12华中科技大学学术前沿青年团队300万元
2014.1-2016.12国家高技术研究发展计划（863计划）《促肝细胞再生金线莲胶囊保健品的研究与开发》625万元（项目编号：2014AA022207）
2013.1-2016.12国家重大新药创制专项课题《化学1类治疗高脂血症CEPT抑制剂TRZ候选药物研究》115万元（项目编号：2013ZX09103-001-020）
2012.1-2014.12武汉市3551人才项目《化药一类降血糖新药KD10临床前研究》100万元
2011.1-2013.12国家重大新药创制专项课题《糖尿病新药临床前研究》2291万元（项目编号：2011ZX09102-004）
2011.1-2013.12国家重大新药创制专项课题《中药6.1类治疗类风湿关节炎新药复方鹿角霜片临床前研究》150万元（项目编号：2011ZX09102-006-05）
2010.1-2014.12武汉长联来福生化药业有限责任公司课题《新型PTP1B抑制剂Kinsenoside结构类似物一类新药研究》250万元
2.课题组发表的主要论文和论著
2.1代表性论著
[1] Yi Guo(#), Fang Huang(#), Weiguang Sun, Yuan Zhou, Chunmei Chen, Changxing Qi, Jing Yang, Xiao-Nian Li, Zengwei Luo, Hucheng Zhu(*), Xiaochuan Wang(*),Yonghui Zhang(*). Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort, Chemical Science,2021,12, 11438. (DOI: 10.1039/d1sc03356e)
[2] Zhengxi Hu, Ying Ye(*),Yonghui Zhang(*). Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons,Natural Product Reports,2021, 38, 1775−1793. (DOI: 10.1039/d0np00069h)
[3] Chunhua Zhao, Shan Yan, Qin Li, Hucheng Zhu, Zhiyu Zhong, Ying Ye, Zixin Deng,Yonghui Zhang(*). An Fe2+‐ and α‐ketoglutarate‐dependent halogenase acts on nucleotide substrates,Angewandte Chemie International Edition,2020, 59, 9478−9484. (DOI: 10.1002/anie.201914994)
[4] Mengting Liu(#), Weiguang Sun(#), Ling Shen, Yan He, Junjun Liu, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Bipolarolides A–G, ophiobolin-derived sesterterpenes representing three new carbon skeletons fromBipolarissp. TJ403-B1,Angewandte Chemie International Edition,2019, 58, 12091−12095. (DOI:10.1002/anie.201905966)
[5] Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong(#), Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, Yonghui Zhang(*). Asperflavipine A: A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System fromAspergillus flavipesQCS12,Angewandte Chemie International Edition,2017, 56, 5242−5246. (DOI: 10.1002/anie.201701125)
[6] Ying Tang(#), Yongbo Xue(#), Guang Du(#), Jianping Wang, Junjun Liu, Bin Sun, Xiao-Nian Li, Guangmin Yao, Zengwei Luo,Yonghui Zhang(*).Structural revisions of a class of natural products: scaffolds of aglycon analogues of fusicoccins and cotylenins isolated from fungi,Angewandte Chemie International Edition,2016, 55, 4069−4073. (DOI: 10.1002/ange.201600313)
[7] Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao,Yonghui Zhang(*). Epicochalasines A and B: two bioactive merocytochalasans bearing caged epicoccine dimer units fromAspergillus flavipes,Angewandte Chemie International Edition,2016, 55, 3486−3490. (DOI: 10.1002/ange.201511315)
[8] Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo,Yonghui Zhang(*). Asperchalasine A, a cytochalasan dimer with an unprecedented decacyclic ring system, fromAspergillus flavipes,Angewandte Chemie International Edition,2015, 54, 13374−13378. (DOI: 10.1002/ange.201506264)
[9] Ming Xiang, Tingting Liu, Wanyue Tan, Hongyu Ren, Hua Li, Junjun Liu, Hui Cao, Qi Cheng, Xiulan Liu, Hucheng Zhu, Yali Tuo, Jianping Wang,Yonghui Zhang(*). Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on DCs-CD8+T cells communication,Hepatology,2016, 64, 2135−2150. (DOI: 10.1002/hep.28825)
[10] Qingyi Tong(#), Huijuan You(#), Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo(*),Yonghui Zhang(*). ZYH005, a novel DNA intercalator, overcomes all-transretinoic acid resistance in acute promyelocytic leukemia,Nucleic Acids Research,2018, 46, 3284−3297. (DOI: 10.1093/nar/gky202)
[11] Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-Guo Chen,Yonghui Zhang(*).Asperterpenes A and B, two unprecedented meroterpenoids fromAspergillus terreuswith BACE1 Inhibitory Activities,Chemical Science,2016, 7, 6563−6572. (DOI: 10.1039/c6sc02464e)
2.2 近5年来发表的主要论文
[1] Fengli Li(#), Shuyuan Mo(#), Jie Yin, Sitian Zhang, Saisai Gu, Zi Ye, Jianping Wang(*), Zhengxi Hu(*),Yonghui Zhang(*), Structurally diverse metabolites from a soil-derived fungusAspergillus calidoustus,Bioorganic Chemistry, 2022, 127, 105988. (DOI: https://doi.org/10.1016/j.bioorg.2022.105988).
[2] Si Yao, Jie Yin, Wen Liu, Yang Li, Jianzheng Huang, Changxing Qi, Zhengxi Hu, Qingyi Tong(*), Lianghu Gu(*),Yonghui Zhang(*), A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma,Bioorganic Chemistry, 2022, 127, 106019. (DOI: https://doi.org/10.1016/j.bioorg.2022.106019).
[3] Shuang Lin(#), Jianzheng Huang(#), Hanxiao Zeng, Qingyi Tong, Xueke Zhang, Beiye Yang, Ying Ye, Jianping Wang(*), Zhengxi Hu(*),Yonghui Zhang(*), Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungusStachybotrys chartarum,Chinese Chemical Letters, 2022, 33, 4587−4594. (DOI: 10.1016/j.cclet.2022.03.064).
[4] Mi Zhang(#), Qin Li(#), Shuangjun Li(#), Yanfang Deng, Muyuan Yu, Jinping Liu, Changxing Qi, Xiliang Yang(*), Hucheng Zhu(*),Yonghui Zhang(*). An unprecedented ergostane with a 6/6/5 tricyclic 13(14→8)abeo-8,14-secoskeleton fromTalaromyces adpressus,Bioorganic Chemistry, 2022, 127, 105943. (DOI: https://doi.org/10.1016/j.bioorg.2022.105943).
[5] Peng Zhou(#), Xiaotian Zhang(#), Chong Dai, Shan Yan, Mengsha Wei, Wenya Feng, Qin Li, Junjun Liu, Hucheng Zhu, Zhengxi Hu(*), Chunmei Chen(*),Yonghui Zhang(*). Talaromynoids A-E: five new fusicoccane diterpenoids from the endophytic fungusTalaromycessp. DC-26,The Journal of Organic Chemistry,2022, 87, 7333−7341. (DOI10.1021/acs.joc.2c00528).
[6] Beiye Yang(#), Jun-Cheng Su(#), Lijuan Huang, Shuang Lin, Xiaoqi Jin, Xueping Lei, Zhengxi Hu(*),Yonghui Zhang(*). Hyperispirones A and B, spiro-bridged polycyclic polyprenylated acylphloroglucinols with anti-angiogenesis activity fromHypericum beanie,Organic Chemistry Frontiers,2022, online ahead of print. (DOI: 10.1039/D2QO00366J).
[7] Xiaotian Zhang(#), Zhaodi Wu(#), Alan Bao, Ziming Zhao, Yu Chen, Huimin Zhao, Jianping Wang, Chunmei Chen, Qingyi Tong(*), Hucheng Zhu(*),Yonghui Zhang(*).Asperflavipines C−E and aspermichalasine A: three cytochalasan heterotetramers and an unusual cytochalasan monomer fromAspergillus micronesiensis,Organic Chemistry Frontiers,2022, 9, 2585−2592. (DOI: 10.1039/d2qo00309k).
[8] Shuang Lin(#), Jianzheng Huang(#), Hanxiao Zeng, Qingyi Tong, Xueke Zhang, Beiye Yang, YingYe, JianpingWang, Zhengxi Hu(*),Yonghui Zhang(*). Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungusStachybotrys chartarum,Chinese Chemical Letters,2022, online ahead of print. (DOI:https://doi.org/10.1016/j.cclet.2022.03.064).
[9] Yuben Qiao(#), Xiaosheng Tan(#), Qianqian Xu(#), Zijun Zhang, Qiaoxin Xu, Li Tao, Junjun Liu, Hucheng Zhu, Chunmei Chen, Ying Ye, Yuanyuan Lu, Gang Chen(*), Changxing Qi(*),Yonghui Zhang(*). Asperosin A, a [4+2] diels–alder cycloaddition polyketide dimer fromAspergillus rugulosawith immunosuppressive activity,Organic Chemistry Frontiers,2022, online ahead of print. (DOI:https://doi.org/10.1039/D1QO01767E).
[10] Yulin Duan, Yi Guo, Yanfang Deng, Pengfei Bu, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Weiguang Sun, Changxing Qi(*),Yonghui Zhang(*). Norprzewalsone A, a rearranged polycyclic polyprenylated acylphloroglucinol with a spiro[cyclopentane-1,3'-tricyclo[7.4.0.01,6]tridecane] core fromHypericum przewalskii. The Journal of Organic Chemistry, 2022, 87, 6824−6831. (DOI: 10.1021/acs.joc.2c00503).
[11] Xia Chen(#),, Cheng Zhong(#),, Xianxian Duan, Zhenhua Guan, Lianghu Gu, Zengwei Luo(*), Yong Chen(*),Yonghui Zhang(*). A removable acyl group promoted the intramolecular dehydro-diels-alder reaction of styrene-tnes: highly chemoselective synthesis of aryldihydronaphthalene derivatives.The Journal of Organic Chemistry,2022, 87, 6601−6611. (DOI: 10.1021/acs.joc.2c00180).
[12] Ming Xiang, Tingting Liu, Cheng Tian, Kun Ma, Jing Gou, Rongrong Huang, Senlin Li, Qing Li, Chuanrui Xu, Lei Li, Chih-Hao Lee,Yonghui Zhang(*). Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cellsviathe PI3K-AKT-FoxO1 pathway.Pharmacological Research,2022, 177, 106092. (DOI: https://doi.org/10.1016/j.phrs.2022.106092).
[13] Xian Shu, Guangzheng Wei, Yuben Qiao, Kexin Zhang, Jun Zhang, Guomin Ai, Man-cheng Tang,Yonghui Zhang, Shu-Shan Gao(*), TerC is a multifunctional and promiscuous flavoprotein monooxygenase that catalyzes bimodal oxidative transformations.Organic letters,2021, 23, 8947–8951. (DOI: 10.1021/acs.orglett.1c03432).
[14] Fengli Li, Zi Ye, Zhangyan Huang, Xia Chen, Weiguang Sun, Weixi Gao, Sitian Zhang, Fei Cao, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Newα-pyrone derivatives with herbicidal activity from the endophytic fungusAlternaria brassicicola,Bioorganic Chemistry,2021, 117, 105452. (DOI: 10.1016/j.bioorg.2021.105452).
[15] Yi Guo(#), Fang Huang(#), Weiguang Sun, Yuan Zhou, Chunmei Chen, Changxing Qi, Jing Yang, Xiao-Nian Li, Zengwei Luo, Hucheng Zhu(*), Xiaochuan Wang(*),Yonghui Zhang(*). Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort, Chemical Science,2021,12, 11438. (DOI: 10.1039/d1sc03356e)
[16] Mengting Liu(#), Lianghu Gu(#), Ling Shen, Xueke Zhang, Shuang Lin, Ying Ye, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Bipolaquinones A–J, immunosuppressive meroterpenoids from a soil-derivedBipolaris zeicola,Journal of Natural Products,2021, 84, 2427–2436.(DOI: 10.1021/acs.jnatprod.1c00327).
[17] Yunfang Cao(#), Xiaosheng Tan(#), Ali Adhab Al Chnani, Pengkun Li, Zhengyi Shi, Hao Feng, Lingjuan Sun, Qiangbing Xia, Xi Yang, Yulin Duan, Yi Guo, Gang Chen(*), Changxing Qi(*),Yonghui Zhang(*). Bioassay-guided isolation of an abetiane-type diterpenoid fromPrunella vulgaristhat protects against concanavalin A-induced autoimmune hepatitis,Journal of Natural Products,2021,84, 2189–2199.(DOI: 10.1021/acs.jnatprod.1c00247).
[18] Yulin Duan(#), Yanfang Deng(#), Pengfei Bu, Yi Guo, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Zhengxi Hu(*), Changxing Qi(*),Yonghui Zhang(*). Discovery of bioactive polycyclic polyprenylated acylphloroglucinols fromHypericum wilsonii,Bioorganic Chemistry,2021, 115, 105246. (DOI: 10.1016/j.bioorg.2021.105246).
[19] Yi Guo, Yunfang Cao, Changxing Qi, Qingyi Tong, Chunmei Chen, Jing Yang(*), Hucheng Zhu(*),Yonghui Zhang(*). Polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity fromHypericum perforatumand absolute configurations assignment of previously reported analogues,Bioorganic Chemistry,2021, 114, 105144. (DOI: 10.1016/j.bioorg.2021.105144).
[20] Shuang Lin(#), Shan Yan(#), Yi Liu(#), Xueke Zhang, Fei Cao, Yan He, Fengli Li, Junjun Liu, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). New secondary metabolites with immunosuppressive and BChE inhibitory activities from an endophytic fungusDaldiniasp, TJ403-LS1,Bioorganic Chemistry,2021, 114, 105091. (DOI:10.1016/j.bioorg.2021.105091).
[21] Xia Chen, Cheng Zhong, Yuling Lu, Meng Yao, Zhenhua Guan, Chunmei Chen, Hucheng Zhu, Zengwei Luo(*),Yonghui Zhang(*). Practical access to fluorescent 2,3-naphthalimide derivativesviadidehydro-diels-alder reaction,Chemical Communication,2021, 57, 5155–5158.(DOI: 10.1039/d1cc01437d).
[22] Yulin Duan(#), Yanfang Deng(#), Pengfei Bu, Sshuangshuang Xie, Yi Guo, Zhengyi Shi, Yun Guo, Yunfang Cao, Changxing Qi(*),Yonghui Zhang(*). Discovery of nor-bicyclic polyprenylated acylphloroglucinols possessing diverse architectures with anti-hepatoma activities fromHypericum patulum,Bioorganic Chemistry,2021, 111, 104902. (DOI: 10.1016/j.bioorg.2021.104902).
[23] Yunlin Duan, Shuangshuang Xie, Pengfei Bu, Yi Guo, Zhengyi Shi, Yun Guo, Yunfang Cao, Weiguang Sun, Changxing Qi(*),Yonghui Zhang(*). Hypaluton A, an immunosuppressive 3,4-nor-polycyclic polyprenylated acylphloroglucinol fromHypericum patulum,The Journal of Organic Chemistry,2021, 86, 6478–6485. (DOI: 10.1021/acs.joc.1c00319)
[24] Xia Chen, Yuling Lu, Zhenhua Guan, Lianghu Gu, Chunmei Chen, Hucheng Zhu, Zengwei Luo(*),Yonghui Zhang(*).Synthesis of succinimidesviaintramolecular alder-ene reaction of 1,6-enynes,Organic letters,2021,23, 3173–3178.(DOI: 10.1021/acs.orglett.1c00888).
[25] Fengli Li(#), Shan Yan(#), Zhangyan Huang, Weixi Gao, Sitian Zhang, Shuyuan Mo, Shuang Lin, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Inducing new bioactive metabolites production from coculture ofPestalotiopsissp. andPenicilliumbialowiezense,Bioorganic Chemistry,2021, 110, 104826. (DOI: 10.1016/j.bioorg.2021.104826).
[26] Song Hu(#), Jie Yin(#), Shan Yan, Ping Hu, Jianzheng Huang, Geng Zhang, Fuqian Wang(*), Qingyi Tong(*),Yonghui Zhang(*). Chaetocochin J, an epipolythiodioxopiperazine alkaloid, induces apoptosis and autophagy in colorectal cancer via AMPK and PI3K/AKT/mTOR pathways,Bioorganic Chemistry,2021, 109, 104693. (DOI: 10.1016/j.bioorg.2021.104693).
[27] Chong Dai, Xiaoxin Li, Kailin Zhang, Xiao-Nian Li, Wenjing Wang, Yi Zang, Xia Chen, Qin Li, Mengsha Wei, Chunmei Chen, Hucheng Zhu(*),Yonghui Zhang(*). Pesimquinolones I–S, eleven new quinolone alkaloids produced byPenicillium simplicissimumand their inhibitory activity on NO production,Bioorganic Chemistry2021, 108, 104635. (DOI: 10.1016/j.bioorg.2021.104635).
[28] Beiye Yang(#), Jianzheng Huang(#), Shuang Lin, Qingyi Tong(*), Zeyu Yao, Fengli Li, Ying Ye, Zhengxi Hu(*),Yonghui Zhang(*). Hyperbeanone A, a 5,6-seco-spirocyclic polycyclic polyprenylated acylphloroglucinol derivative with an unprecedented skeleton fromHypericum beanii,Organic Chemistry Frontiers,2021,8, 6411–6418. (DOI: 10.1039/D1QO01302E).
[29] Mengting Liu(#), Xueke Zhang(#), Ling Shen, Weiguang Sun, Shuang Lin, Junjun Liu, Fei Cao, Changxing Qi, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Bioactive polyketide-terpenoid hybrids from a soil-derived fungusBipolaris zeicola.The Journal of Organic Chemistry,2021, 86, 10962–10974. (DOI: 10.1021/acs.joc.0c02237).
[30] Shuangshuang Xie(#), Yuan Zhou(#), Xiaosheng Tan(#), Weiguang Sun, Yulin Duan, Hao Feng, Lingjuan Sun, Yi Guo, Zhengyi Shi, Xincai Hao, Gang Chen(*), Changxing Qi(*),Yonghui Zhang(*). Norwilsonnol A, an Immunosuppressive polycyclic polyprenylated acylphloroglucinol with spiro[5-oxatricyclo[6.4.0.03,7]dodecane-6',1-1',2'-dioxane] system fromHypericum wilsonii,Organic Chemistry Frontiers,2021, 8, 2280–2284. (DOI: 10.1039/D1QO00271F).
[31] Sitian Zhang(#), Yan He(#), Fengli Li, Shuang Lin, Beiye Yang, Shuyuan Mo, Huaqiang Li, Jianping Wang, Changxing Qi(*), Zhengxi Hu(*),Yonghui Zhang(*). Bioassay-directed isolation of antibacterial metabolites from an arthropod-derivedPenicillium chrysogenum,Journal of Natural Products,2020, 83, 3397–3403. (DOI: 10.1021/acs.jnatprod.0c00873).
[32] Na Zhang(#), Zhengyi Shi(#), Qianqian Xu(#), Weiguang Sun, Lianghu Gu, Shuangshuang Xie, Yi Guo, Yulin Duan, Kailin Zhang, Changxing Qi(*),Yonghui Zhang(*). Longisglucinols A–C, structurally intriguing polycyclic polyprenylated acylphloroglucinols with anti-inflammatory activity fromHypericum longistylum,Organic letters,2020, 22, 7926–7929. (DOI: 10.1021/acs.orglett.0c02853).
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[42] Yu Liang, Qin Li, Mengsha Wei, Chunmei Chen, Weiguang Sun, Lianghu Gu(*), Hucheng Zhu(*),Yonghui Zhang(*). Structurally diverse vibralactones produced by the fungusStereum hirsutum,Bioorganic Chemistry,2020, 96, 103760.(DOI: 10.1016/j.bioorg.2020.103760).
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[46] Shuang Lin(#), Huimin Yu(#), Beiye Yang, Fengli Li, Xia Chen, Huaqiang Li, Sitian Zhang, Jianping Wang, Youcai Hu, Zhengxi Hu(*),Yonghui Zhang(*). Reisolation and configurational reinvestigation of cottoquinazolines E–G from an arthropod-derived strain of the fungusNeosartorya fischeri,Journal of Natural Products,2020, 83, 169−173. (DOI: 10.1021/acs.jnatprod.9b01000).
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[55] Weixi Gao(#), Chenwei Chai(#), Yan He, Fengli Li, Xincai Hao, Fei Cao, Lianghu Gu, Junjun Liu, Zhengxi Hu(*),Yonghui Zhang(*).Periconiastone A, an antibacterial ergosterol with a pentacyclo[8.7.0.01,5.02,14.010,15]heptadecane system fromPericoniasp. TJ403-rc01,Organic letters,2019, 21, 8469–8472.(DOI: 10.1021/acs.orglett.9b03270).
[56] Mengting Liu(#), Weiguang Sun(#), Ling Shen, Xincai Hao, Weaam Hasan Al Anbari, Shuang Lin, Huaqiang Li, Weixi Gao, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Bipolaricins A–I, ophiobolin-type tetracyclic sesterterpenes from a phytopathogenicBipolarissp. fungus,Journal of Natural Products,2019, 82, 2897–2906.(DOI: 10.1021/acs.jnatprod.9b00744).
[57] Fengli Li, Shuang Lin, Sitian Zhang, Xincai Hao, Xiao-Nian Li, Beiye Yang, Junjun Liu, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*).Alterbrassinoids A–D: fusicoccane-derived diterpenoid dimers featuring different carbon skeletons fromAlternaria brassicicola,Organic letters,2019, 21, 8353–8357.(DOI: 10.1021/acs.orglett.9b03133).
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[59] Yuben Qiao(#), Qianqian Xu(#), Wenya Feng, Li Tao, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Yuanyuan Lu, Jianping Wang, Changxing Qi(*), Yongbo Xue(*),Yonghui Zhang(*). Asperpyridone A: an unusual pyridone alkaloid exerts hypoglycemic activity through the insulin signaling pathway,Journal of Natural Products,2019, 82, 2925–2930.(DOI: 10.1021/acs.jnatprod.9b00188).
[60] Weiguang Sun(#), Shanshan Luan(#), Changxing Qi(#), Qingyi Tong, Shan Yan, Hua Li(*),Yonghui Zhang(*). Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism,Cell Communication and Signaling,2019, 17, 111.(DOI: 10.1186/s12964-019-0425-4).
[61] Zhaodi Wu, Xiaotian Zhang, Weaam Hasan Al Anbari, Qun Zhou, Peng Zhou, Mi Zhang, Fanrong Zeng, Chunmei Chen, Qingyi Tong, Jianping Wang, Hucheng Zhu(*),Yonghui Zhang(*).Cysteine residue containing merocytochalasans and 17,18-seco-aspochalasins fromAspergillusmicronesiensis,Journal of Natural Products,2019, 82, 2653–2658.(DOI: 10.1021/acs.jnatprod.9b00016).
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[89] Qingyi Tong(#), Huijuan You(#), Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo(*),Yonghui Zhang(*). ZYH005, a novel DNA intercalator, overcomes all-transretinoic acid resistance in acute promyelocytic leukemia,Nucleic Acids Research,2018,46, 3284−3297.(DOI: 10.1093/nar/gky202).
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