齐昌兴，博士，副教授，博士生导师，湖北省双创团队带头人/湖北省高层次人才（2025）、华中卓越青年学者（2024）、华中科技大学学术新人（2021）。近年来，主持国家自然科学基金面上项目（2024）与青年基金（2020）、湖北省楚天英才·双创团队项目（2025）、湖北省重点研发计划（2025）、湖北省自然科学基金一般面上（2023）、武汉市青年科技晨光计划（2024）等课题；获得中华医学科技奖一等奖（2025）、教育部科学研究优秀成果一等奖（2025）、湖北省科技进步特等奖（2024）；申请专利8项（已授权6项），科学出版社《天然药物化学》第3版与全英教材《Natural Product Products》编委。
主要从事天然创新药物研究与转化，致力于从华中地区药用植物及其内生真菌中发掘活性天然先导化合物，并基于人工智能技术对其进行化学结构改造与优化、活性评价与药理机制研究，发现高效低毒的候选药物。近年来，共分离和鉴定了天然产物1628个，其中新化合物912个，包括具有全新碳架的多环多异戊烯基酰基间苯三酚类、萜类、聚酮类新骨架化合物91个，隶属于70个不同的新骨架类型，发现具有药用开发潜力的先导化合物6个。以第一作者或通讯作者发表SCI论文82篇（IF > 10论文3篇），其中JCR分区Q1论文61篇，中科院分区1区论文38篇，包括Acta Pharm. Sin. B、Adv. Sci.、MedComm、Chem. Sci.、Chinese Chem. Lett.2篇、Cell Commun. Signal.、J. Agric. Food Chem.3篇、Org. Lett.2篇、Org. Chem. Front. 4篇、J Nat. Prod.10篇、J. Org. Chem.4篇、Chinese J. Chem2篇、Bioorg. Chem.9篇，相关成果被Nature（2020, 586, 64−69）、Nature Reviews Chemistry（2022, 6, 806–822）等期刊论文引用。
一、联系方式
邮箱：qichangxing@hust.edu.cn
地址：武汉市硚口区航空路13号同济医学院药学院1号楼507室；邮编430030
二、教育与工作经历
2020.11至今，华中科技大学，药学院，副教授
2024.5~2025.5，国家卫生健康委员会，中国生物技术发展中心，借调干部
2019.7~2020.10，华中科技大学，药学院，讲师
2017.6~2019.6，华中科技大学，药学院/基础医学院，博士后，合作导师：张勇慧教授
2012.9~2017.6，华中科技大学，药学院，药物化学，博士，导师：张勇慧教授
2008.9~2012.6，湖北中医药大学，药学院，药学，本科
三、主持科研项目情况
湖北省委组织部楚天英才双创团队项目，基于人工智能的创新药物研发与转化，20259155，2026.1~2028.12，150万（省拨经费30万），在研，主持
湖北省重点研发计划，基于生成对抗网络的丁内酯I分子优化：靶向JAK1的急性肾损伤新型候选药物开发，2025BCB029，2025.6~2027.5，400万（省拨经费100万），在研，主持
国家自然科学基金面上基金项目，基于SPR-AMRS的金丝桃属植物中靶向SGK1的PPAPs类成分挖掘及其抗自身免疫性肝炎研究，32470422，2025.1~2028.12，50万元，在研，主持
武汉市自然科学基金探索计划，基于湖北药用植物及其微生态圈的新颖小分子TNF-α抑制剂的发现，2024040801020205，2024.6~2026.6，10万元，结题，主持
湖北省自然科学基金一般面上项目，基于aspulvinone型天然产物的新颖GOT1抑制剂的分子设计、合成及治疗胰腺癌活性研究，2023AFB791，2023.7~2025.6，5万元，结题，主持
国家自然科学基金青年科学基金项目，烟色拟盘多毛孢中新颖azaphilone类化合物的发现及其靶向GOT1的抗胰腺癌活性研究，82003633，2021.1~2023.12，24万元，结题，主持
华中科技大学学术新人特别资助基金，基于天然产物的创新药物研究，0198514058，2022.01~2025.01，20万元，结题，主持
华中科技大学人才引进基金，天然药物化学，3004514135，2019.07~2022.07，15万元，结题，主持
中国博士后科学基金第63批面上项目，杂色曲霉中杂萜类成份及其抗阿尔茨海默病活性的研究，2018.07~2019.06，2018M632879，5万元，结题，主持
四、获奖情况
基于天然产物的新药创制关键技术研究，中华医学科技奖一等奖，2025年，202501209P1514
结构新颖活性天然产物的发现与成药性优化，教育部科学研究优秀成果一等奖，2025年，2025-194-R16
天然药物化学研究关键技术与新药创制，湖北省科学技术进步奖特等奖，2024年，2024J-227-特-002-002R12
五、主要代表性学术论文，(#)第一作者，(*)通讯作者
Yeting Zhang(#), Xinye Huang(#), Jiangchun Wei(#), Jiajun Zhou, Ming Chen, Jinlong Zhang, Ying Tang(*),Changxing Qi(*), and Yonghui Zhang(*).Bioorganic Chemistry, 2026, 170, 109473.
Yeting Zhang(#), Qing Li(#), Zhengyi Shi, Xueqi Lan, Jinlong Zhang, Ming Chen, Xinye Huang, Kuansong Wang(*),Changxing Qi(*), Yonghui Zhang(*).Organic Letters, 2025, 27, 11667−11672.
Xinye Huang(#), Xiangli Zhao(#), Xiaosheng Tan(#), Yeting Zhang, Zhengyi Shi, Gang Chen(*),Changxing Qi(*), and Yonghui Zhang(*).Journal of Agricultural and Food Chemistry,2025, 73, 31390−31403.
Yulin Duan(#), Xiaoxia Gu(#), Xincai Hao, Guosheng Cao(*), Weiguang Sun(*),Changxing Qi(*), Yonghui Zhang(*).Natural Products and Bioprospecting, 2025, 15, 40.
Yeting Zhang(#), Xinye Huang(#), Xinming Song(#), Xuan Li, Jinlong Zhang, Ming Chen, Zhengyi Shi, Binbin Song, Wei Wei(*),Changxing Qi(*), Yonghui Zhang(*).Bioorganic Chemistry, 2025, 157, 108303.
Xueqi Lan(#), Xiaoxia Gu(#), Yeting Zhang(#), Hong Hu, Zhengyi Shi, Chaohu Xiong, Xinye Huang, Binbin Song, Yuben Qiao(*), Weiguang Sun(*),Changxing Qi(*), Yonghui Zhang(*).Bioorganic Chemistry, 2025, 156, 108230.
Yeting Zhang(#), Zhengyi Shi(#), Chunhua Zhao(#), Lanqin Li, Ming Chen, Yunfang Cao, Fengqing Wang, Bo Tao, Xinye Huang, Jieru Guo(*),Changxing Qi(*), Weiguang Sun(*), Yonghui Zhang(*).Chinese Journal of Natural Medicines, 2025, 23,111−118.
Zijun Zhang(#), Ziming Zhao(#),Changxing Qi(#), Xiaotian Zhang(#), Yang Xiao, Chengjuan Chen, Yu Zou, Xia Chen, Lianghu Gu, Jianzheng Huang, Kun Huang, Ming Xiang, Tiantai Zhang, Qingyi Tong(*), Yonghui Zhang(*).MedComm, 2025, 6, e70064.
Fengqing Wang(#),Changxing Qi(#), Chunmei Chen(#), Qin Li, Qingyi Tong, Weiguang Sun, Zhengxi Hu, Minyan Wang(*), Hucheng Zhu(*), Lianghu Gu(*), Yonghui Zhang(*).Chinese Chemical Letters, 2025, 36, 110252.
Yulin Duan, Ying Tang(*),Changxing Qi(*), Yonghui Zhang(*).Chinese Journal of Natural Medicines,2025, 23, 824−837.
Bo Tao(#), Xiangli Zhao(#), Zhengyi Shi(#), Jie Li, Yulin Duan, Yi Guo, Xiaosheng Tan(*), Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*).Chinese Journal of Natural Medicines,2025, 23, 1104−1110.
Yeting Zhang(#), Qing Li(#), Jinglong Zhang, Ming Chen, Xuan Li, Yuben Qiao, Kuansong Wang(*),Changxing Qi(*), Yonghui Zhang(*).Journal of Agricultural and Food Chemistry, 2024,72, 16801–16811.
Yeting Zhang(#), Jinbing Kang(#), Qun Zhou(#), Ming Chen, Jinlong Zhang, Zhengyi Shi, Yuben Qiao,Changxing Qi(*), Yonghui Zhang(*).Bioorganic Chemistry, 2024,150, 107575.
Yu Zou(#)(*), Yuying He, Lijuan Tan, Xiaofei Xu,Changxing Qi(*), Yonghui Zhang(*).Journal of Natural Products, 2024,87, 1893−1902.
Yulin Duan(#), Bo Tao(#), Zhengyi Shi(#), Yi Guo, Yeting Zhang, Yu Zou(*),Changxing Qi(*), Yonghui Zhang(*).The Journal of Organic Chemistry, 2024,89, 8076−8083.
Yulin Duan(#), Weiguang Sun(#), Yongqi Li(#), Zhengyi Shi, Lanqin Li, Yeting Zhang, Huang Kun, Zhiping Zhang,Changxing Qi(*), Yonghui Zhang(*).Acta Pharmaceutica Sinica B, 2024,14, 2646–2656.
Bo Tao(#), Yongqi Li(#), Yulin Duan(#), Zhengyi Shi, Jie Li, Yi Guo, Xinye Huang, Yeting Zhang, Weiguang Sun(*),Changxing Qi(*), Yonghui Zhang(*).Bioorganic Chemistry, 2024,144, 107145.
Yulin Duan(#), Zhengyi Shi(#), Fei Song, Zhangrong Hou, Xiaosheng Tan, Yeting Zhang, Xincai Hao, Gang Chen,Changxing Qi(*), Yonghui Zhang(*).Chinese Journal of Natural Medicines, 2024,22, 1–7.
Zhengyi Shi(#), Jie Yin(#), Yang Xiao, Zhangrong Hou, Fei Song, Jianping Wang, Qingyi Tong(*),Changxing Qi(*), Yonghui Zhang(*).Chinese Chemical Letters, 2024,35, 109458.
Hong Hu(#), Lanqin Li(#), Zhengyi Shi(#), Xueqi Lan, Yeting Zhang, Xinye Huang, Xincai Hao, Qun Zhou, Weiguang Sun(*),Changxing Qi(*), Yonghui Zhang(*).Chinese Journal of Chemistry, 2024,42, 743–751.
Zhengyi Shi(#), Xueyan Duan(#), Fengqing Wang(#), Zhangrong Hou, Fei Song, Lianghu Gu(*),Changxing Qi(*), Yonghui Zhang(*).Journal of Natural Products, 2024,87, 68–76.
Zhengyi Shi(#), Xiangli Zhao(#), Fei Song, Zhangrong Hou, Xincai Hao, Jieru Guo, Lingjuan Sun, Hao Feng, Meng Wu, Peiling Xie, Xiaosheng Tan, Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*).Journal of Agricultural and Food Chemistry, 2023,71, 17801–17809.
Yeting Zhang(#), Xiangli Zhao(#), Yunfang Cao(#), Ming Chen, Zhengyi Shi, Meng Wu, Hao Feng, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan(*), Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*).Journal of Natural Products, 2023,86, 2059–2064.
Hong Hu(#), Yanhui Li(#), Zhengyi Shi(#), Xiangli Zhao, Xueqi Lan, Meng Wu, Bo Tao, Yeting Zhang, Xinye Huang, Pengfei Bu, Yi Guo, Xiaosheng Tan(*),Changxing Qi(*), Yonghui Zhang(*).Bioorganic Chemistry, 2023,135, 106530.
Xiaosheng Tan(#),Changxing Qi(#), Xiangli Zhao, Lingjuan Sun, Mi Wu, Weiguang Sun, Lianghu Gu, Fengqing Wang, Hao Feng, Xia Huang, Bin Xie, Zhengyi Shi, Peiling Xie, Meng Wu,Yonghui Zhang(*), Gang Chen(*).Advanced Science, 2023, 2206768.
Yulin Duan, Yi Guo, Yanfang Deng, Pengfei Bu, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Weiguang Sun,Changxing Qi(*), Yonghui Zhang(*).The Journal of Organic Chemistry, 2022,87, 6824−6831.
Beiye Yang(#),Changxing Qi(#), Zeyu Yao, Shuang Lin, Fengli Li, Weiguang Sun, Zhengxi Hu(*), Yonghui Zhang(*).Chinese Journal of Chemistry, 2021,40, 53–58.
Yuben Qiao(#), Xiaosheng Tan(#), Qianqian Xu(#), Zijun Zhang, Qiaoxin Xu, Li Tao, Junjun Liu, Hucheng Zhu, Chunmei Chen, Ying Ye, Yuanyuan Lu, Gang Chen(*),Changxing Qi(*),Yonghui Zhang(*).Organic Chemistry Frontiers, 2022,9, 2477−2485.
Yunfang Cao(#), Xiaosheng Tan(#), Ali Adhab Al Chnani, Pengkun Li, Zhengyi Shi, Hao Feng, Lingjuan Sun, Qiangbing Xia, Xi Yang, Yulin Duan, Yi Guo, Gang Chen(*),Changxing Qi(*),Yonghui Zhang(*).Journal of Natural Products,2021,84, 2189–2199.
Yulin Duan(#), Yanfang Deng(#), Pengfei Bu, Yi Guo, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Zhengxi Hu(*),Changxing Qi(*), Yonghui Zhang(*).Bioorganic Chemistry, 2021,115, 105246.
Yunlin Duan, Shuangshuang Xie, Pengfei Bu, Yi Guo, Zhengyi Shi, Yun Guo, Yunfang Cao, Weiguang Sun,Changxing Qi(*), Yonghui Zhang(*).TheJournal of Organic Chemistry, 2021,86, 6478–6485.
Shuangshuang Xie(#), Yuan Zhou(#), Xiaosheng Tan(#), Weiguang Sun, Yulin Duan, Hao Feng, Lingjuan Sun, Yi Guo, Zhengyi Shi, Xincai Hao, Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*).Organic Chemistry Frontiers, 2021,8, 2280–2286.
Yulin Duan(#), Yanfang Deng(#), Pengfei Bu, Sshuangshuang Xie, Yi Guo, Zhengyi Shi, Yun Guo, Yunfang Cao,Changxing Qi(*), Yonghui Zhang(*).Bioorganic Chemistry, 2021,111, 104902.
Sitian Zhang(#), Yan He(#), Fengli Li, Shuang Lin, Beiye Yang, Shuyuan Mo, Huaqiang Li, Jianping Wang,Changxing Qi(*), Zhengxi Hu(*), Yonghui Zhang(*).Journal of Natural Products, 2020,83, 3397–3403.
Na Zhang(#), Zhengyi Shi(#), Qianqian Xu(#), Weiguang Sun, Lianghu Gu, Shuangshuang Xie, Yi Guo, Yulin Duan, Kailin Zhang,Changxing Qi(*), Yonghui Zhang(*).Organic Letters, 2020,22, 7926–7929.
Changxing Qi(#), Xiaosheng Tan(#), Zhengyi Shi, Hao Feng, Lingjuan Sun, Zhengxi Hu(*), Gang Chen(*), Yonghui Zhang(*).Journal of Natural Products, 2020,83, 2672–2678.
Shuangshuang Xie(#), Xiaosheng Tan(#), Yaping Liu, Yulin Duan, Gang Chen, Hao Feng, Lingjuan Sun, Yingying Huang, Yi Guo, Zhengyi Shi, Yuan Zhou(*),Changxing Qi(*), Yonghui Zhang(*).Journal of Natural Products, 2020,83, 1804−1809.
Shuangshuang Xie(#),Changxing Qi(#), Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Xu Yin, Weiguang Sun(*), Yuan Zhou(*), Yonghui Zhang(*).Organic Chemistry Frontiers, 2020,7, 1349–1357.
Xueyan Duan(#), Xiaosheng Tan(#), Lianghu Gu(#), Junjun Li, Xincai Hao, Li Tao, Hao Feng, Yunfang Cao, Zhengyi Shi, Yulin Duan, Mengyi Deng, GangChen(*),Changxing Qi(*), Yonghui Zhang(*).Bioorganic Chemistry, 2020,99, 103816.
Shuangshuang Xie(#),Changxing Qi(#), Yulin Duan, Xincai Hao, Yi Guo, Mengyi Deng, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Lianghu Gu(*), Yuan Zhou(*), Yonghui Zhang(*).Organic Chemistry Frontiers, 2020,7, 464–471.
Yuben Qiao(#), Qianqian Xu(#), Wenya Feng, Li Tao, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Yuanyuan Lu, Jianping Wang,Changxing Qi(*), Yongbo Xue(*), Yonghui Zhang(*).Journal of Natural Products, 2019,82, 2925–2930.
Weiguang Sun(#), Shanshan Luan(#),Changxing Qi(#), Qingyi Tong, Shan Yan, Hua Li(*), Yonghui Zhang(*).Cell Communication and Signaling, 2019,17, 111.
Changxing Qi(#), Mengting Liu(#), Qun Zhou(#), Weixi Gao, Chunmei Chen, Yongji Lai, Zhengxi Hu, Yongbo Xue, Jinwen Zhang, Dongyan Li, Xiao-Nian Li, Qing Zhang, Jianping Wang(*), Hucheng Zhu(*), Yonghui Zhang(*).Journal of Natural Products,2018,81, 1937−1945.
Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-Guo Chen, Yonghui Zhang(*).Chemical Science, 2016,7, 6563−6572.
