胡正喜

胡正喜，男，湖北武汉人，华中科技大学同济医学院药学院教授、博士/硕士生导师。中药与天然药物学系主任，主要致力于天然药物化学及基于活性天然产物的创新药物研究工作。入选“国家高层次人才特殊支持计划”青年项目、华中“卓越学者”特聘教授、“武汉黄鹤英才”优秀青年人才等，湖北省自然科学基金创新群体负责人，主持国家重点研发计划子课题、国家自然科学基金面上项目和青年项目、中国博士后科学基金面上项目和特别资助项目等。近年来以第一或通讯作者在Angewandte Chemie International Edition、Theranostics、Natural Product Reports、Chinese Chemical Letters、Organic Letters等天然药化专业领域高水平期刊上发表SCI论文90余篇。

通讯地址：湖北省武汉市硚口区航空路13号同济医学院药学院1号楼509室，邮编430030

Emails：huzhengxi@hust.edu.cn; hzx616@126.com

【研究领域】

（1）特境微生物来源新颖活性天然产物的挖掘与功能研究

（2）华中地区中药药效物质基础研究与应用开发

主要从中药与特殊生境来源的微生物等天然药物资源中挖掘新颖活性天然产物，并以此为先导化合物，通过化学结构改造与优化、活性评价与药理机制研究等方法发现高效低毒的前药分子。近年来共分离鉴定1800余个单体化合物，包括新化合物900余个（新骨架化合物100余个），其中17个化合物被权威综述期刊Nat. Prod. Rep.评选为Hot off the press，并开展了针对心脏移植（心脏瓣膜钙化、心肌细胞保护等）、脓毒症等重大疾病的活性筛选研究；通过跨学科交叉研究，发现了若干个具有开发价值的药源分子，为我国创新药物的研发奠定了坚实的物质基础。

【教育与工作经历】

2023.3–至今 华中科技大学同济药学院 教授

2020.11–2023.3 华中科技大学同济药学院 副教授

2019.03–2020.10 华中科技大学同济药学院 讲师

2016.07–2019.02 华中科技大学同济药学院 博士后 合作导师：张勇慧教授&王小川教授

2013.09–2016.06 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室 药物化学 联培博士 导师：孙汉董院士&张勇慧教授

2011.09–2016.06 华中科技大学同济药学院 药物化学 博士 导师：张勇慧教授

2007.09–2011.06 华中科技大学同济药学院 中药学 本科

【学术兼职】

1）武汉市药学会中药与天然药物专业委员会副主任委员

2）中国植物学会植物化学及资源学专业委员会委员

3）湖北省药品监督管理局医疗器械注册评审专家

4）湖北省药品注册审评专家

5）湖北省科技领军人才发展促进会会员

6）期刊Frontiers in Chemistry客座副主编

7）Chinese Journal of Natural Medicines青年编委

8）Natural Products and Bioprospecting青年编委

【主持科研项目】

1）湖北省自然科学基金创新群体，鄂产金丝桃属民族药治疗自身免疫性疾病物质基础的研究，编号2024AFA028，2024.03–2027.03

2）国家重点研发计划，组合生物合成构建新骨架人工产物子课题4：基于机器学习的成药分子设计及新骨架人工产物药效学评价，项目骨干，编号2021YFA0910500，2021.12-2026.11

3）国家自然科学基金面上项目，基于多重诱导策略的蜈蚣内生真菌康宁木霉中靶向抑制ACC新颖甾体-生物碱杂聚体的发现及治疗NAFLD研究，编号82273811，2023.01–2026.12

4）国家自然科学基金青年项目，基于反向虚拟筛选的新颖天然11β-HSD1抑制剂的发现与抗糖尿病活性研究，编号21702067，2018.01–2020.12

5）中国博士后科学基金特别资助项目，芸薹生链格孢中具有IKKβ抑制活性的新颖二萜的研究，编号2018T110777，2018.07–2019.06

6）中国博士后科学基金面上项目（一等），光轮层炭壳菌中新颖抗糖尿病活性次生代谢产物的研究，编号2017M610479，2017.07–2018.06

7）华中科技大学人才引进基金，编号2020kfyXJJS083，2019.03–2022.03

【代表性学术论文】(^#Co-first author, *Corresponding author)

1. Bingchuan Geng^(#), Xing Chen^(#), Jiangyang Chi^(#), Fengli Li, Wai Yen Yim, Kan Wang, Chenghao Li, Minghui Xie, Peng Zhu, Zhengfeng Fan, Jiawei Shi,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾, Nianguo Dong⁽*⁾. Platelet membrane-coated alterbrassicene A nanoparticle inhibits calcification of the aortic valve by suppressing phosphorylation P65 NF-κB.Theranostics2023,13, 3781–3793.

2. Zhengxi Hu, Ying Ye⁽*⁾, Yonghui Zhang⁽*⁾. Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons.Natural Product Reports2021,38, 1775–1793.

3. Mengting Liu^(#), Weiguang Sun^(#), Ling Shen, Yan He, Junjun Liu, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾.Bipolarolides A–G: Ophiobolin-Derived Sesterterpenes with Three New Carbon Skeletons fromBipolarissp. TJ403-B1.Angewandte Chemie International Edition2019,58, 12091–12095.

4. Xiaoqi Jin^(#), Yixuan Zhao^(#), Hao Wang^(#), Rui Jiang, Jiangchun Wei, Hanxiao Zeng, Weiguang Sun, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. Herqupenoid A, an Unparalleled Sesquiterpene-Quinone Hybrid Featuring a Multicyclic Caged 2,7-Dioxatetracyclo[5.4.0.0^4,11.0^5,9]Hendecane Fragment fromPenicillium herquei.Organic Letters2024,26, 10146−10151.

5. Fengli Li, Shuang Lin, Sitian Zhang, Xincai Hao, Xiao-Nian Li, Beiye Yang, Junjun Liu, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Alterbrassinoids A–D: Fusicoccane-Derived Diterpenoid Dimers Featuring Different Carbon Skeletons fromAlternaria brassicicola.Organic Letters2019,21, 8353–8357.

6. Weixi Gao^(#), Chenwei Chai^(#), Yan He, Fengli Li, Xincai Hao, Fei Cao, Lianghu Gu, Junjun Liu,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Periconiastone A, an Antibacterial Ergosterol with a Pentacyclo[8.7.0.0^1,5.0^2,14.0^10,15]heptadecane System fromPericoniasp. TJ403-rc01.Organic Letters2019,21, 8469–8472.

7. Zhengxi Hu^(#), Weiguang Sun^(#), Fengli Li^(#), Jiankun Guan^(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang⁽*⁾, Hucheng Zhu⁽*⁾, Yonghui Zhang⁽*⁾. Fusicoccane-Derived Diterpenoids fromAlternaria brassicicola: Investigation of the Structure-Stability Relationship and Discovery of an IKKβInhibitor.Organic Letters2018,20, 5198–5202.

8. Fengli Li^(#), Weiguang Sun^(#), Jiankun Guan^(#), Yuanyuan Lu^(#), Sitian Zhang, Shuang Lin, Junjun Liu, Weixi Gao, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γAgonistic Activity fromAlternaria brassicicola.Organic Letters2018,20, 7982–7986.

9. Zhengxi Hu^(#), Ye Wu^(#), Shuangshuang Xie, Weiguang Sun, Yi Guo, Xiao-Nian Li, Junjun Liu, Hua Li, Jianping Wang, Zengwei Luo, Yongbo Xue⁽*⁾, Yonghui Zhang⁽*⁾. Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic FungusPhomopsissp. TJ507A.Organic Letters2017,19, 258–261.

10. Zheng-Xi Hu^(#), Yi-Ming Shi^(#), Wei-Guang Wang, Jian-Wei Tang, Min Zhou, Xue Du, Yong-Hui Zhang⁽*⁾, Jian-Xin Pu⁽*⁾, Han-Dong Sun. Structural Characterization of Kadcoccinin A: A Sesquiterpenoid with a Tricyclo[4.4.0.0^3,10]decane Scaffold fromKadsura coccinea.Organic Letters2016,18, 2284–2287.

11. Zheng-Xi Hu^(#), Yi-Ming Shi^(#), Wei-Guang Wang, Xiao-Nian Li, Xue Du, Miao Liu, Yan Li, Yong-Bo Xue, Yong-Hui Zhang⁽*⁾, Jian-Xin Pu⁽*⁾, Han-Dong Sun. Kadcoccinones A–F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons fromKadsura coccinea.Organic Letters2015,17, 4616–4619.

12. Jiangchun Wei, Pingping Fan, Xingpiao Jin, Xinping Li, Zhiyue Li, Xuanluan Chen, Hanxiao Zeng, Zhengzhi Wu⁽*⁾, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. Unprecedentednor-seco-polycyclic polyprenylated acylphloroglucinols counteract myocardial cell injury via activation of the Akt/mTOR signaling pathway.Organic Chemistry Frontiers2024,11, 5350–5357.

13. Jiangchun Wei^(#), Pingping Fan^(#), Yahui Huang^(#), Hanxiao Zeng, Rui Jiang, Zhengzhi Wu⁽*⁾, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. (±)-Hypandrone A, a pair of polycyclic polyprenylated acylphloroglucinol enantiomers with a caged 7/6/5/6/6 pentacyclic skeleton fromHypericum androsaemum.Organic Chemistry Frontiers2024,11, 3459–3464.

14. Beiye Yang^(#), Jun-Cheng Su^(#), Lijuan Huang, Shuang Lin, Xiaoqi Jin, Xueping Lei,Zhengxi Hu⁽*⁾and Yonghui Zhang⁽*⁾. Hyperispirones A and B, spiro-bridged polycyclic polyprenylated acylphloroglucinols with antiangiogenesis activity from Hypericumbeanii.Organic Chemistry Frontiers2022,9, 3460–3466.

15. Beiye Yang^(#), Jianzheng Huang^(#), Shuang Lin, Qingyi Tong⁽*⁾, Zeyu Yao, Fengli Li, Ying Ye,Zhengxi Hu⁽*⁾and Yonghui Zhang⁽*⁾. Hyperbeanone A, a 5,6-seco-spirocyclic polycyclic polyprenylated acylphloroglucinol derivative with an unprecedented skeleton fromHypericum beanii.Organic Chemistry Frontiers2021,8, 6411–6418.

16. Zheng-Xi Hu, Hou-Chao Xu, Kun Hu, Miao Liu, Xiao-Nian Li, Xing-Ren Li, Xue Du, Yong-Hui Zhang⁽*⁾, Pema-Tenzin Puno⁽*⁾, Han-Dong Sun.Structurally diverse diterpenoids fromIsodon pharicus.Organic Chemistry Frontiers2018,5, 2379–2389.

17. Shuang Lin^(#), Jianzheng Huang^(#), Hanxiao Zeng, Qingyi Tong⁽*⁾, Xueke Zhang, Beiye Yang, Ying Ye, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾.Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungusStachybotrys chartarum.Chinese Chemical Letters2022,33, 4587–4594.

18. Fengli Li^(#), Weiguang Sun^(#), Sitian Zhang^(#), Weixi Gao, Shuang Lin, Beiye Yang, Chenwei Chai, Huaqiang Li, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungusPenicilliumsp. TJ403-2.Chinese Chemical Letters2020,31, 197–201.

19. Sitian Zhang^(#), Nanjing Ding^(#), Xinyu Zheng, Yuling Lu, Jiangchun Wei, Hanxiao Zeng, Weiguang Sun, Yuan Zhou, Ya Gao⁽*⁾, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. Chromones Featuring a [6,6]-Spiroketal Moiety Produced by Coculture of the Endophytic FungiChaetomium virescensandXylaria Grammica.Journal of Natural Products2025, DOI: 10.1021/acs.jnatprod.4c00773.

20. Shuyuan Mo^(#), Zhihong Huang^(#), Hanxiao Zeng, Jianping Wang⁽*⁾, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. Penicichrysol A: an unprecedented polyketide produced byPenicillium chrysogenum.Organic & Biomolecular Chemistry2025, DOI: 10.1039/d4ob01742k.

21. Hanxiao Zeng^(#), Yaxing Wang^(#), Chenyang Wang^(#), Yahui Huang, Shuang Lin, Jiangchun Wei, Weiguang Sun, Fei Cao⁽*⁾, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. Structurally Diverse Duclauxins from a Coral-DerivedTalaromycessp. and Insight into Determining the Configuration at C-1 ofHeptacyclic Duclauxins by¹H NMR.Journal of Natural Products2024,87, 2592–2603.

22. Shuang Lin^(#), Hanxiao Zeng^(#), Chenyang Wang, Zixue Chai, Xueke Zhang, Beiye Yang, Jiangyang Chi⁽*⁾, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. Discovery of novel natural cardiomyocyte protectants from a toxigenic fungusStachybotrys chartarum.Bioorganic Chemistry2024,148, 107461.

23. Sitian Zhang^(#), Lianghu Gu^(#), Yongtong Lin, Hanxiao Zeng, Nanjin Ding, Jiangchun Wei, Xiaoxia Gu, Chang Liu, Weiguang Sun, Yuan Zhou⁽*⁾, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. Chaetoxylariones A–G: undescribed chromone-derived polyketides from co-culture ofChaetomium virescensandXylaria grammicaenabled via the molecular networking strategy.Bioorganic Chemistry2024,147, 107329.

24. Jiangchun Wei^(#), Xingpiao Jin^(#), Pingping Fan, Xinping Li, Xuanluan Chen, Wanxia Zhai, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾, Zhengzhi Wu⁽*⁾. Unprecedentednor-seco-diterpene lactones inhibited osteogenic differentiation of valve interstitial cells.Bioorganic Chemistry2024,153, 107837.

25. Shuang Lin^(#), Zixue Chai^(#), Hanxiao Zeng, Beiye Yang, Jiangyang Chi⁽*⁾, Yonghui Zhang⁽*⁾,Zhengxi Hu⁽*⁾. Atranones and dolabellanes with cardiomyocyte protective activity against cold ischemic injury from a coral-associated fungusStachybotrys chartarum.Phytochemistry2024,225, 114199.

26. Xiaoxia Gu, Weiguang Sun⁽*⁾,Zhengxi Hu⁽*⁾. Natural products from untapped sources as a potent reserve against antimicrobial resistance crisis.Chinese Journal of Natural Medicines2024,22, 577–579.

27. Mewlude Rehmutulla^(#), Sitian Zhang^(#), Jie Yin, Jianzheng Huang, Yang Xiao,Zhengxi Hu⁽*⁾, Qingyi Tong⁽*⁾, Yonghui Zhang⁽*⁾. Ustusolate E and 11α-Hydroxy-Ustusolate E induce apoptosis in cancer cell lines by regulating the PI3K/AKT/mTOR and p-53 pathways.Chinese Journal of Natural Medicines2024, DOI: 10.1016/S1875-5364(24)60644-8.

28. Shuyuan Mo^(#), Yaxin Zhang^(#), Rui Jiang^(#), Hanxiao Zeng, Zhihong Huang, Jie Yin, Sitian Zhang, Jun Yao, Jianping Wang⁽*⁾,Zhengxi Hu⁽*⁾, and Yonghui Zhang⁽*⁾. Dipeniroqueforins A−B and Peniroqueforin D: Eremophilane-Type Sesquiterpenoid Derivatives with Cytotoxic Activity fromPenicillium roqueforti.Journal of Organic Chemistry2024,89, 1209−1219.

29. Jie Cao^(#), Lanqin Li^(#), Runge Zhang^(#), Zhou Shu, Yaxin Zhang, Weiguang Sun⁽*⁾, Yonghui Zhang⁽*⁾andZhengxi Hu⁽*⁾. Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition.Natural Products and Bioprospecting2024,14, 17.

30. Xiaoqi Jin^(#), Jiangyang Chi^(#), Yixuan Zhao, Rui Jiang, Jiangchun Wei, Nianguo Dong,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Indoloquinazoline alkaloids with cardiomyocyte protective activity against cold ischemic injury fromAspergillus clavatonanicus.Bioorganic Chemistry2023,135, 106482.

31. Shuyuan Mo^(#), Zhangyan Huang^(#), Zi Ye^(#), Jie Yin, Sitian Zhang, Jun Yao, Yaxin Zhang, Zhihong Huang, Hanxiao Zeng,Zhengxi Hu⁽*⁾, Jianping Wang⁽*⁾, Yonghui Zhang⁽*⁾. Ten undescribed eremophilane and guaiane sesquiterpenes fromPenicillium roqueforti.Phytochemistry2023,212, 113722.

32. Jiangchun Wei^(#), Zhiyue Li^(#), Min Shan, Fengzhi Wu, Limin Li, Yucui Ma, Junhong Wu, Xinping Li, Yaqian Liu,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾, Zhengzhi Wu⁽*⁾. Discovery of twoent-atisane diterpenoid lactones with AChE inhibitory activity from the roots ofEuphorbia fischeriana.Organic & Biomolecular Chemistry2023,21, 6949.

33. Fengli Li^(#), Saisai Gu^(#), Sitian Zhang, Shuyuan Mo, Jieru Guo⁽*⁾,Zhengxi Hu⁽*⁾and Yonghui Zhang⁽*⁾. Three new amide derivatives from the fungusAlternaria brassicicola.Natural Products and Bioprospecting2023,13, 28.

34. Shuyuan Mo, Ziming Zhao, Zi Ye, Zhihong Huang, Yaxin Zhang, Wanqi Yang, Jianping Wang⁽*⁾,Zhengxi Hu⁽*⁾and Yonghui Zhang⁽*⁾. New secondary metabolites with cytotoxicity from fungusPenicilliumroqueforti.Natural Products and Bioprospecting2023,13, 17.

35. Peng Zhou^(#), Xiaotian Zhang^(#), Chong Dai, Shan Yan, Mengsha Wei, Wenya Feng, Qin Li, Junjun Liu, Hucheng Zhu,Zhengxi Hu⁽*⁾, Chunmei Chen⁽*⁾,Yonghui Zhang⁽*⁾. Talaromynoids A−E: Five New Fusicoccane Diterpenoids from the Endophytic FungusTalaromycessp. DC-26.Journal of Organic Chemistry2022,87, 7333−7341.

36. Fengli Li^(#), Shuyuan Mo^(#), Jie Yin^(#), Sitian Zhang, Saisai Gu, Zi Ye, Jianping Wang⁽*⁾,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Structurally diverse metabolites from a soil-derived fungusAspergilluscalidoustus.Bioorganic Chemistry2022,127, 105988.

37. Beiye Yang^(#), Changxing Qi^(#), Zeyu Yao, Shuang Lin, Fengli Li, Weiguang Sun,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Hybeanones A and B, Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols fromHypericum beanii.Chinese Journal of Chemistry2022,40, 53–58.

38. Fengli Li^(#), Zhangyan Huang^(#), Shuyuan Mo^(#), Saisai Gu, Sitian Zhang, Beiye Yang, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Two undescribed pairs of isoprenyl hydroxybenzoic acid derivatives from coculture ofPestalotiopsissp. andPenicillium bialowiezense: enantioseparation and their absolute configurations.New Journal of Chemistry2022,46, 17149–17152.

39. Sitian Zhang^(#), Shuyuan Mo^(#), Fengli Li, Yaxin Zhang, Jianping Wang,Zhengxi Hu⁽*⁾and Yonghui Zhang⁽*⁾. Drimane sesquiterpenoids from a wetland soil‑derived fungusAspergillus calidoustusTJ403‑EL05.Natural Products and Bioprospecting2022,12, 27.

40. Mengting Liu^(#), Xueke Zhang^(#), Ling Shen, Weiguang Sun, Shuang Lin, Junjun Liu, Fei Cao, Changxing Qi, Jianping Wang,Zhengxi Hu⁽*⁾, and Yonghui Zhang⁽*⁾. Bioactive Polyketide-Terpenoid Hybrids from a Soil-Derived FungusBipolaris zeicola.Journal of Organic Chemistry2021,86, 10962–10974.

41. Mengting Liu^(#), Lianghu Gu^(#), Ling Shen, Xueke Zhang, Shuang Lin, Ying Ye, Jianping Wang,Zhengxi Hu⁽*⁾, and Yonghui Zhang⁽*⁾. Bipolaquinones A−J, Immunosuppressive Meroterpenoids from a Soil-DerivedBipolaris zeicola.Journal of Natural Products2021,84, 2427–2436.

42. Mengting Liu^(#), Xueke Zhang^(#), Ling Shen, Shuang Lin, Ying Ye, Changxing Qi, Jianping Wang,Zhengxi Hu⁽*⁾, and Yonghui Zhang⁽*⁾. Meroterpenoids with Potent Immunosuppressive Activity from FungusBipolaris zeicola.Chinese Journal of Chemistry2021,39, 2460–2466.

43. Shuang Lin^(#), Shan Yan^(#), Yi Liu^(#), Xueke Zhang, Fei Cao, Yan He, Fengli Li, Junjun Liu, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. New secondary metabolites with immunosuppressive and BChE inhibitory activities from an endophytic fungusDaldiniasp. TJ403-LS1.Bioorganic Chemistry2021,114, 105091.

44. Fengli Li, Zi Ye, Zhangyan Huang, Xia Chen, Weiguang Sun⁽*⁾, Weixi Gao, Sitian Zhang, Fei Cao, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Newα-pyrone derivatives with herbicidal activity from the endophytic fungusAlternaria brassicicola.Bioorganic Chemistry2021,117, 105452.

45. Fengli Li^(#), Shan Yan^(#), Zhangyan Huang, Weixi Gao, Sitian Zhang, Shuyuan Mo, Shuang Lin, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Inducing new bioactive metabolites production from coculture ofPestalotiopsissp. andPenicillium bialowiezense.Bioorganic Chemistry2021,110, 104826.

46. Yulin Duan^(#), Yanfang Deng^(#), Pengfei Bu, Yi Guo, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu,Zhengxi Hu⁽*⁾, Changxing Qi⁽*⁾, Yonghui Zhang⁽*⁾. Discovery of bioactive polycyclic polyprenylated acylphloroglucinols fromHypericum wilsonii.Bioorganic Chemistry2021,115, 105246.

47. Shuyuan Mo^(#), Jie Yin^(#), Zi Ye, Fengli Li, Shuang Lin, Sitian Zhang, Beiye Yang, Jun Yao, Jianping Wang⁽*⁾,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Asperanstinoids A–E: Undescribed 3,5-dimethylorsellinic acid-based meroterpenoids fromAspergillus calidoustus.Phytochemistry2021,190, 112892.

48. Changxing Qi^(#), Xiaosheng Tan^(#), Zhengyi Shi, Hao Feng, Lingjuan Sun,Zhengxi Hu⁽*⁾, Gang Chen⁽*⁾, Yonghui Zhang⁽*⁾. Discovery of an Oxepine-Containing Diketopiperazine Derivative Active against Concanavalin A‑Induced Hepatitis.Journal of Natural Products2020,83, 2672–2678.

49. Sitian Zhang^(#), Yan He^(#), Fengli Li, Shuang Lin, Beiye Yang, Shuyuan Mo, Huaqiang Li, Jianping Wang, Changxing Qi⁽*⁾,Zhengxi Hu⁽*⁾, and Yonghui Zhang⁽*⁾. Bioassay-Directed Isolation of Antibacterial Metabolites from an Arthropod-DerivedPenicillium chrysogenum.Journal of Natural Products2020,83, 3397−3403.

50. Huaqiang Li, Runge Zhang, Fei Cao, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Proversilins A−E, Drimane-Type Sesquiterpenoids from the EndophyticAspergillus versicolor.Journal of Natural Products2020,83, 2200−2206.

51. Fengli Li^(#), Shuang Lin^(#), Sitian Zhang, Lifen Pan, Chenwei Chai, Jun-Cheng Su, Beiye Yang, Junjun Liu, Jianping Wang⁽*⁾,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Modified Fusicoccane-Type Diterpenoids fromAlternaria brassicicola.Journal of Natural Products2020,83, 1931−1938.

52. Shuang Lin^(#), Huimin Yu^(#), Beiye Yang, Fengli Li, Xia Chen, Huaqiang Li, Sitian Zhang, Jianping Wang, Youcai Hu,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Reisolation and Configurational Reinvestigation of Cottoquinazolines E–G from an Arthropod-Derived Strain of the FungusNeosartorya fischeri.Journal of Natural Products2020,83, 169–173.

53. Ling Shen^(#), Mengting Liu^(#), Yan He^(#), Weaam Hasan Al Anbari, Huaqiang Li, Shuang Lin, Chenwei Chai, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Novel Antimicrobial Compounds as Ophiobolin-Type Sesterterpenes and Pimarane-Type Diterpene FromBipolarisSpecies TJ403-B1.Frontiers in Microbiology2020,11, 856.

54. Shuang Lin^(#),Yan He^(#), Fengli Li, Beiye Yang, Mengting Liu, Sitian Zhang, Junjun Liu, Huaqiang Li, Changxing Qi, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Structurally diverse and bioactive alkaloids from an insect-derived fungusNeosartorya fischeri.Phytochemistry2020,175, 112374.

55. Fengli Li, Lifen Pan, Shuang Lin, Sitian Zhang, Huaqiang Li, Beiye Yang, Junjun Liu, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Fusicoccane-derived diterpenoids with bridgehead double-bond-containing tricyclo[9.2.1.0^3,7]tetradecane ring systems fromAlternaria brassicicola.Bioorganic Chemistry2020,100, 103887.

56. Weixi Gao^(#), Chenwei Chai^(#), Xiao-Nian Li^(#), Weiguang Sun, Fengli Li, Chunmei Chen, Jianping Wang, Hucheng Zhu, Yanyan Wang⁽*⁾,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Two anti-inflammatory chlorinated azaphilones fromChaetomium globosumTW1-1 cultured with 1-methyl-L-tryptophan and structure revision of chaephilone C.Tetrahedron Letters2020,61, 151516.

57. Huaqiang Li^(#), Qianqian Xu^(#), Weiguang Sun, Runge Zhang, Jianping Wang, Yongji Lai⁽*⁾,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. 21-Epi-taichunamide D and (±)-versicaline A, three unusual alkaloids from the endophyticAspergillus versicolorF210.Tetrahedron Letters2020,61, 152219.

58. Mengting Liu^(#), Weiguang Sun^(#), Ling Shen, Xincai Hao, Weaam Hasan Al Anbari, Shuang Lin, Huaqiang Li, Weixi Gao, Jianping Wang,Zhengxi Hu⁽*⁾, and Yonghui Zhang⁽*⁾. Bipolaricins A–I, Ophiobolin-Type Tetracyclic Sesterterpenes from a PhytopathogenicBipolarissp. Fungus.Journal of Natural Products2019,82, 2897–2906.

59. Huaqiang Li, Dan Xu, Weiguang Sun, Beiye Yang, Fengli Li, Mengting Liu, Jianping Wang, Yongbo Xue,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. HPLC-DAD-Directed Isolation of Linearly Fused Prenylated Indole Alkaloids from a Soil-DerivedAspergillus versicolor.Journal of Natural Products2019,82, 2181–2188.

60. Beiye Yang^(#), Yan He^(#), Shuang Lin, Jinwen Zhang, Huaqiang Li, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Antimicrobial Dolabellanes and Atranones from a Marine-Derived Strain of the Toxigenic FungusStachybotrys chartarum.Journal of Natural Products2019,82, 1923–1929.

61. Changxing Qi, Qun Zhou, Weixi Gao, Mengting Liu, Chunmei Chen, Xiao-Nian Li, Yongji Lai, Yuan Zhou, Dongyan Li⁽*⁾,Zhengxi Hu⁽*⁾, Hucheng Zhu⁽*⁾, Yonghui Zhang⁽*⁾. Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungusAspergillus terreusThom.Phytochemistry2019,165, 112041–112048.

62. Jiaojiao Gong, Chunmei Chen, Shuyuan Mo, Junjun Liu, Wenjing Wang, Yi Zang, Huaqiang Li, Chenwei Chai, Hucheng Zhu,Zhengxi Hu⁽*⁾, Jianping Wang⁽*⁾, Yonghui Zhang⁽*⁾. Fusaresters A–E, newγ-pyrone-containing polyketides from fungusFusariumsp. Hungcl and structure revision of fusariumin D.Organic & Biomolecular Chemistry2019,17, 5526–5532.

63. Mengting Liu^(#), Yan He^(#), Ling Shen^(#), Weaam Hasan Al Anbari, Huaqiang Li, Jianping Wang, Changxing Qi⁽*⁾,Zhengxi Hu⁽*⁾, and Yonghui Zhang⁽*⁾. Asperteramide A, an UnusualN-Phenyl-Carbamic Acid Methyl Ester Trimer Isolated from the Coral-Derived FungusAspergillusterreus.European Journal of Organic Chemistry2019,18, 2928–2932.

64. Meng-Ting Liu^(#), Yan He^(#),LingShen,Zheng-Xi Hu⁽*⁾, Yong-Hui Zhang⁽*⁾. Bipolarins A–H, eight new ophiobolin-type sesterterpenes withantimicrobial activity from fungusBipolarissp. TJ403-B1.Chinese Journal of Natural Medicines2019,17, 935–944.

65. Fengli Li^(#), Ying Tang^(#), Weiguang Sun, Jiankun Guan, Yuanyuan Lu, Sitian Zhang, Shuang Lin, Jianping Wang,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. New cytotoxic tricycloalternarenes from fungusAlternaria brassicicola.Bioorganic Chemistry2019,92, 103279.

66. Weixi Gao^(#), Yan He^(#), Fengli Li, Chenwei Chai, Jinwen Zhang, Jieru Guo, Chunmei Chen, Jianping Wang, Hucheng Zhu,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Antibacterial activity against drug-resistant microbial pathogens of cytochalasan alkaloids from the arthropod-associated fungusChaetomiumglobosumTW1-1.Bioorganic Chemistry2019,83, 98–104.

67. Zheng-Xi Hu, Miao Liu, Wei-Guang Wang, Xiao-Nian Li, Kun Hu, Xing-Ren Li, Xue Du, Yong-Hui Zhang⁽*⁾, Pema-Tenzin Puno⁽*⁾, Han-Dong Sun. 7α,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts ofIsodon pharicus.Journal of Natural Products2018,81, 106–116.

68. Beiye Yang^(#), Weiguang Sun^(#), Jianping Wang^(#), Shuang Lin, Xiao-Nian Li , Hucheng Zhu, Zengwei Luo, Yongbo Xue,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. A New Breviane Spiroditerpenoid from the Marine-Derived FungusPenicilliumsp. TJ403-1.Marine Drugs2018,16, 110.

69. Mengting Liu^(#), Weiguang Sun^(#), Jianping Wang^(#), Yan He, Jinwen Zhang, Fengli Li, Changxing Qi, Hucheng Zhu, Yongbo Xue,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Bioactive secondary metabolites from the marine-associated fungusAspergillus terreus.Bioorganic Chemistry2018,80, 525–530.

70. Qing Zhang, Beiye Yang, Fengli Li, Mengting Liu, Shuang Lin, Jianping Wang, Yongbo Xue, Hucheng Zhu, Weiguang Sun⁽*⁾,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Mycophenolic Acid Derivatives with Immunosuppressive Activityfrom the Coral-Derived FungusPenicillium bialowiezense.Marine Drugs2018,16, 230.

71. Mengting Liu^(#), Changxing Qi^(#), Weiguang Sun^(#), Ling Shen, Jianping Wang, Junjun Liu, Yongji Lai, Yongbo Xue,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾.α-Glucosidase Inhibitors from the Coral-Associated FungusAspergillus terreus.Frontiers in Chemistry2018,6, 422.

72. Weixi Gao, Weiguang Sun, Fengli Li, Chenwei Chai, Yan He, Jianping Wang, Yongbo Xue, Chunmei Chen, Hucheng Zhu,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Armochaetoglasins A–I: Cytochalasan alkaloids from fermentation broth ofChaetomium globosumTW1-1 by feedingL-tyrosine.Phytochemistry2018,156,106–115.

73. Fengli Li^(#), Weiguang Sun^(#), Jiankun Guan^(#), Yuanyuan Lu, Shuang Lin, Sitian Zhang, Weixi Gao, Junjun Liu, Guang Du, Jianping Wang, Hucheng Zhu, Changxing Qi⁽*⁾,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungusAlternaria brassicicola.Organic & Biomolecular Chemistry2018,16, 8751–8760.

74. Changxing Qi^(#), Yuben Qiao^(#), Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu,Zhengxi Hu⁽*⁾, Yuan Zhou⁽*⁾, Yonghui Zhang⁽*⁾. New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities fromAspergillus terreus.Organic & Biomolecular Chemistry2018,16, 9046–9052.

75. Changxing Qi^(#), Weixi Gao^(#), Danyingzi Guan^(#), Jianping Wang, Mengting Liu, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Yongji Lai⁽*⁾,Zhengxi Hu⁽*⁾, Qun Zhou⁽*⁾, Yonghui Zhang⁽*⁾. Butenolides from a marine-derived fungusAspergillus terreuswith antitumor activities against pancreatic ductal adenocarcinoma cells.Bioorganic & Medicinal Chemistry2018,26, 5903–5910.

76. Mengting Liu^(#), Qun Zhou^(#), Jianping Wang^(#), Junjun Liu, Changxing Qi, Yongji Lai, Hucheng Zhu, Yongbo Xue,Zhengxi Hu⁽*⁾, Yonghui Zhang⁽*⁾. Anti-inflammatory butenolide derivatives from the coral-derived fungusAspergillus terreusand structure revisions of aspernolides D and G, butyrolactone VI and 4’,8’’-diacetoxy butyrolactone VI.RSC Advances2018,8, 13040–13047.

77. Yan He^(#),Zhengxi Hu^(#), Weiguang Sun, Qin Li, Xiao-Nian Li, Hucheng Zhu, Jinfeng Huang, Junjun Liu, Jianping Wang, Yongbo Xue⁽*⁾, Yonghui Zhang⁽*⁾. Spiroaspertrione A, a bridged spirocyclic meroterpenoid, as a potent potentiator of oxacillin against methicillin-resistantStaphylococcus aureusfromAspergillussp. TJ23.Journal of Organic Chemistry2017,82, 3125–3131.

78. Zheng-Xi Hu, Xiao-Nian Li, Yi-Ming Shi, Wei-Guang Wang, Xue Du, Yan Li, Yong-Hui Zhang⁽*⁾, Jian-Xin Pu⁽*⁾, Han-Dong Sun. Lanostane-type triterpenoids fromKadsura coccinea.Tetrahedron2017,73, 2931–2937.

79. Yan He^(#),Zhengxi Hu^(#), Qin Li^(#), Jinfeng Huang, Xiao-Nian Li, Hucheng Zhu, Junjun Liu, Jianping Wang⁽*⁾, Yongbo Xue⁽*⁾, and Yonghui Zhang⁽*⁾. Bioassay-Guided Isolation of Antibacterial Metabolites fromEmericellasp. TJ29.Journal of Natural Products2017,80, 2399–2405.

80. Zheng-Xi Hu, Kun Hu, Yi-Ming Shi, Wei-Guang Wang, Xue Du, Yan Li, Yong-Hui Zhang⁽*⁾, Jian-Xin Pu⁽*⁾, Han-Dong Sun. Rearranged 6/6/5/6-Fused triterpenoid acids from the stems ofKadsura coccinea.Journal of Natural Products2016,79, 2590–2598.

81. Zheng-Xi Hu^(#), Yong-Bo Xue^(#), Xiao-Bin Bi, Jin-Wen Zhang, Zeng-Wei Luo, Xiao-Nian Li, Guang-Min Yao, Jian-Ping Wang⁽*⁾, Yong-Hui Zhang⁽*⁾. Five New Secondary Metabolites Produced by a Marine-Associated Fungus,Daldinia eschscholzii.Marine Drugs2014,12, 5563–5575.

82. Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue⁽*⁾, Yingda Yang, Zengwei Luo, Guangmin Yao, Yonghui Zhang⁽*⁾. Colletotrichumine A, a novel indole-pyrazine alkaloid with an unprecedented C₁₆N₃-type skeleton from cultures ofColletotrichum capsici.Tetrahedron Letters2014,55, 6093–6095.