导师：张煜
职称及职务：副教授，博士生导师、硕士生导师
研究方向：肝肾疾病中的炎症反应调控机制及相关新药设计
邮箱：yuzhang@hust.edu.cn
地址：武汉市航空路13号同济医学院药学院二号楼604室
教育及工作经历：
2018-至今华中科技大学药学院，副教授
2014-2018华中科技大学药学院，讲师
2009-2014武汉大学，理学博士（导师：舒红兵 院士）
2005-2009兰州大学，理学学士
主持科研项目：
国家自然科学基金面上项目：《ANGPTL3/8复合物调控NF-kB活化和炎症的功能及机制研究》，项目批准号31871411
国家自然科学基金青年基金：《Betatrophin对TNFa或IL-1b诱导NF-kB活化的负调控机制研究》，项目批准号31500706
湖北省自然科学基金青年基金：《Betatrophin对糖尿病中NF-kB激活的调节机制研究》，项目批准号2015CFB245
第一/通讯作者论文(*为通讯作者；#为共第一作者)：
1. Xu, Y. R.#, M. L. Shi#,Y. Zhang#, N. Kong, C. Wang, Y. F. Xiao, S. S. Du, Q. Y. Zhu and C. Q. Lei *(2022). "Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation."Proc Natl Acad Sci U S A 119(26): e2122805119.（IF=12.779）
2.Y. Zhang#, W. Xue, W. Zhang, Y. Yuan, X. Zhu, Q. Wang, Y. Wei, D. Yang, C. Yang, Y. Chen, Y. Sun, S. Wang, K. Huang*, L. Zheng*, Histone methyltransferase G9a protects against acute liver injury through GSTP1,Cell Death Differ27(4): 1243-1258.（IF=12.077）
3. Y. Zhang,X. Guo, W. Yan, Y. Chen, M. Ke, C. Cheng, X. Zhu, W. Xue, Q. Zhou, L. Zheng, S. Wang, B. Wu, X. Liu, L. Ma, L. Huang and K. Huang* (2017). "ANGPTL8 negatively regulates NF-kappaB activation by facilitating selective autophagic degradation of IKKgamma."Nat Commun8(1): 2164. (IF=17.694)
4. Yang, C.#,Y. Zhang#，X. Zeng, H. Chen, Y. Chen, D. Yang, Z. Shen, X. Wang, X. Liu, M. Xiong, H. Chen* and K. Huang* (2021). "Kidney injury molecule-1 is a potential receptor for SARS-CoV-2."J Mol Cell Biol13(3): 185-196. (IF=8.185)
5. Yang, J., Q. Y. Song, S. X. Niu, H. J. Chen, R. B. Petersen,Y. Zhang*and K. Huang* (2022). "Emerging roles of angiopoietin-like proteins in inflammation: Mechanisms and potential as pharmacological targets."J Cell Physiol237(1): 98-117. (IF=6.513)
6. Zhou, Q., C. Cheng, Y. Wei, J. Yang, W. Zhou, Q. Song, M. Ke, W. Yan, L. Zheng,Y. Zhang* and K. Huang* (2020). "USP15 potentiates NF-kappaB activation by differentially stabilizing TAB2 and TAB3."FEBS J287(15): 3165-3183. (IF=5.622)
7. Y. Zhang#,Y. Zhao#, Z. Wang, H. Gong, L. Ma, D. Sun, C. Yang, Y. Li, B. Cheng, R. B. Petersen, F. Jiang, G. Liu and K. Huang* (2018). "Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-beta(1-42)."Biochim Biophys Acta Gen Subj1862(10): 2226-2235. (IF=4.117)
8. Zhang, Y., C. Q. Lei, Y. H. Hu, T. Xia, M. Li, B. Zhong and H. B. Shu (2014). "Kruppel-like factor 6 is a co-activator of NF-kappaB that mediates p65-dependent transcription of selected downstream genes."J Biol Chem289(18): 12876-12885.（IF=5.486）
