曾静,男,湖北利川人,博士,教授,主要从事糖化学和糖药物方面的研究。近年来先后主持国家自然科学基金青年及面上等多项科研项目,在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Letter, Science China Chem., Org. Chem. Front.等国际权威期刊发表论文四十余篇。目前的研究兴趣集中于结构特异稀有糖的合成和生物学功能探索:以稀有糖类抗菌和抗肿瘤药物的发现为目标,开发化学合成新方法和新策略,解决结构特异稀有糖的获取难题,实现含有这类糖结构的复杂天然产物的全合成及结构修饰,并进行活性筛选和构效关系研究,阐释结构特异稀有糖的生物学功能。
联系方式
电子信箱: zengjing0052@hust.edu.cn
研究团队主页:http://sugar.pharm.hust.edu.cn/
地址:武汉市航空路13号华中科技大学同济医学院药学院430030
办公室:药学院3号楼406
研究兴趣
糖化学及糖药物,天然产物及药物合成.
工作经历
2018-至今教授,华中科技大学同济药学院
2014-2018副教授,华中科技大学同济药学院
2013-2014 研究助理,新加坡南洋理工大学化学与生物化学系
2008-2009 项目助理,新加坡南洋理工大学化学与生物化学系
2007-2008 上海开拓者化学
教育背景
2009-2013博士,新加坡南洋理工大学化学与生物化学系
2004-2007 硕士,厦门大学化学化工学院
2000-2004学士,东南大学化学化工学院
主持项目
2021.01-2024.12国家自然科学基金面上项目, No. 22077039
2018.01-2021.12国家自然科学基金面上项目, No. 21772050
2016.01-2018.12华中科技大学自主创新基金
2015.06-2017.06教育部第50批“留学回国科研启动基金”
2015.01-2017.12国家自然科学基金青年基金, No. 21402055
2014.01-2015.12华中科技大学自主创新基金
2013.12-2016.12华中科技大学人才引进基金
文章发表(一作及通讯):
1. Fu D.; Liao Z.;Zeng J.*;Wan Q.* Advances in Research on Synthesis and Glycomodification Based on Antitumor Activity Screening of Digitoxin.Prog Pharm Sci(药学进展),2020,44, 501
2.Zeng J.*; Wang R.; Zhang S.; Fang J.; Liu S.; Sun G.; Xu B.; Xiao Y.; Fu D.; Zhang W.; Hu Y.; Wan Q.* Hydrogen-Bonding-Assisted Exogenous Nucleophilic Reagent Effect for β-Selective Glycosylation of Rare 3-Amino Sugars.J. Am. Chem. Soc.2019,141, 8509-8515。
lHighlighted by研之成理.
lHighlighted byCBG资讯
3.Zeng J.*; Wang R.; Yao W.; Zhang S.; Sun G.; Liao Z.; Meng L.; Wan Q.* Diversified synthesis anda-selective glycosylation of 3-amino-2,3,6-trideoxy sugars.Org. Chem. Front.2018,5, 3391-3395.
4.Zeng J.; Liu Y.; Chen W.; Zhao X.; Meng L.; Wan Q.* Glycosyl Sulfoxides in Glycosylation Reactions.Top. Curr. Chem.2018,376, 27-58。
5. Liu Y.#;Zeng J.#; Sun J.; Cai L.; Zhao Y.; Fang J.; Hu B.; Shu P.; Meng L.; Wan Q.* 1,4-Dithiothreitol Mediated Cleavage of the Acetal and Ketal Type of Diol Protecting Groups.Org. Chem. Front.2018, 5, 2427-2431.
6.Zeng J.;* Sun G.; Wang R.; Zhang S.; Teng S.; Liao Z.; Meng L.; Wan Q.* Gold-catalyzed Diversified Synthesis of 3-Aminosugar Analogues of Digitoxin and Digoxin.Org. Chem. Front.2017,4, 2450(invited in a themed collection: Synthetic Approaches to Natural Products via Catalytic Processes)
lOrganic Chemistry Frontiers HOT article for 2017
7.Zeng J.;* Sun G.; Yao W.; Zhu Y.; Wang, R.; Cai, L.; Liu, K.; Zhang Q.; Liu, X.-W.; Wan, Q.* 3-Amino-deoxypyranoses in Glycosylation: Diversified Synthesis and Assembly in Oligosaccharides.Angew. Chem. Int. Ed.2017,56, 5227.
lSelected as front cover paper:Angew. Chem. Int. Ed.2017,56, 5133
lHighlighted byWiley Advanced Science News China(ASNChina):2017.04.05.
lHighlighted byChemistryViews:2017.04.14.
lHighlighted byWiley Advanced Science News(Chemviews):2017.04.18.
l《有机化学》“亮点介绍”Chin. J. Org. Chem.2017,37,1585
lHighlighted byX-Mol:
l阿达玛斯学术论文优秀奖
8.Zeng J.; Xu Y.; Wang, H.; Meng L.; Wan Q.* Recent Progress on the Synthesis of 2-Deoxy Glycosides.Sci. China Chem.,2017,60, 1162. (invited review)
lHighlighted byScience Trends:
https://sciencetrends.com/recent-progress-synthesis-2-deoxyglycosides/
9.Zeng,J.#; Ma, J.#; Xiang, S.; Cai, S.; Liu,X.-W.*Stereoselectiveβ-C-Glycosylation via Palladium-Catalyzed Decarboxylative Allylation: Formal Synthesis of Aspergillide A.Angew. Chem. Int. Ed.,2013,52, 5134. (IF:11.709) (Highlight in Synfacts2013,8, 870)
10.Zeng, J.; Tan, Y. J.;Leow M. L.;Tirtorahardjo, D.; Liu, X. -W.* Facile Access toCis-2,6-Disubstituted DdihydrapyranesviaPalladium Catalyzed Intramolecular Decarboxylative Allylation: Total Syntheses of (±)-Centrolobine, (+)-Decytospolide A and B.Chem. Eur. J.2014,20, 405.(IF:5.771)
11.Zeng, J.; Zhang, Q.; Zhang, H. K.*; Chen, A.*Synthesis of trans-Dihydroxybutyrolactols as Efficient 4C Building Blocks: Application to the Synthesis of Polyhydroxylated Alkaloids.RSC, Advances,2013,3, 20298. (IF: 3.840)
12.Zeng, J.;Tan, Y.J.; Leow, M. L.; Liu, X. -W.* Copper(II)/Iron(III) Co-catalyzed Intermolecular Diamination of Alkynes: Facile Synthesis of Imidazopyridines.Org. Lett.2012,14, 4386. (IF: 6.364) (Highlight in Synfacts2012,8,1300.)
13.Zeng,J.; Bai, Y. G.; Ma, J. M.; Cai, S. T.; Liu, X.-W.*, Direct Synthesis of Pyrroles via A Silver Promoted Three-component Reaction Involving an Unsual Imidazole Ring Opening.Chem. Commun.2011,47, 12855.(IF:6.834)
14.Zeng,J.; Vedachalam, S.; Xiang, S. H., Liu, X. -W.*,DirectC-Glycosylation by Coupling of Organotrifluoroborates with Glycosyl Flouorides and Iits Application to The Total Synthesis of (+)-Varitriol.Org. Lett.2011,13, 42. (IF: 6. 6.732) (Highlighted in Organic Chemistry Portal, 2012, http://www.organic-chemistry.org/Highlights/2012/16January.shtm).
专利
2.万谦,舒朋华,曾静,赵岳琦,“一种糖基硫醇及金诺芬的合成方法”;中国发明专利,专利号:ZL 2014 1 0459125.0。
1.张洪奎,曾静,“光学活性2,3-二羟基丁内半缩醛衍生物的制备方法”;中国发明专利,公开号:CN 101130529A.
会议报告
7. 2020全国糖生物学会议,无锡,2020.09.19
6.第二届糖复合物研究网络学术大会,2020.06.18
5.中国化学会第三届全国糖化学会议,保定,2019.09.21
4. 2019年全国糖生物工程会议,青岛,2019.05.11
3.第一届糖科学青年论坛,苏州,2018.05.27.
2.Tongji-Marburg Summit Forum on Pharmaceuticals.武汉. 2017.05.21.
1.第二届糖合成化学青年学术研讨会,山东大学,济南. 2017.05.14.