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师资队伍
杰出人才
博士后

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罗增伟

来源:未知 发布时间 2015-09-18 08:29:00 点击数:

罗增伟,华中科技大学同济药学院讲师,博士。2002年-2007年就读于武汉大学化学与分子科学学院并获博学位。主要从事有机合成和药物化学相关方面研究,目前主持国家自然基金一项,参与多项国家级科研项目。

教育及工作经历:

1998.9~2002.7 南昌大学化学系获学士学位

2002.9~2007.12 武汉大学有机化学专业获博士学位

2008.1~2009.12 上海药明康德

2010.1~2012.12 华中科技大学同济药学院天然药物化学教研室/湖北省天然药物化学与资源评价重点室 博士后

2013.4至今 华中科技大学同济药学院天然药物化学教研室/湖北省天然药物化学与资源评价重点室 讲师

主持与参与的项目:

1. 国家自然科学基金《新型PTP1B抑制剂金线莲苷构效关系及降糖作用机制研究》,25万(No. 81102334,2012.01~2014.12),主持

2.国家重大新药创制专项课题《化药一类降血糖新药KD10临床前研究》500万,2011.1-2013.12,参与

3.武汉长联来福生化药业有限责任公司课题《新型PTP1B抑制剂Kinsenoside结构类似物一类新药研究》250万元,2010.1-2014.12,参与

4.国家自然科学基金《基于抑制Streptomyces 85E气生菌丝生成从照山白中寻找新颖蛋白激酶抑制剂先导化合物》,25万(No. 81001368, 2011.01~2013.12),参与

5.国家自然科学基金《黄芫花中抗肿瘤二萜活性成分及抑制肿瘤侵袭转移作用机制研究》,35万(No.31070311, 2011.01~2013.12),参与

发表的文章:

(1) Yuan, Ming; Chen, Li; Wang, Junwei; Chen, Shenjie; Wang, Kongchao; Xue, Yongbo; Yao, Guangmin;Luo, Zengwei*; Zhang, Yonghui*. Transition-Metal-Free Synthesis of Phenanthridinones from Biaryl-2-oxamic Acid under Radical Conditions.Organic Letters,2015, 17 (2), 346–349. (SCI, IF=6.328)

(2) Zengwei Luo,Bo Yang, Cheng Zhong, Fang Tang, Min Yuan, Yongbo Xue, Guanmin Yao, Jingwen Zhang*, Yonghui Zhang* . A dual-channel probe for selective fluoride determination and application in live cell imaging.Dyes and Pigments,2013, 97(1), 52 (SCI, IF = 3.532)

(3) Zengwei Luo#, Fuqian Wang#, Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao, Yongbo Xue, Yan Li, F. David Horgen, Guangmin Yao*, and Yonghui Zhang*. Cytotoxic Alkaloids from the Whole Plants ofZephyranthes candida,Journal of Natural Products,2012, 75(12), 2113 (SCI, IF = 3.285)

(4) Zengwei Luo,Baohua Li, Xiantao Fan, Kai Hu, Xiaojun Wu, Enqin Fu*.Novel chiral solvating agents derived from natural amino acid: enantiodiscrimination for chiral α-arylalkylamines,Tetrahedron Letters, 2007, 48, 1753

(5) Zengwei Luo,Cheng Zhong, Xiaojun Wu, Enqin Fu*.Novel amphiphilic chiral receptors as efficient chiral solvating agents for both lipophilic and hydrophilic Carboxylic Acid,Tetrahedron Letters, 2008, 49, 3385

(6) Yuanyuan Lu(#), Yongbo Xue(#)(*), Junjun Liu, Guangmin Yao, Dongyan Li, Bin, Sun, Jinwen Zhang, Yanfei Liu, Changxing Qi, Ming Xiang,Zengwei Luo, Guang Du(*), Yonghui Zhang(*), (±)-Acortatarinowins A–F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii.Journal of Natural Products,2015, DOI:10.1021/acs.jnatprod.5b00328. (IF 3.798)

(7) Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao,Zengwei Luo, and Yonghui Zhang(*), Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes.Angewandte Chemie-International Edition,2015, DOI: 10.1002/anie.201506264 and 10.1002/ange.201506264. (IF 11.261)

(8) Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xintao Chen, Jing Yang, Junjun Liu, Bin Sun, Jianping Wang, Guangmin Yao,Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*), Hyperisampsins H−M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii,Scientific Reports,2015, (Accepted). (IF 5.578)

(9) Liang Lei(#), Yong-bo Xue(#), Zhong Liu, Si-si Peng, Yan He, Yang Zhang, Rong Fang, Jian-ping Wang,Zeng-wei Luo, Guang-minYao, Jin-wen Zhang, Geng Zhang, Hong-ping Song(*), Yong-hui Zhang(*), Coumarin derivatives from Ainsliaea fragrans and their anticoagulant activity,Scientific Reports,2015, 5:13544. (IF 5.578)

(10) Yongji Lai, Tingting Liu, Rongjian Sa, Xialan Wei, Yongbo Xue, Zhaodi Wu,Zengwei Luo, Ming Xiang, Yonghui Zhang(*), and Guangmin Yao(*), Neolignans with a Rare 2-Oxaspiro[4.5]deca-6,9-dien-8-one Motif from the Stem Bark of Cinnamomum subavenium,Journal of Natural Products, 2015, 78(7): 1740–1744. (IF 3.798)

(11) Chunmei Chen, Jianping Wang, Junjun Liu, Hucheng Zhu, Bin Sun, Jing Wang, Jinwen Zhang,Zengwei Luo, Guangmin Yao, Yongbo Xue(*), and Yonghui Zhang(*), Armochaetoglobins A−J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare, Journal of Natural Products, 2015, 78: 1193−1201. (IF 3.798)

(12) Chunmei Chen, Hucheng Zhu, Jianping Wang, Jing Yang, Xiao-Nian Li, Jing Wang, Keliang Chen, Yanyan Wang,Zengwei Luo, Guangmin Yao, Yongbo Xue(*), and Yonghui Zhang(*), Armochaetoglobins K–R, Anti-HIV Pyrrole-based Cytochalasans from Chaetomium Globosum TW1-1,European Journal of Organic Chemistry, 2015: 3086–3094.

(13) Dongyan Li, Hucheng Zhu, Changxing Qi, Yongbo Xue(*), Guangmin Yao,Zengwei Luo, Jianping Wang, Jinwen Zhang, Guang Du(*), and Yonghui Zhang(*), Two New adamantyl-Like polyprenylated Acylphloroglucinols from Hypericum attenuatum Choisy, Tetrahedron Letters, 2015, 56: 1953–1955.

(14) Chunmei Chen(#), Hucheng Zhu(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao,Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*), Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived Fungus Chaetomium globosum,Organic Letters, 2015, 17(3): 644–647. (IF 6.364)

(15) Hucheng Zhu, Chunmei Chen., Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao,Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue(*), and Yonghui Zhang(*), Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii,Organic letters, 2014, 16(24): 6322–6325. (IF 6.364)

(16) Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue(*), Yingda Yang,Zengwei Luo, Guangmin Yao, and Yonghui Zhang(*), Colletotrichumine A, a novel indole-pyrazine alkaloid with an unprecedented C16N3-type skeleton from cultures of Colletotrichum capsici,Tetrahedron Letters, 2014, 55(44): 6093–6095.

(17) Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li,Zengwei Luo, Guangmin Yao(*), and Yonghui Zhang(*), Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia,Journal of Natural Products, 2014, 77(8): 1948–1954. (IF 3.798)

(18) Hucheng Zhu(#), Lijun Huan(#), Chunmei Chen, Jing Yang, Jiangbo He, Yong Chen, Guangmin Yao,Zengwei Luo,Yongbo Xue(*), and Yonghui Zhang(*), A Pair of Unprecedented Cyclohexylethanoid Enantiomers Containing Unusual Trioxabicyclo[4.2.1]nonane Ring from Clerodendrum bungei,Tetrahedron Letters, 2014, 55: 2277–2279.

(19) 25. Heng Zheng, Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Jinwen Zhang, Yongbo Xue,Zengwei Luo, Yan Li, Guangmin Yao(*), and Yonghui Zhang(*), Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei,Journal of Natural Products, 2013, 76: 2253–2262. (IF 3.798)

(20) Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue,Zengwei Luo, Qian Wan, Guangmin Yao(*), and Yonghui Zhang(*), Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum,Organic Letters, 2013, 15(12): 3094–3097. (IF 6.364)

华中科技大学同济医学院办公室 鄂ICO备030193 地址:湖北省武汉市汉口航空路13号 邮政编码:430030