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师资队伍
杰出人才
博士后

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姜宏梁

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姜宏梁,1976年11月,男,博士,华中科技大学教授、博士生导师,湖北省“楚天学者”,湖北省第五批“百人计划”特聘专家,武汉市首批“黄鹤英才计划”入选者,中国生物分析协会指导委员会委员,世界中联中药鉴定委员会理事,武汉市药学会药物分析专业委员会副主任委员。为人卫版药物分析教材第八版编委,药学学报青年编委,Biomedical Chromatography编委。主持国家自然科学基金、湖北省卫生厅、武汉市人才计划及多项企业合作项目等。曾主持和参与超过60项生物等效性或药代动力学研究项目。为国家科学技术奖励评审、国家自然科学基金、教育部博士点基金评审专家,Journal of Chromatography A, Journal of Chromatography B及 Talanta等学术期刊特邀审稿人。参与国家食品药品监督总局2016年组织的以《药动学参数为终点评价指标的化学药物仿制药人体生物等效性研究技术指导原则》和《仿制药质量和疗效一致性评价临床有效性试验一般考虑的意见》的讨论与制定。目前,已发表学术期刊论文不少于50篇,其中SCI收录论文不少于45篇。

主要研究兴趣与方向:药物分析和代谢、中药药代动力学及代谢组学。

教育背景

2001/08-2005/07 美国亚利桑那大学 (University of Arizona) 药学 博士

1998/09-2001/07 中国协和医科大学 生药学 硕士

1994/09-1998/07 沈阳药科大学 中药制药专业 学士

工作经历

2011/04-现在 华中科技大学 中药化学与分析,药物分析与代谢 教授、博导

2010/11-2011/04 美国Covance Inc.公司 药物分析与药代动力学 资深研究员

2006/12-2010/11 美国Covance Inc. 公司 药物分析与药代动力学 研究员

2005/08-2006/11 美国西北太平洋国家实验室 博士后

部分主持和参与科研项目

1.基于LC-MS/MS特征轮廓谱分析方法的姜黄中强抗肿瘤活性微量姜黄素类化合物的快速发现,项目批准号:31270392,国家自然科学基金,面上项目,2013.01-2016.12,项目主持人。

2.姜黄中姜黄素类化合物的系统分离与抗肿瘤活性研究,湖北省中医药中西医结合科研项目-湖北省卫生厅项目,2012.01-2014.12,项目主持人。

3.药物分析和药代动力学研究技术服务平台建设,武汉市首批“黄鹤英才计划”资助, 2012.03-2014.12,项目主持人。

4.拟靶向代谢组学策略筛选动脉粥样硬化LysoPL标记物群及其在泽泻三萜药效研究中的应用,项目批准号:81603068,国家自然科学基金,青年基金,2017.01-2019.12,项目参与人。

5.基于DNA分子标记-谱效关系的药用紫草品质资源评价研究,项目批准号:U1603104,国家自然科学基金,联合基金项目,2017.01-2019.12,项目主持人

发表论文

1.Guiying Chen#, Chengwu Song#, Shuna Jin, Sen Li, Yang Zhang, Rongzeng Huang, Yulin Feng, Yong Xu, Yi Xiang,Hongliang Jiang*, An integrated strategy for establishment of metabolite profile of endogenous lysoglycerophospholipids by two LC-MS/MS platforms, Talanta, 2017, 162, 530-539.

2. Shuna Jin#, Chengwu Song#, Shuailong Jia, Sen Li, Yang Zhang, Cheng Chen, Yulin Feng, Yong Xu, Chaomei Xiong, Yi Xiang,Hongliang Jiang*, An integrated strategy for establishment of curcuminoid profile in turmeric using two LC-MS/MS platforms, Journal of Pharmaceutical and Biomedical Analysis, 2017, 132, 93-102.

3.Zhongzhe Cheng, Xing Zhou, Bingying Hu, Wenyi Li, Guiying Chen, Yang Zhang, Jingkui Tian, Lin Zhang, Ming Li*,Hongliang Jiang*, Tissue distribution of capilliposide B, capilliposide C and their bioactive metabolite in mice using liquid chromatography-tandem mass spectrometry, Biomedical Chromatography, 2016, doi:10.1002/bmc.3895.

4. Chang Chen, Ariane Wohlfarth, Hui Xu, Dan Su, Xin Wang,Hongliang Jiang, Yulin Feng, Mingshe Zhu, Untargeted screening of unknown xenobiotics and potential toxins in plasma of poisoned patients using high-resolution mass spectrometry: Generation of xenobiotic fingerprint using background subtraction, Analytica Chimica Acta, 2016, 944, 37-43.

5.Chang Chen, Bingying Hu, Tongzhi Wu, Yang Zhang, Yong Xu, Yulin Feng,Hongliang Jiang*, Bile acid profiles in diabetic (db/db) mice and their wild type littermates, Journal of Pharmaceutical and Biomedical Analysis, 2016, 131, 473-481.

6.Zhongzhe Cheng, Xing Zhou, Wenyi Li, Bingying Hu, Yang Zhang, Yong Xu, Lin Zhang*,Hongliang Jiang*, Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for simultaneous determination of capilliposide B and its active metabolite in rat urine and feces: overcoming nonspecific binding, Journal of Pharmaceutical and Biomedical Analysis, 2016, 131, 6-12.

7.Guiying Chen, Zhongzhe Cheng, Kerong Zhang,Hongliang Jiang*, Mingshe Zhu*, An integrated approach for profiling oxidative metabolites and glutathione adducts using liquid chromatography coupled with ultraviolet detection and triple quadrupole-linear ion trap mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2016, 129, 482-491.

8.Xin Zhou, Chang Chen, Fangrong Zhang, Yang Zhang, Yulin Feng, Hui Ouyang, Yong Xu,Hongliang Jiang*, Metabolism and bioactivation of the tricyclic antidepressant amitriptyline in human liver microsomes and human urine, Bioanalysis, 2016, 8(13), 1365-1381.

9.Xin Zhou, Fangrong Zhang, Chang Chen, Zitao Guo, Jia Liu, Jinghua Yu, Yong Xu, Dafang Zhong*,Hongliang Jiang*, Impact of curcumin on the pharmacokinetics of rosuvastatin in rats and dogs based on the conjugated metabolites, Xenobiotica, 2016 May 13: 1-9, DOI:10.1080/00498254.2016.1183060..

10.Chengwu Song, Qingsong Yu, Xiaohua Li, Shuna Jin, Sen Li, Yang Zhang, Shuailong Jia, Cheng Chen, Yi Xiang,Hongliang Jiang*, The hypolipidemic effect mice and its composition characterized by UPLC-QTOF-MS/MS, Journal of Food Science, 2016, 81(5), 1313-1319.

11.Guangjie Yang, Fangrong Zhang, Linfang Deng, Chang Chen, Zhongzhe Cheng, Jiangeng Huang, Jiangyun Liu*,Hongliang Jiang*, Development and validation of an LC-MS/MS method for simultaneous quantification of levodopa and MD01 in rat plasma and its application to a pharmacokinetic study of mucuna pruriens extract, Biomedical Chromatography, 2016, 30(9), 1506-1514.

12.Zhongzhe Cheng, Meilin Huang, Guiying Chen, Guangjie Yang, Xin Zhou, Chang Chen, Yang Zhang, Yong Xu, Yulin Feng, Lin Zhang*,Hongliang Jiang*, Cell-based assays in combination with ultra-high performance liquid chromatography-quadrupole time of flight tandem mass spectrometry for screening bioactive Capilliposide C metabolites generated by rat intestinal microflora, Journal of Pharmaceutical and Biomedical Analysis, 2016, 119, 130-138.

13.Sen Li, Chengwu Song, Chang Chen, Yang Zhang, Yi Xiang, Yong Xu, Yulin Feng, Qian Wan*,Hongliang Jiang*, The metabolic change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis rhizoma on high-fat diet induced hyperlipidemia mice, Journal of Ethnopharmacology, 2016, 177, 10-18.

14.Mei Liao, Aiqian Li, Chang Chen, Hui Ouyang, Yang Zhang, Yong Xu, Yulin Feng,Hongliang Jiang*, Systematic identification of shikonins and shikonofurans in medicinal Zicao species using ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry combined with a data mining strategy, Journal of Chromatography A, 2015,1425,158-172.

15.Yuan Gan#, Yang Zhang#, Aiqian Li, Chengwu Song, Chang Chen, Yong Xu, Hanli Ruan*,Hongliang Jiang*, A novel four-step approach for systematic identification of naphthoquinones in Juglans cathayensis Dode using various scan functions of liquid chromatography-tandem mass spectrometry along with data mining strategies, Phytochemical Analysis, 2015, 26(6): 413-422.

16.Zhongzhe Cheng#, Lian Ding#, Yang Zhang, Guiying Chen, Chang Chen, Yi-Qiang Cheng,Hongliang Jiang*, Determination of Thailandepsin B in Rat Plasma with a LC-MS/MS Method, Bioanalysis, 2015, 7(1): 39-52.

17.Zhifeng Li, Yawei Wang, Hui Ouyang, Yu Lu, Yan Qiu, Yulin Feng*,HongliangJiang*, Xin Zhou, Shilin Yang, A novel dereplication strategy for the identification of two new trace compounds in the extract of Gastrodia elata using UHPLC/Q-TOF-MS/MS, Journal of Chromatography B, 2015, 988: 45-52.

18.Hui Ouyang, Yicheng Guo, Mingzhen He, Jinlian Zhang, Xiaofang Huang, Xin Zhou,HongliangJiang, Yulin Feng*, Shilin Yang, A Rapid and Sensitive LC-MS/MS Method for the Determination of Pulsatilla Saponin D in Rat Plasma and its Application in a Rat Pharmacokinetic and Bioavailability Study, Biomedical Chromatography, 2015, 29(3): 373-378.

19.Cai Huang#, Qiongming Xu#, Chang Chen, Chengwu Song, Yong Xu, Yi Xiang, Yulin Feng, Hui Ouyang, Yang Zhang,HongliangJiang*, The Rapid Discovery and Identification of Physalins in the Calyx of Physalis Alkekengi L.Var.franchetii (Mast.) Makino Using Ultra-high Performance Liquid Chromatography-quadrupole Time of Flight Tandem Mass Spectrometry together with a Novel Three-step Data Mining Strategy. Journal of Chromatography A, 2014, 1361: 139-152.

20.Shuna Jin, Chengwu Song, Sen Li, Yang Zhang, Chang Chen, Xin Zhou, Yong Xu, Yulin Feng, Zhiping Zhang*,HongliangJiang*,Preventative Effects of Turmeric on the High-fat Diet-induced Hyperlipidaemia in Mice Associated with a Targeted Metabolomic Approach for the Analysis of Serum Lysophosphatidylcholine Using LC-MS/MS. Journal of Functional Foods, 2014, 11: 130-141.

21.Zhongzhe Cheng, Lin Zhang, Yang Zhang, Guiying Chen,HongliangJiang*,Simultaneous Determination of Capilliposide B and Capilliposide C in Rat Plasma by LC-MS/MS and its Application to a PK Study, Bioanalysis, 2014, 6(7): 935-945.

22.Ning Li, Xuefeng Zhou, Jiyan Yuan, Guiying Chen,HongliangJiang, Wen Zhang*, Ceftriaxone and Acute Renal Failure in Children, Pediatrics, 2014, 133(4): 917-922.

23.Yang Zhang, Huachuan Cao,HongliangJiang*. Supported Liquid Extraction versus Liquid-liquid Extraction for Sample Preparation in LC-MS/MS-based Bioanalysis, Bioanalysis, 2013, 5(3): 285-288.

24.Daniel Tang*, Dafang Zhong, Kelly Dong, Pei Hu, Huichen Liu,HongliangJiang,Alicia Du. China Bioanalysis Forum, Bioanalysis, 2013, 5(6): 641-643.

25.Pei-pei Zhang, Sha-sha Gao, Tian-tian Zhang, Xiao-gang Wang, Guo-liang Qing,Hong-liangJiang, Jia-chun Chen, Hong-quan Duan, Jin-bo Fang*, Two New Compounds from Schisandra Glaucescens, Journal of Asian Natural Products Research, 2013, 15(5): 466-472.

26.Hongliang Jiang#*, Huachuan Cao#*, Yang Zhang, Douglas M. Fast, Systematic Evaluation of Supported Liquid Extraction in Reducing Matrix Effect and Improving Extraction Efficiency in LC-MS/MS based Bioanalysis for 10 Model Pharmaceutical Compounds, Journal of Chromatography B, 2012, 891-892: 71-80.

27.Yang Zhang,HongliangJiang, Paul Hutson*, Stability of Acetyl-I-carnitine in 5% Dextrose Using a High-performance Liquid Chromatography-mass Spectrometry Times 2 Method, International Journal of Pharmaceutical Compounding, 2012, 16(2): 170-173.

28.Yi Xiang, Liping Zhou, Zhenyu Qian, Kelong Peng, Dongyan Li, Xiaomei Chen,HongliangJiang, Heng Zheng*, Determination of Cyclobenzaprine in Human Plasma by Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry and its Application in a Pharmacokinetic Study, Biomedical Chromatography, 2012, 26(9): 1083-1088.

29.Yifan Shi*,Hongliang Jiang, Assay Dynamic Range for DBS: battles on two Fronts, Bioanalysis, 2011, 3(20): 2259-2262.

30.Hongliang Jiang H*, Yurong Wang, Manjunath S. Shet, Yang Zhang, Duane Zenke, Douglas M. Fast, Development and Validation of a Sensitive LC-MS/MS Method for the Simultaneous Determination of Naloxone and its Metabolites in Mouse Plasma, Journal of Chromatography B, 2011, 879(25): 2663-2668.

31.Hongliang Jiang H*, Yang Zhang, Matt Ida, Amber LaFayette, Douglas M. Fast, Determination of Carboplatin in Human Plasma Using HybridSPE-precipitation along with Liquid Chromatography-tandem Mass Spectrometry, Journal of Chromatography B, 2011,879 (22): 2162-2170.

32.Xiaorong Liang#*, Hongliang Jiang#, Xi Chen, Human DBS Sampling with LC-MS/MS for Enantioselective determination of Metoprolol and its Metabolite O-Desmethyl Metoprolol, Bioanalysis, 2010, 2(8): 1437-1448.

33.Hongliang Jiang*, Michelle J. Cannon, Maria Banach, Anatoly N. Pinchuk, Giangthy N. Ton, Christie Scheuerell, Marc A. Longino, Jamey P. Weichert, Richard Tollefson, William R. Clarke, Qin C. Ji, Xiangyu Jiang, Quantification of CLR1401, a Novel Alkylphosphocholine Anticancer Agent, in Rat Plasma by Hydrophilic Interaction Liquid Chromatography-tandem Mass Spectrometric Detection, Journal of Chromatography B, 2010, 878(19): 1513-1518.

34.Hongliang Jiang*, Christopher Randlett, Heiko Junga, Xiangyu Jiang, Qin C. Ji*, Using Supported Liquid Extraction together with Cellobiohydrolase Chiral Stationary Phases-based Liquid Chromatography with Tandem Mass Spectrometry for Enantioselective Determination of Acebutolol and its Active Metabolite Diacetolol in Spiked Human Plasma, Journal of Chromatography B, 2009, 877(3): 173-180.

35.Hongliang Jiang*, Xiangyu Jiang, Qin C. Ji*, Enantioselective Determination of Alprenolol in Human Plasma by Liquid Chromatography with Tandem Mass Spectrometry Using Cellobiohydrolase Chiral Stationary Phases, Journal of Chromatography B, 2008, 872(1-2): 121-127.

36.Jie Ding, Christina M. Sorensen, Navdeep Jaitly,HongliangJiang, Daniel J. Orton, Matthew E. Monroe, Ronald J. Moore, Richard D. Smith, Thomas O. Metz*, Application of the Accurate Mass and Time Tag Approach in Studies of the Human Blood Lipidome, Journal of Chromatography B, 2008, 871(2): 243-252.

37.Wei-jun Qian, David T. Kaleta, Brianne O. Petritis,HongliangJiang, Tao Liu, Xu Zhang, Heather M. Mottaz, Susan M. Varnum, David G. Camp, Lei Huang, Xiangming Fang, Wei-wei Zhang, Richard D. Smith*, Enhanced Detection of Low Abundance Human Plasma Proteins Using a Tandem IgY12-SuperMix Immunoaffinity Separation Strategy, Molecular & Cellular Proteomics, 2008, 7(10): 1963-1973.

38.Hongliang Jiang*, Yinghe Li, Mary Pelzer, Michelle J. Cannon, Christopher Randlett, Heiko Junga, Xiangyu Jiang, Qin C. Ji*, Determination of Molindone Enantiomers in Human Plasma by High-performance Liquid Chromatography-tandem Mass Spectrometry Using Macrocyclic Antibiotic Chiral Stationary Phases, Journal of Chromatography A, 2008, 1192(2): 230-238.

39.Jie Ding, Christina M. Sorensen, Qibin Zhang,HongliangJiang, Navdeep Jaitly, Eric A. Livesay, Yufeng Shen, Richard D. Smith, Thomas O. Metz*. Capillary LC Coupled with High-Mass Measurement Accuracy Mass Spectrometry for Metabolic Profiling, Analytical Chemistry, 2007, 79(16): 6081-6093.

40.Hongliang Jiang, Barbara N. Timmermann, David R. Gang*, Characterization and Identification of Diarylheptanoids in Ginger (Zingiber officinale Rosc.) Using High-performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2007, 21(4): 509-518.

41.Hongliang Jiang, Arpad Somogyi, Barbara N. Timmermann, David R. Gang*, Instrument Dependence of Electrospray ionization and tandem mass spectrometric fragmentation of the gingerols, Rapid Communications in Mass Spectrometry, 2006, 20(20): 3089-3100.

42.Hongliang Jiang, Barbara N. Timmermann, David R. Gang*, Use of Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry to Identify Diarylheptanoids in Turmeric (Curcuma longa L.) Rhizome, Journal of Chromatography A, 2006, 1111(1): 21-31.

43.Hongliang Jiang, Arpad Somogyi, Neil E. Jacobsen, Barbara N. Timmermann, David R. Gang*, Analysis of Curcuminoids by Positive and Negative Electrospray Ionization and Tandem Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2006, 20(6): 1001-1012.

44.Hongliang Jiang, Zhengzhi Xie, Hyun Jo Koo, Steven P. McLaughlin, Barbara N. Timmermann, David R. Gang*, Metabolic Profiling and Phylogenetic Analysis of Medicinal Zingiber Species: Tools for Authentication of Ginger (Zingiber officinale Rosc), Phytochemistry, 2006, 67(15): 1673-1685.

45.Hongliang Jiang, Aniko M. Solyom, Barbara N. Timmermann, David R. Gang*, Charaterization of Gingerol-related Compounds in Ginger Rhizome (Zingiber officinale Rosc.) by High-performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2005, 19(20): 2957-2964.

46.廖梅,姜宏梁*.HPLC-MS同时测定药用紫草中13种紫草素和紫草呋喃类化合物的含量.中国药学杂志,2016,51(14),1212-1218.

47.屈文,程忠哲,李文溢,余启枝,易平,郑艳华,童瑶,刘嵌崎,程文华,李爽,杨光洁,许中怀,姜宏梁,张杨*.高效液相色谱-串联质谱法研究哌虫啶在大鼠体内的吸收、分布及排泄. 农药学学报,2015,17(6), 680-687.

48.姜宏梁,杨学东,张达,徐丽珍,杨世林,邹忠梅. 中药北刘寄奴的化学成分研究.中国药学杂志,2003,38(2),97-99.

49.姜宏梁,徐丽珍,杨学东,张达,杨世林,邹忠梅. 北刘寄奴中奎尼酸酯类化学成分研究.中国中药杂志,2002,27(12), 923-926.

50.张达,姜宏梁,杨学东,徐丽珍,杨世林,邹忠梅. 北刘寄奴中黄酮类化学成分的研究. 中草药,2002,33(11), 974-975.

五、联系方式

Email:jianghongliang@hust.edu.cn;jianghongliang668@163.com

电话:027-66663909.

地址:湖北省武汉市航空路13号华中科技大学同济医学院药学院2号楼,430030

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030