郑梦竹，博士，华中科技大学生物药学系副教授。研究方向为糖尿病和癌症等疾病相关靶点的药物发现与机制研究。基于蛋白质晶体学和计算机虚拟筛选，从分子、细胞、动物水平研究化合物的活性和作用机制，目前已得到多个先导化合物。主持国家自然科学基金青年基金、湖北省自然科学基金面上项目、中国博士后科学基金面上项目和新冠肺炎疫情防控专项基金各一项。以第一/共同第一作者/共同通讯作者在Clinical and Translational Medicine、Acta Pharmaceutica Sinica B、Journal of Medicinal Chemistry、Pharmacological Research、Organic Letters、Chinese Chemical Letters、Organic Chemistry Frontiers、Food & Function、Journal of Agricultural and Food Chemistry、Bioorganic Chemistry等杂志发表研究性论文共计二十余篇。任湖北省晶体学会副秘书长，湖北省药理学会中药药理专业委员会副秘书长，中华中医药学会中药实验药理分会青年委员、中国康复医学会药学与康复专业委员会委员、《Acta Materia Medica》、《中国临床药学杂志》和《医药导报》青年编委。
联系方式
邮箱zheng_mengzhu@hust.edu.cn
地址：武汉市硚口区航空路13号同济医学院药学院2号楼4楼邮编430030
研究方向
1.基于糖尿病和癌症等重大疾病靶点的药物发现与机制研究
2.生物活性物质靶点的发现与确证研究
3.小分子靶向降解技术（PROTAC）
教育与工作经历
2024/3-至今，华中科技大学，药学院，副教授
2021/11-2024/2，华中科技大学，药学院，讲师
2018/7-2021/10，华中科技大学，博士后
2013/9-2018/6，华中科技大学，药理学，博士
2009/9-2013/6，中南民族大学，药物制剂，学士
主持科研项目
1.国家自然科学基金青年基金,项目批准号81903863, 2020-01至2022-12
2.中国博士后科学基金,新冠肺炎疫情防控专项, 2020T130039ZX, 2020-06至2021-06
3.中国博士后科学基金,面上项目, 2019M652661, 2019-06至2021-06
4.湖北省自然科学基金委员会,面上项目, 2022CFB171, 2022-10至2024-10
5.华中科技大学人才引进基金, 2021/11-2024/11, 15万元
参与编写书籍
1.作为数字编委编写《药理学实验教程》（十三五规划教材，中国医药科技出版社）
2.作为编委编写《微生物天然药物化学研究》（交叉学科研究生高水平课程系列教材，华中科技大学出版社）
3. Zheng M, Chen L*, Li H*. In Silico Drug Design-Chapter 17 -In Silico Modeling of FDA-Approved Drugs for Discovery of Anticancer Agents: A Drug-Repurposing Approach, Elsevier, 2019.2
主要学术论文(#Co-first author,*Correspondence author)
1.Zheng M#, Zhang Q#, Zhang C#, Wu C, Yang K, Song Z, Wang Q, Li C, Zhou Y, Chen J*, Li H*, Chen L*. A natural DYRK1A inhibitor as a potential stimulator for β-cell proliferation in diabetes.Clinical and Translational Medicine. 2021;11(7):e494.
2.Zheng M#, Huo J#, Gu X#, Wang Y, Wu C, Zhang Q, Wang W, Liu Y, Liu Y, Zhou X, Chen L*, Zhou Y*, Li H*. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP.Journal of Medicinal Chemistry. 2021;64(11):7839-7852.
3.Zheng M#, Liu Y#, Wu C#, Yang K, Wang Q, Zhou Y*, Chen L*, Li H*. Novel PROTACs for degradation of SHP2 protein.Bioorganic Chemistry. 2021, 110:104788.
4.Zheng M#, Wu C#, Yang K, Yang Y, Liu Y, Gao S, Wang Q, Li C, Chen L*, Li H*. Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis.Pharmacological Research. 2021, 164:105367.
5. Wu C#, Liu Y#, Yang Y#, Zhang P, Zhong W, Wang Y, Wang Q, Xu Y, Li M, Li X*,Zheng M*, Chen L*, Li H*. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods.Acta Pharmaceutica Sinica B. 2020, 10(5):766-788.ESI热点论文和高被引论文
6. Liu G#,Zheng M#, Tian R, Zhou Y*. Site-Selective Synthesis of Antitumor C5 Aminated Indoles via Neighboring Aldehyde Group Assisted Catellani Reaction.Organic Letters. 2023;25(51):9231-9236
7. Liu Y#,Zheng M#, Ma Z#, Zhou Y, Huo J, Zhang W, Liu Y, Guo Y, Zhou X, Li H*, Chen L*. Design, synthesis, and evaluation of PD-L1 degraders to enhance T cell killing activity against melanoma.Chinese Chemical Letters. 2023, 34:107762.
8. Liang J#,Zheng M#, Xu W#, Chen Y#, Tang P, Wu G, Zou P, Li H*, Chen L*. Acriflavine and proflavine hemisulfate as potential antivirals by targeting Mpro.Bioorganic Chemistry. 2022, 129:106185.
9. Yang Y#,Zheng M#, Han F#, Shang L#, Li M, Gu X, Li H*, Chen L*. Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming.Journal of Molecular Medicine. 2022, 100(4):599-612.
10. Zhou X#,Zheng M#, Zhao N#, Hu Y, Yang K, Huo J, Liu G, Huang J, Chen L*, Zhou Y*, Li H*. Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction.Bioorganic Chemistry. 2022, 119:105569.
11. Wang Y#,Zheng M#, Jiang Q#, Xu Y, Zhou X, Zhang N, Sun D*, Li H*, Chen L*. Chemical Components of the Fruits of Morus nigra Linn.: Methyl Caffeate as a Potential Anticancer Agent by Targeting 3-Phosphoglycerate Dehydrogenase.Journal of Agricultural and Food Chemistry. 2021;69(42):12433-12444.
12. Wu C#,Zheng M#, Yang Y#, Gu X, Yang K, Li M, Liu Y, Zhang Q, Zhang P, Wang Y, Wang Q, Xu Y, Zhou Y, Zhang Y, Chen L*, Li H*. Furin: A Potential Therapeutic Target for COVID-19.iScience. 2020, 23(10):101642.
13. Sun W#, Wu Y#,Zheng M#, Yang Y, Liu Y, Wu C, Zhou Y, Zhang Y*, Chen L*, Li H*. Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor.Journal of Medicinal Chemistry. 2020, 63(15):8146-8156.
14. Hu B#, Liu Y#,Zheng M#, Zhang R, Li M, Bao F, Li H*, Chen L*. Triterpenoids from Anchusa italica and their protective effects on hypoxia/reoxygenation induced cardiomyocytes injury.Bioorganic Chemistry. 2020, 97:103714.
15. Liu Y, Li M, Zhang Y, Wu C, Yang K, Gao S,Zheng M*, Li X*, Li H*, Chen L*. Structure based discovery of novel hexokinase 2 inhibitors.Bioorganic Chemistry. 2020, 96:103609.
16.Zheng M#, Guo J#, Xu J#, Yang K, Tang R, Gu X, Li H*, Chen L*. Ixocarpalactone A from dietary tomatillo inhibits pancreatic cancer growth by targeting PHGDH.Food & Function. 2019, 10(6):3386-3395.
17. Wang Q, Zhang Q, Luan S, Yang K,Zheng M*, Li K*, Chen L*, Li H*. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1.Bioorganic Chemistry. 2019, 93:103315.
18. Yang K#, Wu C#,Zheng M#, Tang R, Li X, Chen L*, Li H*. Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminase.Bioorganic Chemistry. 2019, 92:103186.
19. Guo J#, Gu X#,Zheng M#, Zhang Y*, Chen L*, Li H*. Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.Bioorganic Chemistry. 2019, 87:16-22.
20.Zheng M#, Tang R#, Deng Y, Yang K, Chen L*, Li H*. Steroids from Ganoderma sinense as new natural inhibitors of cancer-associated mutant IDH1.Bioorganic Chemistry. 2018, 79:89-97.
21.Wang J#,Zheng M#, Min Q#, Gao Y*, Sun W*. The dual regulatory function of lienal peptide on immune system.International Immunopharmacology. 2018, 55:245-253.
22. He Y#,Zheng M#, Li Q#,Hu Z, Zhu H, Liu J, Wang J, Xue Y*, Li H*, Zhang Y*. Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1.Organic Chemistry Frontiers, 2017, 4:1137-1144.
