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师资队伍
杰出人才
博士后

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阮汉利

来源:未知 发布时间 2011-09-13 09:55:00 点击数:

阮汉利医学博士,教授,博士生导师。现任华中科技大学同济药学院中药与天然药物学系主任。兼任世界中医药学联合会中药化学专业委员会常务理事、湖北省药学会中药和天然药物专委会委员、武汉市药学教育专业委员会委员。湖北省新世纪高层次人才工程第三层次入选人才。2005年9月-2006年9月、2007年7-10月、2008年7-10月、2014年1-6月国家留学基金委公派访问留学德国,主修生物药学。

主要从事天然药物活性成分的提取分离、结构鉴定、活性测试和生物合成工作。对野核桃、忽地笑、换锦花、长筒石蒜、石蒜、金山五味子、兴山五味子、矢镞叶蟹甲草、湖北贝母、鄂北贝母、杂交贝母、紫花鄂贝北母、鄂西大蓟、莲子心、蛇菰、西南大戟、石蕨、无粉五角叶粉背蕨等多种植物进行过系统研究,并对湖北省民间药材蛇菰和千屈菜的部颁标准进行了制定;对曲霉属真菌中吲哚类生物碱的异戊烯基转移酶相关生物合成基因进行过研究。擅长天然产物的结构解析工作。主持和参加多项国家级和省部级课题。在国内外各种权威期刊发表论文100余篇,其中60多篇为SCI收载。国家精品课程《天然药物化学》主讲教师之一。主讲本、专科生天然药物化学、中药化学、有机化合物波谱解析及研究生天然药物研究方法和天然产物波谱解析等课程。主编、副主编和参编多部人民卫生出版社、高等教育出版社、医药科技出版社和中国中医药出版社的本科生国家统编教材。

学习经历:2001.9-2004.7:华中科技大学同济医学院药学院,获得药理学博士学位;

1996.9-1999.7:同济医科大学药学院,获药物化学专业硕士学位;

1985.9-1989.7:中国药科大学中药系,获理学学士学位;

2014.1-2014.6:德国马尔堡大学,访问学者

2007.7-10;2008.7-10:德国杜塞尔多夫大学,访问学者

2005.9-2006.9:德国图宾根大学及杜塞尔多夫大学,访问学者

工作经历:2014.11-今:华中科技大学同济药学院教授,硕士、博士生导师,中药与天然药物学系主任;

2011.3-2014.11:华中科技大学同济药学院教授,硕士、博士生导师,天然药物化学与中药学系副主任;天然药物化学课程群负责人;

2009.11-2011.2:华中科技大学同济药学院教授,硕士、博士生导师;

2002.7-2009.10:华中科技大学同济药学院副教授,硕士生导师;

1997.1-2002.6:华中科技大学同济医学院药学院讲师;

1992.12-1997.12:同济医科大学药学院助教

近几年研究经历:

2016.01-2019.12:国家自然科学基金《三种核桃属植物PIN1靶向抗肿瘤萘醌类成分及作用机制》/ 77.4万/负责/项目编号21572073;

2013.01-2016.12:国家自然科学基金《金山五味子治疗阿尔茨海默症活性成分及机制》/ 80万/负责/课题编号31270394;

2013.01-2015.12:武汉市科技攻关项目《野核桃中新型凋亡诱导剂YHT-2和YHT-3抗肿瘤成药性评价》/30万/负责;

2011.1-2013.12:国家自然科学基金《换锦花抗AD活性成分及作用机制研究》/ 32万/负责/课题编号81072547;

2010.7-2013.6:科技部国际合作项目《石蒜属植物中化学成分治疗阿尔茨海默症的临床前研究》/ 89万/负责;

2010.1-2010.12:国家大学生创新实验计划《野核桃根皮抗肿瘤活性成分研究》/ 0.4万/负责;

2010.1-2012.12:教育部留学回国人员启动基金《Aspergillus fischerianus次生代谢物生物合成研究》/课题编号:教外司留(2008)890号/负责;

2009.9-2011.8:重大新药创制专项创新药物研究项目《来源于野核桃青果皮的抗肿瘤药物的研究与开发》/ 20万/负责;

2009.1-2009.12:中韩合作课题《从传统中药中开发出天然药物或功能性食品的新原料》/ 3万/负责;

2009.1-2011.12:国家自然科学基金《野核桃青果皮抗肿瘤活性成分及作用机制研究》/ 31万/课题编号30873361/负责;

2008.1-2008.12:国家大学生创新实验计划《米曲霉菌中次生代谢物的生物合成研究》负责;

2007.1-2007.12:华中科技大学校基金启动项目《Aspergillus fisherianus中次生代谢物的生物合成》/ 1.2万/负责;

2006.1-2007.12:湖北省自然科学基金项目野核桃果皮诱导肿瘤细胞Trail基因表达活性成分研究》/ 4万/课题编号:2006ABA125 /负责;

2009.1-2009.12:中德合作PPP项目《生物信息学、分子生物学与化学相结合研究Aspergillus中次生代谢物的生物合成》

2007.1-2008.12:中德合作PPP项目《生物信息学、分子生物学与化学相结合研究真菌Aspergillus fisherianus中次生代谢物的生物合成》课题编号:留金出20063139

2004.1-2006.12:湖北省科技攻关项目《筒鞘蛇菰抗炎镇痛作用的研究与开发》负责;2004AA302B10

2002.1-2005.12:武汉市科技局青年科技晨光计划《湖北大戟抗肿瘤活性成分研究》负责;课题编号:20025001022

2007.1-2009.12:国家科技部国际科技合作重点项目“中药一类新药浙贝乙素胆酸盐的研究”90万元技术骨干课题编号2006DFA33210

2007.1-2007.12:中韩国际科技合作项目“民族药忽地笑抗AD的活性成分及机制研究”3000万韩元技术骨干

2004.1-2004.12:国家中医药管理局新药开发专项课题“新药湖北贝母总碱的开发研究”80万元技术骨干

专利申请:

1. 2004100607538湖北贝母中提取的单体生物碱在制备镇咳祛痰平喘药物中的应用

2. 2004100607542浙贝乙素及其衍生物在制备镇咳祛痰平喘药物中的应用

3. 2004100607523浙贝乙素及其衍生物在制备抗肿瘤药物中的应用

4. 2006100190270浙贝乙素和胆汁酸的衍生物及药物组合物

5. 2008100487229浙贝乙素胆汁酸酯及其制备方法和应用

6. 2009100611697用于预防或治疗痴呆症的组合物

7. KR 2010104064 Lycoris aurea extracts for preventing and treating dementia, Repub. Korean

8. 2010105959577两个萘醌类化合物在制备抗肿瘤类药物中的应用

9. WO 2012/026641 A1 Composition for preventing or treating dementia

10. 2012104169575一种木脂素类化合物及其制备方法和应用

11. 2012104179007一种木脂素类化合物及其在防治阿尔茨海默症中的应用

12. 2013100756654具有神经保护作用的石蒜科生物碱类化合物

13. 2013100764684具有神经保护作用的石蒜伦碱类化合物

14. 2013100764665一个具有神经保护作用的石蒜碱类化合物

15. 2013106738541一种用于预防和治疗阿尔茨海默症的药物及其制备方法

发表的主要论文(标*的为通讯作者):

*Jian Song, Ye Liu, Ming Zhou, Hui Cao, Xiao-Gang Peng, Jing-Jing Liang, Xiao-Ya Zhao, Ming Xiang,Han-Li Ruan*. Spiroschincarins A–E: Five Spirocyclic Nortriterpenoids from the Fruit ofSchisandra incarnata.Organic Letters, 2017, 19 (5), 1196–1199

*Ye Liu, Heng-Yi Yu, Yan-Mei Wang, Tian Tian, Wen-Ming Wu, Ming Zhou, Xiang-Gao Meng,Han-Li Ruan*. Neuroprotective Lignans from the Fruits ofSchisandra bicolorvar.tuberculata.Journal of Natural Products, 2017, accepted

*Ye Liu, Tian Tian, Heng-Yi Yu, Ming Zhou,Han-Li Ruan*. Nortriterpenoids from the stems and leaves ofSchisandra viridis,Fitoterapia, 2017, 118: 38-41

* An Jin, Wen-Ming Wu,Han-Li Ruan*.Sesquiterpenoids and monoterpenoid coumarins fromParasenecio rubescens,Rsc Advances, 2017, 7, 5167–5176

*Ye Liu,Yan-Mei Wang, Wen-Ming Wu, Jian Song,Han-Li Ruan*. Triterpenoids and lignans from the fruit of Schisandra sphenanthera.Fitoterapia, 2017, 116:10–16

*Ming Zhou, Ye Liu, Jian Song, Xiao-Gang Peng, Qi Cheng, Hui Cao, Ming Xiang, andHan-Li Ruan*,Schincalide A, a Schinortriterpenoid with a Tricyclo[5.2.1.01,6]decane-Bridged System from the Stems and Leaves of Schisandra incarnate.Organic Letters, 2016, 18 (18), 4558–4561

*Wen-Ming Wu, Xu Chen, Ye Liu, Yan-Mei Wang, Tian Tian, Xiao-Ya Zhao, Juan Li,Han-Li Ruan*. Triterpenoids from the branch and leaf of Abies fargesii.Phytochemistry, 2016,130, 301–312

*Heng-Yi Yu, Juan Li, Ye Liu, Wen-Ming Wu,Han-Li Ruan*. Triterpenoids from the fruit of Schisandra glaucescens.Fitoterapia, 2016, 113, 64–68.

*Wen-Ming Wu, Ye Liu, Xu Chen, An Jin, Ming Zhou, Tian Tian,Han-Li Ruan*, Diterpenoids from the branch and leaf of Abies fargesii,Fitoterapia, 2016, 110: 123-128.

*毛瑞华,钟志宏,吴文明,刘叶,阮汉利*.鄂西大蓟茎叶化学成分研究[J].中草药, 2016,47(13): 2236-2240.

*Tian Tian, Ye Liu, Heng-Yi Yu, Yun-Yun Zhu, Xiao-Ya Zhao,Han-Li Ruan* Dibenzocyclooctadiene Lignans from the Fruits of Schisandra viridis,Chemistry of Natural Compounds, 2015,51 (6):1046-1048

*An Jin, Wen-Ming Wu, Heng-Yi Yu, Ming Zhou, Ye Liu, Tian Tian, andHan-Li Ruan* Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens,Journal of Natural Products, 2015,78 (8): 2057–2066

*Yun-Yun Zhu, Xue Li, Heng-Yi Yu, Yu-Fang Xiong, Peng Zhang, Hui-Fang Pi,Han-Li Ruan*Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activitiesArchives of Pharmacal Research, 2015, 38 (5): 604-613

*Yuan Gan, Yang Zhang, Aiqian Li, Chengwu Song, Chang Chen, Yong Xu,Hanli Ruan*, Hongliang*. Jiang, A Novel Four-step Approach for Systematic Identification of Naphthoquinones in Juglans cathayensis Dode using Various Scan Functions of Liquid Chromatography-Tandem Mass Spectrometry along with Data Mining Strategies.Phytochemical Analysis,2015, 26(6): 413–422

Zhenzhong Chen, Ling Tong, Yuanli Feng, Jizhou Wu, Xiaoya Zhao,Hanli Ruan, Huifang Pi, Peng Zhang, Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus.Phytochemistry2015, 116, 329-336.

*Heng-Yi Yu, Zu-Yu Chen, Bin Sun, Junjun Liu, Fan-Yu Meng, Ye Liu, Tian Tian, An Jin, andHan-Li Ruan*, Lignans from the Fruit of Schisandra glaucescens with Antioxidant and Neuroprotective Properties,Journal of Natural Products, 2014, 77 (6): 1311–1320

*An Jin, Xue Li, Yun-Yun Zhu, Heng-Yi Yu, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Four New Compounds from the Bulbs of Lycoris aurea with Neuroprotective Effects against CoCl2 and H2O2-induced SH-SY5Y Cell Injuries,Archives of Pharmacal Research2014, 37: 315-323

*Wen-Ming Wu, Yun-Yun Zhu, Hao-ran Li, Heng-Yi Yu, Peng Zhang, Hui-Fang Pi,Han-Li Ruan*Two new alkaloids from the bulb of Lycoris sprengeriJournal of Asian Natural Products Research,2014, 16(2): 192-199.

Ke Jiao, Huo-Yun Li, Peng Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu Two new ent-kaurane diterpenoids from the aerial parts of Isodon excisoidesChinese Chemical Letters2014, 25(1): 131-133.

Ling Tong, Tu Chen, Zhenzhong Chen, Peng Zhang, Huifang Pi,Hanli Ruan, Jizhou. Wu, Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae.Journal of Ethnopharmacology2014, 155 (3), 1553-1560.

Juan Li, Hang Chang, Wenyu Zhao, Huifang Pi, Hanli Ruan, Peng. Zhang, New Alkaloids from Aconitum vaginatum.Helvetica Chimica Acta2014, 97 (5), 689-693.

*Heng-Yi Yu, Xiao-Qiong Zhang, Xue-Li, Fan-Bo Zeng,Han-Li Ruan*2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma Model,Journal of Natural Products2013, 76(5): 889−895

*Juan Li, Jia-Xiang Sun, Heng-Yi Yu, Zu-Yu Chen, Xiao-Ya Zhao,Han-Li Ruan*Diarylheptanoids from the root bark ofJuglans cathayensis,Chinese Chemical Letters2013, 24: 521-523

*Xue Li, Heng-Yi Yu, Zhuo-Yi Wang, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Neuroprotective Compounds from the Bulbs ofLycoris radiate,Fitoterapia2013, 88: 82-90.

Ke Jiao, Huo-Yun Li, Peng Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu Three new ursane-type triterpenoids from the aerial parts of Isodon excisoidesJournal of Asian Natural Products Research2013, 15(9): 962-968.

Kun Yang, Ling Tong, Chunxia Chen, Peng Zhang, Huifang Pi,Hanli Ruan, Jizhou. Wu, Therapeutic effects of extracts from Radix Toddaliae Asiaticae on collagen-induced arthritis in Balb/c mice.Journal of Ethnopharmacology2013, 146 (1), 355-362.

* Heng-Yi Yu, Cui Hao, Fan-Yu Meng, Xue Li, Zu-Yu Chen, Xi Liang,Han-Li Ruan*Neuroprotective Lignans from the Stems ofSchisandra glaucescensPlanta Medica2012,78: 1962-1966

* Jia-Xiang Sun, Xiao-Ya Zhao, Xiao-Fang Fu, Heng-Yi Yu, Xue Li, Shu-Ming Li,Han-Li Ruan*Three new naphthalenyl glycosides from the root bark ofJuglans cathayensis,Chemical and Pharmaceutical Bulletin2012, 60: 785-789.

Kathrin Mundt, Beate Wollinsky,Han-Li Ruan, Tianjiao Zhu and Shu-Ming Li, Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.Chembiochem2012, Nov 26; 13(17): 2583-2592 (This paper was selected as issue cover)

* Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Heng-Yi Yu, Shu-Ming Li, andHan-Li Ruan*. Schiglautone A, a New Tricyclic Triterpenoid with a Unique 6/7/9-Fused Skeleton from the Stems ofSchisandra glaucescens.Organic Letters,2011, 13 (6): 1502–1505

*Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*. Triterpenoids from the Stems ofSchisandra glaucescens.Helvetica Chimica Acta,2011,94(10):1778-1785

* Heng-Yi Yu, Xue Li, Fan-Yu Meng, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Naphthoquinones from the root barks ofJuglans cathayensisDode.Journal of Asian Natural Products Research,2011, 13 (7): 581-587.

Li, Lujun; Zhang, Yue; Zhang, Peng; Pi, Huifang;Ruan, Hanli; Wu, Jizhou. Appraisal of anti-inflammatory and free radical scavenging activities of ethanol extract of Ilex ficoidea Hemsl and Ilex centrochinensis S.Y. Hu.Environmental Toxicology and Pharmacology2011, 32(2), 122-127.

Zhang, Yue; Li, Lu-Jun; Zhang, Peng; Pi, Hui-Fang;Ruan, Han-Li; Wu, Ji-Zhou. Three New E-Secoursane Triterpenoid Saponins from the Leaves of Ilex dunniana.Helvetica Chimica Acta2011, 94(12): 2207-2214.

Chen Chunxia, Zhang Peng, Pi Huifang,Ruan Hanli, Hu Zehua,Wu Jizhou. Extracts of Arisaema rhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice.Journal of Ethnopharmacology. 2011, 133: 573-582

Li, Lu-Jun; Zhang, Yue; Zhang, Peng; Pi, Hui-Fang;Ruan, Han-Li; Wu, Ji-Zhou. Flavans from the leaf of Ilex centrochinensis.Journal of Asian Natural Products Research2011, 13(4): 367-372.

Li, Lu-Jun; Zhang, Yue; Zhang, Peng; Pi, Hui-Fang;Ruan, Han-Li; Wu, Ji-Zhou. Two new 5,8-quinoflavans from the leaf of Ilex centrochinensis.Journal of Asian Natural Products Research2011, 13(4): 341-345.

*陈超,胡钰,孙家祥,皮慧芳,张鹏,阮汉利*.野核桃叶化学成分研究.中草药, 2011,42(11), 2177-2180

张悦,李陆军,张鹏,皮慧芳,阮汉利,吴继洲.冬青属两种植物的抗炎作用及自由基清除能力研究.华中科技大学学报(医学版), 2011, 40(1), 71-74.

*张悦,阮汉利*,张勇慧,皮慧芳,吴继洲鄂西大蓟根的化学成分的研究天然产物研究与开发,2010, 22(1): 58-59

Han-Li Ruan, Edyta Stec and Shu-Ming Li. Production of diprenylated indole derivatives by tandem incubation of two recombinant dimethylallyltryptophan synthasesArch Microb2009, 191: 791-795

*PI Hui-fang, ZHANG Peng,RUAN Han-li*, ZHANG Yong-hui, SUN Han-dong, WU Ji-zhou A new triterpenoid from the leaves and stems ofFritillaria hupehensisJournal of Asian Natural Products Research2009, 11 (9): 779-782

Nicola Steffan, Alexander Grundmann, Shamil Afiyatullov,Hanli Ruanand Shu-Ming Li FtmOx1, a non-heme Fe(II) and a-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatusOrg Biomol Chem. 2009, 7(19): 4082-7

Zhang, Jiu-liang; Wang, Hui; Pi, Hui-fang;Ruan, Han-li; Zhang, Peng; Wu, Ji-zhou. Structural analysis and antitussive evaluation of five novel esters of verticinone and bile acids.Steroids2009, 74(4-5), 424-434.

Zhou, Xue-Feng; Tang, Lan; Zhang, Peng; Zhao, Xiao-Ya; Pi, Hui-Fang; Zhang, Yong-Hui;Ruan, Han-Li; Liu, Yonghong; Wu, Ji-Zhou. The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. hupehensis.Zeitschrift fuer Naturforschung, C: Journal of Biosciences2009, 64(5/6), 369-372.

Zhou, Xue-Feng; Zhang, Peng; Pi, Hui-Fang; Zhang, Yong-Hui;Ruan, Han-Li; Wang, Hui; Wu, Ji-Zhou.Triterpenoids from the Roots of Actinidia chinensis.Chemistry & Biodiversity2009, 6(8), 1202-1207.

徐仿周;张鹏;张勇慧;阮汉利;皮慧芳;吴继洲湖北贝母总生物碱平喘作用及其机理的研究时珍国医国药2009; 20(6): 1335-1337

徐仿周;陈昶;阮汉利;张勇慧;皮慧芳;吴继洲湖北贝母有效部位提取工艺的研究时珍国医国药2009; 20(5): 1033-1034

Han-Li Ruan,Wen-Bing Yin,Ji-Zhou Wu, Shu-Ming Li.Reinvestigation of a Cyclic Dipeptide N-Prenyltransferase Reveals Rearrangement of N-1 Prenylated Indole Derivatives.ChemBioChem2008, 9: 1044-1047.

*Hui Fang Pi Zhi Hong ZhongHan Li Ruan*Peng Zhang Yong Hui Zhang Ji Zhou Wu A new hopane triterpenoid from Saxiglossum angustissimumChinese Chemical Letters2008, 19: 835–836

*LI Yi-xiu;RUAN Han-li*; ZHOU Xue-feng; ZHANG Yong-hui; PI Hui-fang and WU Ji-zhou Cytotoxic Diarylheptanoids from Pericarps ofJuglans CathayensisDodeChem.Res. Chinese Universities2008, 24(4), 427 -429

Zhang Yonghui, Yang, xiliang, Zhang Peng, Zhou, Xuefeng,Ruan Hanli, Pi Huifang, Wu Jizhou, Sun, Han-Dong. Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis.Chemistry & Biodiversity. 2008, 5(2), 259-266.

Zhang Peng, Li Juan, Zhang Guoxin, Pi Huifang, Zhang Yonghui, Ruan Hanli, Wu Jizhou. Analysis of hupehenine in the total alkaloids from Fritillaria hupehensis by HPLC-ELSD. Journal of Huazhong University of Science and Technology, Medical Sciences. 2008, 28(1): 118-120.

*Ruan Han-Li*; Zhou Xue-Feng; Zhang Yong-Hui; Pi Hui-Fang; Wu Ji-Zhou; Sun Han-Dong Ferulic acid esters from Euphorbia hylonoma.Fitoterapia2007, 78(1), 72-73.

*Pi, Hui Fang; Zhang, Peng; Zhu, Tian;Ruan, Han Li*; Zhang, Yong Hui; Sun, Han Dong; Wu, Ji Zhou. A new cycloartane triterpenoid from the leaves and stems of Fritillaria hupehensis.Chinese Chemical Letters2007, 18(4), 418-420.

Yin, Wen-Bing;Ruan, Han-Li; Westrich, Lucia; Grundmann, Alexander; Li, Shu-Ming. CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterization.ChemBioChem2007, 8(10), 1154-1161.

Zhang, Yonghui; Cai, Jinyan;Ruan, Hanli; Pi, Huifang; Wu, Jizhou. Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats.Journal of Ethnopharmacology2007, 114(2), 141-145.

Zhou Xuefeng; Zhao Xiaoya; Tang Lan; Zhang Yonghui;Ruan Hanli;Pi Huifang; Qiu Jun; Wu JizhouImmunomodulatory activity of the rhizomes of Impatiens pritzellii var. hupehensis on collagen-induced arthritis mice.Journal of Ethnopharmacology2007, 109(3), 505-9.

Zhang, Yong-Hui; Yang, Xi-Liang; Zhou, Xue-Feng;Ruan, Han-Li; Pi, Hui-Fang; Wu, Ji-Zhou; Sun, Han-Dong. Alkaloids from Fritillaria hupehensis.Chinese Journal of Chemistry(2007), 25(11), 1728-1731.

Xu, Fang-zhou; Chen, Chang; Zhang, Yong-hui;Ruan, Han-li; Pi, Hui-fang; Zhang, Pong; Wu, Ji-zhou. Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent.Acta Pharmacologica Sinica(2007), 28(10), 1591-1596.

Zhang, Yong Hui; Yang, Xi Liang; Zhou, Xue Feng;Ruan, Han Li;Pi, Hui Fang; Wu, Ji Zhou; Sun, Han Dong; Fujita, Tetsuro. A new veratramine alkaloid from the bulbs of Fritillaria hupehensis.Chinese Chemical Letters2007, 18(2), 175-177.

Zhou, Xue-Feng; Tang, Lan; Zhang, Yong-Hui; Pi, Hui-Fang;Ruan, Han-Li; Wu, Ji-Zhou. Nitrogenous compounds from Impatiens pritzellii var. hupehensis (Balsaminaceae).Biochemical Systematics and Ecology2007, 35(5), 308-310.

Xu Fang-Zhou; Chen Chang; Zhang Yong-Hui;Ruan Han-Li; Pi Hui-Fang; Zhang Pong; Wu Ji-Zhou. Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent.Acta pharmacologica Sinica2007, 28(10), 1591-6.

Zhou X-F; Zhao X-Y; Tang L;Ruan H-L; Zhang Y-H; Pi H-F; Xiao W-L; Sun H-D; Wu J-Z Three new triterpenoid saponins from the rhizomes of Impatiens pritzellii var. hupehensis.Journal of Asian Natural Products Research2007, 9(4), 379-385.

Hui-Fang Pi,Han-Li Ruan, Yong-Hui Zhang, Ji-Zhou Wu.Two new steroidal alkaloids from bulbs of Fritillaria lichuanensisJournal of Asian Natural Products Research2006,8(3):253-257

Hui-Fang Pi,Han-Li Ruan, Yong-Hui Zhang, Lei-Ming Niu, Ji-Zhou Wu. Steroidal alkaloids from bulbs ofFritillaria lichuanensisJournal of Asian Natural Products Research2006, 8(1-2): 133-136

Zhang Yong-hui,Ruan Han-li. A new steroidal alkaloid from bulbs of Fritillaria Hupehensis Hsiao et K.C. Hsia.Chemical Research of Chinese Universities, 2004,20(6):804-806

Zhang Yong-hui,Ruan Han-li. Structural elucidation of fritillahupehin from bulbs of Fritillaria Hupehensis Hsiao et K. C. Hsia.Journal of Asian Natural Products Research2004; 6(1): 29-34

Ruan Han-li, Zhang Yong-hui,Wu Ji-zhou. Two new diterpenoid dimers, fritillebinide D and E, from bulbs offritillaria ebeiensisJournal of Asian Natural Products Research2002;4(4): 309-314

Ruan Han-li, Zhang Yong-hui,Wu Ji-zhou.Structure of a novel diterpenoid ester, fritillahupehin, from bulbs offritillaria hupehensisHsiaoetK. C. HsiaFitoterapia2002: 73(4): 288-291

Wu Ji-zhou,Ruan Han-li, Yao Nian-huan.Structures of Two Diterpenoid Dimers from Bulbs ofFritillaria ebeiensis.Journal of Asian Natural Products Research2000, 2 (3): 161-167

Wu Ji-zhou, Wen Yu-ping,Ruan Han-li. Structural Elucidation of TwoEnt-kauran Dimers from Bulbs ofFritillariaebeiensisvar.purpurea.Journal of Asian Natural Products Research2000, 2(3): 213-218

Wu Ji-zhou,Ruan Han-li, Zeng Chun-lan. Structures of Two New Diterpenoid Dimers from Bulbs of Fritillaria ebeiensis. J Asia Nat Prod Reseach 1999; 1: 251-257

副主编和参编教材:

主编《天然药物化学》(医药科技出版社,2016年出版);

参编《波谱解析》第二版(人民卫生出版社,2016年出版);

副主编《天然药物化学》(医药科技出版社,2015年8月出版);

参编《波谱解析》(中医药出版社,2014年出版);

副主编《天然药物化学》(高等教育出版社,2010年5月出版);

参编《波谱解析》(人民卫生出版社,2011年7月出版);

参编《天然药物化学》(医药科技出版社,2008年8月出版);

参编《天然药物化学图表解》(人民卫生出版社,2008年10月出版);

参编《天然药物化学学习指导》(人卫出版社,2005年2月出版);

参编《天然药物化学习题集》第二版(人卫出版社,2007年8月出版);

参编《药物计量学》(医药科技出版社,2006年4月出版)。

参加会议:

2016. 9. 25-28,中国化学会第十一届全国天然有机化学学术会议,上海,中国

2014. 11. 21-23,中国化学会第十届全国天然有机化学学术会议,广州,中国

2014. 10. 20-24, 28th International Symposium on the Chemistry of Natural Products and the 8th International Conference on Biodiversity (ISCNP28 & ICOB8), Shanghai, China

2012. 8. 23-26,韩国首尔the 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy (第7届中日韩三国生药学联合学术研讨会)交流论文Diarylheptanoids from the root bark of Juglans cathayensis Dode

2011. 8. 10-12,昆明野核桃根皮化学成分研究,第十届全国药用植物及植物药学术研讨会PP159

Zongfang Wang, Hengyi Yu, Hanli Ruan*, Huifang Pi, Peng Zhang, Jizhou Wu.Five new compounds fromJuglans cathayensisthe 5th JSP-CCTCNM-KSP Joint Symposium. September 24th 2010.Tokushima-Japan.

Nicola Steffan, Inge Unsöld, Alexander Grundmann, Wen-Bing Yin, Anika Kremer, Hanli Ruan, Shu-Ming Li.Evolution of aromatic prenyltransferases in the biosynthesis of indole derivatives.7thColloquium of SPP 1152: Evolution of Metabolic Diversity, 3.04.2008,Halle (Saale), Germany.

Wen-Bing Yin, Han-Li Ruan, Lucia Westrich, Alexander Grundmann and Shu-Ming Li. CdpNPT, an N-prenyltransferase fromAspergillus fumigatus: Overproduction, purification and biochemical characterization.„Tag des Wissenschaftlichen Nachwuchses“, 22.06.2007, HHU Düsseldorf.

Wen-Bing Yin, Han-Li Ruan, Lucia Westrich, Alexander Grundmann and Shu-Ming Li.CdpNPT, a tryptophan-containing cyclic dipeptide N1-prenyltransferase fromAspergillus fumigatus.VAAM International Workshop: Biology of Bacteria Producing Natural Products,4-6.10.2007, European Academy Otzenhausen, Germany.

2007. 12. 4-5:江西南昌交流论文A new Diarylheptanoid from Juglans Cathayensis Dode第九届全国中药和天然药物学术研讨会

2000.3.17-19:中国昆明交流论文Diterpenoids from the bulbs of fritillaria ebeiensis var. purpurea。UNESCO Regional Symposium on Chemistry of Medicinal Plants.

1997. 10.28-31:日本京都交流论文Structures of Six Novel Diterpenoids from Fritillaria ebeiensis. International Symposium on Natural Medicines, Kyoto, Japan, Oct. 28-30, 1997

获奖情况:

所写论文所写论文‘Structures of Two Diterpenoid Dimers from Bulbs of Fritillaria ebeiensis’和‘StructuralElucidation of Two Ent-kaurane Dimers from Bulbs of Fritillaria ebeiensis var. purpurea’获湖北省第九届自然科学优秀学术论文一等奖;‘鄂贝缩醛A的结构解析与合成’获湖北省第八届自然科学优秀学术论文二等奖;Two new diterpenoid dimers, fritillebinide D and E, from bulbs of fritillaria ebeiensis获武汉市第九届自然科学优秀学术论文二等奖。作为骨干力量参加的课题“湖北贝母、鄂北贝母、紫花鄂北贝母品质评价的系统研究”获卫生部科技进步三等奖、省科技进步二等奖;作为骨干力量参加的国家教委课题“湖北贝母非生物碱的化学研究”1997年获校先进课题组二等奖。2003年被评为华中科技大学“三育人积极分子”。2001-2002学年获华中科技大学教学质量优秀二等奖。1999、2000、2001连续三年考核优秀。2005年湖北省自然科学三等奖(排名第二)。2005年华中科技大学优秀博士学位论文。2009和2010年指导本科生论文获湖北省大学本科生毕业论文一等奖。

联系方式:华中科技大学同济医学院药学院阮汉利;邮编430030

Email:ruanhl@hust.edu.cn;ruanhl@mails.tjmu.edu.cn

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