聂秋玥，华中科技大学教授，博士生导师，入选国家级青年人才项目。中国地质大学（武汉）材料化学及武汉大学药学（辅修）双学士学位；于中国科学院上海有机化学研究所获得博士学位。先后在美国莱斯大学和宾夕法尼亚大学进行博士后研究。以第一作者或通讯作者身份在领域内Nat.Chem.Biol.,J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,ACS Catal.等国际权威期刊发表论文10余篇。
联系方式
邮箱：nieqy@hust.edu.cn
地址：湖北省武汉市硚口区航空路13号（邮编430030）
华中科技大学同济医学院转化医学大楼1310室
研究方向
1）微生物来源新型活性天然产物的基因组挖掘
2）微生物来源天然产物的生物合成与酶学机制研究
发表论文（*：通讯作者，#：共同第一作者）
1.Qiu-Yue Nie#; Shi-Qi Fang#; Lian Wu#; Ruo-Qin Gao; Yu Hu; Dian Ding; Hai-Xue Pan; Zeng-Fei Pei; Jun-Bin He; Qiang Zhou; Zi-Hui Chen; Xian-Feng Hou; Xin-Qing Zhao; Gong-Li Tang*; Targeted Discovery and Characterization of Type-II PKS-NRPS Hybrid DNA-Alkylating Antibiotics, Angewandte Chemie-international Edition, 2025, 64(39).
2.Qiuyue Nie; Fanglong Zhao; Xuerong Yu; Mithun C. Madhusudhanan; Caleb Chang; Siting Li;Sandipan Roy Chowdhury; Bryce Kille; Andy Xu; Rory Sharkey; Chunxiao Sun; Hongzhi Zeng; ShuaiLiu; Dishu Zhou; Xin Yu; Kevin Yang; Sandra A. C. Figueiredo; Maria Zotova; Zichen Hu; Alan Y.Du; Dongyin Guan; Rui Tang; Todd Treangen; Jin Wang; Pedro N. Leão; Yang Gao; Junjie Chen; PengLiu; Hans Renata; Xue Gao*; A class of benzofuranoindoline-bearing heptacyclic fungal RiPPs withanticancer activities, Nature Chemical Biology, 2025, 21(12): 1938-1947.
3.Qiuyue Nie; Chunxiao Sun; Shuai Liu; Qiang Li; Maria Zotova; Tong Zhu; Xue Gao*; EnzymaticRing Contraction for the Biosynthesis of Sulfur-Containing Cyclopentachromone, Journal of theAmerican Chemical Society, 2025, 47(1): 548-556.
4.Yu Hu#; Shu-Ya Peng#;Xueyang Ma#; Hongwei Chen#;Qiu‐Yue Nie; Jun‐Bin He; Qianqian Chen;Qiang Zhou; Xin‐Hua Lu; Qiang Hua; Donghui Yang; Yong Liang*; Ming Ma*; Gong‐Li Tang*; FunctionalCharacterization and Molecular Basis of a Multi‐Site Halogenase in Naphthacemycin Biosynthesis,Angewandte Chemie International Edition, 2025, 64: e202418843.
5.Qiuyue Nie; Chunxiao Sun; Shuai Liu; Xue Gao*; Exploring Bioactive Fungal RiPPs:Advances, Challenges, and Future Prospects, Biochemistry, 2024, 63: 2948-2957.
6.Jia-Liang Zhou;Qiu-Yue Nie; Xian-Feng Hou; Kuan Zheng; Ran Hong; Gong-Li Tang*;Multienzyme Cascade Catalyzed Skeleton Rearrangement in a Caged Polyketide Biosynthesis, OrganicLetter, 2024, 27: 375-380.
7.Shuai Liu#;Qiuyue Nie#; Zhiwen Liu; Siddhant Patil; Xue Gao*; Fungal P450 Deconstructs the2,5-Diazabicyclo[2.2.2]octane Ring En Route to the Complete Biosynthesis of 21R-Citrinadin A,Journal of the American Chemical Society, 2023, 145(26),
Zhiwen Liu#; Sebastian Rivera#; Sean A. Newmister#; Jacob N. Sanders#;Qiuyue Nie; Shuai Liu;Fanglong Zhao; Joseph D. Ferrara; Hao-Wei Shih; Siddhant Patil; Weijun Xu; Mitchell D. Miller;George N. Phillips; K. N. Houk; David H. Sherman*; Xue Gao*; An NmrA-like enzyme-catalysed redoxmediated Diels–Alder cycloaddition with anti-selectivity, Nature Chemistry, 2023, 15: 524-534.
8.Fanglong Zhao#; Chunxiao Sun#; Zhiwen Liu; Alan Cabrera; Mario Escobar; Shunyu Huang;Qichen Yuan;Qiuyue Nie; Kevin Lee Luo; Angela Lin; Jeffrey A. Vanegas; Tong Zhu; Isaac B.Hilton; Xue Gao*; Multiplex Base-Editing Enables Combinatorial Epigenetic Regulation for GenomeMining of Fungal Natural Products, Journal of the American Chemical Society, 2022, 145: 413-421.
9.Qiuyue Nie; Shuqi Guo; Xue Gao*; Unraveling the biosynthesis of penicillenols by genomemining polyketide synthase and nonribosomal peptide synthetase gene clusters in Penicilliumcitrinum, AIChE Journal, 2022, 68(11): e17885.
10.Yu-Hang Gao;Qiu-Yue Nie*; Yu Hu; Xinhua Lu; Wensheng Xiang; Xiangjing Wang; Gong-Li Tang*; Discovery of glycosylated naphthacemycins and elucidation of the glycosylation, Biochemical andBiophysical Research Communications, 2022, 622: 122-128.
11.Qiu-Yue Nie; Yu Hu; Xian-Feng Hou; Gong-Li Tang*; Biosynthesis of DNA-AlkylatingAntitumor Natural Products, Molecules, 2022, 27: 6387.
12.Qiu-Yue Nie; Zhen-Yu Ji; Yu Hu; Gong-Li Tang*; Characterization of Highly ReductiveModification of Tetracycline D-Ring Reveals Enzymatic Conversion of Enone to Alkane, ACSCatalysis, 2021, 11(14),
13.Qiuyue Nie; Zhenyu Ji; Gongli Tang*; Discovery of a Novel Spiro-Naphthoquinone Compoundin Streptomyces aureus SP-371, Chinese Journal of Organic Chemistry, 2020, 40: 3467-3470.
14.Zhen-Yu Ji#;Qiu-Yue Nie#; Yue Yin; Mei Zhang; Hai-Xue Pan; Xian-Feng Hou; Gong-Li Tang*; Activation and Characterization of Cryptic Gene Cluster: Two Series of Aromatic Polyketides Biosynthesized by Divergent Pathways, Angewandte Chemie International Edition, 2019, 58(50): 18046-18054.
