童擎一，博士，副教授，硕士、博士生导师。2014年6月毕业于四川大学生物治疗国家重点实验室，获医学博士学位；2014年7月进入华中科技大学同济医学院药学院从事博士后研究，2018年5月留校任讲师；2019年11月至今任副教授。承担本科生《药理学》，研究生《药学生物技术》、《应用药理学》等课程的理论和实验教学，参与的《药理学》获2021年度省级一流本科课程认定。已在Nucleic Acids Research，Angewandte Chemie-International Edition, Frontiers in Immunology，Organic Letters和Chinese Chemical Letters等学术期刊上发表SCI论文50余篇，其中一作和通讯（含共同）SCI论文20余篇，总引用超过1000，H因子21。主持国家自然科学基金青年基金和面上项目各1项，中国博士后科学基金面上项目2项，湖北省自然科学基金面上项目1项，华中科技大学博士后科学基金和自主创新研究基金各1项，申请专利多项。作为参与人获2021年度湖北省科学技术奖一等奖1项。任中国药理学会会员、抗炎免疫药理专业青委会委员，湖北省毒理学会、药理学会理事，中国免疫学会会员、中医药免疫分会委员。Current Medical Science、医药导报、中国药师等杂志编委、审稿人。
联系方式
邮箱：qytong@hust.edu.cn
地址：武汉市硚口区航空路13号同济药学院2号楼4楼 邮编430030
本课题组有一支包括多名教师、博士后在内的科研团队，长期招收优秀博士后、博士生、硕士生，欢迎联系报考！
研究方向
1.肿瘤药理研究：从肿瘤的分子病理出发，采用分子生物学、细胞生物学等方法，开发针对恶性肿瘤的新药或治疗策略，并研究相关机制。
2.新药发现与机制研究：建立多种新颖的疾病模型，在此基础上采用高通量筛选方法筛选出具有抗肿瘤、抗炎、免疫调节、代谢调节等活性的化合物，并采用多学科交叉方法评价其疗效和安全性、阐明其作用机制。
3.药物靶点发现和确证研究：采用化学生物学、蛋白组学等技术在分子和细胞水平上研究药物的靶点，并采用多学科交叉方法在体外和体内对靶点进行确证。
主持的科研项目
1. 国家自然科学基金面上项目，项目号82073886，2021/01-2024/12
2. 湖北省科技重大项目子课题，项目号2021ACA012，2021/07/01-2024/06/20
3. 湖北省中医药管理局面上项目，项目号ZY2023M063，2023/01/01-2024/12/31
4. 湖北省自然科学基金面上项目，项目号2019CFB428，2019/09-2021/08
5. 华中科技大学自主创新研究基金，项目号2172019kfyXJJS166，2019/01-2021/12
6. 国家自然科学基金青年科学基金，项目号81503305，2016/01-2018/12
7. 中国博士后科学基金第66批面上项目，项目号2019M660125，2018/01-2019/12
8. 中国博士后科学基金第58批面上项目，项目号2015M582227，2014/08-2016/07
9. 华中科技大学博士后科学基金,项目号2006514110，2014/08-2016/07
参编教材
1.《药理研究方法学》2021中国医药科技出版社，编委
2.《药物毒理学》2019中国医药科技出版社 第四版，编委
主要学术论文(#Co-first author, *Correspondence author)
1. Qingyi Tong#, Huijuan You#, Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo*, Yonghui Zhang*, ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acidresistance in acute promyelocytic leukemia. Nucleic Acids Research, 2018,46(7):3284–3297.（IF=19.2, Q1）
2. Hucheng Zhu#, Chunmei Chen#,Qingyi Tong#, Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang*, Asperflavipine A, an unprecedented cytochalasan heterotetramer uniquely defined by a highly complicated tetradecacyclic ring system from Aspergillus flavipes QCS12, Angewandte Chemie-International Edition, 2017,56(19):5242–5246.（IF=16.8,Q1）
3. Yi Kong#, Jian Jiang#, Yuqiong Huang, Xin Liu, Zilin Jin, Li Li, Fen Wei, Xinxin Liu, Jie Yin, Yonghui Zhang*,Qingyi Tong* and Hongxiang Chen*, Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis. Frontiers in Immunology, 10.3389/fimmu.2022.1094375（IF=8.786, Q1）
4. Yi Kong, Jian Jiang, Yuqiong Huang, Li Li, Xin Liu, Zilin Jin, Fen Wei, Xinxin Liu, Song Zhang, Xiaoru Duan, Yonghui Zhang*,Qingyi Tong*, Hongxiang Chen*,Endoplasmic reticulum stress in melanoma pathogenesis and resistance.Biomedicine & Pharmacotherapy.2022,155:113741.（IF=7.419, Q1）
5. Shuang Lin#, Jianzheng Huang#, Hanxiao Zeng,Qingyi Tong*, Xueke Zhang, Beiye Yang, Ying Ye, Jianping Wang, Zhengxi Hu*, Yonghui Zhang*.Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungus Stachybotrys chartarum. Chinese Chemical Letters. 2022 (33) 4587–4594（IF=8.5,Q1）
6. Xiaotian Zhang#, Zhaodi Wu#,Alan Bao, Ziming Zhao, Yu Chen, Huimin Zhao, Jianping Wang, Chunmei Chen,Qingyi Tong*, Hucheng Zhu*, Yonghui Zhang*. Asperflavipines C–E and aspermichalasine A: three cytochalasan heterotetramers and an unusual cytochalasan monomer from Aspergillus micronesiensis. Organic Chemistry Frontier, 2022,9, 2585-2592（IF=5.5,Q1）
7. Yulin Duan#, PingHu#, YiGuo, Pengfei Bu, Zhengyi Shi,Yunfang Cao, Yeting Zhang, Hong Hu,Qingyi Tong*, Changxing Qi*, Yonghui Zhang*. Kiiacylphnols A−H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim. Phytochemistry. 2022 (199) 113166.(IF=4.004,Q1）
8. Si Yao, Jie Yin, Wen Liu, Yang Li, Jianzheng Huang, Changxing Qi, Zhengxi Hu,Qingyi Tong*, Lianghu Gu*, Yonghui Zhang*. A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma. Bioorganic Chemistry, 2022, 127, 106019.（IF=5.3, Q1）
9. Beiye Yang#,Jianzheng Huang#,Shuang Lin,Qingyi Tong*, Zeyu Yao, Fengli Li, Ying Ye, Zhengxi Hu *, Yonghui Zhang*, Hyperbeanone A, a 5,6-seco-spirocyclic polycyclic polyprenylated acylphloroglucinol derivative with an unprecedented skeleton from Hypericum beanie. Organic Chemistry Frontiers, 2021,8, 6411-6418（IF=5.5, Q1）
10. Mengsha Wei#, Peng Zhou#, Liping Huang, Jie Yin, Qin Li, Chong Dai, Jianping Wang, Lianghu Gu*,Qingyi Tong*, Hucheng Zhu*,Yonghui Zhang*,Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis, Phytochemistry, 2021, 191 112910. (IF=4.004,Q1）
11. Jiaxiong Ming, Qianqian Xu, Limin Gao, Yanfang Deng, Jie Yin, Qun Zhou*,Qingyi Tong*, Yonghui Zhang*.Kinsenoside Alleviates 17α-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis.Pharmaceuticals, 2021,14(5):452.（IF=5.863,Q1）
12. Song Hu#, Jie Yin#, Shan Yan, Ping Hu, Jianzheng Huang, Geng Zhang, Fuqian Wang*,Qingyi Tong*, Yonghui Zhang*, Chaetocochin J, an epipolythiodioxopiperazine alkaloid, induces apoptosis and autophagy in colorectal cancer via AMPK and PI3K/AKT/mTOR pathways. Bioorganic Chemistry, 2021, 109, 104693.（IF=5.3, Q1）
13. Zhaodi Wu#; Xiaotian Zhang#, Chunmei Chen#, Peng Zhou, Mi Zhang, Lianghu Gu, Zengwei Luo, Jianping Wang,Qingyi Tong*, Hucheng Zhu*, Yonghui Zhang*, Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from Aspergillus micronesiensis PG-1.Organic Letters, 2020，22(6), 2162-2166.（IF=6.1, Q1）
14. Zhaodi Wu#,Qingyi Tong#, Xiaotian Zhang, Peng Zhou, Chong Dai, Jianping Wang, Chunmei Chen*, Hucheng Zhu*, and Yonghui Zhang*，Amichalasines A–C: Three Cytochalasan Heterotrimers from Aspergillus micronesiensis PG-1. Organic Letters 2019, 21 (4), 1026–1030.（IF=6.1, Q1）
15. Yi Guo#,Qingyi Tong#,Na Zhang, Xueyan Duan, Yunfang Cao, Hucheng Zhu, Shuangshuang Xie, Jing Yang, Jinwen Zhang, Yanfei Liu, Yongbo Xue* and Yonghui Zhang*, Highly-functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols fromHypericum perforatuminduce leukemia cell apoptosis. Organic Chemistry Frontiers, 2019,6, 817-824.（IF=5.5, Q1）
16. Guangzheng Wei#, ChunmeiChen#,Qingyi Tong#, Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang, Hucheng Zhu*, and Yonghui Zhang*,Aspergilasines A–D: four merocytochalasans with new carbon skeletons from Aspergillus flavipes QCS12, Organic Letters, 2017, 19, 4399−4402.（IF=6.1, Q1）
17. Qingyi Tong#, Yong Qing#, Dan Shu, Yang He, Yinglan Zhao, Yi Li, Zhengling Wang, Shiyuan Zhang, Zhihua Xing, Cheng Xu, Yuquan Wei, Wen Huang*, Xiaohua Wu*.Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and anti-angiogenesis.Cellular Physiology and Biochemistry, 2011, 27, 233–242.
18. Qingyi Tong,Yong Qing*, Yang Wu, Xiaojuan Hu, Lei Jiang, Xiaohua Wu*, Dioscin inhibits colon tumor growth and angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.Toxicology and Applied Pharmacology, 2014, 281, 166–173.
19. Qingyi Tong, QingbingZhao, Yong Qing, Xiaojuan Hu, Lei Jiang, Xiaohua Wu*.Deltonin inhibits angiogenesis by regulating VEGFR2 and subsequent signaling pathways in endothelial cells.Steroids, 2015, 96, 30–36.
20. Qingyi Tong#, YangHe#, Qingbing Zhao, Yong Qing*, Wen Huang*, Xiaohua Wu* Cytotoxicity and apoptosis-inducing effect of steroidal saponins from dioscorea zingiberensis wright against cancer cells. Steroids, 2012,77, 1219–1227.
21. Chunmei Chen#,Qingyi Tong#, Hucheng Zhu, Dongdong Tan, Jinwen Zhang, Yongbo Xue, Guangmin Yao, Zengwei Luo, Wang Jianping*, Wang Yanyan*, Zhang Yonghui*. Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales). Scientific Reports, 2016, 6:18711.
22. Weiguang Sun#, Xintao Chen#,Qingyi Tong#, Hucheng Zhu#, Yan He, Liang Lei, Yongbo Xue,Guangmin Yao, Zengwei Luo, Jianping Wang, Hua Li ,Yonghui Zhang.Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune. Scientific Reports, 2016, 6:26418.
